Jamal Mahajna

Summary

Affiliation: Migal
Location: Kiryat Shmona, Israel
Publications:


Oleic acid is the active component in the mushroom Daedalea gibbosa inhibiting Bcr-Abl kinase autophosphorylation activity.


Khamaisie H, Sussan S, Tal M, Najajreh Y, Ruthardt M, Mahajna J.

Anticancer Res. 2011 Jan;31(1):177-83.


PMID: [PubMed - indexed for MEDLINE]
Related citations


2.


The Culinary-Medicinal Mushroom Coprinus comatus as a Natural Antiandrogenic Modulator.


Dotan N, Wasser SP, Mahajna J.

Integr Cancer Ther. 2010 Dec 14. [Epub ahead of print]


PMID: [PubMed - as supplied by publisher]
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3.


Inhibition of TNFα-induced iNOS expression in HSV-tk transduced 9L glioblastoma cell lines by Marasmius oreades substances through NF-κB- and MAPK-dependent mechanisms.


Ruimi N, Petrova RD, Agbaria R, Sussan S, Wasser SP, Reznick AZ, Mahajna J.

Mol Biol Rep. 2010 Dec;37(8):3801-12. Epub 2010 Mar 12.


PMID: [PubMed - indexed for MEDLINE]
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4.


Daedalea gibbosa substances inhibit LPS-induced expression of iNOS by suppression of NF-kappaB and MAPK activities in RAW 264.7 macrophage cells.


Ruimi N, Rwashdeh H, Wasser S, Konkimalla B, Efferth T, Borgatti M, Gambari R, Mahajna J.

Int J Mol Med. 2010 Mar;25(3):421-32.


PMID: [PubMed - indexed for MEDLINE]
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5.


Pharmacological values of medicinal mushrooms for prostate cancer therapy: the case of Ganoderma lucidum.


Mahajna J, Dotan N, Zaidman BZ, Petrova RD, Wasser SP.

Nutr Cancer. 2009;61(1):16-26. Review.


PMID: [PubMed - indexed for MEDLINE]
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6.


Substances from the medicinal mushroom Daedalea gibbosa inhibit kinase activity of native and T315I mutated Bcr-Abl.


Yassin M, Wasser SP, Mahajna J.

Int J Oncol. 2008 Jun;32(6):1197-204.


PMID: [PubMed - indexed for MEDLINE]
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7.


Marasmius oreades substances block NF-kappaB activity through interference with IKK activation pathway.


Petrova RD, Mahajna J, Wasser SP, Ruimi N, Denchev CM, Sussan S, Nevo E, Reznick AZ.

Mol Biol Rep. 2009 Apr;36(4):737-44. Epub 2008 Apr 4.


PMID: [PubMed - indexed for MEDLINE]
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8.


Fungal metabolites modulating NF-kappaB activity: an approach to cancer therapy and chemoprevention (review).


Petrova RD, Reznick AZ, Wasser SP, Denchev CM, Nevo E, Mahajna J.

Oncol Rep. 2008 Feb;19(2):299-308. Review.


PMID: [PubMed - indexed for MEDLINE]
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9.


Androgen receptor-dependent and -independent mechanisms mediate Ganoderma lucidum activities in LNCaP prostate cancer cells.


Zaidman BZ, Wasser SP, Nevo E, Mahajna J.

Int J Oncol. 2007 Oct;31(4):959-67.


PMID: [PubMed - indexed for MEDLINE]
Related citations


10.


Coprinus comatus and Ganoderma lucidum interfere with androgen receptor function in LNCaP prostate cancer cells.


Zaidman BZ, Wasser SP, Nevo E, Mahajna J.

Mol Biol Rep. 2008 Jun;35(2):107-17. Epub 2007 Mar 13.


PMID: [PubMed - indexed for MEDLINE]
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11.


Fungal substances as modulators of NF-kappaB activation pathway.


Petrova RD, Mahajna J, Reznick AZ, Wasser SP, Denchev CM, Nevo E.

Mol Biol Rep. 2007 Sep;34(3):145-54. Epub 2006 Nov 9.


PMID: [PubMed - indexed for MEDLINE]
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12.


The involvement of nuclear factor-kappa B in cyclooxygenase-2 overexpression in murine colon cancer cells transduced with herpes simplex virus thymidine kinase gene.


Konson A, Mahajna JA, Danon A, Rimon G, Agbaria R.

Cancer Gene Ther. 2006 Dec;13(12):1093-104. Epub 2006 Jul 14.


