Evans L N Taracha

Summary

Affiliation: International Food Policy Research Institute

Publications

  1. ncbi Heterologous priming-boosting immunization of cattle with Mycobacterium tuberculosis 85A induces antigen-specific T-cell responses
    Evans L N Taracha
    International Livestock Research Institute, Nairobi, Kenya
    Infect Immun 71:6906-14. 2003
  2. ncbi Evaluation of the recognition of Theileria parva vaccine candidate antigens by cytotoxic T lymphocytes from Zebu cattle
    Lavoisier Akoolo
    International Livestock Research Institute, PO Box 30709, Nairobi 00100, Kenya
    Vet Immunol Immunopathol 121:216-21. 2008
  3. ncbi Treatment of cattle with DNA-encoded Flt3L and GM-CSF prior to immunization with Theileria parva candidate vaccine antigens induces CD4 and CD8 T cell IFN-? responses but not CTL responses
    Duncan M Mwangi
    International Livestock Research Institute, P O Box 30709, Nairobi 00100, Kenya
    Vet Immunol Immunopathol 140:244-51. 2011
  4. ncbi Fusion of a cell penetrating peptide from HIV-1 TAT to the Theileria parva antigen Tp2 enhances the stimulation of bovine CD8+ T cell responses
    Alex N Tinega
    International Livestock Research Institute, P O Box 30709, Nairobi 00100, Kenya
    Vet Immunol Immunopathol 130:107-13. 2009
  5. ncbi Immunostimulatory CpG oligodeoxynucleotides enhance the induction of bovine CD4+ cytotoxic T-lymphocyte responses against the polymorphic immunodominant molecule of the protozoan parasite Theileria parva
    Simon P Graham
    International Livestock Research Institute, PO Box 30709, Nairobi 00100, Kenya
    Vet Immunol Immunopathol 115:383-9. 2007
  6. ncbi Characterization of the fine specificity of bovine CD8 T-cell responses to defined antigens from the protozoan parasite Theileria parva
    Simon P Graham
    International Livestock Research Institute, PO Box 30709, Nairobi 00100, Kenya
    Infect Immun 76:685-94. 2008
  7. ncbi Two Theileria parva CD8 T cell antigen genes are more variable in buffalo than cattle parasites, but differ in pattern of sequence diversity
    Roger Pelle
    International Livestock Research Institute, Nairobi, Kenya
    PLoS ONE 6:e19015. 2011
  8. ncbi Analysis of the transcriptome of the protozoan Theileria parva using MPSS reveals that the majority of genes are transcriptionally active in the schizont stage
    Richard Bishop
    The International Livestock Research Institute ILRI, PO Box 30709, Nairobi, Kenya
    Nucleic Acids Res 33:5503-11. 2005
  9. ncbi Assessment of in vitro interferon-gamma responses from peripheral blood mononuclear cells of cattle infected with Mycoplasma mycoides ssp. mycoides small colony type
    Joerg Jores
    International Livestock Research Institute, Old Naivasha Road, P O Box 30709, 00100 Nairobi, Kenya
    Vet Immunol Immunopathol 124:192-7. 2008
  10. ncbi Theileria parva candidate vaccine antigens recognized by immune bovine cytotoxic T lymphocytes
    Simon P Graham
    International Livestock Research Institute, Nairobi, Kenya
    Proc Natl Acad Sci U S A 103:3286-91. 2006

