Research Topics
| M PinesSummaryAffiliation: The Hebrew University Country: Israel Publications
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Detail Information
Publications
Halofuginone and muscular dystrophyMark Pines
Institute of Animal Sciences, Volcani Center, Bet Dagan, Israel
Histol Histopathol 26:135-46. 2011..In summary, halofuginone improves muscle histopathology and muscle functions in various MDs, via inhibition of muscle fibrosis on the one hand, and increased myotube fusion on the other...- Halofuginone to treat fibrosis in chronic graft-versus-host disease and sclerodermaMark Pines
Institute of Animal Science, ARO, The Volcani Center, Bet Dagan, 50250, Israel
Biol Blood Marrow Transplant 9:417-25. 2003..As a first step toward future treatment of internal organ involvement, an oral administration study was performed in which halofuginone was well tolerated and plasma levels surpassed the predicted therapeutic exposure... - Reduction in dermal fibrosis in the tight-skin (Tsk) mouse after local application of halofuginoneM Pines
Institute of Animal Science, Agricultural Research Organization, The Volcani Center, 50250, Bet Dagan, Israel
Biochem Pharmacol 62:1221-7. 2001..These results suggest that target-oriented application of halofuginone may become a novel therapy for fibrotic disorders in general and for scleroderma in particular... - Halofuginone, a specific inhibitor of collagen type I synthesis, prevents dimethylnitrosamine-induced liver cirrhosisM Pines
Institute of Animal Science, Volcani Center, Bet Dagan, Israel
J Hepatol 27:391-8. 1997..We evaluated the effect of halofuginone-a specific inhibitor of collagen type alpha 1(I) gene expression-on dimethylnitrosamine (DMN)-induced liver fibrosis/cirrhosis in rats... - Increased skin tearing in broilers and reduced collagen synthesis in skin in vivo and in vitro in response to the coccidiostat halofuginoneI Granot
Institute of Animal Science, Agricultural Research Organization, Volcani Center, Bet Dagan, Isreal
Poult Sci 70:1559-63. 1991..Results of both in vivo and in vitro trials suggest that the increase of skin tearing during processing, induced by halofuginone, is caused by direct suppression of skin collagen synthesis... - Inhibition of Wilms tumor xenograft progression by halofuginone is accompanied by activation of WT-1 gene expressionJehonathan H Pinthus
Institute of Animal Science, Agricultural Research Organization, The Volcani Center, Bet Dagan, Israel
J Urol 174:1527-31. 2005..CONCLUSIONS: These results suggest that halofuginone is a potent inhibitor of WT progression. Because of its unique mode of action, halofuginone may decrease the treatment burden when combined with chemotherapy... - Growth inhibition of prostate cancer xenografts by halofuginoneZohar Gavish
Institute of Animal Science, The Volcani Center, PO Box 6, Bet Dagan, Israel
Prostate 51:73-83. 2002..CONCLUSIONS: Oral administration of halofuginone slowed the progression of PC xenografts representing a broad range of phenotypes. Halofuginone may become a new modality for PC prevention... - Vitamin A deficiency interferes with proliferation and maturation of cells in the chicken small intestineZ Uni
Department of Animal Sciences, The Faculty of Agricultural, Food and Environmental Quality Services, The Hebrew University of Jerusalem, Rehovot, Israel
Br Poult Sci 41:410-5. 2000.... - Vitamin A deficiency exacerbates inflammation in a rat model of colitis through activation of nuclear factor-kappaB and collagen formationR Reifen
School of Nutritional Sciences, The Hebrew University of Jerusalem, Rehovot, Israel
J Nutr 132:2743-7. 2002..Colitis is amplified by deficiency and ameliorated by supplementation of the vitamin. These findings have implications for the management of inflammatory bowel disease... - Treatment with halofuginone results in marked growth inhibition of a von Hippel-Lindau pheochromocytoma in vivoDavid J Gross
Endocrinology and Metabolism Service and Department of Bone Marrow Transplantation and Cancer Immunobiology, Hadassah University Hospital, Jerusalem 91120, USA
Clin Cancer Res 9:3788-93. 2003.... - Na(+)-K(+)-ATPase gene expression in the avian eggshell gland: distinct regulation in different cell typesI Lavelin
Institute of Animal Sciences, Agricultural Research Organization, The Volcani Center, Bet Dagan 50250, Israel
