Silvio Aprile

Summary

Country: Italy

Publications

  1. ncbi Identification of the human UDP-glucuronosyltransferases involved in the glucuronidation of combretastatin A-4
    Silvio Aprile
    Dipartimento di Scienze Chimiche, Alimentari, Farmaceutiche e Farmacologiche and Drug and Food Biotechnology Center, Universita degli Studi del Piemonte Orientale A Avogadro, 28100 Novara, Italy
    Drug Metab Dispos 38:1141-6. 2010
  2. ncbi In vitro metabolism study of 2-isopropyl-9H-thioxanthen-9-one (2-ITX) in rat and human: evidence for the formation of an epoxide metabolite
    Silvio Aprile
    Dipartimento di Scienze Chimiche, Alimentari, Farmaceutiche e Farmacologiche and Drug and Food Biotechnology Center, Universita degli Studi del Piemonte Orientale A Avogadro, Largo Donegani 2, 28100 Novara, Italy
    Xenobiotica 41:212-25. 2011
  3. ncbi Development and validation of a stability-indicating HPLC-UV method for the determination of alizapride and its degradation products
    Ilaria Tamaro
    Dipartimento di Scienze Chimiche, Alimentari, Farmaceutiche e Farmacologiche and Drug and Food Biotechnology Center, Universita degli Studi del Piemonte Orientale Amedeo Avogadro, Via Bovio 6, 28100 Novara, Italy
    J Pharm Biomed Anal 51:1024-31. 2010
  4. ncbi In vitro metabolism study of combretastatin A-4 in rat and human liver microsomes
    Silvio Aprile
    Dipartimento di Scienze Chimiche, Alimentari, Farmaceutiche e Farmacologiche and Drug and Food Biotechnology Center, Universita degli Studi del Piemonte Orientale A Avogadro, Largo Donegani 2, 28100, Novara, Italy
    Drug Metab Dispos 35:2252-61. 2007
  5. ncbi Regioselective Suzuki coupling of dihaloheteroaromatic compounds as a rapid strategy to synthesize potent rigid combretastatin analogues
    Sewan Theeramunkong
    Dipartimento di Scienze Chimiche, Alimentari, Farmaceutiche e Farmacologiche, Universita degli Studi del Piemonte Orientale A Avogadro, Via Bovio 6, 28100 Novara, Italy
    J Med Chem 54:4977-86. 2011

Collaborators

Detail Information

Publications5

  1. ncbi Identification of the human UDP-glucuronosyltransferases involved in the glucuronidation of combretastatin A-4
    Silvio Aprile
    Dipartimento di Scienze Chimiche, Alimentari, Farmaceutiche e Farmacologiche and Drug and Food Biotechnology Center, Universita degli Studi del Piemonte Orientale A Avogadro, 28100 Novara, Italy
    Drug Metab Dispos 38:1141-6. 2010
    ..Finally, experiments conducted to inhibit the glucuronosyltransferase activity in the human liver microsomes assay showed that phenylbutazone, trifluoperazine, propofol, and 1-naphthol effectively inhibited CA-4 glucuronidation...
  2. ncbi In vitro metabolism study of 2-isopropyl-9H-thioxanthen-9-one (2-ITX) in rat and human: evidence for the formation of an epoxide metabolite
    Silvio Aprile
    Dipartimento di Scienze Chimiche, Alimentari, Farmaceutiche e Farmacologiche and Drug and Food Biotechnology Center, Universita degli Studi del Piemonte Orientale A Avogadro, Largo Donegani 2, 28100 Novara, Italy
    Xenobiotica 41:212-25. 2011
    ..5. On the basis of these data, we propose that the metabolite 6 could be included in toxicological studies of 2-ITX...
  3. ncbi Development and validation of a stability-indicating HPLC-UV method for the determination of alizapride and its degradation products
    Ilaria Tamaro
    Dipartimento di Scienze Chimiche, Alimentari, Farmaceutiche e Farmacologiche and Drug and Food Biotechnology Center, Universita degli Studi del Piemonte Orientale Amedeo Avogadro, Via Bovio 6, 28100 Novara, Italy
    J Pharm Biomed Anal 51:1024-31. 2010
    ..The robustness was also evaluated by variations of mobile phase composition and pH. Finally, the applicability of the method was evaluated in commercial dosage form analysis as well as in stability studies...
  4. ncbi In vitro metabolism study of combretastatin A-4 in rat and human liver microsomes
    Silvio Aprile
    Dipartimento di Scienze Chimiche, Alimentari, Farmaceutiche e Farmacologiche and Drug and Food Biotechnology Center, Universita degli Studi del Piemonte Orientale A Avogadro, Largo Donegani 2, 28100, Novara, Italy
    Drug Metab Dispos 35:2252-61. 2007
    ..Metabolites M4 and M5, arising from O-demethylation of phenyl ring B, did not form the ortho-quinones. O-Demethylation of phenyl ring A formed the metabolite M3 with a complete isomerization of the stilbenic double bond...
  5. ncbi Regioselective Suzuki coupling of dihaloheteroaromatic compounds as a rapid strategy to synthesize potent rigid combretastatin analogues
    Sewan Theeramunkong
    Dipartimento di Scienze Chimiche, Alimentari, Farmaceutiche e Farmacologiche, Universita degli Studi del Piemonte Orientale A Avogadro, Via Bovio 6, 28100 Novara, Italy
    J Med Chem 54:4977-86. 2011
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