Yosefa Avraham

Summary

Affiliation: The Hebrew University
Country: Israel

Publications

  1. ncbi Animal models in the investigation of anorexia
    Zahava Siegfried
    Department of Human Nutrition and Metabolism, Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    Physiol Behav 79:39-45. 2003
  2. ncbi Leptin induces neuroprotection neurogenesis and angiogenesis after stroke
    Y Avraham
    Department of Human Nutrition and Metabolism, Hebrew University Hadassah Medical Center, Jerusalem, Israel
    Curr Neurovasc Res 8:313-22. 2011
  3. ncbi Cannabidiol improves brain and liver function in a fulminant hepatic failure-induced model of hepatic encephalopathy in mice
    Y Avraham
    Department of Human Nutrition and Metabolism, Braun School of Public Health, Hadassah Hebrew University Medical School, Jerusalem, Israel
    Br J Pharmacol 162:1650-8. 2011
  4. ncbi Fish oil promotes survival and protects against cognitive decline in severely undernourished mice by normalizing satiety signals
    Yosefa Avraham
    Department of Human Nutrition and Metabolism and School of Public Health, Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    J Nutr Biochem 22:766-76. 2011
  5. ncbi Leptin reduces infarct size in association with enhanced expression of CB2, TRPV1, SIRT-1 and leptin receptor
    Yosefa Avraham
    Department of Human Nutrition and Metabolism, Braun School of Public Health, Hebrew University Hadassah Medical School, Jerusalem, Israel
    Curr Neurovasc Res 7:136-43. 2010
  6. ncbi Capsaicin affects brain function in a model of hepatic encephalopathy associated with fulminant hepatic failure in mice
    Y Avraham
    Department of Metabolism and Human Nutrition, Braun School of Public Health, Hadassah Hebrew University Medical School, Jerusalem, Israel
    Br J Pharmacol 158:896-906. 2009
  7. ncbi Endocannabinoids affect neurological and cognitive function in thioacetamide-induced hepatic encephalopathy in mice
    Yosefa Avraham
    Department of Metabolism and Human Nutrition, Braun School of Public Health, Hadassah Hebrew University Medical School, Jerusalem, Israel 91120
    Neurobiol Dis 21:237-45. 2006
  8. ncbi 2-Arachidonoylglycerol, an endogenous cannabinoid receptor agonist, in various rat tissues during the evolution of experimental cholestatic liver disease
    Yosefa Avraham
    Department of Human Nutrition and Metabolism, Braun School of Public Health, Hadassah Hebrew University Medical School, Jerusalem, Israel
    Prostaglandins Leukot Essent Fatty Acids 79:35-40. 2008
  9. ncbi Effects of the endocannabinoid noladin ether on body weight, food consumption, locomotor activity, and cognitive index in mice
    Yosefa Avraham
    Department of Human Nutrition and Metabolism and Braun School of Public Health, Hebrew University Hadassah Medical School, Ein Kerem Campus, P O Box 12272, Jerusalem 91120, Israel
    Brain Res Bull 65:117-23. 2005
  10. ncbi Cannabidiol ameliorates cognitive and motor impairments in mice with bile duct ligation
    Iddo Magen
    Department of Human Nutrition and Metabolism, Braun s School of Public Health, Hadassah Hebrew University Medical Faculty, 91120 Jerusalem, Israel
    J Hepatol 51:528-34. 2009

