Research Topics
| Mark TangneySummaryAffiliation: University College Cork Country: Ireland Publications
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Detail Information
Publications
Anti-metastatic effects of viral and non-viral mediated Nk4 delivery to tumoursAlexandra Buhles
Cork Cancer Research Centre, Mercy University Hospital, Leslie C Quick Junior Laboratory, University College Cork, Cork, Ireland
Genet Vaccines Ther 7:5. 2009..Overall, this study demonstrates the potential for Nk4 gene therapy of metastatic tumours, when delivered by AAV or non-viral methods...- Sonoporation mediated immunogene therapy of solid tumorsGarrett Casey
Cork Cancer Research Centre, Mercy University Hospital, University College Cork, Cork, Ireland
Ultrasound Med Biol 36:430-40. 2010..US-mediated delivery of an immune-gene construct to growing tumors was therapeutically effective. Sonoporation has the potential to be a major factor in the development of nonviral gene delivery approaches... - Gene therapy for prostate cancerMark Tangney
Cork Cancer Research Centre, Mercy University Hospital, Cork, Ireland
Postgrad Med 122:166-80. 2010.... - In vivo optical imaging in gene & cell therapyMark Tangney
Cork Cancer Research Centre, Mercy University Hospital and Leslie C Quick Jnr Laboratory, University College Cork, Cork, Ireland
Curr Gene Ther 12:2-11. 2012.... - Optimised electroporation mediated DNA vaccination for treatment of prostate cancerSarfraz Ahmad
Cork Cancer Research Centre, Mercy University Hospital, Cork, Ireland
Genet Vaccines Ther 8:1. 2010..In vivo electroporation mediated vaccination is a safe and effective modality for the treatment of prostate cancer and has a potential to be used as a neo-adjuvant or adjuvant therapy... - AAV2-mediated in vivo immune gene therapy of solid tumoursSara A Collins
Cork Cancer Research Centre, Mercy University Hospital and Leslie C, Quick Jnr, Laboratory, University College Cork, Cork, Ireland
Genet Vaccines Ther 8:8. 2010..In this study, the feasibility of AAV2 mediated immunotherapy of growing tumours was examined, in isolation and combined with anti-angiogenic therapy... - Non-viral in vivo immune gene therapy of cancer: combined strategies for treatment of systemic diseaseM Tangney
Cork Cancer Research Centre, Mercy University Hospital and Leslie C Quick Jnr Laboratory, University College Cork, Cork, Ireland
Cancer Immunol Immunother 55:1443-50. 2006..We discuss the potential for enhancement of this therapy by its application as a neoadjuvant to surgical excision and by its use in combination with suppressor T cell depletion... - Gene therapy for cancer: dairy bacteria as delivery vectorsMark Tangney
David Geffen School of Medicine, University of California Los Angeles, 675 Charles E Young Drive South, Los Angeles, California 90095, USA
Discov Med 10:195-200. 2010.... - A novel Listeria monocytogenes-based DNA delivery system for cancer gene therapyJan Peter van Pijkeren
Cork Cancer Research Centre, Mercy University Hospital and Leslie C Quick Jnr Laboratory, University College Cork, Cork, Ireland
Hum Gene Ther 21:405-16. 2010..For the first time, our results reveal the potential of Listeria monocytogenes for in vivo gene delivery... - Induction of effective antitumor response after mucosal bacterial vector mediated DNA vaccination with endogenous prostate cancer specific antigenSarfraz Ahmad
Leslie C Quick Jr Laboratory, Cork Cancer Research Centre, and Department of Surgery, Mercy University Hospital, University College Cork, Cork, Ireland
J Urol 186:687-93. 2011..We generated specific antitumor immune responses in a murine model of prostate cancer by oral administration of an attenuated strain of Salmonella typhimurium containing a plasmid coding for murine prostate stem cell antigen... - Targeting of breast metastases using a viral gene vector with tumour-selective transcriptionSimon Rajendran
Cork Cancer Research Centre, Mercy University Hospital, Cork, Ireland
Anticancer Res 31:1627-35. 2011..Adeno-associated virus (AAV) vectors have significant potential as gene delivery vectors for cancer gene therapy. However, broad AAV2 tissue tropism results in nonspecific gene expression... - Bacteria as vectors for gene therapy of cancerChwanrow K Baban
