Research Topics
| Eugene LeibovitzSummaryAffiliation: Ben-Gurion University of the Negev Country: Israel Publications
| Collaborators
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Detail Information
Publications
Clinical outcome in children with culture-negative acute otitis mediaEugene Leibovitz
Pediatric Infectious Diseases Unit, Soroka University Medical Center, Ben Gurion University of the Negev, Beer Sheva, Israel
Pediatr Infect Dis J 28:1105-10. 2009..Culture-negative AOM is often milder and associated with lower local/systemic inflammatory responses than culture-positive AOM...- Acute otitis media in children aged less than 2 years: drug treatment issuesEugene Leibovitz
Pediatric Infectious Disease Unit, Soroka University Medical Center, Ben Gurion University of the Negev, Beer Sheva, Israel
Paediatr Drugs 8:337-46. 2006.... - Current management of pediatric acute otitis mediaEugene Leibovitz
Pediatric Infectious Disease Unit, Soroka University Medical Center, PO Box 151, Beer Sheva 84101, Israel
Expert Rev Anti Infect Ther 8:151-61. 2010.... - Complicated otitis media and its implicationsEugene Leibovitz
Pediatric Infectious Disease Unit, Soroka University Medical Center, Ben Gurion University of the Negev, Beer Sheva, Israel
Vaccine 26:G16-9. 2008..The seven-valent pneumococcal conjugate vaccine (PCV7) targets Streptococcus pneumoniae, one of the main AOM pathogens, and data on the impact of PCV7 on complications of AOM, such as mastoiditis, are presented... - Is bilateral acute otitis media clinically different than unilateral acute otitis media?Eugene Leibovitz
Pediatric Infectious Disease Unit, Soroka University Medical Center and the Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
Pediatr Infect Dis J 26:589-92. 2007..Information regarding the specific characteristics of bilateral acute otitis media (BAOM) versus unilateral acute otitis media (UAOM) is lacking... - Epidemiologic and microbiologic characteristics of culture-positive spontaneous otorrhea in children with acute otitis mediaEugene Leibovitz
Pediatric Infectious Diseases Unit, Soroka University Medical Center, Beer Sheva 84101, Israel
Pediatr Infect Dis J 28:381-4. 2009..We aimed to describe the epidemiologic and microbiologic characteristics of acute otitis media (AOM) with spontaneous otorrhea in children and compare it with AOM with intact tympanic membrane in children who underwent tympanocentesis... - Recurrent acute otitis media occurring within one month from completion of antibiotic therapy: relationship to the original pathogenEugene Leibovitz
Pediatric Infectious Disease Unit, Soroka University Medical Center and the Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
Pediatr Infect Dis J 22:209-16. 2003.... - Potential contribution by nontypable Haemophilus influenzae in protracted and recurrent acute otitis mediaGalia Barkai
Soroka University Medical Center, Beer Sheva, Israel
Pediatr Infect Dis J 28:466-71. 2009..To characterize NTHi AOM a large database of culture-positive AOM cases was analyzed... - Bacteriologic and clinical efficacy of high dose amoxicillin for therapy of acute otitis media in childrenLolita Piglansky
Pediatric Infectious Disease Unit, Soroka University Medical Center and Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
Pediatr Infect Dis J 22:405-13. 2003..Because its overall clinical efficacy is good, high dose amoxicillin is still an appropriate choice as first line empiric therapy for AOM, followed by a beta-lactamase-stable drug in the event of failure... - Can acute otitis media caused by Haemophilus influenzae be distinguished from that caused by Streptococcus pneumoniae?Eugene Leibovitz
Pediatric Infectious Disease Unit, Soroka University Medical Center and Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
Pediatr Infect Dis J 22:509-15. 2003.... - Persistence of pathogens despite clinical improvement in antibiotic-treated acute otitis media is associated with clinical and bacteriologic relapseElad Asher
Pediatric Infectious Disease Unit, Soroka University Medical Center and the Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
Pediatr Infect Dis J 27:296-301. 2008..We investigated the relationship between MEF culture-positivity during treatment in patients with clinical improvement/cure, and the occurrence of subsequent AOM... - Relationship among peripheral leukocyte counts, etiologic agents and clinical manifestations in acute otitis mediaAri Polachek
