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Species | Sun Min ParkSummaryAffiliation: Hoseo University Publications
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Publications
Glyceollin-containing fermented soybeans improve glucose homeostasis in diabetic miceSunmin Park
Department of Food and Nutrition, Department of Semiconductor and Display Engineering College of Natural Science, Hoseo University, Asan 336 795, Korea
Nutrition 28:204-11. 2012..Here, we investigated whether fermented soybeans containing glyceollins had an antidiabetic action in type 2 diabetic animals...- Melatonin receptor 1 B polymorphisms associated with the risk of gestational diabetes mellitusJason Y Kim
Department of Life Science, Sogang University, Department of Obstetrics and Gynecology, Cheil General Hospital and Women s Healthcare Center, 1 Shinsu dong, Mapo gu, Seoul, 121 742, Republic of Korea
BMC Med Genet 12:82. 2011..Furthermore, we also examined genetic effects of the two polymorphisms with various diabetes-related phenotypes... - Glyceollins, one of the phytoalexins derived from soybeans under fungal stress, enhance insulin sensitivity and exert insulinotropic actionsSunmin Park
Department of Food and Nutrition, Obesity Diabetes Center, College of Science, Natural Hoseo University, Asan 336 795, Korea
J Agric Food Chem 58:1551-7. 2010..In conclusion, glyceollins help normalize glucose homeostasis by potentiating beta-cell function and survival and improving glucose utilization in adipocytes... - Olanzapine, not resperidone, exacerbates beta-cell function and mass in ovariectomized diabetic rats and estrogen replacement reverses themSunmin Park
Department of Food and Nutrition, Diabetes Obesity Center, College of Natural Science, Hoseo University, Chungnam Do, Korea
J Psychopharmacol 24:1105-14. 2010..Further human studies are needed to support the claim that olanzapine should be avoided in the treatment of schizophrenic postmenopausal patients with diabetes... - Huang-Lian-Jie-Du-Tang supplemented with Schisandra chinensis Baill. and Polygonatum odoratum Druce improved glucose tolerance by potentiating insulinotropic actions in islets in 90% pancreatectomized diabetic ratsSunmin Park
Deptartment of Food and Nutrition, College of Natural Science, Hoseo University, Asan Si, Korea
Biosci Biotechnol Biochem 73:2384-92. 2009..The rise in hyperplasia was associated with elevated IRS2 and PDX-1 expression in the islets. In conclusion, HLJDT-M worked as an anti-diabetic prescription by enhancing insulinotropic actions in diabetic rats... - Exendin-4 and exercise improve hepatic glucose homeostasis by promoting insulin signaling in diabetic ratsSunmin Park
Department of Food and Nutrition, College of Natural Science, Institute of Basic Science, Hoseo University, Asan Si, ChungNam Do 336 795, South Korea
Metabolism 59:123-33. 2010..Exendin-4 in combination with exercise had no additive effects. In conclusion, exendin-4 and exercise improve hepatic glucose homeostasis by promoting hepatic insulin signaling in diabetic rats... - Long-term intracerebroventricular infusion of insulin, but not glucose, modulates body weight and hepatic insulin sensitivity by modifying the hypothalamic insulin signaling pathway in type 2 diabetic ratsSunmin Park
Department of Food and Nutrition, Hoseo University, Asan Si, Korea
Neuroendocrinology 89:387-99. 2009..We investigated how intracerebroventricular (ICV) infusion of insulin and glucose modified body weight and peripheral glucose homeostasis in 90% pancreatectomized rats that exhibited symptoms of mild and non-obese type 2 diabetes... - Can splenocytes enhance pancreatic beta-cell function and mass in 90% pancreatectomized rats fed a high fat diet?Sunmin Park
Dept of Food and Nutrition, Institute of Basic Science, College of Natural Science, Hoseo University, Asan Si 336 795, South Korea
Life Sci 84:358-63. 2009..Accordingly, we sought to determine whether splenocytes played an important role in promoting beta-cell function and mass among type 2 diabetic rats with and without spleen... - Exendin-4 and exercise promotes beta-cell function and mass through IRS2 induction in islets of diabetic ratsSunmin Park
Department of Food and Nutrition, College of Natural Science, Hoseo University, Asan Si, South Korea
Life Sci 82:503-11. 2008..In conclusion, exendin-4 and exercise equivalently improved glucose homeostasis due to the induction of IRS-2 in the islets of diabetic rats through a cAMP dependent common pathway... - Extracts of Rehmanniae radix, Ginseng radix and Scutellariae radix improve glucose-stimulated insulin secretion and beta-cell proliferation through IRS2 inductionSun Min Park
Department of Food and Nutrition, College of Natural Science, Hoseo University, 165 Sechul ri, Baebang myun, Asan Si, Chungchongnam do, 336 795, Republic of Korea
Genes Nutr 2:347-51. 2008..Increased PDX-1 expression was associated with beta-cell proliferation, which was consistent with the cell viability assay. In conclusion, R. radix, Ginseng radix and S. radix had an insulinotropic action similar to that of exendin-4... - Exercise improves glucose homeostasis that has been impaired by a high-fat diet by potentiating pancreatic beta-cell function and mass through IRS2 in diabetic ratsSunmin Park
Dept of Food and Nutrition, College of Natural Science, Institutes of Basic Sciences, Hoseo Univ, 165 Sechul Ri Baebang Myun Asan Si, Chungnam Do, 336 795, Korea