Detail Information

Publications12

  1. ncbi Heterologous priming-boosting immunization of cattle with Mycobacterium tuberculosis 85A induces antigen-specific T-cell responses
    Evans L N Taracha
    International Livestock Research Institute, Nairobi, Kenya
    Infect Immun 71:6906-14. 2003
    ..These data illustrate the general applicability of priming-boosting vaccination strategies for induction of antigen-specific T-cell responses and suggest that the method may be useful for development of veterinary vaccines...
  2. ncbi Evaluation of the recognition of Theileria parva vaccine candidate antigens by cytotoxic T lymphocytes from Zebu cattle
    Lavoisier Akoolo
    International Livestock Research Institute, PO Box 30709, Nairobi 00100, Kenya
    Vet Immunol Immunopathol 121:216-21. 2008
    ..Immunoscreening of the T. parva genome with these CTL lines should identify novel antigens that will constitute valuable additions to the vaccine candidates currently being evaluated...
  3. ncbi Treatment of cattle with DNA-encoded Flt3L and GM-CSF prior to immunization with Theileria parva candidate vaccine antigens induces CD4 and CD8 T cell IFN-? responses but not CTL responses
    Duncan M Mwangi
    International Livestock Research Institute, P O Box 30709, Nairobi 00100, Kenya
    Vet Immunol Immunopathol 140:244-51. 2011
    ....
  4. ncbi Fusion of a cell penetrating peptide from HIV-1 TAT to the Theileria parva antigen Tp2 enhances the stimulation of bovine CD8+ T cell responses
    Alex N Tinega
    International Livestock Research Institute, P O Box 30709, Nairobi 00100, Kenya
    Vet Immunol Immunopathol 130:107-13. 2009
    ..This work describes for the first time the utility of a CPP to enhance MHC-I presentation in a veterinary species and supports the evaluation of CPP fusion proteins in the induction of CD8+ T cell responses in vivo...
  5. ncbi Immunostimulatory CpG oligodeoxynucleotides enhance the induction of bovine CD4+ cytotoxic T-lymphocyte responses against the polymorphic immunodominant molecule of the protozoan parasite Theileria parva
    Simon P Graham
    International Livestock Research Institute, PO Box 30709, Nairobi 00100, Kenya
    Vet Immunol Immunopathol 115:383-9. 2007
    ....
  6. ncbi Characterization of the fine specificity of bovine CD8 T-cell responses to defined antigens from the protozoan parasite Theileria parva
    Simon P Graham
    International Livestock Research Institute, PO Box 30709, Nairobi 00100, Kenya
    Infect Immun 76:685-94. 2008
    ..These data demonstrate that the identified antigens are inherently dominant in animals with the corresponding MHC genotypes...
  7. ncbi Two Theileria parva CD8 T cell antigen genes are more variable in buffalo than cattle parasites, but differ in pattern of sequence diversity
    Roger Pelle
    International Livestock Research Institute, Nairobi, Kenya
    PLoS ONE 6:e19015. 2011
    ..This study set out to determine the nature and extent of polymorphism in two of these antigens, Tp1 and Tp2, which contain defined CD8(+) T-cell epitopes, and to analyse the sequences for evidence of selection...
  8. ncbi Analysis of the transcriptome of the protozoan Theileria parva using MPSS reveals that the majority of genes are transcriptionally active in the schizont stage
    Richard Bishop
    The International Livestock Research Institute ILRI, PO Box 30709, Nairobi, Kenya
    Nucleic Acids Res 33:5503-11. 2005
    ..The data suggests a low level of baseline transcription from the majority of protein-coding genes...
  9. ncbi Assessment of in vitro interferon-gamma responses from peripheral blood mononuclear cells of cattle infected with Mycoplasma mycoides ssp. mycoides small colony type
    Joerg Jores
    International Livestock Research Institute, Old Naivasha Road, P O Box 30709, 00100 Nairobi, Kenya
    Vet Immunol Immunopathol 124:192-7. 2008
    ..Additionally, we applied immunocytochemistry on affected lung tissue and detected no build up of T-lymphocytes (CD4 T-cells, CD8 T-cells) but a high presence of myeloid cells...
  10. ncbi Theileria parva candidate vaccine antigens recognized by immune bovine cytotoxic T lymphocytes
    Simon P Graham
    International Livestock Research Institute, Nairobi, Kenya
    Proc Natl Acad Sci U S A 103:3286-91. 2006
    ..These data provide a basis for developing a CTL-targeted anti-East Coast fever subunit vaccine. In addition, orthologs of these antigens may be vaccine targets for other apicomplexan parasites...
  11. ncbi Genome sequence of Theileria parva, a bovine pathogen that transforms lymphocytes
    Malcolm J Gardner
    Institute for Genomic Research TIGR, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Science 309:134-7. 2005
    ..Several biosynthetic pathways are incomplete or absent, suggesting substantial metabolic dependence on the host cell. One protein family that may generate parasite antigenic diversity is not telomere-associated...
  12. ncbi Extensive genotypic diversity in a recombining population of the apicomplexan parasite Theileria parva
    Frank Katzer
    Division of Veterinary Clinical Sciences, Royal (Dick) School of Veterinary Studies, Easter Bush Veterinary Centre, Roslin, Midlothian, EH25 9RG, United Kingdom
    Infect Immun 74:5456-64. 2006
    ....