Research Topics
Genomes and GenesSpecies | Efrat KesslerSummaryAffiliation: Tel Aviv University Country: Israel Publications
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Publications
A histone deacetylase inhibitory prodrug - butyroyloxymethyl diethyl phosphate - protects the heart and cardiomyocytes against ischemia injuryG Kessler-Icekson
Felsenstein Medical Research Center, Tel Aviv University, Israel
Eur J Pharm Sci 45:592-9. 2012..Our findings indicate that AN-7 imparts cardioprotection against ischemia both in vivo and in vitro and emerges as a potential treatment modality for cardiac injury...- Expression of procollagen C-proteinase enhancer-1 in the remodeling rat heart is stimulated by aldosteroneGania Kessler-Icekson
Basil and Gerald Felsenstein Medical Research Center, Sackler Faculty of Medicine, Tel Aviv University, Petach Tikva 49100, Israel
Int J Biochem Cell Biol 38:358-65. 2006..Since PCPE-1 itself is a positive regulator of collagen deposition, this finding suggests PCPE-1 as a new potential target for intervention with cardiac fibrosis... - The myocardial profile of the cytosolic isozymes of creatine kinase is apparently not related to cyanosis in congenital heart diseaseG Kessler-Icekson
Basil and Gerald Felsenstein Medical Research Center, The Rabin Medical Center, Petach Tikva, Israel
Mol Med 5:110-6. 1999..In patients with cyanotic heart disease the myocardium is perfused with partially saturated blood. We questioned whether the myocardium of cyanotic subjects contains higher proportions of CKMB... - Association of tetralogy of Fallot with a distinct region of del22q11.2Gania Kessler-Icekson
Basil and Gerald Felsenstein Medical Research Center, Tel Aviv University, Tel Aviv, Israel
Am J Med Genet 107:294-8. 2002..Our findings support an association between TOF and hemizygosity in 22q11.2, suggesting a distinct region, between markers D22S1638 and COMT, that may harbor TOF susceptibility genes... - Expression of procollagen C-proteinase enhancer in cultured rat heart fibroblasts: evidence for co-regulation with type I collagenNoa Shalitin
Basil and Gerald Felsenstein Medical Research Center, Rabin Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel
J Cell Biochem 90:397-407. 2003..The observed augmentation of PCP activity may be a consequence of the increase in the levels of PCP enhancer in the culture media... - A continuous spectrophotometric assay for Pseudomonas aeruginosa LasA protease (staphylolysin) using a two-stage enzymatic reactionEfrat Kessler
Maurice and Gabriela Goldschleger Eye Research Institute, Tel Aviv University Sackler Faculty of Medicine, Sheba Medical Center, Tel Hashomer 52621, Israel
Anal Biochem 328:225-32. 2004..The assay is highly sensitive and reproducible, providing a convenient tool for further studies of LasA protease function(s) and mechanism of action... - Evaluation of Pseudomonas aeruginosa staphylolysin (LasA protease) in the treatment of methicillin-resistant Staphylococcus aureus endophthalmitis in a rat modelIrina S Barequet
Maurice and Gabriela Goldschleger Eye Research Institute, Sackler Faculty of Medicine, Tel Aviv University, Sheba Medical Center, Tel Hashomer, Israel
Graefes Arch Clin Exp Ophthalmol 247:913-7. 2009..The purpose of this study was to evaluate the efficacy of staphylolysin as a therapy for experimental methicillin-resistant Staphylococcus aureus (MRSA) endophthalmitis, focusing on its bactericidal activity... - Pseudomonas aeruginosa LasA protease in treatment of experimental staphylococcal keratitisIrina S Barequet
Maurice and Gabriela Goldschleger Eye Research Institute, Sheba Medical Center, Tel Aviv University Sackler Faculty of Medicine, Tel-Hashomer 52621, Israel
Antimicrob Agents Chemother 48:1681-7. 2004..We conclude that LasA protease is effective in the treatment of experimental S. aureus keratitis in rabbits and may have potential for the treatment of disease in humans... - Identification of residues in the Pseudomonas aeruginosa elastase propeptide required for chaperone and secretion activitiesKevin S McIver
Department of Microbiology, University of Texas Southwestern, Dallas, TX, USA
Microbiology 150:3969-77. 2004..Overall, the data from this preliminary study show that conserved residues within the elastase propeptide are essential for its function and begin to define the mechanisms of action of IMCs in the TNP family... - Identification of critical residues in the propeptide of LasA protease of Pseudomonas aeruginosa involved in the formation of a stable mature proteaseKerian K Grande
Department of Microbiology and Immunology, Virginia Commonwealth University, Richmond, VA 23298 0678, USA
J Bacteriol 189:3960-8. 2007..These data suggest that these clustered residues in the propeptide may play an important role in promoting the correct protein conformation of the mature LasA protease domain... - Interaction properties of the procollagen C-proteinase enhancer protein shed light on the mechanism of stimulation of BMP-1Sylvie Ricard-Blum
Laboratoire d Ingénierie des Macromolécules, Institut de Biologie Structurale, CNRS UMR 5075, 38027 Grenoble Cedex 1, France
J Biol Chem 277:33864-9. 2002.... - A procollagen C-proteinase inhibitor diminishes collagen and lysyl oxidase processing but not collagen cross-linking in osteoblastic culturesNicole Pischon
Division of Oral Biology, Goldman School of Dental Medicine, Boston University, Boston, MA 02118, USA
J Cell Physiol 203:111-7. 2005..Finally, electron microscopy studies show that collagen fibril diameter increased. Thus, inhibition of procollagen C-proteinases results in perturbed collagen deposition primarily via decreased collagen processing...