Research Topics
| Omer BonneSummaryAffiliation: Hadassah University Hospital Country: Israel Publications
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Detail Information
Publications
PTSD symptoms and cognitive performance in recent trauma survivorsDalia Brandes
Center for Traumatic Stress, Department of Psychiatry, Hadassah University Hospital, P.O. Box 12000, Jerusalem, Israel
Psychiatry Res 110:231-8. 2002..It disappeared, however, when the effect of depressive symptoms was controlled for. Lower IQ and impaired attention are associated with early PTSD and depressive symptoms. Poorer attention may have a role in shaping traumatic memories...- Corticotropin-releasing factor, interleukin-6, brain-derived neurotrophic factor, insulin-like growth factor-1, and substance P in the cerebrospinal fluid of civilians with posttraumatic stress disorder before and after treatment with paroxetineOmer Bonne
Department of Psychiatry, Hadassah Hebrew University Medical Center, POB 12000, Jerusalem, Israel 91120
J Clin Psychiatry 72:1124-8. 2011..Furthermore, no study to date has evaluated the effects of successful antidepressant treatment on cerebrospinal fluid (CSF) abnormalities in PTSD... - Reduced posterior hippocampal volume in posttraumatic stress disorderOmer Bonne
Department of Psychiatry, Hadassah Hebrew University Medical Center, Jerusalem, Israel
J Clin Psychiatry 69:1087-91. 2008..Hippocampal volume is reduced in posttraumatic stress disorder (PTSD). In the present study, we sought to determine whether volume loss is homogenously distributed or confined to a certain part of the structure... - Brain SPECT study of common ground between hypothyroidism and depressionYodphat Krausz
Department of Medical Biophysics and Nuclear Medicine, Hadassah Hebrew University Medical Center, Jerusalem, Israel
Int J Neuropsychopharmacol 10:99-106. 2007..Following treatment, rCBF in depressed patients increased and normalized, but remained unchanged in hypothyroidism. Affective symptoms in hypothyroidism may be mediated by neurocircuitry different from that of major depression... - Cerebral perfusion after a 2-year remission in major depressionYoav Kohn
Department of Psychiatry and Medical Biophysics, Hadassah Hebrew University Medical Center, Jerusalem, Israel
Int J Neuropsychopharmacol 11:837-43. 2008..These findings suggest that perfusion increases in parieto/cerebellar regions may be involved in acute response to treatment whereas increases in frontal regions may be related to its consolidation... - Depressive tendencies and lower levels of self-sacrifice in mothers, and selflessness in their anorexic daughtersEytan Bachar
Department of Psychology, Hebrew University of Jerusalem, Jerusalem, Israel
Eur Eat Disord Rev 16:184-90. 2008..The results support the clinical literature that depicts the anorexic daughters' readiness to sacrifice themselves for the family's needs. Clinical implications are drawn... - Resting regional cerebral perfusion in recent posttraumatic stress disorderOmer Bonne
Department of Psychiatry, Hadassah University Hospital, Jerusalem, Israel
Biol Psychiatry 54:1077-86. 2003..This warrants attention because the cerebellum is often used as a reference region in regional cerebral blood flow studies. The inverse correlation between plasma cortisol and medial temporal lobe perfusion may herald hippocampal damage... - Hyperintensities on T2-weighted images in the basal ganglia of patients with major depression: cerebral perfusion and clinical implicationsNoa Vardi
Department of Psychiatry, Hadassah Hebrew University Medical Center, POB 12000, Jerusalem 91120, Israel
Psychiatry Res 192:125-30. 2011..Clinical symptoms are largely reversible even in depressed patients with WMH T2-WI in basal ganglia... - 99mTc-HMPAO SPECT study of cerebral perfusion after treatment with medication and electroconvulsive therapy in major depressionYoav Kohn
Department of Psychiatry, Hadassah Hebrew University Medical Center, Jerusalem, Israel
J Nucl Med 48:1273-8. 2007..However, it is not known if the reversal of rCBF compromise is dependent on the mode of antidepressant treatment. The current study aimed to address this question... - Regional cerebral blood flow in patients with mild hypothyroidismYodphat Krausz
Department of Medical Biophysics and Nuclear Medicine, Hadassah Hebrew University Medical Center, Jerusalem, Israel
J Nucl Med 45:1712-5. 2004..The aims of this study were to compare regional cerebral blood flow (rCBF) between hypothyroid patients and healthy subjects and assess flow during the euthyroid state after treatment... - Cerebral glucose utilization and platelet mitochondrial complex I activity in schizophrenia: A FDG-PET studyDorit Ben-Shachar
Laboratory of Psychobiology, Department of Psychiatry, Rambam Medical Center and B Rappaport Faculty of Medicine Technion IIT, Haifa, Israel