PMID: [PubMed - indexed for MEDLINE]
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13.


Medicinal mushroom modulators of molecular targets as cancer therapeutics.


Zaidman BZ, Yassin M, Mahajna J, Wasser SP.

Appl Microbiol Biotechnol. 2005 Jun;67(4):453-68. Epub 2005 Feb 23. Review.


PMID: [PubMed - indexed for MEDLINE]
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14.


Herpes simplex virus thymidine kinase gene transduction enhances tumor growth rate and cyclooxygenase-2 expression in murine colon cancer cells.


Konson A, Ben-Kasus T, Mahajna JA, Danon A, Rimon G, Agbaria R.

Cancer Gene Ther. 2004 Dec;11(12):830-40.


PMID: [PubMed - indexed for MEDLINE]
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15.


Ethnobotanical survey in the Palestinian area: a classification of the healing potential of medicinal plants.


Ali-Shtayeh MS, Yaniv Z, Mahajna J.

J Ethnopharmacol. 2000 Nov;73(1-2):221-32.


PMID: [PubMed - indexed for MEDLINE]
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16.


Identification and characterization of baxepsilon, a novel bax variant missing the BH2 and the transmembrane domains.


Shi B, Triebe D, Kajiji S, Iwata KK, Bruskin A, Mahajna J.

Biochem Biophys Res Commun. 1999 Jan 27;254(3):779-85.


PMID: 9920818 [PubMed - indexed for MEDLINE]
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17.


A four-amino-acid insertion in the ligand-binding domain inactivates hRXRbeta and renders dominant negative activity.


Mahajna J, Shi B, Bruskin A.

DNA Cell Biol. 1997 Apr;16(4):463-76.


PMID: 9150434 [PubMed - indexed for MEDLINE]
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18.


Autoregulation of cloned human protein kinase C beta and gamma gene promoters in U937 cells.


Mahajna J, King P, Parker P, Haley J.

DNA Cell Biol. 1995 Mar;14(3):213-22.


PMID: 7880442 [PubMed - indexed for MEDLINE]
Related citations


19.


Translation initiation of bacteriophage lambda gene cII requires integration host factor.


Mahajna J, Oppenheim AB, Rattray A, Gottesman M.

J Bacteriol. 1986 Jan;165(1):167-74.


PMID: 2934377 [PubMed - indexed for MEDLINE] Free PMC Article
Free full text Related citations


20.


Plasmid vectors designed for the analysis of transcription termination signals.


Honigman A, Mahajna J, Altuvia S, Koby S, Teff D, Locker-Giladi H, Hyman H, Kronman C, Oppenheim AB.

Gene. 1985;36(1-2):131-41.


PMID: 2998929 [PubMed - indexed for MEDLINE]

Publications

  1. ncbi Autoregulation of cloned human protein kinase C beta and gamma gene promoters in U937 cells
    J Mahajna
    Ludwig Institute for Cancer Research, London, UK
    DNA Cell Biol 14:213-22. 1995
  2. ncbi Inhibition of TNF?-induced iNOS expression in HSV-tk transduced 9L glioblastoma cell lines by Marasmius oreades substances through NF-?B- and MAPK-dependent mechanisms
    Nili Ruimi
    Migal Galilee Technology Center, Cancer Drug Discovery Program, P O Box 831, Kiryat Shmona, Israel
    Mol Biol Rep 37:3801-12. 2010
  3. ncbi Daedalea gibbosa substances inhibit LPS-induced expression of iNOS by suppression of NF-kappaB and MAPK activities in RAW 264.7 macrophage cells
    Nili Ruimi
    Cancer Drug Discovery Program, MIGAL, Galilee Technology Center, Kiryat Shmona, Israel
    Int J Mol Med 25:421-32. 2010
  4. ncbi Pharmacological values of medicinal mushrooms for prostate cancer therapy: the case of Ganoderma lucidum
    Jamal Mahajna
    Cancer Drug Discovery Program, Migal Galilee Technology Center, Kiryat Shmona, Israel
    Nutr Cancer 61:16-26. 2009
  5. ncbi Substances from the medicinal mushroom Daedalea gibbosa inhibit kinase activity of native and T315I mutated Bcr-Abl
    Majed Yassin
    Cancer Drug Discovery Program, MIGAL, Galilee Technology Center, Kiryat Shmona 11016, Israel
    Int J Oncol 32:1197-204. 2008
  6. ncbi Marasmius oreades substances block NF-kappaB activity through interference with IKK activation pathway
    Roumyana D Petrova
    International Center for Cryptogamic Plants and Fungi, Institute of Evolution, University of Haifa, Mt Carmel, Haifa 31905, Israel
    Mol Biol Rep 36:737-44. 2009
  7. ncbi Fungal metabolites modulating NF-kappaB activity: an approach to cancer therapy and chemoprevention (review)
    Roumyana D Petrova
    Migal Galilee Technology Center, Cancer Drug Discovery Program, Kiryat Shmona 11016, Israel
    Oncol Rep 19:299-308. 2008
  8. ncbi Androgen receptor-dependent and -independent mechanisms mediate Ganoderma lucidum activities in LNCaP prostate cancer cells
    Ben Zion Zaidman
    MIGAL, Galilee Technology Center, Cancer Drug Discovery Program, Kiryat Shmona, Israel
    Int J Oncol 31:959-67. 2007
  9. ncbi Coprinus comatus and Ganoderma lucidum interfere with androgen receptor function in LNCaP prostate cancer cells
    Ben Zion Zaidman
    Institute of Evolution, University of Haifa, Mount Carmel, Haifa, 31905, Israel
    Mol Biol Rep 35:107-17. 2008
  10. ncbi Fungal substances as modulators of NF-kappaB activation pathway
    Roumyana D Petrova
    International Center for Cryptogamic Plants and Fungi, Institute of Evolution, University of Haifa, Mt Carmel, Haifa, Israel
    Mol Biol Rep 34:145-54. 2007