Am J Physiol Regul Integr Comp Physiol 281:R1169-76. 2001.... - Gene expression during chemically induced liver fibrosis: effect of halofuginone on TGF-beta signalingY Gnainsky
Institute of Animal Sciences, The Volcani Center, P O Box 6, Bet Dagan 50250, Israel
Cell Tissue Res 328:153-66. 2007..Halofuginone, which has demonstrated efficacy and tolerance in animals and humans, could become an effective and novel therapy for liver fibrosis... - Prevention of muscle fibrosis and improvement in muscle performance in the mdx mouse by halofuginoneTidhar Turgeman
Institute of Animal Sciences, The Volcani Center, P O Box 6, Bet Dagan 50250, Israel
Neuromuscul Disord 18:857-68. 2008..We suggest that via its effect on Smad3 phosphorylation, halofuginone inhibits muscle fibrosis and improves cardiac and skeletal muscle functions in mdx mice... - Halofuginone, an inhibitor of collagen synthesis by rat stellate cells, stimulates insulin-like growth factor binding protein-1 synthesis by hepatocytesYulia Gnainsky
Institute of Animal Sciences, Agricultural Research Organization, The Volcani Center, PO Box 6, Bet Dagan 50250, Israel
J Hepatol 40:269-77. 2004..The IGFBP-1 secreted by HepG2-inhibited stellate cell motility. CONCLUSIONS: Halofuginone is an anti-fibrotic drug that inhibits collagen synthesis by stellate cells and preventing alteration in the synthesis of IGFBPs by hepatic cells... - Inhibition of transforming growth factor beta signaling by halofuginone as a modality for pancreas fibrosis preventionOrit Zion
Institute of Animal Sciences, The Volcani Center, Bet Dagan, Israel
Pancreas 38:427-35. 2009..Chronic pancreatitis is characterized by inflammation and fibrosis. We evaluated the efficacy of halofuginone, an inhibitor of collagen synthesis and myofibroblast activation, in preventing cerulein-induced pancreas fibrosis... - The role of intravenous immunoglobulin therapy in mediating skin fibrosis in tight skin miceMiri Blank
Sheba Medical Center, Tel Hashomer, Israel, Tel Aviv University, Tel Aviv, Israel
Arthritis Rheum 46:1689-90. 2002 - Expression of chicken 75-kDa gelatinase B-like enzyme in perivascular chondrocytes suggests its role in vascularization of the growth plateA Tong
Institute of Animal Science, The Volcani Center, Bet Dagan, Israel
J Bone Miner Res 18:1443-52. 2003..Despite its low homology to mammalian gelatinase-B, the avian 75-kDa seems to function similarly in the context of endochondral bone formation... - Inhibition of fibroblast to myofibroblast transition by halofuginone contributes to the chemotherapy-mediated antitumoral effectYuval Sheffer
Institute of Animal Sciences, Volcani Center, P O Box 6, Bet Dagan 50250, Israel
Mol Cancer Ther 6:570-7. 2007.... - Hypoxia, hypoxia-inducible factor-1alpha (HIF-1alpha), and heat-shock proteins in tibial dyschondroplasiaO Genin
Institute of Animal Sciences, Volcani Center, Bet Dagan 50250, Israel
Poult Sci 87:1556-64. 2008..Hypoxia leads to an increase in the transcription factor HIF-1alpha, causing increases in the levels of Hsp90 and Hsp70... - Weight loading young chicks inhibits bone elongation and promotes growth plate ossification and vascularizationA Reich
Institute of Animal Science, The Volcani Center, Bet Dagan, The Hebrew Univ. of Jerusalem, Rehovot, Israel
J Appl Physiol 98:2381-9. 2005..OPN recruits the osteoclasts to the cartilage-bone border, thus accelerating cartilage resorption in this zone and subsequent ossification which, in turn, contributes to the observed phenotype of narrower growth plate and shorter bones... - Hsp90 and angiogenesis in bone disorders--lessons from the avian growth plateAyelet Herzog
Institute of Animal Sciences, The Volcani Center, P O Box 6, Bet Dagan, 50250, Israel
Am J Physiol Regul Integr Comp Physiol 301:R140-7. 2011.... - Involvement of the tyrosine phosphatase early gene of liver regeneration (PRL-1) in cell cycle and in liver regeneration and fibrosis effect of halofuginoneYulia Gnainsky
Institute of Animal Sciences, Volcani Center, P.O. Box 6, 50250 Bet Dagan, Israel
Cell Tissue Res 324:385-94. 2006..The regulation of the expression of the early genes of regeneration such as PRL-1 and IGFBP-1 is thus part of the mode of action of halofuginone and results in the prevention of liver fibrosis and improved cirrhotic liver regeneration... - Halofuginone, a collagen type I inhibitor improves liver regeneration in cirrhotic ratsGadi Spira
