Nanoparticulate systems for nasal delivery of drugs: a real improvement over simple systems?Lisbeth Illum
Identity, 19 Cavendish Crescent North, The Park, Nottingham NG7 1BA, United Kingdom
J Pharm Sci 96:473-83. 2007
..However, apparently no studies have been published comparing directly other adjuvant nasal systems with nanoparticulate systems...
- Nasal clearance in health and disease
Lisbeth Illum
Identity, Nottingham, United Kingdom
J Aerosol Med 19:92-9. 2006
..A selected bioadhesive material, chitosan, which has been shown to have excellent absorption enhancer properties for a variety of drugs is discussed in some detail...
- Is nose-to-brain transport of drugs in man a reality?
Lisbeth Illum
Identity, 19 Cavendish Crescent North, The Park, Nottingham NG7 1BA, UK
J Pharm Pharmacol 56:3-17. 2004
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- The effect of blood sampling site and physicochemical characteristics of drugs on bioavailability after nasal administration in the sheep model
L Illum
West Pharmaceutical Services, Drug Delivery and Clinical Research Centre Ltd, Albert Einstein Centre, Nottingham Science and Technology Park, Nottingham NG7 2TN, United Kingdom
Pharm Res 20:1474-84. 2003
..Investigate the effect of blood sampling site and physicochemical characteristics of drugs on the pharmacokinetic (PK) parameters obtained after intravenous and nasal administration in sheep and compare results with computer simulations...
- Effect of physicochemical properties on intranasal nanoparticle transit into murine olfactory epithelium
Alpesh Mistry
Advanced Drug Delivery Group, School of Pharmacy, University of Nottingham, Nottingham, UK
J Drug Target 17:543-52. 2009
..Both 100 nm PS and 100 nm P80-PS were observed in olfactory epithelial cells but were absent from the olfactory bulbs; therefore, it is speculated that an optimal nanoparticle diameter for axonal transport is <100 nm in mice...
- Nasal drug delivery--possibilities, problems and solutions
Lisbeth Illum
West Pharmaceutical Services, Drug Delivery and Clinical Research Centre Ltd, Albert Einstein Centre, Nottingham Science and Technology Park, Nottingham, UK
J Control Release 87:187-98. 2003
..Recent results from Phase I/II studies in man with a novel nasal chitosan vaccine delivery system are also described. Finally, the author's thoughts about the future for nasal drug delivery are also depicted...
- Nanoparticles for direct nose-to-brain delivery of drugs
Alpesh Mistry
Advanced Drug Delivery and Tissue Engineering Division, School of Pharmacy, University of Nottingham, Nottingham, NG7 2RD, UK
Int J Pharm 379:146-57. 2009
..Furthermore, toxicity of nanoparticulate drug delivery systems in the nasal cavity and/or in the CNS has not been extensively studied and needs to be considered carefully...
- Absorption enhancers for nasal drug delivery
Stanley S Davis
Institute of Pharmaceutical Sciences, University of Nottingham, Nottingham, UK
Clin Pharmacokinet 42:1107-28. 2003
..Finally, the mucosal use of absorption enhancers (chitosan) for the improved nasal delivery of vaccines is reported with reference to recent phase I/II clinical studies...
- Evaluation of effect of ephedrine on the transport of drugs from the nasal cavity to the systemic circulation and the central nervous system
Stuart T Charlton
The School of Pharmacy, University of Nottingham, University Park, Nottingham, UK
J Drug Target 15:370-7. 2007
..The pectin formulation with ephedrine resulted in lower systemic absorption of GR138950 and lower brain uptake compared to the simple solution formulation containing ephedrine...
- Nasal drug delivery: new developments and strategies
Lisbeth Illum
19 Cavendish Crescent North, The Park, Nottingham UK, NG7 1BA
Drug Discov Today 7:1184-9. 2002
..An exiting discovery that drugs can be transported directly from nose to brain via the olfactory pathway is discussed and examples of proof-of-concept in man are given...
- Evaluation of direct transport pathways of glycine receptor antagonists and an angiotensin antagonist from the nasal cavity to the central nervous system in the rat model
Stuart T Charlton
The School of Pharmacy, University of Nottingham, University Park, Nottingham NG72RD, UK
Pharm Res 25:1531-43. 2008
..The aim of this study was to investigate and quantify drug movement to the brain via the neuro-olfactory system after intranasal dosing of four model drugs; three glycine receptor antagonists and one angiotensin antagonist...
- Intranasal delivery: physicochemical and therapeutic aspects
Henry R Costantino
Nastech Pharmaceutical Company, Inc, Bothell, WA 98021, USA
Int J Pharm 337:1-24. 2007
..Case examples are provided to illustrate the utility of IN dosing. It is anticipated that the present review will prove useful for formulation scientists considering IN delivery as a delivery route...
- Effective nasal influenza vaccine delivery using chitosan
Robert C Read
Academic Unit of Infection and Immunity, Division of Genomic Medicine, University of Sheffield Medical School, Beech Hill Road, Sheffield S10 2RX, UK
Vaccine 23:4367-74. 2005
..These data show that nasal immunisation with chitosan plus trivalent inactivated influenza is a potentially effective, easily-administered form of vaccination...
- Intranasal immunization with genetically detoxified diphtheria toxin induces T cell responses in humans: enhancement of Th2 responses and toxin-neutralizing antibodies by formulation with chitosan
Edel A McNeela
Immune Regulation Research Group, Department of Biochemistry, Trinity College, Dublin 2, Ireland
Vaccine 22:909-14. 2004
..Furthermore, our findings demonstrate that mucosal subunit vaccines with appropriate delivery systems have considerable potential for booster immunization of adults...
- Protective levels of diphtheria-neutralizing antibody induced in healthy volunteers by unilateral priming-boosting intranasal immunization associated with restricted ipsilateral mucosal secretory immunoglobulin a
Kingston H G Mills
Immune Regulation Research Group, Department of Biochemistry, Trinity College, Dublin 2, Ireland
Infect Immun 71:726-32. 2003
..However, a restricted sIgA response suggests that care must be taken in the priming-boosting strategy and clinical sampling techniques when evaluating such vaccines for the induction of local mucosal immunity...
- Correlation of SEC/MALLS with ultracentrifuge and viscometric data for chitosans
Monica Fee
NCMH Physical Biochemistry Laboratory, School of Biosciences, University of Nottingham, Sutton Bonington, LE12 5RD, UK
Eur Biophys J 32:457-64. 2003
..With regard to viscosity, a logeta versus logMw scaling plot appeared to also fit a straight line with power-law exponent a=0.96 +/- 0.10, again between the coil (0.5-0.7) and rod (1.8) limits...