Detail Information

Publications23

  1. ncbi Animal models in the investigation of anorexia
    Zahava Siegfried
    Department of Human Nutrition and Metabolism, Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    Physiol Behav 79:39-45. 2003
    ..It is hoped that a combination of the study of such models, together with genetic and clinical studies in patients, will lead to more rational and successful prevention/treatment of this tragic, and often fatal, disease...
  2. ncbi Leptin induces neuroprotection neurogenesis and angiogenesis after stroke
    Y Avraham
    Department of Human Nutrition and Metabolism, Hebrew University Hadassah Medical Center, Jerusalem, Israel
    Curr Neurovasc Res 8:313-22. 2011
    ..This may explain at least in part the better functional outcome observed in leptin treated animals after stroke...
  3. ncbi Cannabidiol improves brain and liver function in a fulminant hepatic failure-induced model of hepatic encephalopathy in mice
    Y Avraham
    Department of Human Nutrition and Metabolism, Braun School of Public Health, Hadassah Hebrew University Medical School, Jerusalem, Israel
    Br J Pharmacol 162:1650-8. 2011
    ....
  4. ncbi Fish oil promotes survival and protects against cognitive decline in severely undernourished mice by normalizing satiety signals
    Yosefa Avraham
    Department of Human Nutrition and Metabolism and School of Public Health, Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    J Nutr Biochem 22:766-76. 2011
    ....
  5. ncbi Leptin reduces infarct size in association with enhanced expression of CB2, TRPV1, SIRT-1 and leptin receptor
    Yosefa Avraham
    Department of Human Nutrition and Metabolism, Braun School of Public Health, Hebrew University Hadassah Medical School, Jerusalem, Israel
    Curr Neurovasc Res 7:136-43. 2010
    ..There was also a non-significant increase in Bcl-2 gene expression following leptin administration. These results suggest that leptin may be used for attenuating ischemic injury after stroke via induction of an anti-apoptotic state...
  6. ncbi Capsaicin affects brain function in a model of hepatic encephalopathy associated with fulminant hepatic failure in mice
    Y Avraham
    Department of Metabolism and Human Nutrition, Braun School of Public Health, Hadassah Hebrew University Medical School, Jerusalem, Israel
    Br J Pharmacol 158:896-906. 2009
    ....
  7. ncbi Endocannabinoids affect neurological and cognitive function in thioacetamide-induced hepatic encephalopathy in mice
    Yosefa Avraham
    Department of Metabolism and Human Nutrition, Braun School of Public Health, Hadassah Hebrew University Medical School, Jerusalem, Israel 91120
    Neurobiol Dis 21:237-45. 2006
    ..Modulation of this system either by exogenous agonists specific for the CB2 receptors or possibly also by antagonists to the CB1 receptors may have therapeutic potential...
  8. ncbi 2-Arachidonoylglycerol, an endogenous cannabinoid receptor agonist, in various rat tissues during the evolution of experimental cholestatic liver disease
    Yosefa Avraham
    Department of Human Nutrition and Metabolism, Braun School of Public Health, Hadassah Hebrew University Medical School, Jerusalem, Israel
    Prostaglandins Leukot Essent Fatty Acids 79:35-40. 2008
    ..Changes in tissue levels of 2-arachidonoylglycerol (2-AG), an endocannabinoid, during the evolution of bile duct ligation (BDL) may indicate that endocannabinoids have a role in the hemodynamic changes that occur in this condition...
  9. ncbi Effects of the endocannabinoid noladin ether on body weight, food consumption, locomotor activity, and cognitive index in mice
    Yosefa Avraham
    Department of Human Nutrition and Metabolism and Braun School of Public Health, Hebrew University Hadassah Medical School, Ein Kerem Campus, P O Box 12272, Jerusalem 91120, Israel
    Brain Res Bull 65:117-23. 2005
    ..Noladin seems to signal food consumption and weight through CB1 receptors based on effects observed with the CB1 antagonist, while the cognition and activity are probably mediated by non-cannabinoid receptors...
  10. ncbi Cannabidiol ameliorates cognitive and motor impairments in mice with bile duct ligation
    Iddo Magen
    Department of Human Nutrition and Metabolism, Braun s School of Public Health, Hadassah Hebrew University Medical Faculty, 91120 Jerusalem, Israel
    J Hepatol 51:528-34. 2009
    ..We report now the therapeutic effects of cannabidiol (CBD), a non-psychoactive constituent of Cannabis sativa, on HE caused by bile duct ligation (BDL), a model of chronic liver disease...
  11. ncbi Cannabinoids and capsaicin improve liver function following thioacetamide-induced acute injury in mice
    Yosefa Avraham
    Department of Human Nutrition and Metabolism, Braun School of Public Health, Hadassah Hebrew University Medical School, Jerusalem, Israel
    Am J Gastroenterol 103:3047-56. 2008
    ..We have shown the beneficial effects of cannabinoids in a murine model of hepatic encephalopathy following thioacetamide and now report their effects on the liver injury...
  12. ncbi Cannabinoids ameliorate cerebral dysfunction following liver failure via AMP-activated protein kinase
    Yossi Dagon
    Department of Human Nutrition and Metabolism, Braun School of Public Health, Faculty of Medicine Hebrew University Hadassah Medical School, Jerusalem, Israel