Pediatric Infectious Disease Unit, Soroka University Medical Center, Beer-Sheva, Israel
Pediatr Infect Dis J 23:406-13. 2004..Isolation of S. pneumoniae and fever were each significantly associated with increased peripheral leukocyte and ANCs... - Acute mastoiditis in Southern Israel: a twelve year retrospective study (1990 through 2001)Anna Katz
Pediatric Infectious Disease Unit, Ben-Gurion University of the Negev, Beer-Sheva, Israel
Pediatr Infect Dis J 22:878-82. 2003..pyogenes and lower rates of nontypable H. influenzae recovery; (5) penicillin-nonsusceptible S. pneumoniae played only a minor role in the etiology of acute mastoiditis in Southern Israel... - Increasing importance of multidrug-resistant serotype 6A Streptococcus pneumoniae clones in acute otitis media in southern IsraelNurith Porat
Pediatric Infectious Disease Unit, Soroka University Medical Center and the Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
Pediatr Infect Dis J 29:126-30. 2010..The major aim of this study was to establish the molecular epidemiology dynamics of Streptococcus pneumoniae serotype 6A in acute otitis media, before the introduction of the 7-valent pneumococcal conjugate vaccine... - Acute otitis media in infants younger than two months of age: microbiology, clinical presentation and therapeutic approachDan Turner
Pediatric Infectious Disease Unit, Soroka University Medical Center and the Faculty of Health Scienes, Ben-Gurion University of the Negev, Beer-Sheva, Israel
Pediatr Infect Dis J 21:669-74. 2002.... - Distribution, dynamics and antibiotic resistance patterns of Streptococcus pneumoniae serotypes causing acute otitis media in children in southern Israel during the 10 year-period before the introduction of the 7-valent pneumococcal conjugate vaccineIdo Somech
Pediatric Infectious Disease Unit, Soroka University Medical Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
Vaccine 29:4202-9. 2011.... - Failure to achieve early bacterial eradication increases clinical failure rate in acute otitis media in young childrenRon Dagan
Pediatric Infectious Disease Unit, Soroka University Medical Center and the Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
Pediatr Infect Dis J 27:200-6. 2008..The objective of this study was to determine the association between early bacteriologic failure and clinical failure in acute otitis media (AOM)... - Acute otitis media in children: association with day care centers--antibacterial resistance, treatment, and preventionDavid Greenberg
Pediatric Infectious Disease Unit, Soroka University Medical Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
Paediatr Drugs 10:75-83. 2008..However, the recent observation of increased rates of antibacterial-resistant non-vaccine serotype S. pneumoniae may erode the success of PCV7... - Introduction and proliferation of multidrug-resistant Streptococcus pneumoniae serotype 19A clones that cause acute otitis media in an unvaccinated populationRon Dagan
Pediatric Infectious Disease Unit, Soroka University Medical Center, and Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
J Infect Dis 199:776-85. 2009..A causative role of PCV7 was speculated. We prospectively studied the dynamics of acute otitis media (AOM) caused by Sp19A in southern Israel before the introduction of PCV7... - Complicated community acquired pneumonia in children prior to the introduction of the pneumococcal conjugated vaccineAviv D Goldbart
Department of Paediatrics, Soroka University Medical Centre, Beer Sheva, Israel
Scand J Infect Dis 41:182-7. 2009..Future introduction of PCV7 or equivalents in the immunization schedule may impact clinical presentation and epidemic trends and will require future consideration... - Cytology of middle ear fluid during acute otitis mediaArnon Broides
Pediatric Infectious Disease Unit, Soroka University Medical Center and the Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
Pediatr Infect Dis J 21:57-61. 2002..samples negative for bacterial pathogens. CONCLUSIONS: WBC counts were higher in the MEF of patients with culture-positive AOM than in those with culture-negative AOM and in those with AOM caused by S. pneumoniae... - Nasopharyngeal carriage of Streptococcus pneumoniae at the completion of successful antibiotic treatment of acute otitis media predisposes to early clinical recurrenceShai Libson
Pediatric Infectious Disease Unit, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel
J Infect Dis 191:1869-75. 2005..CONCLUSIONS: Early RAOM was more commonly caused by SP if the organism was present in NP at EOT during the initial AOM episode. Most SP-RAOM episodes were caused by SP isolates present in NP at EOT during the previous AOM episode... - Bacteriologic and clinical efficacy of oral gatifloxacin for the treatment of recurrent/nonresponsive acute otitis media: an open label, noncomparative, double tympanocentesis studyEugene Leibovitz
Pediatric Infectious Disease Unit, Soroka University Medical Center, Ben Gurion University, PO Box 151, Beer Sheva 84101, Israel
Pediatr Infect Dis J 22:943-9. 2003..Gatifloxacin is an 8-methoxyfluoroquinolone with good activity against respiratory pathogens... - Dynamics of pneumococcal nasopharyngeal carriage in children with nonresponsive acute otitis media treated with two regimens of intramuscular ceftriaxoneTamar Haiman
Pediatric Infectious Disease Unit, Soroka University Medical Center and the Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
Pediatr Infect Dis J 21:642-7. 2002..The reduction of overall S. pneumoniae nasopharyngeal carriage by both ceftriaxone regimens was a short-lived phenomenon followed by rapid recolonization of the nasopharynx... - Acute otitis media caused by Moraxella catarrhalis: epidemiologic and clinical characteristicsArnon Broides
Pediatric Immunology Clinic, Pediatric Emergency Department, Soroka University Medical Center, Beer Sheva, Israel
Clin Infect Dis 49:1641-7. 2009..This study describes the epidemiologic, microbiologic, and otologic features and selected signs and symptoms of acute otitis media (AOM) caused by Moraxella catarrhalis and compares them with AOM caused by other bacterial pathogens... - Antibiotic susceptibility, serotype distribution and vaccine coverage of nasopharyngeal and oropharyngeal Streptococcus pneumoniae in a day-care centre in St. Petersburg, RussiaAnna Katz
Paediatric Infectious Disease Unit, Soroka University Medical Centre, Ben Gurion University, Beer Sheva, Israel
Scand J Infect Dis 39:293-8. 2007..pneumoniae... - The challenge of recalcitrant acute otitis media: pathogens, resistance, and treatment strategyEugene Leibovitz
Department of Pediatrics, Pediatric Infectious Disease Unit, Soroka Medical Center and the Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
Pediatr Infect Dis J 26:S8-S11. 2007..The findings emphasize the importance of bacteriologic eradication in the prevention of recurrent AOM episodes... - Rates of tympanic membrane closure in double-tympanocentesis studiesYouval Slovik
Department of Otolaryngology, Soroka University Medical Center, Israel
Pediatr Infect Dis J 27:490-3. 2008..Data on the outcome of tympanic membrane (TM) closure after tympanocentesis in acute otitis media (AOM) patients is limited... - Acute otitis media in children: current epidemiology, microbiology, clinical manifestations, and treatmentEugene Leibovitz
Pediatric Infectious Disease Unit, Soroka University Medical Center, Beer Sheva, Israel
Chang Gung Med J 27:475-88. 2004..A seven-valent pneumococcal conjugate vaccine recently licensed in the United States for universal immunization of infants <2 years has demonstrated efficacy for prevention of serotype-specific pneumococcal AOM... - Adherence to therapeutic guidelines for acute otitis media in children younger than 2 yearsHaim Reuveni
Department of Health Care Policy and Management, Ben Gurion University of the Negev, Beer Sheva, Israel
Int J Pediatr Otorhinolaryngol 70:267-73. 2006..to analyze adherence to therapeutic guidelines for AOM... - Bacterial eradication in the treatment of otitis mediaRon Dagan
Pediatric Infectious Disease Unit, Soroka University Medical Center, Beer Sheva, Israel
Lancet Infect Dis 2:593-604. 2002..In this review we attempt to highlight the evidence regarding bacteriological response to antibiotics in AOM and to draw attention to potential flaws that may mislead clinicians... - Haemophilus influenzae: a significant pathogen in acute otitis mediaEugene Leibovitz
Pediatric Infectious Disease Unit, Soroka University Medical Center and the Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
Pediatr Infect Dis J 23:1142-52. 2004..influenzae from the middle ear space. In the United States, widespread pneumococcal vaccination has increased the importance of H. influenzae as a major therapeutic challenge in the treatment of AOM... - Will reduction of antibiotic use reduce antibiotic resistance?: The pneumococcus paradigmRon Dagan
