Research Topics
| Laszlo BudaySummaryAffiliation: Semmelweis University Country: Hungary Publications
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Detail Information
Publications
The Nck family of adapter proteins: regulators of actin cytoskeletonLaszlo Buday
Department of Medical Chemistry, Semmelweis University Medical School, 9 Puskin Str, 1088, Budapest, Hungary
Cell Signal 14:723-31. 2002..The proteins of Nck family are implicated in organisation of actin cytoskeleton, cell movement or axon guidance in flies. In this review, the author attempts to summarise signalling pathways in which Nck plays a critical role...
Many faces of Ras activationLaszlo Buday
Department of Medical Chemistry, Semmelweis University Medical School, 9 Puskin Street, 1088 Budapest, Hungary
Biochim Biophys Acta 1786:178-87. 2008..Although all of them are able to activate Ras, their structure, tissue expression and regulation are significantly diverse. In this review we will summarize the various mechanisms by which these exchange factors activate Ras...
Roles of cortactin in tumor pathogenesisLaszlo Buday
Department of Medical Chemistry, Semmelweis University Medical School, 9 Puskin Street, 1088 Budapest, Hungary
Biochim Biophys Acta 1775:263-73. 2007..This review aims to focus on cortactin-mediated signaling pathways, with emphasis on its contribution to tumor progression and metastasis formation...
Phorbol ester-induced migration of HepG2 cells is accompanied by intensive stress fibre formation, enhanced integrin expression and transient down-regulation of p21-activated kinase 1Annamária Gujdár
Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University of Medicine, PO Box 260, 1444 Budapest, Hungary
Cell Signal 15:307-18. 2003..Protein kinase C stimulated the activation of p21-activated kinase (PAK), as well. However, it also stimulated the selective and transient down-regulation of PAK1, which coincided with the formation of stress fibres...
Mechanism of epidermal growth factor regulation of Vav2, a guanine nucleotide exchange factor for RacPeter Tamas
Department of Medical Chemistry, Semmelweis University Medical School, 9 Puskin Street, 1088 Budapest, Hungary
J Biol Chem 278:5163-71. 2003..These results suggest that EGF regulates Vav2 activity basically through phosphatidylinositol 3-kinase activation, whereas tyrosine phosphorylation of Vav2 may rather be necessary for mediating protein-protein interactions...
High levels of structural disorder in scaffold proteins as exemplified by a novel neuronal protein, CASK-interactive protein1Annamária Balázs
Department of Medical Chemistry, Semmelweis University Medical School, Budapest, Hungary
FEBS J 276:3744-56. 2009....
Intrinsic structural disorder confers cellular viability on oncogenic fusion proteinsHedi Hegyi
Institute of Enzymology, Biological Research Center, Hungarian Academy of Sciences, Budapest, Hungary
PLoS Comput Biol 5:e1000552. 2009..g. EWS-ATF). Our findings also suggest novel strategies of intervention against the ensuing neoplastic transformations...
Functional classification of scaffold proteins and related moleculesLaszlo Buday
Institute of Enzymology, Biological Research Center, Hungarian Academy of Sciences, Budapest, Hungary
FEBS J 277:4348-55. 2010..Thus, the field is in a state of continuous advance and expansion, which demands that the classification scheme be regularly updated and, if needed, revised...