Cork Cancer Research Centre, Mercy University Hospital and Leslie C Quick Jr Laboratory, University College Cork, Cork, Ireland
Bioeng Bugs 1:385-94. 2010..Here, we review the use of bacteria as vehicles for gene therapy of cancer, detailing the mechanisms of action and successes at preclinical and clinical levels... - Effective tumor treatment using optimized ultrasound-mediated delivery of bleomycinJohn O Larkin
Cork Cancer Research Centre, Leslie C Quick Laboratory, University College Cork, Cork, Ireland
Ultrasound Med Biol 34:406-13. 2008..This technique could be used with focused ultrasound or with endoscopic ultrasound probes to develop a localized and effective anticancer treatment with little or no systemic toxicity. (E-mail: Geraldc@ccrc.ie)... - Viral vectors in cancer immunotherapy: which vector for which strategy?Sara A Collins
Cork Cancer Research Centre, Mercy University Hospital and Leslie C Quick Jnr Laboratory, University College Cork, Cork, Ireland
Curr Gene Ther 8:66-78. 2008.... - Orally administered bifidobacteria as vehicles for delivery of agents to systemic tumorsMichelle Cronin
Cork Cancer Research Centre, Mercy University Hospital and Leslie C Quick Jnr Laboratory, University College Cork, Cork, Ireland
Mol Ther 18:1397-407. 2010..These findings indicate potential for safe and efficient gene-based treatment and/or detection of tumors via ingestion of nonpathogenic bacteria expressing therapeutic or reporter genes... - Prostate stem cell antigen DNA vaccination breaks tolerance to self-antigen and inhibits prostate cancer growthSarfraz Ahmad
Cork Cancer Research Centre, Mercy University Hospital and Leslie C Quick Jnr Laboratory, University College Cork, Cork, Ireland
Mol Ther 17:1101-8. 2009.... - The use of Listeria monocytogenes as a DNA delivery vector for cancer gene therapyMark Tangney
Cork Cancer Research Centre, Mercy University Hospital and Leslie C Quick Jnr Laboratory, University College Cork, Cork, Ireland
Bioeng Bugs 1:284-7. 2010..Here, we discuss the implications of this technology and the potential for future improvements of the system... - Electrochemotherapy: aspects of preclinical development and early clinical experienceJohn O Larkin
Cork Cancer Research Centre, Leslie C Quick Jr Cancer Laboratory, Biosciences Institute and Mercy University Hospital, National University of Ireland, Cork, Ireland
Ann Surg 245:469-79. 2007.... - Tumour targeting with systemically administered bacteriaDavid Morrissey
Cork Cancer Research Centre, Mercy University Hospital, University College Cork, Ireland
Curr Gene Ther 10:3-14. 2010..Here, we consider the pre-clinical data supporting the use of bacteria as a tumour-targeting tool, recent advances in the area, and future work required to develop it into a beneficial clinical tool... - Listeria monocytogenes as a vector for anti-cancer therapiesMark Tangney
Cork Cancer Research Centre, Mercy University Hospital, University College Cork, Ireland
Curr Gene Ther 10:46-55. 2010..monocytogenes as a vector for tumour-specific vaccine delivery... - Effective immunotherapy of weakly immunogenic solid tumours using a combined immunogene therapy and regulatory T-cell inactivationM C Whelan
Cork Cancer Research Centre, Mercy University Hospital and Leslie C Quick Jnr Laboratory, University College Cork, Cork, Ireland
Cancer Gene Ther 17:501-11. 2010..Combined gene-based immune effector therapy and Treg inactivation represents an effective treatment for weakly antigenic solid growing tumours and that could be considered for clinical development... - Local gene therapy of solid tumors with GM-CSF and B7-1 eradicates both treated and distal tumorsC G Collins
Cork Cancer Research Centre, Mercy University Hospital and Leslie C Quick Jnr Laboratory, University College Cork, Cork, Ireland
Cancer Gene Ther 13:1061-71. 2006..This treatment strategy could be applicable in the clinical setting for effective elimination of both primary tumors and associated metastatic disease... - Preclinical evaluation of gene delivery methods for the treatment of loco-regional disease in breast cancerSimon Rajendran