Department of Anatomy and Cell Biology, The Bruce Rappaport Faculty of Medicine, Rappaport Family Institute for Research in the Medical Sciences, Technion, Haifa, Israel
J Hepatol 37:331-9. 2002..The aim of the present study was to determine the potential of halofuginone, a collagen type I inhibitor, in improving liver regeneration in cirrhotic rats... - Halofuginone inhibition of COL1A2 promoter activity via a c-Jun-dependent mechanismTracy L McGaha
Department of Microbiology, The Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA
Arthritis Rheum 46:2748-61. 2002..CONCLUSION: Our findings illustrate the powerful down-regulatory property of c-Jun toward type I collagen and establish that halofuginone exerts its effect on collagen synthesis in a c-Jun-dependent manner... - Effect of halofuginone on the development of tight skin (TSK) syndromeTracy McGaha
Department of Microbiology, The Mount Sinai School of Medicine, Box 1124, One Gustave L Levy Place, New York NY 10029, USA
Autoimmunity 35:277-82. 2002..These results indicate that halofuginone may have use as a therapeutic in the treatment of fibrotic disease... - Halofuginone upregulates the expression of heparanase in thioacetamide-induced liver fibrosis in ratsOlga Ohayon
Department of Anatomy and Cell Biology, The Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
Lab Invest 88:627-33. 2008..Accordingly, HF seems to possess ideal properties required to become an excellent antifibrogenic agent in humans... - Functional resolution of fibrosis in mdx mouse dystrophic heart and skeletal muscle by halofuginoneKyla D Huebner
Dept of Biological Sciences, Faculty of Science, Univ of Manitoba, Winnipeg, Manitoba, R3T 2N2, Canada
Am J Physiol Heart Circ Physiol 294:H1550-61. 2008..Marked improvements in vital-organ functions implicate Halo as a strong candidate drug to reduce morbidity and mortality in Duchenne muscular dystrophy... - Prevention of esophageal strictures in a caustic burn model using halofuginone, an inhibitor of collagen type I synthesisDan Arbell
Department of Pediatric Surgery, Hadassah University Hospital, Kyriat Hadassah, PO Box 12000, 91120 Jerusalem, Israel
Laryngoscope 115:1632-5. 2005..We tried to assess whether HF would have an effect on the formation of strictures after inducing caustic esophageal... - Halofuginone inhibits tumor growth in the polyoma middle T antigen mouse via a thrombospondin-1 independent mechanismKaren O Yee
Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massuchusetts 02215, USA
Cancer Biol Ther 5:218-24. 2006..Our data demonstrate that halofuginone inhibits mammary tumor growth in a transgenic mouse model via a TSP-1 independent pathway, by decreasing tumor angiogenesis and by inhibiting TGF-beta signaling... - Halofuginone prevents subglottic stenosis in a canine modelRon Eliashar
Department of Otolaryngology-Head and Neck Surgery, The Hebrew University School of Medicine, Hadassah Medical Center, Jerusalem, Israel
Ann Otol Rhinol Laryngol 115:382-6. 2006..CONCLUSIONS: This preliminary study shows that halofuginone is effective in preventing SGS caused by an acute injury. Halofuginone has a potential therapeutic role in preventing SGS in humans... - Inhibition of rat renal fibroblast proliferation by halofuginoneNurit Haran
Department of Nephrology and Hypertension, Kaplan Medical Center, Rehovot, Israel
Nephron Exp Nephrol 104:e35-40. 2006..CONCLUSIONS: Halofuginone exhibits antifibrotic effects in rat renal papillary fibroblasts in culture, in terms of inhibition of proliferation and inhibition of MMP-2. These findings could have therapeutic potential... - Prevention of liver cirrhosis in rats by curcuminRafael Bruck
The Department of Gastroenterology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
Liver Int 27:373-83. 2007..The aim of the present study was to examine the efficacy of curcumin in preventing thioacetamide-induced cirrhosis and to unravel the mechanism of curcumin's effect on hepatic fibrosis in rats... - Prevention of fibrosis in experimental colitis by captopril: the role of tgf-beta1Dov Wengrower
Department of Gastroenterology, Hadassah University Hospital, Hebrew University Medical School, Jerusalem, Israel
Inflamm Bowel Dis 10:536-45. 2004..The antifibrotic action of captopril could be due to the blockade of TGFbeta-1 overexpression, and/or to a direct down-regulation of TGFbeta-1 transcript...