A randomized trial of artemether-lumefantrine versus mefloquine-artesunate for the treatment of uncomplicated multi-drug resistant Plasmodium falciparum on the western border of ThailandRobert Hutagalung
Shoklo Malaria Research Unit, Mae Sod, Tak Province, Thailand
Malar J 4:46. 2005
..The trial presented here was conducted to monitor the efficacy of the six-dose regimen of artemether-lumefantrine (ALN) in an area of multi-drug resistance, along the Thai-Myanmar border...
- A randomized, controlled study of a simple, once-daily regimen of dihydroartemisinin-piperaquine for the treatment of uncomplicated, multidrug-resistant falciparum malaria
Elizabeth A Ashley
Shoklo Malaria Research Unit, Mae Sot, Thailand
Clin Infect Dis 41:425-32. 2005
..This simple, safe, and relatively inexpensive fixed combination could become the treatment of choice for falciparum malaria...
- Changes in the treatment responses to artesunate-mefloquine on the northwestern border of Thailand during 13 years of continuous deployment
Verena Ilona Carrara
Shoklo Malaria Research Unit, Tak, Thailand
PLoS ONE 4:e4551. 2009
....
- Randomized, controlled dose-optimization studies of dihydroartemisinin-piperaquine for the treatment of uncomplicated multidrug-resistant falciparum malaria in Thailand
Elizabeth A Ashley
Shoklo Malaria Research Unit, Mae Sot, and Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
J Infect Dis 190:1773-82. 2004
..2 mg/kg piperaquine phosphate) given over the course of 48 h is highly effective, safe, and well tolerated for the treatment of multidrug-resistant falciparum malaria, and its efficacy is not improved by the addition of more DHA...
- A randomized comparison of artesunate-atovaquone-proguanil versus quinine in treatment for uncomplicated falciparum malaria during pregnancy
Rose McGready
Shoklo Malaria Research Unit, Mae Sot, Tak, Thailand
J Infect Dis 192:846-53. 2005
..Despite the small number of subjects, our results add to the growing body of evidence that AAP is safe for the mother and the fetus...
- Pharmacokinetic study of artemether-lumefantrine given once daily for the treatment of uncomplicated multidrug-resistant falciparum malaria
Elizabeth A Ashley
Shoklo Malaria Research Unit, Mae Sot, Thailand
Trop Med Int Health 12:201-8. 2007
..If the fixed antimalarial drug combination artemether-lumefantrine (AL) could be given once daily, this should improve adherence and thus effectiveness and lower the risk of selecting for resistance...
- Population pharmacokinetic assessment of a new regimen of mefloquine used in combination treatment of uncomplicated falciparum malaria
Elizabeth A Ashley
Shoklo Malaria Research Unit, P O Box 46, Mae Sot, Tak 63110, Thailand
Antimicrob Agents Chemother 50:2281-5. 2006
..This new regimen is well tolerated and results in an equivalent therapeutic response...
- A case-control auditory evaluation of patients treated with artemether-lumefantrine
Robert Hutagalung
Shoklo Malaria Research Unit, Mae Sot, Tak Province, Thailand
Am J Trop Med Hyg 74:211-4. 2006
..There were no differences in the test results between cases and controls. There was no neurophysiologic evidence of auditory brainstem toxicity that could be attributed to artemether-lumefantrine in this study population...
- Seasonal variation in hyperparasitaemia and gametocyte carriage in patients with Plasmodium falciparum malaria on the Thai-Burmese border
Mathieu Nacher
Shoklo Malaria Research Unit, P O Box 46, Mae Sot, Tak 63110, Thailand
Trans R Soc Trop Med Hyg 98:322-8. 2004
..3 (95% CI 1.03-1.6; P = 0.02). Migrations, changes in transmission patterns, the haematological burden of cumulative infections, and ultraviolet immunosuppression are discussed as potential explanations for these observations...
- Molecular and pharmacological determinants of the therapeutic response to artemether-lumefantrine in multidrug-resistant Plasmodium falciparum malaria
Ric N Price
Centre for Vaccinology and Tropical Medicine, Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Headington, Oxford, United Kingdom
Clin Infect Dis 42:1570-7. 2006
..Our study examined the relative contributions of host, pharmacokinetic, and parasitological factors in determining the therapeutic response to artemether-lumefantrine (AL)...
