Kamlesh K Bhutani

Summary

Affiliation: National Institute of Pharmaceutical Education and Research
Country: India

Publications

  1. ncbi Natural products drug discovery research in India: status and appraisal
    Kamlesh K Bhutani
    Department of Natural Products, National Institute of Pharmaceutical Education and Research, Sector 67, SAS Nagar 160 062, India
    Indian J Exp Biol 48:199-207. 2010
  2. ncbi Apoptosis inducing activity of steroidal constituents from Solanum xanthocarpum and Asparagus racemosus
    K K Bhutani
    Department of Natural Products, National Institute of Pharmaceutical Education and Research, Sector 67, SAS Nagar, Mohali 160062, Punjab, India
    Phytomedicine 17:789-93. 2010
  3. ncbi Antiobesity and lipid lowering effects of Glycyrrhiza chalcones: experimental and computational studies
    Rahul B Birari
    Department of Natural Products, National Institute of Pharmaceutical Education and Research, Mohali, Punjab, India
    Phytomedicine 18:795-801. 2011
  4. ncbi Synthesis and evaluation of beta-carboline derivatives as inhibitors of human immunodeficiency virus
    Keyur G Brahmbhatt
    Department of Natural Products, National Institute of Pharmaceutical Education and Research NIPER, Punjab, India
    Bioorg Med Chem Lett 20:4416-9. 2010
  5. ncbi Antileishmanial phenylpropanoids from Alpinia galanga (Linn.) Willd
    Amandeep Kaur
    Department of Natural Products, National Institute of Pharmaceutical Education and Research, Sector 67, S A S Nagar, 160 062, India
    Indian J Exp Biol 48:314-7. 2010
  6. ncbi Synthesis, biological evaluation and molecular docking of aryl hydrazines and hydrazides for anticancer activity
    Vikrantsinh M Gohil
    Department of Natural Products, National Institute of Pharmaceutical Education and Research Sector 67, SAS Nagar, Punjab 160 062, India
    Indian J Exp Biol 48:265-8. 2010
  7. ncbi Anti-inflammatory, cyclooxygenase (COX)-2, COX-1 inhibitory, and free radical scavenging effects of Rumex nepalensis
    Raju Gautam
    Department of Natural Products, National Institute of Pharmaceutical Education and Research, SAS Nagar, India
    Planta Med 76:1564-9. 2010
  8. ncbi Synthesis and anti-HIV activity of alkylated quinoline 2,4-diols
    Nafees Ahmed
    Department of Natural Products, National Institute of Pharmaceutical Education and Research NIPER, Sector 67, S A S Nagar, Mohali 160062 Punjab, India
    Bioorg Med Chem 18:2872-9. 2010
  9. ncbi Pancreatic lipase inhibitors from natural sources: unexplored potential
    Rahul B Birari
    Department of Natural Products, National Institute of Pharmaceutical Education and Research NIPER, Sector 67, S A S Nagar, Punjab 160062, India
    Drug Discov Today 12:879-89. 2007
  10. ncbi Modulating TNF-alpha signaling with natural products
    Atish T Paul
    Department of Natural Products, National Institute of Pharmaceutical Education and Research (NIPER, Sector-67, S.A.S. Nagar, Punjab 160062, India
    Drug Discov Today 11:725-32. 2006

Collaborators

  • Inder Pal Singh
  • S Linder
  • Sanjay M Jachak
  • C Gopi Mohan
  • Rahul B Birari
  • Nafees Ahmed
  • Keyur G Brahmbhatt
  • Vikrantsinh M Gohil
  • Amandeep Kaur
  • Raju Gautam
  • Sudeep Sabde
  • Debashis Mitra
  • Atish T Paul
  • Shikhar Gupta
  • C Gopimohan
  • Satyam K Agrawal
  • Shyam Sundar Sharma
  • Kailas V Karkhile
  • Divita Garg
  • Ranvir Singh
  • Chinmoy Sankar Dey
  • Ajit K Saxena

