B Gesundheit

..The curative potential of immunotherapy in hematological malignancies is discussed...

..Better understanding of micro-environmental regulators affecting human NB tumor cell growth and survival may be seminal to the development of therapeutic strategies and clinically effective agents for this condition...

..Therefore, we call upon the international medical and bioethical community to reject the Groningen Protocol that permits euthanization and to develop ethical guidelines for the optimal care of severely compromised neonates...

..Such a course would provide future physicians with a varied cultural and intercultural background, help shape their image, and improve the quality of medical care...

..We present a patient treated with DLI 4 years post-SCT, who developed acute GVHD after administration of progesterone to induce menstruation. This rare allergic reaction warrants further investigation...

..This sequence of events suggests a relationship between an immunological reaction induced by INF-alpha and the prolonged phase of stable disease...

..This patient with poor clinical status tolerated the treatment very well. He had a remarkable clinical response and achieved complete remission. The mechanisms of ATO are presented and the potential role of ATO for MM is discussed...

..Over the course of history, abuse of the term has led to medical atrocities. Familiarity with the relevant bioethical issues and the development of practical guidelines might improve clinical performance...

..Clinically, it is important to raise the medical community's awareness of the phenomenon and treat infected infants accordingly...

..The influence of graft composition on the outcome of RIC allo-PBSC should be further investigated via well-controlled randomized prospective studies...

..Future developments using cell therapy with selective or targeted anticancer activity are warranted, with special attention to prophylactic treatment of T cell depleted mismatched allografts recipients...

..In conclusion, alefacept is effective for the treatment of cGVHD, and dose and time intervals of treatment should be explored further...

..Although the results of our study look promising, larger cohorts of patients and prospective clinical trials are required to confirm the benefits of our approach as a possible better alternative to the existing protocols...

..We suggest that the longer duration of post transplant pancytopenia that is frequently observed in MDS patients may also influence post transplant outcome...

..We consider that the results of our study are promising and the efficacy of sodium hyaluronate in the treatment of post-transplant HC should be tested in larger cohorts of patients...

..The assay should be evaluated prospectively in clinical trials...

..Three patients had CMV reactivation while on alefacept. We conclude that alefacept may have a beneficial effect in controlling aGVHD. Further investigations in larger cohorts of patients and controlled studies are warranted...

..The balance between the pro- and anti-inflammatory effects of HDC should be investigated further in order to acquire a clinically effective topical medication based on its anti-inflammatory properties...

..We suggest avoiding or interrupting treatment with androgens in patients preparing for BMT...

..The cysteinyl leukotrienes (cysLTs) and eosinophils play an important role in the pathogenesis of GvHD, which is the rationale for the combined use of montelukast (Mk) in the treatment of this illness...

..With a median follow-up of 4.5 years, 25 patients (17.2%) are alive, and 18 are disease-free. We conclude that although toxic, a second allo-SCT can lead to long-term survival...

..The results of this study look promising, while prospective clinical trials may be required to confirm the benefits of this regimen as an alternative to existing protocols...

..We consider that the results of our study are promising but need to be verified within large randomized trials...

..In conclusion, reduced intensity stem cell transplantation is feasible and effective in patients > or =55 years. Age per se, should no longer be considered as a contra-indication to stem cell transplantation...

..Terrorists, using violence to create fear in order to further their political objectives, might require life-saving medical care if injured during the course of their terror activities...

..Larger clinical investigations are necessary to establish the indications and therapeutic regimen for CsA in immune thrombocytopenia...

..Oral metzitzah after ritual circumcision may be hazardous to the neonate...