Eran Kozer

..Montelukast, a selective leukotriene-receptor antagonist, is an effective treatment of asthma and allergic rhinitis...

..To characterise the incidence and nature of medication errors during paediatric resuscitations...

..To describe the effects of combined trimedoxime (TMB4) and atropine poisoning from automatic injectors (AI) in children...

..To determine whether implementation of criteria for performing a toxicology screen and increasing staff awareness improve detection of substance abuse among adolescents presenting to the emergency department...

..Tenfold errors in calculation of paediatric drug doses are often life threatening. The magnitude and characteristics of this phenomenon have not been fully described...

..The objective of the current study was to compare the pain that is experienced during these 2 procedures when performed in young infants...

..The cumulative dose of paracetamol should not exceed 75 mg/kg/d. Children treated with higher doses for more than 2 d should be evaluated for possible liver injury and treated with N-acetyl cysteine if evidence of liver injury is found...

..In the paediatric emergency department (ED) trainees are more likely to commit prescribing errors...

..Strategies that have been found to be effective in reducing medication errors include the use of computerized physician order entry systems, pre-printed order forms, color-coded systems, and involving pharmacists in clinical care...

..The objective of this study was to determine whether the use of a structured order sheet reduces the incidence of medication errors in a pediatric ED...

..Clinicians' impression of adolescents' alcohol or drug involvement may underestimate substance-related pathology...

..This study aimed to determine whether mothers and fathers assess pain in their offspring differently and to assess other variables that may affect the way parents assess their child's pain...

..High concentrations of acetaminophen in the CSF, exceeding a certain level, are not associated with greater temperature decrement...

..These results indicate that in a rat model of acute iron intoxication, orally administered NAC may increase mortality...

..We postulate that beyond the first hour after iron administration, serum hepcidin levels provide a better estimate of the amount of iron intake than do serum iron levels...

..002). In a rat model of acute iron intoxication, i.p. administration of NAC may decrease serum iron levels and mortality...

..The aim of the study was to identify clinical findings associated with increased likelihood of testicular torsion (TT) in children...

..CONCLUSION: For women with moderate- and high-risk pregnancies, aspirin treatment seemed to have a small but significant effect on reducing the rate of preterm deliveries, but did not reduce the rate of perinatal death...

..41, p = 0.48, p = 0.49, p = 0.53, p = 01.4, and p = 0.84, respectively). In conclusion, acute iron intoxication in rats is associated with depletion of reduced glutathione in the liver...

..Diarrhea is a leading cause of child mortality worldwide. Rotavirus is one of the most common causes of severe diarrhea and dehydration in children...

..9%) among untreated rats to 6 of 30 (20%). Surprisingly, in the treatment group, levels of oxidative stress markers were higher. We postulate that hyperbaric oxygen has a potentially beneficial effect in acute iron intoxication...

..The objective of this study was to describe the incidence and type of drug errors in a pediatric ED and determine factors associated with risk of errors...

..Ill children receiving repeated supratherapeutic doses of acetaminophen may show abnormalities in liver function. However, severe liver injury was rare...

..Our study suggests that this view is the result of a publication bias, with several small (< 100 participants) positive studies leading to a premature conclusion...

..1%) patients. In the pediatric ED, abnormal AED levels do not correlate with clinical management. Before ordering tests, physicians should consider whether their results would alter patient treatment...

..To systematically review the published experience on intratympanic gentamicin treatment for intractable Menière's disease...

..To describe the incidence of acute renal insufficiency after dipyrone overdose in children...

..To determine the clinical significance of extreme leucocytosis (white blood cell (WBC) count >25,000/mm(3)) as a predictor of serious bacterial infection (SBI) in children...

..To report our experience with blunt pancreatic trauma in pediatric patients and evaluate several various management strategies...

..However, it is unclear if a combination of these drugs intensifies the effects of morphine on the respiratory system and, if so, whether these effects are due to pharmacokinetic or pharmacodynamic interaction...

..To compare the defervescent effect of high-dose rectal suppository acetaminophen with the recommended oral and rectal dosages and to evaluate acceptability of rectal acetaminophen...

..Adopting the "systems approach" to medication errors is crucial to every health system where practitioners seek to enhance patient safety...

..She was discharged after 4 days with no neurological sequelae. CONCLUSIONS: We suggest, that in patients with organophosphate poisoning who have mainly central nervous system toxicity scopolamine administration might be considered...

..With increasing workloads for hospital doctors, routine funduscopy may be abandoned. It is not known how often pediatricians perform funduscopy and how skilled they are in performing it...

..Reducing exposure in pregnancy is merited until more refined risk assessment is possible. Further studies that address exposure to specific solvents, dose, and gestational timing of exposure are needed...

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..The clinical effects of self injections of atropine-trimedoxime auto-injectors distributed to the civilian population as a field antidote for nerve agent attack were assessed...

..Several immunisations are associated with suboptimal seroconversion rates leaving a substantial part of the population exposed to infection...

..Clinicians should be careful not to treat "numbers" (i.e., serum concentrations), but rather the patient's clinical condition, with a careful balance between therapeutic advantage and adverse effects...

..Our objective was to evaluate the expression of hepcidin in the liver in acute iron poisoning in a rat model...

..Most samples harbored potential pathogens. Few cultures were positive in the control group, demonstrating that regular disinfection is carried out, but apparently religious artifacts are overlooked...

..The aim of this study was to describe the incidence of ICT in children suffering from cardiac failure with left ventricular dysfunction and to identify risk factors on admission for developing ICT...

..CONCLUSION: We found no evidence of an overall increase in the risk of congenital malformations that could be associated with aspirin. Aspirin exposure during the first trimester may be associated with an increased risk of gastroschisis...

..During the last few years there has been an increase in the number of reports of liver failure associated with prolonged paracetamol (acetaminophen) administration in children for therapeutic reasons...

..To assess pediatric bicycle-related traumatization in view of types of injuries, incidence and modes of prevention...

..Our objective was to determine if an active intervention by a drug consultation center (DCC) will increase contraceptive use among women taking isotretinoin...

..53; 95% confidence interval, 1.14-79.3). CONCLUSION: When used near term, paroxetine is associated with a high rate of neonatal complications, possibly caused by its common discontinuation syndrome...

..The authors hereby present the clinical course and a prospective evaluation of the neurological outcome. A review of the literature regarding this infrequent syndrome is presented...

..Bioequivalence of the suspension was not different from the tablets. These results support the use of the suspension in children who cannot take the tablet...

..These significant changes may indicate an increased risk for hepatotoxicity and liver damage...