Cork Cancer Research Centre, Mercy University Hospital and Leslie C Quick Jnr Laboratory, University College Cork, Cork, Ireland
Exp Biol Med (Maywood) 236:423-34. 2011..The results highlight the importance of in-depth preclinical assessment of novel therapeutics and may serve as a platform for further testing of current, novel gene delivery approaches... - Oral immune tolerance mediated by suppressor T cells may be responsible for the poorer prognosis of foregut cancersJohn Larkin
Cork Cancer Research Centre, Leslie C. Quick Jnr. Laboratory, Mercy University Hospital, Cork, Ireland
Med Hypotheses 66:541-4. 2006..Abrogation of oral immune tolerance to the tumour by immune based therapy could represent a significant advance in the management of upper gastrointestinal cancers... - Evaluation of cellular uptake and gene transfer efficiency of pegylated poly-L-lysine compacted DNA: implications for cancer gene therapyM Walsh
School of Pharmacy, University College Cork, Cork, Ireland
Mol Pharm 3:644-53. 2006..Such mechanistic studies are an essential step to support future rational design of pegylated poly-L-lysine vectors to improve the efficiency of gene delivery... - High resolution in vivo bioluminescent imaging for the study of bacterial tumour targetingMichelle Cronin
Cork Cancer Research Centre, Mercy University Hospital and Leslie C Quick Jr Laboratory, University College Cork, Cork, Ireland
PLoS ONE 7:e30940. 2012..This study demonstrates for the first time the potential to simultaneously image multiple BLI reporter genes three dimensionally in vivo using approaches that provide unique information on spatial locations... - Modulation of p21-activated kinase 1 alters the behavior of renal cell carcinomaGerald C O'Sullivan
Cork Cancer Research Center, Leslie C Quick Jnr Cancer Laboratories, Bioscience Institute and Mercy University Hospital, Cork, Ireland
Int J Cancer 121:1930-40. 2007..Together these findings point to Pak1 as an exciting target for therapy of renal cancer, which remains highly refractory to existing treatments... - PET imaging for gene & cell therapySara A Collins
UCLA School of Medicine, Los Angeles, USA
Curr Gene Ther 12:20-32. 2012..This review outlines the principles of PET imaging in the context of gene and cell therapy at both pre-clinical and clinical levels, comparing PET with other relevant modalities, and describes the progress to date in this field... - Improved luciferase tagging system for Listeria monocytogenes allows real-time monitoring in vivo and in vitroChristian U Riedel
Alimentary Pharmabiotic Centre and Department of Microbiology, University College Cork, Cork, Ireland
Appl Environ Microbiol 73:3091-4. 2007..This construct gave 100-fold-higher activity in broth than any native promoter tested and allowed for imaging of lux-tagged L. monocytogenes in food products, during murine infections, and in tumor targeting studies... - Successful application of targeted electrochemotherapy using novel flexible electrodes and low dose bleomycin to solid tumoursDeclan M Soden
Cork Cancer Research Centre, Mercy University Hospital and Leslie C. Quick Jnr Laboratory, Grenville Place, Cork, Ireland
Cancer Lett 232:300-10. 2006.... - Combined electric field and ultrasound therapy as a novel anti-tumour treatmentJ Larkin
Cork Cancer Research Centre, Leslie C. Quick Jnr. Cancer Laboratory, Biosciences Institute and Mercy University Hospital, National University of Ireland, Cork, Ireland
Eur J Cancer 41:1339-48. 2005..032). Our preliminary data suggest that this novel technology could potentially be of wide application in clinical practice for the treatment of solid tumours and is worth further investigation... - Identification of a DNA region from lactococcal phage sk1 protecting phage 712 from the abortive infection mechanism AbiFA Rince
National Food Biotechnology Centre, University College, Cork, Ireland
FEMS Microbiol Lett 182:185-91. 2000..Sequence analysis of a 3.2-kb segment containing the middle operon and the cos ends of phage 712 genome allowed comparison of this part of the phage 712 genome with the equivalent sequences of four other small isometric-headed phages...