Chaya Brodie

Summary

Affiliation: Bar-Ilan University
Country: Israel

Publications

  1. ncbi PKCdelta associates with and is involved in the phosphorylation of RasGRP3 in response to phorbol esters
    Chaya Brodie
    Faculty of Life Sciences, Bar Ilan University, Ramat Gan 52900, Israel
    Mol Pharmacol 66:76-84. 2004
  2. ncbi Regulation of cell apoptosis by protein kinase c delta
    C Brodie
    Gonda Goldschmied Medical Diagnosis Research Center, Faculty of Life Sciences, Bar Ilan University, Ramat Gan 52900, Israel
    Apoptosis 8:19-27. 2003
  3. ncbi Infection of glioma cells with Sindbis virus induces selective activation and tyrosine phosphorylation of protein kinase C delta. Implications for Sindbis virus-induced apoptosis
    Avi Zrachia
    Gonda (Goldschmied) Medical Diagnosis Research Center, Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel
    J Biol Chem 277:23693-701. 2002
  4. ncbi RTVP-1 expression is regulated by SRF downstream of protein kinase C and contributes to the effect of SRF on glioma cell migration
    Amotz Ziv-Av
    The Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat Gan, Israel
    Cell Signal 23:1936-43. 2011
  5. ncbi Insulin stimulation of PKC? triggers its rapid degradation via the ubiquitin-proteasome pathway
    Chagit Brand
    The Faculty of Life Science, Bar Ilan University, Ramat Gan, Israel
    Biochim Biophys Acta 1803:1265-75. 2010
  6. ncbi The regulatory domain of protein kinase C delta positively regulates insulin receptor signaling
    Avraham I Jacob
    Mina and Everard Goodman Faculty of Life Sciences, Gonda Diagnostic Center, Bar Ilan University, Ramat Gan 52900, Israel
    J Mol Endocrinol 44:155-69. 2010
  7. ncbi Role of protein kinase C delta in reactivation of Kaposi's sarcoma-associated herpesvirus
    Einat Deutsch
    Faculty of Life Sciences, Bar Ilan University, Ramat Gan 52900, Israel
    J Virol 78:10187-92. 2004
  8. ncbi Roles of tyrosine phosphorylation and cleavage of protein kinase Cdelta in its protective effect against tumor necrosis factor-related apoptosis inducing ligand-induced apoptosis
    Hana Okhrimenko
    Gonda Goldschmied Medical Diagnosis Research Center, Faculty of Life Sciences, Bar Ilan University, Ramat Gan, Israel 52900
    J Biol Chem 280:23643-52. 2005
  9. ncbi PKCepsilon induces astrocytic differentiation of multipotential neural precursor cells
    Rivka Steinhart
    Gonda Goldschmied Medical Diagnosis Research Center, The Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat Gan 52900, Israel
    Glia 55:224-32. 2007
  10. ncbi NGF rescues human B lymphocytes from anti-IgM induced apoptosis by activation of PKCzeta
    Ilana Kronfeld
    Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel
    Eur J Immunol 32:136-43. 2002

Collaborators

  • Sanford R Sampson
  • Ronit Sarid
  • Hadara Rubinfeld
  • Asher Shainberg
  • P M Blumberg
  • Attila Toth
  • Tamir Ben-Hur
  • J C Stone
  • Y Zick
  • Richard L Eckert
  • K A Jacobson
  • Ronald S Goldstein
  • Wei Lu
  • Gila Kazimirsky
  • Cunli Xiang
  • Hana Okhrimenko
  • Hae Kyung Lee
  • Susan Finniss
  • Simona Cazacu
  • Sarit Kahana
  • Amotz Ziv-Av
  • Michal Blass
  • Rivka Steinhart
  • Ruth Gomel
  • Ilana Kronfeld
  • Adina Cohen
  • Avraham I Jacob
  • Chagit Brand
  • Miriam Horovitz-Fried
  • Tom Mikkelsen
  • Stephanie L Lomonaco
  • Ling Zhu
  • Shlomit Aga-Mizrachi
  • Tovit Rosenzweig
  • Michal Cipok
  • Isabelle Petit
  • Einat Deutsch
  • Seong G Kim
  • Fidi Schwartz
  • Avi Zrachia
  • Shimon Slavin
  • Shlomit Brodie
  • Vered Roitman
  • Dvir Taller
  • Moshe Attia
  • Aya Inbar
  • - Tamar-Brutman-Barazani
  • Tamar Brutman-Barazani
  • Yehuda Brody
  • Nancy Lemke
  • Hae-Kyung Lee
  • Sivaprakasam Balasubramanian
  • Sandra A Rempel
  • Norman L Lehman
  • Dvir Taler
  • Tamar Feurstein
  • Reuven Reich
  • Cathie G Miller
  • Asia Bak
  • Yair Anikster
  • Yigal Shoshan
  • Ronen Alon
  • Arnon Nagler
  • Amnon Peled
  • Polina Goichberg
  • Rony Seger
  • Nathan Hamburger
  • Tsvee Lapidot
  • Donghong Ju
  • Asaf Spiegel
  • Sara Dovrat
  • Zhan-Guo Gao
  • Kelly A Soltysiak
  • Tong-Shin Chang
  • Elana Appel
  • David Kobiler
  • Erwin W Gelfand
  • Shlomo Lustig
  • Melamed Dobroslav

