Ramesh C Gupta

Summary

Affiliation: Torrent Research Centre
Country: India

Publications

  1. ncbi Novel N-substituted 4-hydrazino piperidine derivative as a dipeptidyl peptidase IV inhibitor
    Ramesh C Gupta
    Medicinal Chemistry, Torrent Research Centre, Torrent Pharmaceuticals Ltd, Gandhinagar, Gujarat, India
    Bioorg Med Chem Lett 19:5021-5. 2009
  2. ncbi TRC120038, a Novel Dual AT(1)/ET(A) Receptor Blocker for Control of Hypertension, Diabetic Nephropathy, and Cardiomyopathy in ob-ZSF1 Rats
    Anookh Mohanan
    Torrent Research Centre, Torrent Pharmaceuticals Ltd, Gujarat, Gandhinagar 382428, India
    Int J Hypertens 2011:751513. 2011
  3. ncbi Synthesis of spiro[chroman-2,4'-piperidin]-4-one derivatives as acetyl-CoA carboxylase inhibitors
    Pundlik Shinde
    Medicinal Chemistry, Torrent Research Centre, Torrent Pharmaceuticals Ltd, PO Bhat, Gandhinagar 382428, Gujarat, India
    Bioorg Med Chem Lett 19:949-53. 2009
  4. ncbi TRC4186, a novel AGE-breaker, improves diabetic cardiomyopathy and nephropathy in Ob-ZSF1 model of type 2 diabetes
    Deepa Joshi
    Torrent Research Centre, Torrent Pharmaceuticals Ltd, Dist Gandhinagar, 382428, Gujarat, India
    J Cardiovasc Pharmacol 54:72-81. 2009
  5. ncbi Delayed intervention in experimental stroke with TRC051384--a small molecule HSP70 inducer
    Anookh Mohanan
    Department of Pharmacology, Torrent Research Centre, Torrent Pharmaceuticals Ltd, PO Bhat, Gandhinagar 382428, Gujarat, India
    Neuropharmacology 60:991-9. 2011

Collaborators

  • Anookh Mohanan
  • Vijay Chauthaiwale
  • Chaitanya Dutt
  • Amita Dubey
  • Pundlik Shinde
  • Deepa Joshi
  • Shailesh Deshpande
  • Appaji Mandhare
  • Vikrant Jagtap
  • Prashant G Jamadarkhana
  • Prabhat Kumar
  • Sanjay K Srivastava
  • Ajay Shiwalkar
  • Jitendra Patel
  • Shitalkumar P Zambad
  • Siralee Munshi
  • Davinder Tuli
  • Padmaja Pathak
  • Rajesh Sonawane
  • Rajendra Odedara

Detail Information

Publications5

  1. ncbi Novel N-substituted 4-hydrazino piperidine derivative as a dipeptidyl peptidase IV inhibitor
    Ramesh C Gupta
    Medicinal Chemistry, Torrent Research Centre, Torrent Pharmaceuticals Ltd, Gandhinagar, Gujarat, India
    Bioorg Med Chem Lett 19:5021-5. 2009
    ..In vivo efficacy indicates that compound 22e stimulates insulin release in response to glucose load and improves glucose tolerance in n5-STZ and Zucker Diabetic Fatty (ZDF) rats...
  2. ncbi TRC120038, a Novel Dual AT(1)/ET(A) Receptor Blocker for Control of Hypertension, Diabetic Nephropathy, and Cardiomyopathy in ob-ZSF1 Rats
    Anookh Mohanan
    Torrent Research Centre, Torrent Pharmaceuticals Ltd, Gujarat, Gandhinagar 382428, India
    Int J Hypertens 2011:751513. 2011
    ..TRC120038 showed greater fall in both systolic and diastolic BP in comparison to candesartan at its maximum antihypertensive dose. TRC120038 also reduced the severity of renal dysfunction and preserved cardiac function in ob-ZSF1 rat...
  3. ncbi Synthesis of spiro[chroman-2,4'-piperidin]-4-one derivatives as acetyl-CoA carboxylase inhibitors
    Pundlik Shinde
    Medicinal Chemistry, Torrent Research Centre, Torrent Pharmaceuticals Ltd, PO Bhat, Gandhinagar 382428, Gujarat, India
    Bioorg Med Chem Lett 19:949-53. 2009
    ..Compound 38j reduced the respiratory quotient (RQ) in C57BL/6J mice indicating increase in whole body fat oxidation even in the presence of high carbohydrate diet. Structure-activity relationship (SAR) has been discussed...
  4. ncbi TRC4186, a novel AGE-breaker, improves diabetic cardiomyopathy and nephropathy in Ob-ZSF1 model of type 2 diabetes
    Deepa Joshi
    Torrent Research Centre, Torrent Pharmaceuticals Ltd, Dist Gandhinagar, 382428, Gujarat, India
    J Cardiovasc Pharmacol 54:72-81. 2009
    ..TRC4186, an AGE-breaker, clearly preserved cardiac function and reduced the severity of renal dysfunction in Ob-ZSF1, an animal model with persistent severe hyperglycemia leading to diabetic heart failure and renal failure...
  5. ncbi Delayed intervention in experimental stroke with TRC051384--a small molecule HSP70 inducer
    Anookh Mohanan
    Department of Pharmacology, Torrent Research Centre, Torrent Pharmaceuticals Ltd, PO Bhat, Gandhinagar 382428, Gujarat, India
    Neuropharmacology 60:991-9. 2011
    ..These results show that TRC051384 has the potential to be developed as a novel pharmacological agent for the treatment of ischemic stroke...