Detail Information

Publications10

  1. ncbi Natural products drug discovery research in India: status and appraisal
    Kamlesh K Bhutani
    Department of Natural Products, National Institute of Pharmaceutical Education and Research, Sector 67, SAS Nagar 160 062, India
    Indian J Exp Biol 48:199-207. 2010
    ..This review focuses on the contributions made from India in the drug discovery and development process and provides future directions in the area...
  2. ncbi Apoptosis inducing activity of steroidal constituents from Solanum xanthocarpum and Asparagus racemosus
    K K Bhutani
    Department of Natural Products, National Institute of Pharmaceutical Education and Research, Sector 67, SAS Nagar, Mohali 160062, Punjab, India
    Phytomedicine 17:789-93. 2010
    ..The carbohydrate moieties linked to the steroid backbones were found to strongly influence cytotoxic activity and cell death mode (apoptosis or necrosis). Compound 10, from A. racemosus was found to be a potent inducer of apoptosis...
  3. ncbi Antiobesity and lipid lowering effects of Glycyrrhiza chalcones: experimental and computational studies
    Rahul B Birari
    Department of Natural Products, National Institute of Pharmaceutical Education and Research, Mohali, Punjab, India
    Phytomedicine 18:795-801. 2011
    ..8±6.0 mg/dl. Compound 10 also lowered the plasma TC and TG levels considerably. The results indicate the potential of the chalcone scaffold as a source of PL inhibitors for preventing obesity...
  4. ncbi Synthesis and evaluation of beta-carboline derivatives as inhibitors of human immunodeficiency virus
    Keyur G Brahmbhatt
    Department of Natural Products, National Institute of Pharmaceutical Education and Research NIPER, Punjab, India
    Bioorg Med Chem Lett 20:4416-9. 2010
    ..3) virus. 1-Formyl-beta-carboline-3-carbxylic acid methyl ester (15) showed inhibition of human immunodeficiency virus at IC(50)=2.9 microM...
  5. ncbi Antileishmanial phenylpropanoids from Alpinia galanga (Linn.) Willd
    Amandeep Kaur
    Department of Natural Products, National Institute of Pharmaceutical Education and Research, Sector 67, S A S Nagar, 160 062, India
    Indian J Exp Biol 48:314-7. 2010
    ..donovani with IC50 values of 39.3, 32.9, 18.9 and 79.9 microM respectively. This is the first report of antileishmanial activity of the extracts and isolated constituents of A. galanga...
  6. ncbi Synthesis, biological evaluation and molecular docking of aryl hydrazines and hydrazides for anticancer activity
    Vikrantsinh M Gohil
    Department of Natural Products, National Institute of Pharmaceutical Education and Research Sector 67, SAS Nagar, Punjab 160 062, India
    Indian J Exp Biol 48:265-8. 2010
    ..Anolgues 12 and 15 emerged as molecules with significant in vitro anticancer activity. Molecular docking study revealed the binding orientations of aryl hydrazines and hydrazides analogues in the active sites of thymidylate synthase...
  7. ncbi Anti-inflammatory, cyclooxygenase (COX)-2, COX-1 inhibitory, and free radical scavenging effects of Rumex nepalensis
    Raju Gautam
    Department of Natural Products, National Institute of Pharmaceutical Education and Research, SAS Nagar, India
    Planta Med 76:1564-9. 2010
    ..Thus, the anti-inflammatory effect of R. NEPALENSIS roots was assumed to be mediated through COX inhibition by anthraquinones and naphthalene derivatives and through the radical scavenging activities of naphthalene derivatives...
  8. ncbi Synthesis and anti-HIV activity of alkylated quinoline 2,4-diols
    Nafees Ahmed
    Department of Natural Products, National Institute of Pharmaceutical Education and Research NIPER, Sector 67, S A S Nagar, Mohali 160062 Punjab, India
    Bioorg Med Chem 18:2872-9. 2010
    ..64) as compared to AZT (23.07). Five derivatives 7, 19a, 19d, 21 and 24 have displayed good noticeable anti-HIV activity. All active compounds showed higher CC(50) values which indicate that they have better therapeutic indices...
  9. ncbi Pancreatic lipase inhibitors from natural sources: unexplored potential
    Rahul B Birari
    Department of Natural Products, National Institute of Pharmaceutical Education and Research NIPER, Sector 67, S A S Nagar, Punjab 160062, India
    Drug Discov Today 12:879-89. 2007
    ..This article reviews various extracts and secondary metabolites from plants and microbial origin with PL inhibitory activity that can be focused for drug development programs...
  10. ncbi Modulating TNF-alpha signaling with natural products
    Atish T Paul
    Department of Natural Products, National Institute of Pharmaceutical Education and Research (NIPER, Sector-67, S.A.S. Nagar, Punjab 160062, India
    Drug Discov Today 11:725-32. 2006
    ..This review briefly highlights the physiological and pathological roles of TNF-alpha, and covers those natural compounds capable of interfering with TNF-alpha activity...