Pediatric Infectious Disease Unit, Soroka University Medical Center, Beer Sheva, Israel
Pediatr Infect Dis J 25:981-6. 2006..Although antibiotics differ in their resistant-promotion potential, all still do promote resistance... - Acute otitis media-diagnosis and treatment in the era of antibiotic resistant organisms: updated clinical practice guidelinesNili Segal
Department of Otolaryngology - Head and Neck Surgery, Soroka University Medical Center and the Faculty of Health Sciences, Ben-Gurion University of the Negev, P.O. Box 151, Beer-Sheva 84101, Israel
Int J Pediatr Otorhinolaryngol 69:1311-9. 2005..Immunization against S. pneumoniae with the heptavalent pneumococcal conjugated vaccines was showed to result in a decrease in the frequency of AOM caused by this pathogen, including AOM caused by antibiotic-resistant S. pneumoniae... - Acute otitis media in pediatric medicine: current issues in epidemiology, diagnosis, and managementEugene Leibovitz
Pediatric Infectious Disease Unit, Soroka University Medical Center, Beer Sheva, Israel
Paediatr Drugs 5:1-12. 2003.... - Community-acquired complicated intra-abdominal infections in children hospitalized during 1995-2004 at a paediatric surgery departmentNitza Newman
Pediatric Surgery Department, Soroka University Medical Center, Ben Gurion University of the Negev, Beer Sheva, Israel
Scand J Infect Dis 41:720-6. 2009.... - Salmonella diskitis in a 2-year old immunocompetent childGalia Barkai
Paediatric Infectious Disease Unit, Ben Gurion University of the Negev, Soroka University Medical Center, Beer Sheva, Israel
Scand J Infect Dis 37:232-5. 2005..Salmonella spp. are a rare cause of spine infections, usually affecting children with sickle-cell anaemia. We present a case of group C1 Salmonella diskitis in a previously healty 2-y-old child, and review the relevant literature... - Epidemiologic, clinical, laboratory, and therapeutic characteristics of influenza A/H1N1 in moslem Bedouin and Jewish children hospitalized in southern Israel during 2009Lior Goldberg
Pediatric Emergency Medicine Department, Soroka University Medical Center and the Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
Pediatr Infect Dis J 30:530-3. 2011..As compared with influenza-like illness patients, patients with 2009 influenza A/H1N1 were characterized by older age, more vomiting, less hypoxemia and wheezing, lower white blood cell counts, less neutrophilia, and severe lymphopenia... - Hospitalization of children with influenza A(H1N1) virus in Israel during the 2009 outbreak in Israel: a multicenter surveyMichal Stein
Pediatric Infectious Disease Unit, Department of Pediatrics, Edith Wolfson Medical Center, Holon, Israel
Arch Pediatr Adolesc Med 164:1015-22. 2010..To describe the clinical characteristics of children hospitalized with 2009 influenza A(H1N1) infection in Israel and the risk factors associated with this infection... - The use of fluoroquinolones in childrenEugene Leibovitz
Pediatric Infectious Disease Unit, Soroka University Medical Center and the Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
Curr Opin Pediatr 18:64-70. 2006..Their use in children is limited as a result of possible fluoroquinolone-induced joint/cartilage toxicity observed mainly in juvenile animal studies... - [Joint cartilage lesions caused by quinolones in young animals--can we generalize to children?]Hana Polachek
Pharmaceutical Services, Soroka University Medical Center and School of Pharmacy, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheba, Israel
Harefuah 150:721-4, 750. 2011..Magnesium is known to play an essential role in several biochemical processes that take place in cartilage... - Conservative treatment of malignant (invasive) external otitis caused by Aspergillus flavus with oral itraconazole solution in a neutropenic patientGal Finer
Pediatric Department, Soroka University Medical Center, and Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
Scand J Infect Dis 34:227-9. 2002..We report a case of invasive external otitis due to A. flavus that was treated successfully with a short course of amphotericin B and long-term oral itraconazole without surgical intervention... - Pre-screening and follow-up of childhood acute leukemia using biochemical infrared analysis of peripheral blood mononuclear cellsUdi Zelig
Department of Biomedical Engineering, Ben Gurion University of the Negev, Beer Sheva, Israel