Collaborators

Detail Information

Publications16

  1. ncbi Autoregulation of cloned human protein kinase C beta and gamma gene promoters in U937 cells
    J Mahajna
    Ludwig Institute for Cancer Research, London, UK
    DNA Cell Biol 14:213-22. 1995
    ..although no homology between PKC beta and PKC-gamma 5'-flanking sequences was observed, both PKC beta and PKC gamma promoters were potently induced by 12-phorbol 13-myristate in transfected U937 cells...
  2. ncbi Inhibition of TNF?-induced iNOS expression in HSV-tk transduced 9L glioblastoma cell lines by Marasmius oreades substances through NF-?B- and MAPK-dependent mechanisms
    Nili Ruimi
    Migal Galilee Technology Center, Cancer Drug Discovery Program, P O Box 831, Kiryat Shmona, Israel
    Mol Biol Rep 37:3801-12. 2010
    ....
  3. ncbi Daedalea gibbosa substances inhibit LPS-induced expression of iNOS by suppression of NF-kappaB and MAPK activities in RAW 264.7 macrophage cells
    Nili Ruimi
    Cancer Drug Discovery Program, MIGAL, Galilee Technology Center, Kiryat Shmona, Israel
    Int J Mol Med 25:421-32. 2010
    ..Interestingly, all active fractions significantly enhanced levels of phospho-JNK. In addition, the three active fractions also showed differential inhibitory effects on NF-kappaB DNA binding activity...
  4. ncbi Pharmacological values of medicinal mushrooms for prostate cancer therapy: the case of Ganoderma lucidum
    Jamal Mahajna
    Cancer Drug Discovery Program, Migal Galilee Technology Center, Kiryat Shmona, Israel
    Nutr Cancer 61:16-26. 2009
    ..To date, no effective therapy is available for clinically hormone-insensitive or hormone-refractory stages of prostate cancer...
  5. ncbi Substances from the medicinal mushroom Daedalea gibbosa inhibit kinase activity of native and T315I mutated Bcr-Abl
    Majed Yassin
    Cancer Drug Discovery Program, MIGAL, Galilee Technology Center, Kiryat Shmona 11016, Israel
    Int J Oncol 32:1197-204. 2008
    ..Our data illustrated the potential of natural products in cancer therapeutics...
  6. ncbi Marasmius oreades substances block NF-kappaB activity through interference with IKK activation pathway
    Roumyana D Petrova
    International Center for Cryptogamic Plants and Fungi, Institute of Evolution, University of Haifa, Mt Carmel, Haifa 31905, Israel
    Mol Biol Rep 36:737-44. 2009
    ..oreades as a natural source of low-molecular-weight bioactive substances able to affect the process of tumorogenesis through the direct blockage of NF-kappaB activation at the IKK level...
  7. ncbi Fungal metabolites modulating NF-kappaB activity: an approach to cancer therapy and chemoprevention (review)
    Roumyana D Petrova
    Migal Galilee Technology Center, Cancer Drug Discovery Program, Kiryat Shmona 11016, Israel
    Oncol Rep 19:299-308. 2008
    ..This review compiles the available data on fungal metabolites, known to modulate the activity of NF-kappaB, thus demonstrating their potential use as novel anti-cancer agents in the rapidly advancing field of molecular therapy...
  8. ncbi Androgen receptor-dependent and -independent mechanisms mediate Ganoderma lucidum activities in LNCaP prostate cancer cells
    Ben Zion Zaidman
    MIGAL, Galilee Technology Center, Cancer Drug Discovery Program, Kiryat Shmona, Israel
    Int J Oncol 31:959-67. 2007
    ..These results indicate that G. lucidum extracts have profound activity against LNCaP cells that merits further investigation as a potential therapeutic agent for the treatment of prostate cancer...
