Hypothermia decreases excitatory neurotransmitter release in bacterial meningitis in rabbitsJ E Irazuzta
Division of Critical Care, Children s Hospital Medical Center, Cincinnati, OH, USA
Brain Res 847:143-8. 1999
..These data demonstrate that hypothermia produces an attenuation of the release of excitatory neurotransmitters in meningitis and suggest that this treatment may attenuate neuronal stress...
Mercaptoethylguanidine attenuates inflammation in bacterial meningitis in rabbitsJ E Irazuzta
Division of Critical Care, Children s Hospital Medical Center, Cincinnati, OH, USA
Life Sci 67:365-72. 2000
..Furthermore, treatment with MEG markedly reduced brain tissue levels of myeloperoxidase and malondialdehyde. These data demonstrate that MEG could have a therapeutic role in meningitis...
Hypothermia as an adjunctive treatment for severe bacterial meningitisJ E Irazuzta
Division of Critical Care, Children s Hospital Medical Center, Cincinnati, OH, USA
Brain Res 881:88-97. 2000
..We conclude that in the treatment of severe bacterial meningitis, the application of moderate hypothermia initiated shortly after antibiotic therapy improves short-term physiologic measures associated with brain injury...
Serum cleaved Tau protein and neurobehavioral battery of tests as markers of brain injury in experimental bacterial meningitisJ E Irazuzta
Division of Critical Care, Children s Hospital Medical Center, Cincinnati, OH, USA
Brain Res 913:95-105. 2001
..We conclude that serum C-tau and a composite of neurobehavioral tests could become useful markers for assessing the severity of neurological damage in experimental bacterial meningitis...
Caspases inhibition decreases neurological sequelae in meningitisJose Irazuzta
University of Florida at Jacksonville, Wolfson s Children Hospital, Jacksonville, FL, USA
Crit Care Med 36:1603-6. 2008
..To evaluate the effects of sustained caspase inhibition during the acute phase of meningitis-induced brain injury. Changes in neurobehavioral performance were the primary outcome variables...
Dexamethasone decreases neurological sequelae and caspase activityJose Irazuzta
Division of Critical Care Medicine, The Floating Hospital for Children, 750 Washington Street, NEMC 093, Boston, MA 02111, USA
Intensive Care Med 31:146-50. 2005
..Changes in neurobehavioral performance were the primary outcome variables. Changes in caspase activation and markers of neuronal injury were the secondary outcome variables...