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Genomes and GenesSpecies | Maria Carla BoscoSummaryCountry: Italy Publications
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Publications
Hypoxia modifies the transcriptome of primary human monocytes: modulation of novel immune-related genes and identification of CC-chemokine ligand 20 as a new hypoxia-inducible geneMaria Carla Bosco
Laboratory of Molecular Biology, G Gaslini Institute, Genova, Italy
J Immunol 177:1941-55. 2006..CCL20 up-regulation by hypoxia may constitute an important mechanism to promote recruitment of specific leukocyte subsets at pathological sites and may have implications for the pathogenesis of chronic inflammatory diseases...- Monocytes and dendritic cells in a hypoxic environment: Spotlights on chemotaxis and migrationMaria Carla Bosco
Laboratory of Molecular Biology, Giannina Gaslini Institute, L go G Gaslini 5, 16147 Genova Quarto, Italy
Immunobiology 213:733-49. 2008.... - Hypoxic synovial environment and expression of macrophage inflammatory protein 3gamma/CCL20 in juvenile idiopathic arthritisMaria Carla Bosco
G Gaslini Institute, Genoa, Italy
Arthritis Rheum 58:1833-8. 2008.... - Macrophage activating properties of the tryptophan catabolite picolinic acidMaria Carla Bosco
Laboratory of Molecular Biology, G Gaslini Institute, 16147 Genova, Italy
Adv Exp Med Biol 527:55-65. 2003.... - Hypoxia inhibits the expression of the CCR5 chemokine receptor in macrophagesMaria Carla Bosco
Laboratory of Molecular Biology, G Gaslini Institute, 16147 Genova, Italy
Cell Immunol 228:1-7. 2004..CCR5 inhibition may be a way to retain/concentrate recruited macrophages at hypoxic sites or a feedback mechanism to control the autocrine activation of macrophages which produce CCR5 ligands... - Hypoxia selectively inhibits monocyte chemoattractant protein-1 production by macrophagesMaria Carla Bosco
Laboratory of Molecular Biology, G Gaslini Institute, Genova, Italy
J Immunol 172:1681-90. 2004..Inhibition of MCP-1 may represent a negative regulatory mechanism to control macrophage-mediated leukocyte recruitment in pathological tissues... - Hypoxia modulates the gene expression profile of immunoregulatory receptors in human mature dendritic cells: identification of TREM-1 as a novel hypoxic marker in vitro and in vivoMaria Carla Bosco
Laboratory of Molecular Biology, G Gaslini Institute, Genova, Italy
Blood 117:2625-39. 2011.... - The hypoxic synovial environment regulates expression of vascular endothelial growth factor and osteopontin in juvenile idiopathic arthritisMaria Carla Bosco
Laboratory of Molecular Biology, Department of Pediatrics, G Gaslini Institute, Genova, Italy
J Rheumatol 36:1318-29. 2009..We characterized the contribution of the local hypoxic environment to VEGF and OPN production by monocytic cells recruited to the synovium in JIA... - Antagonistic effect of picolinic acid and interferon-gamma on macrophage inflammatory protein-1alpha/beta productionAnnamaria Rapisarda
Laboratory of Molecular Biology, G. Gaslini Institute, 16147, Genoa, Italy
Cell Immunol 220:70-80. 2002..The antagonistic effect of PA and IFN-gamma on MIPs production may be important for the regulation of the inflammatory responses in vivo... - Induction of apoptosis by flavopiridol in human neuroblastoma cells is enhanced under hypoxia and associated with N-myc proto-oncogene down-regulationMaura Puppo
Laboratory of Molecular Biology, Giannina Gaslini Institute, Genoa, Italy
Clin Cancer Res 10:8704-19. 2004..CONCLUSIONS: These results indicate that flavopiridol has growth-inhibitory and apoptotic activity against advanced-stage neuroblastomas in vitro and is worthy of further investigation for the treatment of this disease... - Topotecan inhibits vascular endothelial growth factor production and angiogenic activity induced by hypoxia in human neuroblastoma by targeting hypoxia-inducible factor-1alpha and -2alphaMaura Puppo
Laboratory of Molecular Biology, G Gaslini Institute, L go Gerolamo Gaslini 5, 16147 Genova Quarto, Italy
Mol Cancer Ther 7:1974-84. 2008..An important clinical implication of these findings is that therapies targeted to the HIF pathway have the potential to inhibit neuroblastoma angiogenesis and growth... - Hypoxia transcriptionally induces macrophage-inflammatory protein-3alpha/CCL-20 in primary human mononuclear phagocytes through nuclear factor (NF)-kappaBFlorinda Battaglia
Laboratory of Molecular Biology, Istituto Giannina Gaslini, Padiglione 2, Largo Gerolamo Gaslini 5, Genoa Quarto, Italy
J Leukoc Biol 83:648-62. 2008.... - Macrophage-inflammatory protein-3alpha/CCL-20 is transcriptionally induced by the iron chelator desferrioxamine in human mononuclear phagocytes through nuclear factor (NF)-kappaBLuigi Varesio
Laboratory of Molecular Biology, G Gaslini Institute, 16147 Genova, Italy
Mol Immunol 47:685-93. 2010..These results add new insights into our understanding of the mechanisms by which iron perturbations affect mononuclear phagocyte immune functions and regulate inflammatory responses... - Hypoxia inhibits Moloney murine leukemia virus expression in activated macrophagesMaura Puppo
Laboratory of Molecular Biology, Istituto Giannina Gaslini, Padiglione 2, L go Gerolamo Gaslini 5, 16147 Genova Quarto, Italy
J Leukoc Biol 81:528-38. 2007.... - Flavopiridol inhibits vascular endothelial growth factor production induced by hypoxia or picolinic acid in human neuroblastomaAnnamaria Rapella
Laboratory of Molecular Biology, G. Gaslini Institute, Genoa, Italy
Int J Cancer 99:658-64. 2002..Our findings demonstrate that PA can modulate angiogenic factor production by tumor cells and establish the importance of Flp as an inhibitor of VEGF production by human NB... - The tumor suppressor hamartin enhances Dbl protein transforming activity through interaction with ezrinMarzia Ognibene
Laboratorio di Biologia Molecolare, Istituto G Gaslini, Genova, Italy
J Biol Chem 286:29973-83. 2011..These results suggest that Dbl is regulated by hamartin through association with ezrin... - Treatment of newborn G6pc(-/-) mice with bone marrow-derived myelomonocytes induces liver repairRoberta Resaz
Laboratory of Molecular Biology, G Gaslini Institute, Genova, Italy
J Hepatol 55:1263-71. 2011..We sought to determine whether bone marrow-derived myelomonocytic cells could be effective for liver reconstitution in newborn mice knock-out for glucose-6-phosphatase-?...