Prog Neuropsychopharmacol Biol Psychiatry 31:807-13. 2007..These results suggest that the correlation between peripheral complex I activity and rCGM in regions implicated in schizophrenia, could be a pathological factor that is differentially expressed in subgroups of schizophrenic patients... - Prospective evaluation of plasma cortisol in recent trauma survivors with posttraumatic stress disorderOmer Bonne
The Center for Traumatic Stress, Hadassah University Hospital, Jerusalem, Israel
Psychiatry Res 119:171-5. 2003..Survivors with and without PTSD had similar mean levels of cortisol at both time points. Cortisol levels at 6 months negatively correlated with self-reported PTSD symptoms within PTSD subjects... - Acetazolamide-enhanced neuroSPECT scan reveals functional impairment after minimal traumatic brain injury not otherwise discernibleGavriel Barkai
Department of Psychiatry, Tel Aviv Sourasky Medical Center and Tel Aviv University Sackler Faculty of Medicine, 6 Weizmann St, Tel Aviv 64239, Israel
Psychiatry Res 132:279-83. 2004..Valproate treatment was associated with increased prefrontal perfusion concomitant with clinical improvement and abolished response to acetazolamide challenge... - Parent-daughter discrepancies in perception of family function in bulimia nervosaOmer Bonne
Outpatient Clinic, Department of Psychiatry, Hadassah University Hospital, Jerusalem
Psychiatry 66:244-54. 2003..Future research should aim to replicate these findings, incorporate them into treatment paradigms, and employ them to monitor treatment outcome... - T2-weighted image hyperintensities in major depression: focus on the basal gangliaRonit Agid
Department of Radiology, Hadassah University Hospital, PO Box 12000, Jerusalem, 91120, Israel
Int J Neuropsychopharmacol 6:215-24. 2003..Depressed patients with T2-WIH in basal ganglia were clearly the most severely depressed and cognitively impaired subjects, and may constitute a clinically distinct subgroup within major depression... - A randomized, double-blind, placebo-controlled study of classical homeopathy in generalized anxiety disorderOmer Bonne
Department of Psychiatry, Hadassah University Medical School and the Department of Psychiatry, Hadassah University Hospital, Jerusalem, Israel
J Clin Psychiatry 64:282-7. 2003..This study evaluates the effect of homeopathic treatment in generalized anxiety disorder, a prevalent mental disorder characterized by an enduring pattern of excessive apprehension and distress and by mental and bodily complaints... - Does short-term diet restriction in mice precipitate the development of anorexia?Omer Bonne
Department of Psychiatry, Hebrew University Hadassah Medical School, PO Box 12000, Jerusalem 91120, Israel
Nutr Neurosci 6:197-9. 2003..All mice regained appetite and weight. Our conclusions are that diet restriction does not precipitate anorexia in mice. Our findings do not support a role for diet restriction per se in triggering AN... - [Emotional distress in Israeli medical students]Omer Bonne
Department of Psychiatry, Hadassah University Hospital, Hadassah Hebrew University Medical Faculty, Jerusalem, Israel
Harefuah 142:588-91, 647. 2003..CONCLUSIONS: Considering medical students' reluctance to utilize mental health services, the attempt to modify stress-eliciting elements inherent to the Medical Faculty environment is particularly warranted... - Cerebral blood flow in depressed patients: a methodological comparison of statistical parametric mapping and region of interest analysesOmer Bonne
Department of Psychiatry, Hadassah Hebrew University Hospital, Kiryat Hadassah, PO Box 12000, Jerusalem 91120, Israel
Psychiatry Res 122:49-57. 2003..Given the advantages and drawbacks of each procedure, the choice of methodology should be determined in accordance with the study design, and complementary use of both methods may be considered... - Exposure and susceptibility: schizophrenia in a young man following prolonged high exposures to organic solventsYael Stein
Unit of Occupational and Environmental Medicine, Hebrew University Hadassah School of Medicine, Jerusalem, Israel
Neurotoxicology 31:603-7. 2010..In the meantime, policies to prevent such exposures at the source can be expected to contribute to the prevention of a non-trivial proportion of neurotoxic diseases, including, possibly, schizophrenia in worker populations... - Neuropathology of stress: prospects and caveatsOmer Bonne
Department of Psychiatry, Hadassah Hebrew University Hospital, Jerusalem, Israel
Psychiatry 67:407-11. 2004 - Rejection of life in anorexic and bulimic patientsEytan Bachar
Department of Psychiatry, Hadassah University Medical Center, Jerusalem, Israel
Int J Eat Disord 31:43-8. 2002..Clinically, the findings might direct clinicians to help patients reduce their "self-guilt," that is, guilt of promoting their own interests... - Sustained low-grade pro-inflammatory state in unmedicated, remitted women with major depressive disorder as evidenced by elevated serum levels of the acute phase proteins C-reactive protein and serum amyloid AMitchel A Kling
