A CiechanoverSummaryAffiliation: Technion-Israel Institute of Technology Country: Israel Publications
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Publications
The ubiquitin-proteasome pathway: on protein death and cell lifeA Ciechanover
Department of Biochemistry, The Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, P.O.Box 9649, Efron Street, Bat Galim, Haifa 31096
EMBO J 17:7151-60. 1998- Mutation of the E6-AP ubiquitin ligase reduces nuclear inclusion frequency while accelerating polyglutamine-induced pathology in SCA1 miceC J Cummings
Program in Cell and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
Neuron 24:879-92. 1999..Taken together, NIs are not necessary to induce neurodegeneration, but impaired proteasomal degradation of mutant ataxin-1 may contribute to SCA1 pathogenesis... - The nuclear ubiquitin-proteasome system degrades MyoDZ E Floyd
Edward Mallinckrodt Department of Pediatrics and Molecular Biology and Pharmacology, Washington University School of Medicine, and Division of Pediatric Hematology-Oncology, St. Louis Children's Hospital, St. Louis, Missouri 63110, USA
J Biol Chem 276:22468-75. 2001..In addition, in vivo studies, using leptomycin B to inhibit nuclear export, demonstrate that MyoD is degraded in HeLa cells by the nuclear ubiquitin-proteasome system... - Processing of p105 is inhibited by docking of p50 active subunits to the ankyrin repeat domain, and inhibition is alleviated by signaling via the carboxyl-terminal phosphorylation/ ubiquitin-ligase binding domainS Cohen
Department of Biochemistry and the Rappaport Family Institute for Research in the Medical Sciences, The Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa 31096, Israel
J Biol Chem 276:26769-76. 2001..Following stimulation, the C-terminal domain is involved in rapid processing/degradation of p105 with release of a large amount of the stored subunits that now become transcriptionally active... - Structural motifs involved in ubiquitin-mediated processing of the NF-kappaB precursor p105: roles of the glycine-rich region and a downstream ubiquitination domainA Orian
Department of Biochemistry and Rappaport Family Institute for Research in the Medical Sciences, The Bruce Rappaport Faculty of Medicine, Haifa 31096, Israel
Mol Cell Biol 19:3664-73. 1999..In particular, both Lys 441 and Lys 442 appear to serve as major ubiquitination targets, while residues 446 to 454 are independently important for processing and may serve as the ubiquitin ligase recognition motif... - Functional interaction between SEL-10, an F-box protein, and the nuclear form of activated Notch1 receptorN Gupta-Rossi
Unité de Biologie Moléculaire de l Expression Génique, FRE 2364, CNRS, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
J Biol Chem 276:34371-8. 2001..Taken together, these data suggest that SEL-10 is involved in shutting off Notch signaling by ubiquitin-proteasome-mediated degradation of the active transcriptional factor after a nuclear phosphorylation event... - Differential interaction of plakoglobin and beta-catenin with the ubiquitin-proteasome systemE Sadot
Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot, Israel
Oncogene 19:1992-2001. 2000.... - Regulation of stability and function of the epithelial Na+ channel (ENaC) by ubiquitinationO Staub
Hospital for Sick Children, Division of Respiratory Research, Toronto, Ontario, Canada
EMBO J 16:6325-36. 1997..Our results suggest that ENaC function is regulated by ubiquitination, and propose a paradigm for ubiquitination-mediated regulation of ion channels... - [The ubiquitin-proteasome system: the relationship between protein degradation and human diseases]R Amir
Department of Biochemistry, Faculty of Medicine Baruch Rappaport, Research Institute in Medical Sciences Rappaport, Technion, Department of Internal Medicine A, Carmel Medical Center, Haifa, Israel
Harefuah 140:1172-6, 1229. 2001.... - Thermolability of ubiquitin-activating enzyme from the mammalian cell cycle mutant ts85D Finley
Cell 37:43-55. 1984..We discuss possible roles of ubiquitin-dependent pathways in DNA transactions, the cell cycle, and the heat shock response... - The ubiquitin-dependent proteolytic pathway: specificity of recognition of the proteolytic substratesA Ciechanover
Department of Biochemistry, Rappaport Institute for Research in Medical Sciences, Haifa, Israel
Revis Biol Celular 20:217-34. 1989..The scope of this review is to discuss recent developments in our understanding of the specificity and selection of substrates for conjugation and subsequent degradation via the ubiquitin system... - The ubiquitin proteolytic system and pathogenesis of human diseases: a novel platform for mechanism-based drug targetingA Ciechanover
Department of Biochemistry, The Bruce Rappaport Faculty of Medicine and the Rappaport Family Institute for Research in the Medical Sciences, Technion Israel Institute of Technology, Haifa 31096, Israel
Biochem Soc Trans 31:474-81. 2003.... - Intracellular protein degradation: from a vague idea thru the lysosome and the ubiquitin-proteasome system and onto human diseases and drug targetingA Ciechanover
Cancer and Vascular Biology Research Center, The Rappaport Faculty of Medicine and Research Institute, Technion Israel Institute of Technology, Haifa 31096, Israel
Cell Death Differ 12:1178-90. 2005..Not surprisingly, aberrations in the system have been implicated in the pathogenesis of human disease, such as malignancies and neurodegenerative disorders, which led subsequently to an increasing effort to develop mechanism-based drugs... - E2A protein degradation by the ubiquitin-proteasome system is stage-dependent during muscle differentiationL Sun
Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine and St Louis Children s Hospital, St Louis, MO 63110, USA
Oncogene 26:441-8. 2007..Our findings reveal an important role for both translational and post-translational regulatory mechanisms in mediating the complex program of muscle differentiation determined by the E2A proteins... - Complete switch from Mdm2 to human papillomavirus E6-mediated degradation of p53 in cervical cancer cellsA Hengstermann
Institute of Biochemistry I, Medical Faculty, University of Cologne, Joseph-Stelzmann-Strasse 52, , Germany
Proc Natl Acad Sci U S A 98:1218-23. 2001.... - c-Abl regulates p53 levels under normal and stress conditions by preventing its nuclear export and ubiquitinationR V Sionov
Lautenberg Center for General and Tumor Immunology, The Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
Mol Cell Biol 21:5869-78. 2001..Our results help to explain how p53 is accumulated in the nucleus in response to DNA damage... - SCF(beta)(-TrCP) ubiquitin ligase-mediated processing of NF-kappaB p105 requires phosphorylation of its C-terminus by IkappaB kinaseA Orian
Department of Biochemistry and the Rappaport Institute for Research in the Medical Sciences, The Bruce Rappaport Faculty of Medicine, Haifa 31096, Israel
EMBO J 19:2580-91. 2000..Since p105-Delta918-934 is also conjugated and processed, it appears that p105 can be recognized under different physiological conditions by two different ligases, targeting two distinct recognition motifs... - Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1G Levkowitz
Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel
Mol Cell 4:1029-40. 1999..Our study identifies Cbl proteins as components of the ubiquitin ligation machinery and implies that they similarly suppress many other signaling pathways... - Ubiquitin dependence of selective protein degradation demonstrated in the mammalian cell cycle mutant ts85A Ciechanover
Cell 37:57-66. 1984..We suggest that the contribution of ubiquitin-independent pathways to the degradation of short-lived proteins in this higher eucaryotic cell is no more than 10%, and possibly less... - Purification and characterization of a novel species of ubiquitin-carrier protein, E2, that is involved in degradation of non-"N-end rule" protein substratesN Blumenfeld
Department of Biochemistry, Faculty of Medicine, Technion Israel Institute of Technology, Haifa
J Biol Chem 269:9574-81. 1994..The enzyme is also involved in the conjugation and degradation of the tumor suppressor protein p53... - Immunofluorescent localization of the ubiquitin-activating enzyme, E1, to the nucleus and cytoskeletonJ S Trausch
Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri
Am J Physiol 264:C93-102. 1993..The variable distribution of E1 among cell lines, including its apparent cytoskeletal association, suggests pleiotropic functions of this enzyme and the ubiquitin-conjugating system... - The ubiquitin-activating enzyme E1 is phosphorylated and localized to the nucleus in a cell cycle-dependent mannerA G Stephen
Edward Mallincrodt Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Biol Chem 271:15608-14. 1996.... - Role of UEV-1, an inactive variant of the E2 ubiquitin-conjugating enzymes, in in vitro differentiation and cell cycle behavior of HT-29-M6 intestinal mucosecretory cellsE Sancho
Departamento de Biologia Molecular, Instituto de Biología del Cáncer, IMIM CSIC, Barcelona, Spain
Mol Cell Biol 18:576-89. 1998..This was accompanied with a profound inhibition of the mitotic kinase, cdk1. These results suggest that UEV proteins are involved in the control of differentiation and could exert their effects by altering cell cycle distribution... - A novel site for ubiquitination: the N-terminal residue, and not internal lysines of MyoD, is essential for conjugation and degradation of the proteinK Breitschopf
Department of Biochemistry and the Rappaport Family Institute for Research in the Medical Sciences, Technion Israel Institute of Technology, Haifa
EMBO J 17:5964-73. 1998..The polyubiquitin chain is then synthesized on an internal Lys residue of the linearly attached first ubiquitin moiety... - Identification of the ubiquitin carrier proteins, E2s, involved in signal-induced conjugation and subsequent degradation of IkappaBalphaH Gonen
Department of Biochemistry and the Rappaport Family Institute for Research in the Medical Sciences, Bruce Rappaport Faculty of Medicine, Haifa 31096, Israel
J Biol Chem 274:14823-30. 1999..It is possible that different conjugating machineries operate under different physiological conditions or in different cells... - Molecular cloning, sequence, and tissue distribution of the human ubiquitin-activating enzyme E1P M Handley
Department of Cell Biology, Washington University School of Medicine, St Louis, MO
Proc Natl Acad Sci U S A 88:258-62. 1991..Tissue distribution reveals a single 3.5-kilobase E1 message ubiquitous among tissues and cell lines... - Itch: a HECT-type E3 ligase regulating immunity, skin and cancerG Melino
IDI IRCCS Biochemistry Laboratory, Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Via Montpellier 1, Rome 00133, Italy
Cell Death Differ 15:1103-12. 2008..Our contribution is also an endeavor to correlate Itch substrate specificity with the pathological defects manifested by the mutant Itchy mice...