Detail Information

Publications25

  1. ncbi PKCdelta associates with and is involved in the phosphorylation of RasGRP3 in response to phorbol esters
    Chaya Brodie
    Faculty of Life Sciences, Bar Ilan University, Ramat Gan 52900, Israel
    Mol Pharmacol 66:76-84. 2004
    ..PKCdelta points to the existence of complex cross-talk between various members of the phorbol ester receptors which can have important impact on major signal transduction pathways and cellular processes induced by phorbol esters or DAG..
  2. ncbi Regulation of cell apoptosis by protein kinase c delta
    C Brodie
    Gonda Goldschmied Medical Diagnosis Research Center, Faculty of Life Sciences, Bar Ilan University, Ramat Gan 52900, Israel
    Apoptosis 8:19-27. 2003
    ..Recent findings on these aspects of the PKCdelta cascades are the major focus of this review...
  3. ncbi Infection of glioma cells with Sindbis virus induces selective activation and tyrosine phosphorylation of protein kinase C delta. Implications for Sindbis virus-induced apoptosis
    Avi Zrachia
    Gonda (Goldschmied) Medical Diagnosis Research Center, Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel
    J Biol Chem 277:23693-701. 2002
    ..We conclude that PKCdelta exerts an inhibitory effect on the apoptosis induced by SV and that phosphorylation of PKCdelta on specific tyrosines is required for this function...
  4. ncbi RTVP-1 expression is regulated by SRF downstream of protein kinase C and contributes to the effect of SRF on glioma cell migration
    Amotz Ziv-Av
    The Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat Gan, Israel
    Cell Signal 23:1936-43. 2011
    ..We conclude that RTVP-1 is a PKC-regulated gene and that this regulation is at least partly mediated by SRF. Moreover, RTVP-1 plays a role in the effect of SRF on glioma cell migration...
  5. ncbi Insulin stimulation of PKC? triggers its rapid degradation via the ubiquitin-proteasome pathway
    Chagit Brand
    The Faculty of Life Science, Bar Ilan University, Ramat Gan, Israel
    Biochim Biophys Acta 1803:1265-75. 2010
    ..These studies provide additional evidence for unique effects of insulin on regulation of PKC? protein levels...
  6. ncbi The regulatory domain of protein kinase C delta positively regulates insulin receptor signaling
    Avraham I Jacob
    Mina and Everard Goodman Faculty of Life Sciences, Gonda Diagnostic Center, Bar Ilan University, Ramat Gan 52900, Israel
    J Mol Endocrinol 44:155-69. 2010
    ..Thus, the regulatory domain of PKCdelta via interaction with Src appears to determine the role of PKCdelta as a positive regulator of IR signaling in skeletal muscle...
  7. ncbi Role of protein kinase C delta in reactivation of Kaposi's sarcoma-associated herpesvirus
    Einat Deutsch
    Faculty of Life Sciences, Bar Ilan University, Ramat Gan 52900, Israel
    J Virol 78:10187-92. 2004
    ....
  8. ncbi Roles of tyrosine phosphorylation and cleavage of protein kinase Cdelta in its protective effect against tumor necrosis factor-related apoptosis inducing ligand-induced apoptosis
    Hana Okhrimenko
    Gonda Goldschmied Medical Diagnosis Research Center, Faculty of Life Sciences, Bar Ilan University, Ramat Gan, Israel 52900
    J Biol Chem 280:23643-52. 2005
    ..Our results indicate that PKCdelta protects glioma cells from the apoptosis induced by TRAIL and implicate the phosphorylation of PKCdelta on tyrosine 155 and its cleavage as essential factors in the anti-apoptotic effect of PKCdelta...
  9. ncbi PKCepsilon induces astrocytic differentiation of multipotential neural precursor cells
    Rivka Steinhart
    Gonda Goldschmied Medical Diagnosis Research Center, The Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat Gan 52900, Israel
