Andras Malnasi-Csizmadia

Summary

Country: Hungary

Publications

  1. ncbi Relating the shape of protein binding sites to binding affinity profiles: is there an association?
    Zoltán Simon
    Department of Biochemistry, Institute of Biology, Eotvos Lorand University, Pazmany Peter setany 1 C, H 1117 Budapest, Hungary
    BMC Struct Biol 10:32. 2010
  2. ncbi Emerging complex pathways of the actomyosin powerstroke
    Andras Malnasi-Csizmadia
    Department of Biochemistry, Eotvos University, Pazmany P stny 1 C, H 1117 Budapest, Hungary
    Trends Biochem Sci 35:684-90. 2010
  3. ncbi Kinetic characterization of the function of myosin loop 4 in the actin-myosin interaction
    Máté Gyimesi
    Department of Biochemistry, Eotvos University, Institute of Biology, Budapest, H 1117, Hungary
    Biochemistry 47:283-91. 2008
  4. ncbi Thermodynamic analysis reveals structural rearrangement during the acylation step in human trypsin 4 on 4-methylumbelliferyl 4-guanidinobenzoate substrate analogue
    Julia Toth
    Department of Biochemistry, Eotvos Lorand University, Pazmany Peter setany 1 C, H 1117 Budapest, Hungary
    J Biol Chem 281:12596-602. 2006
  5. ncbi Myosin complexed with ADP and blebbistatin reversibly adopts a conformation resembling the start point of the working stroke
    Balazs Takacs
    Department of Biochemistry, Eotvos University, H 1117 Budapest, Pazmany Peter setany 1 C, Hungary
    Proc Natl Acad Sci U S A 107:6799-804. 2010
  6. ncbi Engineering lysine reactivity as a conformational sensor in the Dictyostelium myosin II motor domain
    Mihaly Kovacs
    Department of Biochemistry, Eotvos Lorand University, H 1117 Budapest, Pázmány P sétány 1 C, Hungary
    J Muscle Res Cell Motil 25:95-102. 2004
  7. ncbi Drug effect prediction by polypharmacology-based interaction profiling
    Zoltán Simon
    Department of Biochemistry, Institute of Biology, Eotvos Lorand University, Pazmany Peter setany 1 C, H 1117 Budapest, Hungary
    J Chem Inf Model 52:134-45. 2012
  8. ncbi Experimental investigation of the seesaw mechanism of the relay region that moves the myosin lever arm
    Balint Kintses
    Department of Biochemistry, Eotvos Lorand University, Budapest H 1117, Hungary
    J Biol Chem 283:34121-8. 2008
  9. ncbi The mechanism of the reverse recovery step, phosphate release, and actin activation of Dictyostelium myosin II
    Máté Gyimesi
    Department of Biochemistry, Institute of Biology, Eotvos University, Pazmany Peter setany 1 A, Budapest, Hungary
    J Biol Chem 283:8153-63. 2008
  10. ncbi Temperature dependence of internal friction in enzyme reactions
    Anna A Rauscher
    Department of Biochemistry, Eotvos Lorand University, Pazmany Peter setany 1 C, Budapest H 1117, Hungary
    FASEB J 25:2804-13. 2011