Clinical Neuroendocrinology Branch, Division of Intramural Research Programs, National Institute of Mental Health, Bethesda, MD 20892 1284, USA
Biol Psychiatry 62:309-13. 2007..Elevations of the inflammatory markers C-reactive protein (CRP) and serum amyloid A (SAA) predict increased CAD risk in populations; few data on these markers exist in MDD, particularly in remitted patients... - Differential effects of 5-HTTLPR genotypes on the behavioral and neural responses to tryptophan depletion in patients with major depression and controlsAlexander Neumeister
Molecular Imaging Program of the Clinical Neuroscience Division, Department of Psychiatry, Yale University School of Medicine, 950 Campbell Avenue, West Haven, CT 06516, USA
Arch Gen Psychiatry 63:978-86. 2006.... - Effects of a alpha 2C-adrenoreceptor gene polymorphism on neural responses to facial expressions in depressionAlexander Neumeister
Department of Psychiatry, Yale University School of Medicine, West Haven, CT 06516, USA
Neuropsychopharmacology 31:1750-6. 2006..These results suggest that the alpha2CDel322-325-AR confers a change in brain function implicating this alpha2-AR subtype into the pathophysiology of MDD... - Adaptive and maladaptive psychobiological responses to severe psychological stress: implications for the discovery of novel pharmacotherapyOmer Bonne
Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institute of Health, 15K North Drive, Rm 200, Bethesda, MD 20892 2670, USA
Neurosci Biobehav Rev 28:65-94. 2004..The implications of this model for the discovery of novel pharmacological approaches to the treatment of severe psychological distress are discussed... - Neural and behavioral responses to tryptophan depletion in unmedicated patients with remitted major depressive disorder and controlsAlexander Neumeister
Section on Experimental Therapeutics, Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, MD 20892 2670, USA
Arch Gen Psychiatry 61:765-73. 2004.... - Reduced serotonin type 1A receptor binding in panic disorderAlexander Neumeister
National Institutes of Health, National Institute of Mental Health, Mood and Anxiety Disorders Program, Bethesda, Maryland 20892 2670, USA
J Neurosci 24:589-91. 2004..These results provide for the first time in vivo evidence for the involvement of 5-HT(1A)Rs in the pathophysiology of PD... - Evidence for continuing neuropsychological impairments in depressionPetra Weiland-Fiedler
Mood and Anxiety Disorders Program, National Institute of Mental Health, North Drive, Building 15K, Room 200, Bethesda, MD 20892-2670, USA
J Affect Disord 82:253-8. 2004..CONCLUSIONS: These findings suggest deficits in sustained attention as vulnerability marker for MDD. The functional importance of this finding and the neuronal networks involved remain to be elucidated... - Cerebral blood flow in chronic symptomatic mild traumatic brain injuryOmer Bonne
Departments of Psychiatry, Hadassah University Hospital, Kiryat Hadassah P O Box 12000, 91120 Jerusalem, Israel
Psychiatry Res 124:141-52. 2003..Such competence is still to be attained... - No change in serotonin type 1A receptor binding in patients with posttraumatic stress disorderOmer Bonne
Section of Experimental Therapeutics, NIMH Mood and Anxiety Disorders Program, Bethesda, MD 20892 2670, USA
Am J Psychiatry 162:383-5. 2005..In the present study, the authors sought an association between 5HT1AR binding and posttraumatic stress disorder (PTSD)... - Effects of tryptophan depletion on serum levels of brain-derived neurotrophic factor in unmedicated patients with remitted depression and healthy subjectsAlexander Neumeister
NIMH Mood and Anxiety Disorders Program, Bethesda, MD, USA
Am J Psychiatry 162:805-7. 2005.... - Reduced hippocampal volume in unmedicated, remitted patients with major depression versus control subjectsAlexander Neumeister
Section on Experimental Therapeutics and Pathophysiology, Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, Maryland, USA
Biol Psychiatry 57:935-7. 2005..Hippocampal volumes obtained from a group of medication-free, remitted subjects with recurrent major depressive disorder (MDD) were compared against corresponding measures from healthy controls... - Hydrocortisone impairs hippocampal-dependent trace eyeblink conditioning in post-traumatic stress disorderMeena Vythilingam
Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, MD 20892 2670, USA
Neuropsychopharmacology 31:182-8. 2006..Patients with PTSD had increased glucocorticoid sensitivity in the focal brain regions mediating trace eyeblink conditioning... - Functional connectivity of the prefrontal cortex and the amygdala in posttraumatic stress disorderAsaf Gilboa
Department of Psychology, University of Toronto, Toronto, Ontario, Canada
Biol Psychiatry 55:263-72. 2004..The present data suggest that inferences of direct correspondence between animal studies and pathophysiology of PTSD should be made with caution...