Rotem Karni

Summary

Affiliation: The Hebrew University
Country: Israel

Publications

  1. ncbi The splicing-factor oncoprotein SF2/ASF activates mTORC1
    Rotem Karni
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Proc Natl Acad Sci U S A 105:15323-7. 2008
  2. ncbi Arginine methylation controls the subcellular localization and functions of the oncoprotein splicing factor SF2/ASF
    Rahul Sinha
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Mol Cell Biol 30:2762-74. 2010
  3. ncbi The gene encoding the splicing factor SF2/ASF is a proto-oncogene
    Rotem Karni
    Cold Spring Harbor Laboratory, PO Box 100, Cold Spring Harbor, New York 11724, USA
    Nat Struct Mol Biol 14:185-93. 2007
  4. ncbi SF2/ASF autoregulation involves multiple layers of post-transcriptional and translational control
    Shuying Sun
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA
    Nat Struct Mol Biol 17:306-12. 2010
  5. ncbi The splicing factor SRSF1 regulates apoptosis and proliferation to promote mammary epithelial cell transformation
    Olga Anczukow
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA
    Nat Struct Mol Biol 19:220-8. 2012

Collaborators

Detail Information

Publications5

  1. ncbi The splicing-factor oncoprotein SF2/ASF activates mTORC1
    Rotem Karni
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Proc Natl Acad Sci U S A 105:15323-7. 2008
    ..These results suggest that clinical tumors with SF2/ASF up-regulation could be especially sensitive to mTOR inhibitors...
  2. ncbi Arginine methylation controls the subcellular localization and functions of the oncoprotein splicing factor SF2/ASF
    Rahul Sinha
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Mol Cell Biol 30:2762-74. 2010
    ....
  3. ncbi The gene encoding the splicing factor SF2/ASF is a proto-oncogene
    Rotem Karni
    Cold Spring Harbor Laboratory, PO Box 100, Cold Spring Harbor, New York 11724, USA
    Nat Struct Mol Biol 14:185-93. 2007
    ..Knockdown of either SF2/ASF or isoform-2 of S6K1 is sufficient to reverse transformation caused by the overexpression of SF2/ASF in vitro and in vivo. Thus, SF2/ASF can act as an oncoprotein and is a potential target for cancer therapy...
  4. ncbi SF2/ASF autoregulation involves multiple layers of post-transcriptional and translational control
    Shuying Sun
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA
    Nat Struct Mol Biol 17:306-12. 2010
    ..Thus, multiple post-transcriptional and translational mechanisms are involved in fine-tuning the expression of SF2/ASF...
  5. ncbi The splicing factor SRSF1 regulates apoptosis and proliferation to promote mammary epithelial cell transformation
    Olga Anczukow
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA
    Nat Struct Mol Biol 19:220-8. 2012
    ..Thus, SRSF1 can promote breast cancer, and SRSF1 itself or its downstream effectors may be valuable targets for the development of therapeutics...