Collaborators

Detail Information

Publications13

  1. ncbi Relating the shape of protein binding sites to binding affinity profiles: is there an association?
    Zoltán Simon
    Department of Biochemistry, Institute of Biology, Eotvos Lorand University, Pazmany Peter setany 1 C, H 1117 Budapest, Hungary
    BMC Struct Biol 10:32. 2010
    ....
  2. ncbi Emerging complex pathways of the actomyosin powerstroke
    Andras Malnasi-Csizmadia
    Department of Biochemistry, Eotvos University, Pazmany P stny 1 C, H 1117 Budapest, Hungary
    Trends Biochem Sci 35:684-90. 2010
    ..g. kinesin-microtubule, G protein exchange factor and kinase-scaffold protein) systems that perform chemomechanical or signal transduction...
  3. ncbi Kinetic characterization of the function of myosin loop 4 in the actin-myosin interaction
    Máté Gyimesi
    Department of Biochemistry, Eotvos University, Institute of Biology, Budapest, H 1117, Hungary
    Biochemistry 47:283-91. 2008
    ....
  4. ncbi Thermodynamic analysis reveals structural rearrangement during the acylation step in human trypsin 4 on 4-methylumbelliferyl 4-guanidinobenzoate substrate analogue
    Julia Toth
    Department of Biochemistry, Eotvos Lorand University, Pazmany Peter setany 1 C, H 1117 Budapest, Hungary
    J Biol Chem 281:12596-602. 2006
    ....
  5. ncbi Myosin complexed with ADP and blebbistatin reversibly adopts a conformation resembling the start point of the working stroke
    Balazs Takacs
    Department of Biochemistry, Eotvos University, H 1117 Budapest, Pazmany Peter setany 1 C, Hungary
    Proc Natl Acad Sci U S A 107:6799-804. 2010
    ..The results indicate that a significant fraction of the myosin.ADP.blebbistatin complex populates a previously inaccessible conformation of myosin resembling the start of the powerstroke...
  6. ncbi Engineering lysine reactivity as a conformational sensor in the Dictyostelium myosin II motor domain
    Mihaly Kovacs
    Department of Biochemistry, Eotvos Lorand University, H 1117 Budapest, Pázmány P sétány 1 C, Hungary
    J Muscle Res Cell Motil 25:95-102. 2004
    ....
  7. ncbi Drug effect prediction by polypharmacology-based interaction profiling
    Zoltán Simon
    Department of Biochemistry, Institute of Biology, Eotvos Lorand University, Pazmany Peter setany 1 C, H 1117 Budapest, Hungary
    J Chem Inf Model 52:134-45. 2012
    ..Our results show that the prediction power is independent of the composition of the protein set used for interaction profile generation...
  8. ncbi Experimental investigation of the seesaw mechanism of the relay region that moves the myosin lever arm
    Balint Kintses
    Department of Biochemistry, Eotvos Lorand University, Budapest H 1117, Hungary
    J Biol Chem 283:34121-8. 2008
    ....
  9. ncbi The mechanism of the reverse recovery step, phosphate release, and actin activation of Dictyostelium myosin II
    Máté Gyimesi
    Department of Biochemistry, Institute of Biology, Eotvos University, Pazmany Peter setany 1 A, Budapest, Hungary
    J Biol Chem 283:8153-63. 2008
    ..Even at low actin concentrations the power stroke occurs in the actin-attached states despite the low actin affinity of myosin in the pre-power stroke conformation...
  10. ncbi Temperature dependence of internal friction in enzyme reactions
    Anna A Rauscher
    Department of Biochemistry, Eotvos Lorand University, Pazmany Peter setany 1 C, Budapest H 1117, Hungary
    FASEB J 25:2804-13. 2011
    ..Based on the coupling of the internal and external movements of the protein during its conformational change, we constructed a model that quantitatively relates activation energy, internal friction, and protein flexibility...
  11. ncbi Probing conformational plasticity of the activation domain of trypsin: the role of glycine hinges
    Linda Gombos
    Department of Biochemistry, Eotvos Lorand University, Pazmany Peter setany 1 C, H 1117 Budapest, Hungary
    Biochemistry 47:1675-84. 2008
    ..Transient kinetic measurements confirmed the existence of an inactive to active conformational transition occurring prior to substrate binding...
  12. ncbi A novel actin binding site of myosin required for effective muscle contraction
    Boglárka H Várkuti
    Department of Biochemistry, Eotvos Lorand University, Budapest, Hungary
    Nat Struct Mol Biol 19:299-306. 2012
    ..We conclude that the binding of actin to myosin's activation loop specifically increases the ratio of mechanically productive to futile myosin heads, leading to efficient muscle contraction...
  13. ncbi Localization and characterization of the inhibitory Ca2+-binding site of Physarum polycephalum myosin II
    Laszlo Farkas
    Department of Biochemistry, , Budapest 1117, Hungary
    J Biol Chem 278:27399-405. 2003
    ....