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Genomes and Genes | Janos SzolcsanyiSummaryCountry: Hungary Publications
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Direct evidence for activation and desensitization of the capsaicin receptor by N-oleoyldopamine on TRPV1-transfected cell, line in gene deleted mice and in the ratJ Szolcsanyi
Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, Neuropharmacology Research Group of the Hungarian Academy of Sciences, University of Pecs, Szigeti u 12, H 7624 Pecs, Hungary
Neurosci Lett 361:155-8. 2004..It is concluded that on TRPV1 capsaicin receptors OLDA is 50 times less potent than capsaicin and it might serve as an endogenous ligand for TRPV1 in the rat, but more likely in humans...- Hot target on nociceptors: perspectives, caveats and unique featuresJ Szolcsanyi
Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Pecs, Pecs, Hungary
Br J Pharmacol 155:1142-4. 2008..TRPV1 gene-deleted mice show subtle changes in physiological regulations, therefore TRPV1 is a promising but challenging target for drug research... - Inhibition of the function of TRPV1-expressing nociceptive sensory neurons by somatostatin 4 receptor agonism: mechanism and therapeutical implicationsJanos Szolcsanyi
Department of Pharmacology and Pharmacotherapy, University of Pecs, Faculty of Medicine, H 7624 Pecs, Szigeti u 12, Hungary
Curr Top Med Chem 11:2253-63. 2011..In sstR4 receptor knockout mice an aggravation of inflammation and hyperalgesia was observed... - Forty years in capsaicin research for sensory pharmacology and physiologyJanos Szolcsanyi
Department of Pharmacology and Pharmacotherapy, University Medical School of Pecs, Szigeti u 12, H 7624 Pecs, Hungary
Neuropeptides 38:377-84. 2004..g. in Freund's adjuvant-induced chronic arthritis. Nociceptors supplied by TRPV1 and sst4 somatostatin receptors has become nowadays promising targets for drug development... - Analgesic effect of TT-232, a heptapeptide somatostatin analogue, in acute pain models of the rat and the mouse and in streptozotocin-induced diabetic mechanical allodyniaJanos Szolcsanyi
Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Pecs, H 7643, Pecs, Szigeti u 12, Hungary
Eur J Pharmacol 498:103-9. 2004.... - Role of capsaicin-sensitive afferents and sensory neuropeptides in endotoxin-induced airway inflammation and consequent bronchial hyperreactivity in the mouseKrisztian Elekes
Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Pecs, H 7624 Pecs, Szigeti u 12, Hungary
Regul Pept 141:44-54. 2007..Activation of CGRP1 receptors or NK(1)+NK(2) receptors participate in granulocyte accumulation, but NK(2) receptors play predominant role in enhanced airway resistance... - Investigation of the role of TRPV1 receptors in acute and chronic nociceptive processes using gene-deficient miceKata Bölcskei
Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Pecs, H 7643, Pecs, Szigeti u 12, Pecs, Hungary
Pain 117:368-76. 2005.... - Impaired defense mechanism against inflammation, hyperalgesia, and airway hyperreactivity in somatostatin 4 receptor gene-deleted miceZsuzsanna Helyes
Department of Pharmacology and Pharmacotherapy, Institute of Pharmacognosy, Analgesic Research Laboratory of Gedon Richter Plc, University of Pecs, H 7624 Pecs, Hungary
Proc Natl Acad Sci U S A 106:13088-93. 2009..Thus, this receptor is a promising novel target for developing anti-inflammatory, analgesic, and anti-asthmatic drugs... - Divergent peripheral effects of pituitary adenylate cyclase-activating polypeptide-38 on nociception in rats and miceKatalin Sandor
Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Pecs, H 7624, Pecs, Szigeti u 12, Hungary
Pain 141:143-50. 2009..It has no significant peripheral role in traumatic mononeuropathy, but induces mechanical sensitization of knee joint primary afferents... - Inhibitory effects of synthetic somatostatin receptor subtype 4 agonists on acute and chronic airway inflammation and hyperreactivity in the mouseKrisztian Elekes
Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Pecs, H 7624 Pecs, Szigeti u 12, Hungary
Eur J Pharmacol 578:313-22. 2008.... - Pituitary adenylate cyclase-activating polypeptide plays an anti-inflammatory role in endotoxin-induced airway inflammation: in vivo study with gene-deleted miceKrisztian Elekes
Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Pecs, Szigeti str 12, H 7624 Pecs, Hungary
Peptides 32:1439-46. 2011..In contrast, there was no difference between the IL-1? concentrations of the PACAP?/? and PACAP?/? mice. These results provide evidence for a protective role for PACAP in endotoxin-induced airway inflammation and hyperreactivity... - Role of transient receptor potential vanilloid 1 receptors in adjuvant-induced chronic arthritis: in vivo study using gene-deficient miceArpád Szabó
Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Pecs, Pecs 7624, Szigeti u 12, Hungary
J Pharmacol Exp Ther 314:111-9. 2005..Thus, whereas bradykinin and lipoxygenase products seem to act exclusively via TRPV1 activation, prostanoids do not, or at least only partially, to enhance murine experimental arthritis and related hyperalgesia... - Involvement of capsaicin-sensitive afferents and the Transient Receptor Potential Vanilloid 1 Receptor in xylene-induced nocifensive behaviour and inflammation in the mouseKatalin Sandor
Department of Pharmacology and Pharmacotherapy, University of Pecs, Szigeti u 12, Hungary
Neurosci Lett 451:204-7. 2009..Reactive oxygen or carbonyl species participate in this process presumably via stimulation of the TRPA1 channel... - Expression of the somatostatin receptor subtype 4 in intact and inflamed pulmonary tissuesZoltan Varecza
Department of Immunology and Biotechnology, University of Pecs, Pecs, Hungary
J Histochem Cytochem 57:1127-37. 2009..Inasmuch as tissue distribution of this receptor is highly similar, extrapolation of murine experimental results to human conditions might be possible... - Antinociceptive desensitizing actions of TRPV1 receptor agonists capsaicin, resiniferatoxin and N-oleoyldopamine as measured by determination of the noxious heat and cold thresholds in the ratKata Bölcskei
Analgesic Research Laboratory of the University of Pécs, Pecs, Hungary
Eur J Pain 14:480-6. 2010..This could be differentiated from desensitization of TRPV1 receptor evoked by lower doses of resiniferatoxin or N-oleoyldopamine... - Effects of analgesics on the plantar incision-induced drop of the noxious heat threshold measured with an increasing-temperature water bath in the ratRéka Füredi
Department of Pharmacology and Pharmacotherapy, University of Pecs, Pecs, Hungary
Eur J Pharmacol 605:63-7. 2009..The thermal antihyperalgesic actions of systemically and/or locally applied morphine, diclofenac and paracetamol could be detected with high temporal resolution and sensitivity in this model... - Static magnetic field-induced anti-nociceptive effect and the involvement of capsaicin-sensitive sensory nerves in this mechanismKatalin Sandor
Department of Pharmacology and Pharmacotherapy, University of Pecs, Szigeti ut 12, Pecs, 7624, Hungary
Life Sci 81:97-102. 2007.... - Hepatic insulin sensitizing substance: a novel 'sensocrine' mechanism to increase insulin sensitivity in anaesthetized ratsRobert Porszasz
Department of Pharmacology and Pharmacotherapy, University of Debrecen, H 4032, Nagyerdei krt 98, Debrecen, Hungary
Br J Pharmacol 139:1171-9. 2003..The results also suggest that HISS is identical to somatostatin of AHP sensory neural origin... - Inhibitory effect of anandamide on resiniferatoxin-induced sensory neuropeptide release in vivo and neuropathic hyperalgesia in the ratZsuzsanna Helyes
Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Pecs, H 7624, Pecs, Szigeti u 12, Hungary
Life Sci 73:2345-53. 2003..AEA and PEA exert inhibitory effect on mechanonociceptive hyperalgesia and sensory neuropeptide release in vivo suggesting their potential therapeutical use to treat chronic neuropathic pain... - Role of transient receptor potential vanilloid 1 receptors in endotoxin-induced airway inflammation in the mouseZsuzsanna Helyes
Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Pecs, Pecs, Hungary
Am J Physiol Lung Cell Mol Physiol 292:L1173-81. 2007..It reaches the systemic circulation and inhibits inflammation and consequent bronchial hyperreactivity... - Involvement of preprotachykinin A gene-encoded peptides and the neurokinin 1 receptor in endotoxin-induced murine airway inflammationZsuzsanna Helyes
Department of Pharmacology and Pharmacotherapy, University of Pecs, Hungary
Neuropeptides 44:399-406. 2010..However, in inflammatory bronchial hyper-responsiveness other tachykinins, such as hemokinin-1 acting through NK1 receptors also might be involved... - Evidence for a novel protective role of the vanilloid TRPV1 receptor in a cutaneous contact allergic dermatitis modelAgnes Bánvölgyi
Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Pecs, H 7624 Pecs, Szigeti u 12, Hungary
J Neuroimmunol 169:86-96. 2005..A protective involvement of the TRPV1 receptor was identified of contact dermatitis distinct from mechanisms involving the major pro-inflammatory neuropeptides... - The role of transient receptor potential vanilloid 1 (TRPV1) receptors in dextran sulfate-induced colitis in miceIstvan Szitter
Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Pecs, 7624 Pecs, Szigeti u 12, Hungary
J Mol Neurosci 42:80-8. 2010..Elucidating the modulator role of TRPV1 channels in inflammatory bowel diseases may contribute to the development of novel anti-inflammatory drugs for their therapy... - Comparison of the peripheral mediator background of heat injury- and plantar incision-induced drop of the noxious heat threshold in the ratRéka Füredi
Department of Pharmacology and Pharmacotherapy, University of Pecs, Szigeti ut 12, H 7624 Pecs, Hungary
Life Sci 86:244-50. 2010..Only very few peripheral mediators of these phenomena have been identified. Therefore the present study aimed at comparing the peripheral mediator background of heat hyperalgesia evoked by mild heat injury or surgical incision... - Pharmacological characterisation of the somatostatin analogue TT-232: effects on neurogenic and non-neurogenic inflammation and neuropathic hyperalgesiaErika Pinter
Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Pecs, Szigeti u 12, Hungary
Naunyn Schmiedebergs Arch Pharmacol 366:142-50. 2002..These data suggest that TT-232, a somatostatin analogue devoid of endocrine effects, is a promising lead molecule in the search for novel, broad-spectrum anti-inflammatory and analgesic agents... - Comparison of the anti-inflammatory and anti-nociceptive effects of cortistatin-14 and somatostatin-14 in distinct in vitro and in vivo model systemsAdrienn Markovics
Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Pecs, Szigeti str 12, 7624, Pecs, Hungary
J Mol Neurosci 46:40-50. 2012..However, CST-14 exerts remarkably greater inhibition on cytokine production... - Investigation of sensory neurogenic components in a bleomycin-induced scleroderma model using transient receptor potential vanilloid 1 receptor- and calcitonin gene-related peptide-knockout miceArpád Szabó
University of Pecs, Pecs, Hungary
Arthritis Rheum 58:292-301. 2008..The aim of the present study was to examine the role of this modulatory role of TRPV1 receptor and that of calcitonin gene-related peptide (CGRP) in bleomycin-induced scleroderma, using transgenic mice... - Actions of 3-methyl-N-oleoyldopamine, 4-methyl-N-oleoyldopamine and N-oleoylethanolamide on the rat TRPV1 receptor in vitro and in vivoRóbert Almási
Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Pecs, Szigeti u 12, H 7624 Pecs, Hungary
Life Sci 82:644-51. 2008..These data show that 3-MOLDA behaves as an agonist, whereas 4-MOLDA and OEA appear to be antagonists, at the rat TRPV1 receptor... - Heat injury-induced drop of the noxious heat threshold measured with an increasing-temperature water bath: a novel rat thermal hyperalgesia modelKata Bölcskei
Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Pecs, Szigeti u 12, H 7624 Pecs, Hungary
Eur J Pharmacol 564:80-7. 2007.... - Effect of transient receptor potential vanilloid 1 (TRPV1) receptor antagonist compounds SB705498, BCTC and AMG9810 in rat models of thermal hyperalgesia measured with an increasing-temperature water bathValéria Tékus
Analgesic Research Laboratory, University of Pécs and Gedeon Richter Plc Budapest, Hungary, Szigeti u 12, Pecs, Hungary
Eur J Pharmacol 641:135-41. 2010..In conclusion, measurement of the noxious heat threshold with the increasing-temperature water bath is suitable to sensitively detect the effects of TRPV1 receptor antagonists in thermal hyperalgesia models... - Nociception, neurogenic inflammation and thermoregulation in TRPV1 knockdown transgenic miceDániel Márton Tóth
Analgesics Research Laboratory, University of Pécs and Gedeon Richter PLC, Szigeti ut 12, Pecs, 7624, Hungary
Cell Mol Life Sci 68:2589-601. 2011..Thermoregulatory behaviour in response to heat was inhibited, but enhanced hyperthermia was not observed... - Effect of lipid raft disruption on TRPV1 receptor activation of trigeminal sensory neurons and transfected cell lineEva Szoke
Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Pecs, Pecs, Hungary
Eur J Pharmacol 628:67-74. 2010..Evidence for a supporting role of cholesterol, sphingomyelin and gangliosides were obtained both in native and TRPV1-transfected cells. Differential modulation of responses to capsaicin and RTX was often observed... - Upregulation of transient receptor potential vanilloid type-1 receptor expression in oral lichen planusAgnes Bán
Department of Dentistry, Oral and Maxillofacial Surgery, University of Pecs, Pecs, Hungary
Neuroimmunomodulation 17:103-8. 2010..The aim of the present study was to detect the presence of TRPV1 receptors and peripheral expression of receptor mRNA in normal oral mucosa and mucous membranes from OLP patients... - Sensory nitrergic meningeal vasodilatation and non-nitrergic plasma extravasation in anaesthesized ratsBarna Peitl
Department of Pharmacology and Pharmacotherapy, University of Debrecen, Nagyerdei krt 98, Debrecen H 4032, Hungary
Eur J Pharmacol 497:293-9. 2004..This neurogenic oedema formation was not inhibited by neither L-NNA nor 3Br-7NI. It is concluded that neural nitrergic mechanisms are involved in the meningeal vasodilatation evoked by electrical stimulation of the trigeminal ganglion... - Inhibitory effect of somatostatin on inflammation and nociceptionErika Pinter
Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Pecs, H 7624 Pecs, Szigeti u 12, Hungary
Pharmacol Ther 112:440-56. 2006..These compounds might provide novel perspectives in the pharmacotherapy of acute and chronic painful inflammatory diseases, as well as neuropathic conditions... - Noxious heat threshold measured with slowly increasing temperatures: novel rat thermal hyperalgesia modelsKata Bölcskei
Analgesic Research Laboratory, University of Pecs, Gedeon Richter Plc, Pecs, Hungary
Methods Mol Biol 617:57-66. 2010..Acute thermal hyperalgesia models based on the drop of the heat threshold are also described for each equipment which proved to be highly sensitive to standard analgesics... - Peripheral and central alterations of pituitary adenylate cyclase activating polypeptide-like immunoreactivity in the rat in response to activation of the trigeminovascular systemBernadett Tuka
Department of Neurology, Faculty of Medicine, University of Szeged, H 6725 Szeged, Semmelweis u 6, Hungary
Peptides 33:307-16. 2012..The selective increases in both forms of PACAP in the TNC suggest its important role in the central sensitization involved in migraine-like headache... - Lutein inhibits the function of the transient receptor potential A1 ion channel in different in vitro and in vivo modelsGyörgyi Horváth
Department of Pharmacognosy, Medical School, University of Pecs, Rókus utca 2, Pecs, 7624, Hungary
