Selenium prevents cognitive decline and oxidative damage in rat model of streptozotocin-induced experimental dementia of Alzheimer's typeTauheed Ishrat
Department of Medical Elementology and Toxicology, Neurotoxicology Laboratory, Jamia Hamdard Hamdard University, New Delhi, India
Brain Res 1281:117-27. 2009
..Our study reveals that Se, as a powerful antioxidant, prevents cognitive deficits, oxidative damage and morphological changes in the ICV-STZ rats. Thus, it may have a therapeutic value for the treatment of SDAT...
- Behavioral and histologic neuroprotection of aqueous garlic extract after reversible focal cerebral ischemia
Sofiyan Saleem
Neurotoxicology Laboratory, Department of Medical Elementology and Toxicology, Jamia Hamdard (Hamdard University, Hamdard Nagar, New Delhi, India
J Med Food 9:537-44. 2006
..These findings suggest that AGE effectively modulates neurobehavioral and neurochemical changes in focal ischemia, most probably by virtue of its antioxidant properties...
- Resveratrol attenuates 6-hydroxydopamine-induced oxidative damage and dopamine depletion in rat model of Parkinson's disease
Mohd Moshahid Khan
Department of Medical Elementology and Toxicology, Jamia Hamdard Hamdard University, Hamdard Nagar, New Delhi, India
Brain Res 1328:139-51. 2010
..Thus, RES may be used to reduce the deterioration caused by free radicals thereby preventing subsequent behavioral, biochemical, and histopathological changes that occur during PD...
- Attenuation by Nardostachys jatamansi of 6-hydroxydopamine-induced parkinsonism in rats: behavioral, neurochemical, and immunohistochemical studies
Muzamil Ahmad
Neurotoxicology Laboratory, Department of Medical Elementology and Toxicology, Jamia Hamdard Hamdard University, Hamdard Nagar, New Delhi 110062, India
Pharmacol Biochem Behav 83:150-60. 2006
..This study indicates that the extract of Jatamansi might be helpful in attenuating Parkinsonism...
- Sesamin attenuates behavioral, biochemical and histological alterations induced by reversible middle cerebral artery occlusion in the rats
Mohd Moshahid Khan
Neurotoxicology Laboratory, Department of Medical Elementology and Toxicology Fund for the Improvement of Science and Technology sponsored by DST and Special Assistance Programme sponsored by UGC, Jamia Hamdard Hamdard University, Hamdard Nagar, New Delhi 110062, India
Chem Biol Interact 183:255-63. 2010
..Thus, sesamin may be a potential compound in stroke therapy...
- Effects of Pycnogenol and vitamin E on cognitive deficits and oxidative damage induced by intracerebroventricular streptozotocin in rats
Tauheed Ishrat
Department of Medical Elementology and Toxicology, Neurotoxicology Laboratory, Jamia Hamdard Hamdard University, New Delhi, India
Behav Pharmacol 20:567-75. 2009
..These findings suggest that PYC and Vit E may provide a promising approach for the treatment of oxidative stress-related neurodegeneration in conditions such as AD...
- Effect of Saffron (Crocus sativus) on neurobehavioral and neurochemical changes in cerebral ischemia in rats
Sofiyan Saleem
Neurotoxicology Laboratory, Department of Medical Elementology and Toxicology, Jamia Hamdard University, Hamdard Nagar, New Delhi, India
J Med Food 9:246-53. 2006
..The present results may suggest the effectiveness of CS in focal ischemia most probably by virtue of its antioxidant property...
- Effect of dietary sesame oil as antioxidant on brain hippocampus of rat in focal cerebral ischemia
Saif Ahmad
Neurotoxicology Laboratory, Department of Medical Elementology and Toxicology, Faculty of Science, Jamia Hamdard Hamdard University, New Delhi 110 062, India
Life Sci 79:1921-8. 2006
..The results of neurobehavioral activity also support our biochemical data. The results obtained suggest protective effect of SO against cerebral ischemia in rat brain through their antioxidant properties...
- Coenzyme Q10 modulates cognitive impairment against intracerebroventricular injection of streptozotocin in rats
Tauheed Ishrat
Neurotoxicology Laboratory, Department of Medical Elementology and Toxicology, Jamia Hamdard (Hamdard University, New Delhi, India
Behav Brain Res 171:9-16. 2006
..However, supplementation with CoQ10 in STZ-infused rats reversed all the parameters significantly. Thus, the study demonstrates that CoQ10 may have a therapeutic importance in the treatment of Alzheimer's type dementia...