  9. ncbi Coprinus comatus and Ganoderma lucidum interfere with androgen receptor function in LNCaP prostate cancer cells
    Ben Zion Zaidman
    Institute of Evolution, University of Haifa, Mount Carmel, Haifa, 31905, Israel
    Mol Biol Rep 35:107-17. 2008
    ..Our findings suggest that AR and non-AR mediated mechanisms underlie the effects of C. comatus and G. lucidum...
  10. ncbi Fungal substances as modulators of NF-kappaB activation pathway
    Roumyana D Petrova
    International Center for Cryptogamic Plants and Fungi, Institute of Evolution, University of Haifa, Mt Carmel, Haifa, Israel
    Mol Biol Rep 34:145-54. 2007
    ..Taken together, our results support the notion of the presence of novel activities that might be utilized as cancer therapeutics...
  11. ncbi The involvement of nuclear factor-kappa B in cyclooxygenase-2 overexpression in murine colon cancer cells transduced with herpes simplex virus thymidine kinase gene
    A Konson
    Department of Clinical Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
    Cancer Gene Ther 13:1093-104. 2006
    ..These findings suggest that HSV-tk gene transduction results in NF-kappaB pathway activation, which is essential for COX-2 overexpression by HSV-tk...
  12. ncbi Medicinal mushroom modulators of molecular targets as cancer therapeutics
    Ben-Zion Zaidman
    Biodiversity and Biotechnology Center of Cryptogamic Plants and Fungi, The Institute of Evolution, University of Haifa, Mount Carmel, Israel
    Appl Microbiol Biotechnol 67:453-68. 2005
    ....
  13. ncbi Herpes simplex virus thymidine kinase gene transduction enhances tumor growth rate and cyclooxygenase-2 expression in murine colon cancer cells
    Alexander Konson
    Department of Clinical Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, POB 653, Beer-Sheva 84105, Israel
    Cancer Gene Ther 11:830-40. 2004
    ..Taken together, these results provide a better understanding of the direct effect of HSV-tk gene transduction on tumor cell biology and target tumor development...
  14. ncbi Ethnobotanical survey in the Palestinian area: a classification of the healing potential of medicinal plants
    M S Ali-Shtayeh
    Department of Biological Sciences, Faculty of Science, An Najah National University, P O Box 696, Palestine, West Bank, Nablus, Israel
    J Ethnopharmacol 73:221-32. 2000
    ..Fifty-nine plants were claimed to be effective against cancer and prostate disorders, which include Arum dioscorides, U. pilulifera, Allium sativum, Viscum cruciatum, and Allium cepa...
  15. ncbi Identification and characterization of baxepsilon, a novel bax variant missing the BH2 and the transmembrane domains
    B Shi
    OSI Pharmaceuticals, Inc, 106 Charles Lindbergh Boulevard, Uniondale, New York, 11553, USA
    Biochem Biophys Res Commun 254:779-85. 1999
    ..Although the newly identified Bax variant was detectable by RT-PCR in several normal mouse tissues, the role of this variant in controlling programmed cell death is currently unknown...
  16. ncbi Oleic acid is the active component in the mushroom Daedalea gibbosa inhibiting Bcr-Abl kinase autophosphorylation activity
    Hazem Khamaisie
    Cancer Drug Discovery Program, MIGAL, Kiryat Shmona, 11016, Israel
    Anticancer Res 31:177-83. 2011
    ..Here we report on the identification of the active component of Daedalea gibbosa, oleic acid, which inhibited Bcr-Abl kinase autophosphorylation in Ba/F3 cells and exhibited anti-CML activity in a BCR/ABL-positive mouse model...