Research Topics
Genomes and GenesSpecies | Yoav GiladSummaryAffiliation: Weizmann Institute of Science Country: Israel Publications
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Detail Information
Publications
Evidence for positive selection and population structure at the human MAO-A geneYoav Gilad
Department of Molecular Genetics and the Crown Human Genome Center, The Weizmann Institute of Science, Rehovot 76100, Israel
Proc Natl Acad Sci U S A 99:862-7. 2002....- Population differences in the human functional olfactory repertoireYoav Gilad
Department of Molecular Genetics and the Crown Human Genome Center, The Weizmann Institute of Science, Rehovot, Israel
Mol Biol Evol 20:307-14. 2003..Our observations are unlikely to be accounted for by simple demographic models but may be explained by positive selection acting on OR loci in Caucasians... - Different noses for different peopleIdan Menashe
Department of Molecular Genetics and the Crown Human Genome Center, The Weizmann Institute of Science, Rehovot 76100, Israel
Nat Genet 34:143-4. 2003..The results show an unprecedented prevalence of segregating pseudogenes, identifying one of the most pronounced cases of functional population diversity in the human genome... - A framework for exploring functional variability in olfactory receptor genesOrna Man
Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
PLoS ONE 2:e682. 2007..However, the assumption that overall protein sequence diversity is a good proxy for functional properties is untested... - Population differences in haplotype structure within a human olfactory receptor gene clusterIdan Menashe
Department of Molecular Genetics and the Crown Human Genome Center, The Weizmann Institute of Science, Rehovot 76100, Israel
Hum Mol Genet 11:1381-90. 2002..Our data suggests that OR genes may have evolved to create different functional repertoires in distinct human populations... - Prediction of the odorant binding site of olfactory receptor proteins by human-mouse comparisonsOrna Man
Department of Molecular Genetics and the Crown Human Genome Center, The Weizmann Institute of Science, Rehovot 76100, Israel
Protein Sci 13:240-54. 2004..This conclusion is supported by the observation that all but one of the predicted binding site residues correspond to ligand-contact positions in other rhodopsin-like GPCRs... - Human specific loss of olfactory receptor genesYoav Gilad
Max Planck Institute for Evolutionary Anthropology, Inselstrasse 22, Leipzig D 04103, Germany
Proc Natl Acad Sci U S A 100:3324-7. 2003..As a consequence, the fraction of OR pseudogenes in humans is almost twice as high as in the non-human primates, suggesting a human-specific process of OR gene disruption, likely due to a reduced chemosensory dependence relative to apes... - Absence of the TAP2 human recombination hotspot in chimpanzeesSusan E Ptak
Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
PLoS Biol 2:e155. 2004.... - Using reporter gene assays to identify cis regulatory differences between humans and chimpanzeesAdrien Chabot
Department of Human Genetics, University of Chicago, 920 E 58th Street, Chicago, IL 60637, USA
Genetics 176:2069-76. 2007..High-throughput application of this approach can provide a map of regulatory element differences between humans and our close evolutionary relatives... - Characterizing the expression of the human olfactory receptor gene family using a novel DNA microarrayXiaohong Zhang
Department of Biological Sciences, Columbia University, New York, NY 10027, USA
Genome Biol 8:R86. 2007..To rectify this, we have developed a DNA microarray that contains probes for most predicted human OR loci and used that array to examine OR gene expression profiles in olfactory epithelium tissues from three individuals... - Expression profiling in primates reveals a rapid evolution of human transcription factorsYoav Gilad
Department of Genetics, Yale University, New Haven, Connecticut 06510, USA
Nature 440:242-5. 2006..Among the gene set with a human-specific increase in expression, there is an excess of transcription factors; the same is not true for genes with increased expression in chimpanzee... - A comparison of the human and chimpanzee olfactory receptor gene repertoiresYoav Gilad
Yale University School of Medicine, Department of Genetics, New Haven, Connecticut 06520, USA
Genome Res 15:224-30. 2005..Thus, although overall there is relaxed constraint on human olfaction relative to chimpanzee, species-specific sensory requirements appear to have shaped the evolution of the functional OR gene repertoires in both species... - Loss of olfactory receptor genes coincides with the acquisition of full trichromatic vision in primatesYoav Gilad
Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
PLoS Biol 2:E5. 2004..Our findings suggest that the deterioration of the olfactory repertoire occurred concomitant with the acquisition of full trichromatic color vision in primates... - Natural selection on the olfactory receptor gene family in humans and chimpanzeesYoav Gilad
Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
Am J Hum Genet 73:489-501. 2003..These observations are likely due to differences in lifestyle, between humans and great apes, that have led to distinct sensory needs... - A combination of genomic approaches reveals the role of FOXO1a in regulating an oxidative stress response pathwayPaola de Candia
Department of Human Genetics, University of Chicago, Chicago, Illinois, USA
PLoS ONE 3:e1670. 2008..We concentrated on this gene because of its known role in the regulation of metabolism and in longevity...