Research Topics
Genomes and Genes
Species | Laufey TryggvadottirSummaryAffiliation: Icelandic Cancer Society Country: Iceland Publications
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Detail Information
Publications
Breastfeeding and reduced risk of breast cancer in an Icelandic cohort studyL Tryggvadottir
Epidemiological Unit, Icelandic Cancer Society, Skogarhlid 8, P O Box 5420, IS 125 Reykjavik, Iceland
Am J Epidemiol 154:37-42. 2001..33 (95% confidence interval: 0.19, 0.56) for women diagnosed at all ages. This is the first cohort study to indicate a negative association between breastfeeding and breast cancer...- Breast cancer risk factors and age at diagnosis: an Icelandic cohort studyLaufey Tryggvadottir
Icelandic Cancer Registry, Icelandic Cancer Society, Reykjavik, Iceland
Int J Cancer 98:604-8. 2002..The results confirm that age at diagnosis should be taken into account when studying the effects of breast cancer risk factors... - BRCA2 mutation carriers, reproductive factors and breast cancer riskLaufey Tryggvadottir
Icelandic Cancer Registry, Reykjavik, Iceland
Breast Cancer Res 5:R121-8. 2003..In the general population, breast cancer risk is affected by age at menarche, by age at first birth, by the number of births and by the duration of breast feeding. Whether this is true for mutation carriers is not clear... - Population-based study of changing breast cancer risk in Icelandic BRCA2 mutation carriers, 1920-2000Laufey Tryggvadottir
Icelandic Cancer Registry, Skógarhlío 8, Reykjavik, Iceland
J Natl Cancer Inst 98:116-22. 2006..We examined the cumulative breast cancer incidence and mortality before age 70 over a diagnosis period of 80 years in Icelandic women who carried the BRCA2 founder mutation 999del5... - Trends in the survival of patients diagnosed with malignant melanoma of the skin in the Nordic countries 1964-2003 followed up to the end of 2006Laufey Tryggvadottir
Icelandic Cancer Registry, Icelandic Cancer Society, Reykjavik, Iceland
Acta Oncol 49:665-72. 2010..A previous Nordic study showed a marked and steady increase in the age-adjusted 5-year relative survival of skin melanoma patients diagnosed during the period 1958 through 1987. Males had considerably poorer survival than females... - Prostate cancer progression and survival in BRCA2 mutation carriersLaufey Tryggvadottir
Icelandic Cancer Registry, PO Box 5420, Iceland
J Natl Cancer Inst 99:929-35. 2007..We compared prostate cancer-specific survival, disease stage, and tumor grade between prostate cancer patients carrying the Icelandic BRCA2 999del5 founder mutation and noncarriers... - Trends in the survival of patients diagnosed with breast cancer in the Nordic countries 1964-2003 followed up to the end of 2006Laufey Tryggvadottir
Icelandic Cancer Registry, Icelandic Cancer Society, Reykjavik, Iceland
Acta Oncol 49:624-31. 2010..European patients have generally high 5-year relative survival ratios, and the Nordic countries, except for Denmark, have ratios among the highest... - Genome-wide association study identifies sequence variants on 6q21 associated with age at menarchePatrick Sulem
deCODE Genetics, Reykjavik, Iceland
Nat Genet 41:734-8. 2009..Given the link between body fat and AAM, we also assessed 11 variants recently associated with higher body mass index (BMI) and 5 of those associated with earlier AAM... - Discovery of common variants associated with low TSH levels and thyroid cancer riskJulius Gudmundsson
deCODE Genetics, Reykjavik, Iceland
Nat Genet 44:319-22. 2012..A strong association (P = 9.1 × 10(-91)) was observed between rs2439302 on 8p12 and expression of NRG1, which encodes the signaling protein neuregulin 1, in blood... - Mutations in BRIP1 confer high risk of ovarian cancerThorunn Rafnar
deCODE Genetics, Reykjavik, Iceland
Nat Genet 43:1104-7. 2011..0079). Ovarian tumors from heterozygous carriers of the Icelandic mutation show loss of the wild-type allele, indicating that BRIP1 behaves like a classical tumor suppressor gene in ovarian cancer... - Breast cancer risk associated with AURKA 91T -->A polymorphism in relation to BRCA mutationsLinda Vidarsdottir
Molecular and Cell Biology Research Laboratory, Icelandic Cancer Society, Skogarhlid 8, 105 Reykjavik, Iceland
Cancer Lett 250:206-12. 2007..This may throw light on previously conflicting results... - Cancer risk by education in Iceland; a census-based cohort studyHalldora Vidarsdottir
Icelandic Cancer Registry, Icelandic Cancer Society, Reykjavik, Iceland
Acta Oncol 47:385-90. 2008..The relationship between education and cancer risk has not been studied in the small, but ethnically homogenous, Icelandic population postulated to be outstanding as regards social equity... - A germline variant in the TP53 polyadenylation signal confers cancer susceptibilitySimon N Stacey
deCODE Genetics, Reykjavik, Iceland
Nat Genet 43:1098-103. 2011..35, P = 1.0 × 10(-5)) and colorectal adenoma (OR = 1.39, P = 1.6 × 10(-4)). However, we observed no effect for breast cancer, a common Li-Fraumeni syndrome tumor (OR = 1.06, P = 0.57, 95% confidence interval 0.88-1.27)... - Genome-wide association yields new sequence variants at seven loci that associate with measures of obesityGudmar Thorleifsson
deCODE Genetics, Reykjavik, Iceland
Nat Genet 41:18-24. 2009..6 x 10(-7). This includes previously identified variants close to or in the FTO, MC4R, BDNF and SH2B1 genes, in addition to variants at seven loci not previously connected with obesity... - Positive association between DNA strand breaks in peripheral blood mononuclear cells and polyunsaturated fatty acids in red blood cells from womenAudur Y Thorlaksdottir
Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Iceland, Reykjavik, Iceland
Nutr Cancer 59:21-8. 2007....