- Amelioration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced behavioural dysfunction and oxidative stress by Pycnogenol in mouse model of Parkinson's disease
Mohammad Moshahid Khan
Department of Medical Elementology and Toxicology, Jamia Hamdard, Hamdard University, Hamdard Nagar, New Delhi, India
Behav Pharmacol 21:563-71. 2010
..Thus, PYC may be used to prevent or reduce the deterioration caused by free radicals, thereby preventing subsequent behavioural and biochemical changes that occur in Parkinsonian mice...
- Resveratrol exerts its neuroprotective effect by modulating mitochondrial dysfunctions and associated cell death during cerebral ischemia
Seema Yousuf
Neurotoxicology Laboratory, Department of Medical Elementology and Toxicology, Jamia Hamdard Hamdard University, New Delhi 110062, India
Brain Res 1250:242-53. 2009
..The findings of this study highlight the ability of resveratrol in anatomical and functional preservation of ischemic neurovascular units and its relevance in the treatment of ischemic stroke...
- Quercetin protects against oxidative stress associated damages in a rat model of transient focal cerebral ischemia and reperfusion
Ajmal Ahmad
Neurotoxicology Laboratory, Department of Medical Elementology and Toxicology, Jamia Hamdard Hamdard University, Hamdard Nagar, New Delhi, 110062, India
Neurochem Res 36:1360-71. 2011
..Our study reveals that Q, as a powerful antioxidant, could prevent free radicals associated oxidative damage and morphological changes in the MCAO rats. Thus, it may have a therapeutic value for the treatment of stroke...
- Neuroprotective effects of curcumin on 6-hydroxydopamine-induced Parkinsonism in rats: behavioral, neurochemical and immunohistochemical studies
Gulrana Khuwaja
Neurotoxicology Laboratory, Department of Medical Elementology and Toxicology, Jamia Hamdard Hamdard University, Hamdard Nagar, New Delhi 110062, India
Brain Res 1368:254-63. 2011
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- Rutin protects the neural damage induced by transient focal ischemia in rats
Mohd Moshahid Khan
Neurotoxicology Laboratory, Department of Medical Elementology and Toxicology, Jamia Hamdard Hamdard University, Hamdard Nagar, New Delhi, 110062, India
Brain Res 1292:123-35. 2009
..Thus, rutin treatment may represent a novel approach in lowering the risk or improving the function of ischemia-reperfusion brain injury-related disorders...
- Synergistic effect of selenium and melatonin on neuroprotection in cerebral ischemia in rats
Ajmal Ahmad
Neurotoxicology Laboratory, Department of Medical Elementology and Toxicology, Jamia Hamdard Hamdard University, Hamdard Nagar, New Delhi 110062, India
Biol Trace Elem Res 139:81-96. 2011
..In conclusion, we demonstrated that the pretreatment with Se-Mel at the onset of reperfusion, reduced post-ischemic damage, and improved neurological outcome following transient focal cerebral ischemia in male Wistar rat...
- Selenium plays a modulatory role against cerebral ischemia-induced neuronal damage in rat hippocampus
Seema Yousuf
Neurotoxicology Laboratory, Department of Medical Elementology and Toxicology, Jamia Hamdard Hamdard University, New Delhi 110062, India
Brain Res 1147:218-25. 2007
..The present study suggests that selenium may be able to salvage the ischemic penumbral zone neurons, thereby limiting ischemic cell death...
- Ginkgo biloba affords dose-dependent protection against 6-hydroxydopamine-induced parkinsonism in rats: neurobehavioural, neurochemical and immunohistochemical evidences
Muzamil Ahmad
Neurotoxicology Laboratory, Department of Medical Elementology and Toxicology, Jamia Hamdard Hamdard University, Hamdard Nagar New Delhi, India
J Neurochem 93:94-104. 2005
..Considering our behavioural studies, biochemical analysis, and immunohistochemical observation, we conclude that EGb can be used as a therapeutic approach to check the neuronal loss following parkinsonism...
- Prevention of cognitive impairments and neurodegeneration by Khamira Abresham Hakim Arshad Wala
M Badruzzaman Khan
Neurotoxicology Laboratory, Department of Medical Elementology and Toxicology, Jamia Hamdard (Hamdard University, Hamdard Nagar, New Delhi 110062, India
J Ethnopharmacol 108:68-73. 2006
..The study concludes that the therapeutic intervention of KAHAW may be used to prevent or to decrease the deterioration of cognitive function and neurobehavioral activities, often associated with the generation of free radicals...
- Selenium protects cerebral ischemia in rat brain mitochondria
Mubeen Ahmad Ansari
Neurotoxicology Laboratory, Department of Medical Elementology and Toxicology, Jamia Hamdard, Hamdard University, Hamdard Nagar, New Delhi-110062, India
Biol Trace Elem Res 101:73-86. 2004
..It is concluded that selenium, which is an essential part of our diet, might be helpful in protection against neurodegeneration in cerebral ischemia...