Biochim Biophys Acta 1810:827-35. 2011..In the present clinical study, we have investigated the usefulness of Fourier transform infrared microscopy (FTIR-MSP) for pre-screening and follow-up of leukemia patients undergoing chemotherapy... - Community-acquired pneumonia in children: from diagnosis to treatmentDavid Greenberg
The Pediatric Infectious Disease Unit, Soroka University Medical Center and the Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
Chang Gung Med J 28:746-52. 2005..The wider use of pneumococcal vaccines may represent an important advance in the prevention of pneumonia caused by Streptococcus pneumoniae... - The use of piperacillin/tazobactam (in association with amikacin) in neonatal sepsis: efficacy and safety dataOrna Flidel-Rimon
Department of Neonatology, Kaplan Medical Center, Rehovot, Hebrew University, Jerusalem, Israel
Scand J Infect Dis 38:36-42. 2006..We conclude that P/T in association with amikacin is microbiologically and clinically efficacious and safe in the treatment of sepsis in newborns... - A multicenter, open label, double tympanocentesis study of high dose cefdinir in children with acute otitis media at high risk of persistent or recurrent infectionAdriano Arguedas
Instituto de Atención Pediátrica, Neeman ICIC, Hospital Nacional de Ninos, San Jose, Costa Rica
Pediatr Infect Dis J 25:211-8. 2006.... - Community-acquired bloodstream infections in children > one month old in southern Israel (1992-2001): epidemiological, clinical and microbiological aspectsElvira Gur
Paediatric Infectious Disease Unit, Soroka University Medical Centre and the Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
Scand J Infect Dis 38:604-12. 2006..Coverage of 7-valent pneumococcal conjugated vaccine for CABI was 38.5%. 38 (2.7%) patients died; 16 cases were caused by S. pneumoniae... - Accuracy of acute otitis media diagnosis in community and hospital settingsElad Asher
Department of Health Care Policy and Management, Ben-Gurion University of the Negev, Beer-Sheva, Israel
Acta Paediatr 94:423-8. 2005..0, p < 0.001). CONCLUSIONS: Inaccurate diagnosis of AOM in community settings is common, occurring more frequently in simple than in complicated AOM, and is unrelated to physician specialty and children's ethnicity... - An open-label, double tympanocentesis study of levofloxacin therapy in children with, or at high risk for, recurrent or persistent acute otitis mediaAdriano Arguedas
Instituto de Atención Pediátrica, Neeman ICIC, Universidad de Ciencias Medicas, San Jose, Costa Rica
Pediatr Infect Dis J 25:1102-9. 2006..Levofloxacin has excellent activity against common respiratory pathogens and therefore is likely to be effective in treating children with persistent or recurrent otitis media... - Activity of faropenem against middle ear fluid pathogens from children with acute otitis media in Costa Rica and IsraelKimberley Clawson Stone
Replidyne Inc, 1450 Infinite Drive, Louisville, CO 80027, USA
Antimicrob Agents Chemother 51:2230-5. 2007..Faropenem was also active against Moraxella catarrhalis and Streptococcus pyogenes... - Acute otitis media caused by Streptococcus pyogenes in childrenNili Segal
Department of Otorhinolaryngology, Ben-Gurion University of the Negev, Beer-Sheva, Israel
Clin Infect Dis 41:35-41. 2005.... - Nosocomial bloodstream infections in children and adolescents in southern Israel: a 10-year prospective study (1992-2001)Maya Frank
Paediatric Infectious Disease Unit, Soroka University Medical Centre, Ben-Gurion University of the Negev, Beer-Sheva, Israel
Scand J Infect Dis 37:177-83. 2005..A significant decrease in the susceptibility of Enterobacteriaceae spp. to piperacillin, ceftazidime, gentamicin and ceftriaxone was recorded during the study period. 33 (8.9%) patients with NBI died... - Characterization and dynamics of middle ear fluid and nasopharyngeal isolates of Streptococcus pneumoniae from 12 children treated with levofloxacinTodd A Davies
Johnson and Johnson Pharmaceutical Research and Development, LLC, Room B225, 1000 Route 202, Raritan, NJ 08869, USA
Antimicrob Agents Chemother 52:378-81. 2008..All nasopharynx isolates (n = 59) from 12 children were levofloxacin susceptible without parC/E or gyrA/B mutations. Pneumococcal nasopharynx persistence was not associated with levofloxacin resistance... - Large dosage amoxicillin/clavulanate, compared with azithromycin, for the treatment of bacterial acute otitis media in childrenAlejandro Hoberman
Children s Hospital of Pittsburgh, PA 15213, USA
Pediatr Infect Dis J 24:525-32. 2005....