    FASEB J 21:2431-41. 2007
    ..These results suggest that HE is a disease of energy flux. CB-2 signaling is a cerebral stress response mechanism and makes AMPK a promising target for its treatment by modulating the cannabinoid system...
  13. ncbi Endocannabinoids and liver disease--review
    Ezra Gabbay
    Department of Metabolism and Human Nutrition, Hadassah Hebrew University Medical School, Jerusalem 91120, Israel
    Liver Int 25:921-6. 2005
    ..In this review we aim to elucidate current knowledge as to their role in liver physiology and disease...
  14. ncbi Very low doses of delta 8-THC increase food consumption and alter neurotransmitter levels following weight loss
    Yosefa Avraham
    Department of Human Nutrition and Metabolism, Hebrew University Hadassah Medical School, POB 12272, Jerusalem 91120, Israel
    Pharmacol Biochem Behav 77:675-84. 2004
    ..001 mg/kg) caused increased food consumption and tendency to improve cognitive function, without cannabimimetic side effects. Hence, a low dose of THC might be a potential therapeutic agent in the treatment of weight disorders...
  15. ncbi The synthetic cannabinoid HU-210 attenuates neural damage in diabetic mice and hyperglycemic pheochromocytoma PC12 cells
    Yossi Dagon
    Department of Human Nutrition and Metabolism, Braun School of Public Health, Faculty of Medicine Hebrew University, Hadassah Medical School, Israel
    Neurobiol Dis 27:174-81. 2007
    ..These results suggest cannabinoids might have a therapeutic role in the management of the neurological complications of diabetes...
  16. ncbi Nutritional status, cognition, and survival: a new role for leptin and AMP kinase
    Yossi Dagon
    Department of Human Nutrition and Metabolism, Braun School of Public Health, Faculty of Medicine, Hebrew University Hadassah Medical School, Jerusalem 91120
    J Biol Chem 280:42142-8. 2005
    ..Should these findings extend to Man, then controlled activation of AMPK may improve neurodegenerative diseases, and leptin may have a new role in treating stress-associated malnutrition...
  17. ncbi Short-term fasting and prolonged semistarvation have opposite effects on 2-AG levels in mouse brain
    Lumir Hanus
    Department of Medicinal Chemistry and Natural Products, Medical Faculty, Hebrew University, Ein Kerem Campus, Jerusalem 91120, Israel
    Brain Res 983:144-51. 2003
    ..We confirmed the elevation of 2-AG levels. It seems possible that these time-dependent variations of 2-AG levels may be of importance as a general coping strategy by animals during periods of starvation...
  18. ncbi The differential effects of food restriction on 5-HT1A and 5-HT1B receptor mediated control of serotonergic transmission in the hippocampus and hypothalamus of rats
    Eitan Gur
    Biological Psychiatry Laboratory, Department of Psychiatry, Hadassah Hospital, POB 12000, Jerusalem 91120, Israel
    Nutr Neurosci 6:169-75. 2003
    ..The fact that such differential effects on 5-HT release appeared only in the hypothalamus, the center of regulation of energy balance, suggests a compensatory role in FR by increasing 5-HT secretion, thereby reducing feeding behavior...
  19. ncbi Hypothalamic-pituitary-adrenal responses to weight loss in mice following diet restriction, activity or separation stress: effects of tyrosine
    Yosefa Avraham
    Department of Human Nutrition and Metabolism, Hebrew University-Hadassah Medical School, Jerusalem, Israel
    Nutr Neurosci 5:327-35. 2002
    ..Tyrosine might alleviate some of the different pathophysiological problems associated with the stress of weight loss...
  20. ncbi A novel transgenic mouse expressing double mutant tau driven by its natural promoter exhibits tauopathy characteristics
    Hanna Rosenmann
    The Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah University Medical Center, Jerusalem, Israel
    Exp Neurol 212:71-84. 2008
    ....
  21. ncbi Endocannabinoids in liver disease and hepatic encephalopathy
    Iddo Magen
    Department of Nutrition and Metabolism, Hebrew University Medical Faculty, Ein Kerem Campus, Jerusalem 91120, Isreal
    Curr Pharm Des 14:2362-9. 2008
    ..The present review summarizes the literature on the association between ECs and liver disease, as well as the therapeutic potential of ECs and exogenous cannabinoids in liver disease with emphasis on hepatic encephalopathy...
  22. ncbi AMPK activation regulates apoptosis, adipogenesis, and lipolysis by eIF2alpha in adipocytes
    Yossi Dagon
    Department of Human Nutrition and Metabolism, Braun School of Public Health, Faculty of Medicine, Hebrew University, Hadassah Medical School, Israel
    Biochem Biophys Res Commun 340:43-7. 2006
    ..Thus, AMPK may diminish adiposity via reduction of fat cell number through eIF2alpha-dependent translation shutdown...
  23. ncbi Immunomodulation of experimental colitis via caloric restriction: role of Nk1.1+ T cells
    Oren Shibolet
    Liver Unit, Department of Medicine, Hebrew University Hadassah Medical Center, Jerusalem, Israel
    Clin Immunol 105:48-56. 2002
    ..This effect was mediated via an increase in NK1.1+ T lymphocytes, which may play a critical role in keeping the T-cell balance in immunoregulation...