    Glia 55:224-32. 2007
    ..Our data suggest an important role of PKCepsilon in astrocytic differentiation and implicate Notch1 as a possible mediator of this effect...
  10. ncbi NGF rescues human B lymphocytes from anti-IgM induced apoptosis by activation of PKCzeta
    Ilana Kronfeld
    Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel
    Eur J Immunol 32:136-43. 2002
    ..The results of this study indicate that NGF is involved in B cell survival and that this effect is mediated by PI3-kinase-dependent activation of PKCzeta...
  11. ncbi An essential role of ERK signalling in TPA-induced reactivation of Kaposi's sarcoma-associated herpesvirus
    Adina Cohen
    Bar-Ilan University, Faculty of Life Sciences, 52900 Ramat-Gan, Israel
    J Gen Virol 87:795-802. 2006
    ..c-Fos and c-Jun jointly form an active AP-1 complex, which functions to activate the lytic cascade of KSHV...
  12. ncbi Proteasome inhibitors sensitize glioma cells and glioma stem cells to TRAIL-induced apoptosis by PKC?-dependent downregulation of AKT and XIAP expressions
    Sarit Kahana
    Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat Gan 52900 CB, Israel
    Cell Signal 23:1348-57. 2011
    ..Combining proteasome inhibitors with TRAIL may be useful therapeutically in the treatment of gliomas and the eradication of GSCs...
  13. ncbi Protein kinase Calpha regulates insulin receptor signaling in skeletal muscle
    Michal Cipok
    Gonda Diagnostic Center, Faculty of Life Sciences, Bar Ilan University, Ramat Gan, Israel
    Biochem Biophys Res Commun 345:817-24. 2006
    ..Blockade of PKCalpha increased threonine phosphorylation of PKB. We suggest that PKCalpha regulates insulin signaling in skeletal muscle through its disassociation from IRS-1 and association with PKB...
  14. ncbi Tyrosine phosphorylation of protein kinase Cdelta is essential for its apoptotic effect in response to etoposide
    Michal Blass
    Gonda (Goldschmied) Medical Diagnosis Research Center, Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel
    Mol Cell Biol 22:182-95. 2002
    ..Our results suggest a role of PKCdelta in the apoptosis induced by etoposide and implicate tyrosine phosphorylation of PKCdelta as an important regulator of this effect...
  15. ncbi Effect of helium/neon laser irradiation on nerve growth factor synthesis and secretion in skeletal muscle cultures
    Fidi Schwartz
    Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel
    J Photochem Photobiol B 66:195-200. 2002
    ..The NGF is probably responsible for the beneficial effects of low-level light...
  16. ncbi Protein kinase C-epsilon regulates the apoptosis and survival of glioma cells
    Hana Okhrimenko
    Gonda (Goldschmied) Medical Diagnosis Research Center, Faculty of Life-Sciences, Bar-Ilan University, Ramat Gan, Israel
    Cancer Res 65:7301-9. 2005
    ..Our results suggest that the cleavage of PKCepsilon and its down-regulation play important roles in the apoptotic effect of TRAIL. Moreover, PKCepsilon regulates AKT expression and is essential for the survival of glioma cells...
  17. ncbi Tyrosine 311 is phosphorylated by c-Abl and promotes the apoptotic effect of PKCdelta in glioma cells
    Wei Lu
    William and Karen Davidson Laboratory of Cell Signaling and Tumorigenesis, Hermelin Brain Tumor Center, Department of Neurosurgery, Henry Ford Hospital, Detroit, MI, USA
    Biochem Biophys Res Commun 352:431-6. 2007
    ..These results suggest an important role of tyrosine 311 in the apoptotic function of PKCdelta and implicate c-Abl as the kinase that phosphorylates this tyrosine...
  18. ncbi The localization of protein kinase Cdelta in different subcellular sites affects its proapoptotic and antiapoptotic functions and the activation of distinct downstream signaling pathways