J Mol Neurosci 46:1-9. 2012..Based on these distinct actions and the carotenoid structure, the ability of lutein to modulate lipid rafts in the membrane around TRP channels can be suggested... - Pituitary adenylate cyclase-activating polypeptide deficiency enhances oxazolone-induced allergic contact dermatitis in miceAgnes Kemeny
Department of Pharmacology and Pharmacotherapy, University of Pecs, Pecs, Hungary
J Mol Neurosci 42:443-9. 2010..These results suggest that PACAP exerts anti-inflammatory, particularly edema-inhibiting effects in allergic contact dermatitis... - Substance P released from sensory nerve endings influences tear secretion and goblet cell function in the ratIlles Kovacs
Department of Pharmacology and Pharmacotherapy, Neuropharmacology Research Group of the Hungarian Academy of Sciences, University of Pecs, 12 Szigeti Str, Pecs, Hungary
Neuropeptides 39:395-402. 2005..It is suggested that the sensory neuropeptide substance P plays a pivotal role in this neurogenic regulatory mechanism... - Surgery and sepsis increase somatostatin-like immunoreactivity in the human plasmaBalazs Suto
Department of Anesthesiology and Intensive Therapy, Faculty of Medicine, University of Pecs, Ifjusag str 13, H 7624 Pecs, Hungary
Peptides 31:1208-12. 2010..It is concluded, that the endogenous protective mechanism mediated by neural somatostatin, which has been evidenced in animals, is likely to operate in patients... - Participation of vanilloid/capsaicin receptors, calcitonin-gene-related peptide and substance P in gastric protection of omeprazole and omeprazole-like compoundsGyula Mozsik
First Department of Medicine, Medical and Health Centre, University of Pecs, H 7643 Pecs, Hungary
Inflammopharmacology 13:139-59. 2005.... - Gastroprotection induced by capsaicin in healthy human subjectsGyula Mozsik
First Department of Medicine, Medical and Health Center, University of Pecs, Hungary
World J Gastroenterol 11:5180-4. 2005..To evaluate the gastro-protective effect of capsaicin against the ethanol- and indomethacin (IND)-induced gastric mucosal damage in healthy human subjects... - NO-induced migraine attack: strong increase in plasma calcitonin gene-related peptide (CGRP) concentration and negative correlation with platelet serotonin releaseGabriella Juhasz
Laboratory of Neurochemistry and Experimental Medicine, Department of Vascular Neurology, Faculty of Medicine, Semmelweis University, National Institute of Psychiatry and Neurology, Huvosvolgyi ut 116, Budapest, H-1021, Hungary
Pain 106:461-70. 2003..In contrast, serotonin release from platelets does not provoke migraine, it may even counteract the headache and the concomitant CGRP release in this model... - Capsaicin-induced nonneural vasoconstriction in canine mesenteric arteriesRobert Porszasz
Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, Debrecen University, Nagyerdei krt 98, H 4032 Debrecen, Hungary
Eur J Pharmacol 441:173-5. 2002..The maximum contraction produced by tyramine was decreased with time. The results suggest that capsaicin may attain vasoconstriction independent of neural elements... - Pituitary adenylate cyclase-activating polypeptide plays a key role in nitroglycerol-induced trigeminovascular activation in miceAdrienn Markovics
Department of Pharmacology and Pharmacotherapy, University of Pecs, Faculty of Medicine, H 7624, Pecs, Szigeti u 12, Hungary
Neurobiol Dis 45:633-44. 2012..We provide the first experimental results that PACAP is a pivotal mediator of trigeminovascular activation/sensitization and meningeal vasodilation related to migraine... - The sensory nitrergic nature of the hepatic insulin sensitizing substance mechanism in conscious rabbitsRobert Porszasz
Department of Pharmacology and Pharmacotherapy, Medical University of Debrecen, H-4032, Nagyerdei krt 98, Debrecen 4032, Hungary
Eur J Pharmacol 443:211-2. 2002..Intraportal nitroglycerin restored insulin sensitivity in either case. We conclude that NO of sensory neural origin plays a major role in endogenous neurogenic insulin sensitizing mechanisms...