    Ruth Gomel
    Hermelin Brain Tumor Center, Department of Neurosurgery, Henry Ford Hospital, Detroit, MI 48202, USA
    Mol Cancer Res 5:627-39. 2007
    ..Our results indicate that the subcellular localization of PKCdelta plays important roles in its proapoptotic and antiapoptotic functions and in the activation of downstream signaling pathways...
  19. ncbi Multiple PKCdelta tyrosine residues are required for PKCdelta-dependent activation of involucrin expression--a key role of PKCdelta-Y311
    Ling Zhu
    Department of Physiology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    J Invest Dermatol 128:833-45. 2008
    ..These findings indicate that PKCdelta activity requires Y(311) and a second tyrosine residue; however, any one of the several tyrosine residues can serve in the secondary role...
  20. ncbi P2Y6 nucleotide receptor activates PKC to protect 1321N1 astrocytoma cells against tumor necrosis factor-induced apoptosis
    Seong G Kim
    Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-0810, USA
    Cell Mol Neurobiol 23:401-18. 2003
    ..6. The addition of phospholipase C (PLC) inhibitors, D609 or U73122, partially antagonized both UDP-induced protection and PKC activation...
  21. ncbi Phosphorylation of protein kinase Cdelta on distinct tyrosine residues induces sustained activation of Erk1/2 via down-regulation of MKP-1: role in the apoptotic effect of etoposide
    Stephanie L Lomonaco
    William and Karen Davidson Laboratory of Cell Signaling and Tumorigenesis, Hermelin Brain Tumor Center, Department of Neurosurgery, Henry Ford Hospital, Detroit, Michigan 48202, USA
    J Biol Chem 283:17731-9. 2008
    ..These results indicate that distinct phosphorylation of PKCdeltaon tyrosines 64 and 187 specifically activates the Erk1/2 pathway by the down-regulation of MKP-1, resulting in the persistent phosphorylation of Erk1/2 and cell apoptosis...
  22. ncbi Atypical PKC-zeta regulates SDF-1-mediated migration and development of human CD34+ progenitor cells
    Isabelle Petit
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    J Clin Invest 115:168-76. 2005
    ..Our results demonstrate a central role for PKC-zeta in SDF-1-dependent regulation of hematopoietic stem and progenitor cell motility and development...
  23. ncbi GRP78 is overexpressed in glioblastomas and regulates glioma cell growth and apoptosis
    Hae Kyung Lee
    Department of Neurosurgery and Hermelin Brain Tumor Center, Henry Ford Health System, Detroit, MI 48202, USA
    Neuro Oncol 10:236-43. 2008
    ..Thus, GRP78 contributes to the increased apoptosis resistance and growth of glioma cells and may provide a target for enhancing the therapeutic responsiveness of these tumors...
  24. ncbi The phosphorylation of tyrosine 332 is necessary for the caspase 3-dependent cleavage of PKCdelta and the regulation of cell apoptosis
    Wei Lu
    William and Karen Davidson Laboratory of Cell Signaling and Tumorigenesis, Hermelin Brain Tumor Center, Department of Neurosurgery, Henry Ford Hospital, Detroit, MI, USA
    Cell Signal 19:2165-73. 2007
    ..These results demonstrate that the phosphorylation of tyrosine 332 by Src modulates the cleavage of PKCdelta and the sensitivity of glioma cells to TRAIL and cisplatin...
  25. ncbi Related to testes-specific, vespid, and pathogenesis protein-1 (RTVP-1) is overexpressed in gliomas and regulates the growth, survival, and invasion of glioma cells
    Tovit Rosenzweig
    Gonda (Goldschmied) Medical Diagnosis Research Center, Faculty of Life-Sciences, Bar-Ilan University, Ramat-Gan, Israel
    Cancer Res 66:4139-48. 2006
    ..Collectively, these findings suggest that RTVP-1 is a potential therapeutic target in gliomas...