J Appl Physiol 103:1764-71. 2007..This study suggests that dietary fat contents and exercise modulate beta-cell function and mass to overcome insulin resistance in two different pathways... - Anti-obesity effects of Chang-Chul-Eui-Ee-In-Tang [see text] in female rats with diet-induced obesitySunmin Park
Department of Food and Nutrition, Obesity Diabetes Research Institutes, Hoseo University, Asan, South Korea
Chin J Integr Med 17:925-32. 2011..The possible mechanism of action of CCEET was also determined... - Central infusion of leptin improves insulin resistance and suppresses beta-cell function, but not beta-cell mass, primarily through the sympathetic nervous system in a type 2 diabetic rat modelSunmin Park
Department of Food and Nutrition, College of Natural Science, Obesity Diabetes Research Center, Hoseo University, Asan, Chungnam, Republic of Korea
Life Sci 86:854-62. 2010..We investigated whether hypothalamic leptin alters beta-cell function and mass directly via the sympathetic nervous system (SNS) or indirectly as the result of altered insulin resistant states... - Gastrodia elata Blume water extracts improve insulin resistance by decreasing body fat in diet-induced obese rats: vanillin and 4-hydroxybenzaldehyde are the bioactive candidatesSunmin Park
Department of Food and Nutrition, Hoseo University, 165 Sechul ri, BaeBang Yup, Asan Si, Chungnam Do, South Korea
Eur J Nutr 50:107-18. 2011..Insulin resistance is a common symptom of metabolic diseases such as obesity, type 2 diabetes and hyperlipidemia... - A ketogenic diet impairs energy and glucose homeostasis by the attenuation of hypothalamic leptin signaling and hepatic insulin signaling in a rat model of non-obese type 2 diabetesSunmin Park
Department of Food and Nutrition, Obesity Diabetes Research Center, Institutes of Basic Sciences, Hoseo University, Asan 336 795, Korea
Exp Biol Med (Maywood) 236:194-204. 2011..These changes are not associated with increased serum ketone levels... - Ischemic hippocampal cell death induces glucose dysregulation by attenuating glucose-stimulated insulin secretion which is exacerbated by a high fat dietSunmin Park
Dept of Food and Nutrition, College of Natural Science, Obesity Diabetes Research Institutes, Hoseo University, 165 Sechul ri, BaeBang Yup, Asan Si, Chungnam Do, South Korea
Life Sci 88:766-73. 2011.... - Serum prolactin concentrations determine whether they improve or impair ?-cell function and insulin sensitivity in diabetic ratsSunmin Park
College of Natural Sciences, Department of Food and Nutrition, Obesity Diabetes Research Center, Institutes of Basic Science, Hoseo University, Asan Si, South Korea
Diabetes Metab Res Rev 27:564-74. 2011.... - Long-term central infusion of adiponectin improves energy and glucose homeostasis by decreasing fat storage and suppressing hepatic gluconeogenesis without changing food intakeS Park
Department of Food and Nutrition, College of Natural Science, Obesity Diabetes Research Institutes, Hoseo University, Asan Si, Chungnam Do, Korea
J Neuroendocrinol 23:687-98. 2011.... - Central infusion of ketone bodies modulates body weight and hepatic insulin sensitivity by modifying hypothalamic leptin and insulin signaling pathways in type 2 diabetic ratsSunmin Park
Dept of Food and Nutrition, Obesity Diabetes Center, College of Natural Science, Hoseo University, Asan Si, Republic of Korea
Brain Res 1401:95-103. 2011..In conclusion, mild ketosis by central infusion of ketones improves energy and glucose metabolism through the potentiation of leptin and insulin signaling in the hypothalamus of diabetic rats... - Long-term effects of central leptin and resistin on body weight, insulin resistance, and beta-cell function and mass by the modulation of hypothalamic leptin and insulin signalingSunmin Park
Department of Food and Nutrition, Hoseo University, Asan Si, Chungnam Do, Korea
Endocrinology 149:445-54. 2008..In conclusion, long-term ICV infusion of leptin and resistin independently improved energy and glucose homeostasis by modulating in different ways hypothalamic leptin and insulin signaling... - Estrogen replacement reverses olanzapine-induced weight gain and hepatic insulin resistance in ovariectomized diabetic ratsSunmin Park
Department of Food and Nutrition, Diabetes Obesity Center, College of Natural Science, Hoseo University, Asan, South Korea smpark hoseo edu
Neuropsychobiology 61:148-61. 2010.... - Chlorpromazine exacerbates hepatic insulin sensitivity via attenuating insulin and leptin signaling pathway, while exercise partially reverses the adverse effectsSunmin Park
Department of Food and Nutrition, College of Natural Science, Hoseo University, Asan Si, Chungnam Do, Republic of Korea
Life Sci 80:2428-35. 2007..Enhancement of insulin and leptin signaling through an induction of IRS2 may play an important role in improving hepatic glucose homeostasis... - A high carbohydrate diet induces insulin resistance through decreased glucose utilization in ovariectomized ratsSun Min Park
Department of Food and Nutrition, College of Natural Science, Hoseo University, Asan, Korea
Korean J Intern Med 19:87-92. 2004..OVX-induced obesity may be involved in the induction of insulin resistance from an increased triacylglycerol content, decreased glucose uptake and glycogen synthesis in skeletal muscles, regardless of dietary carbohydrate subtypes... - Antecedent intake of traditional Asian-style diets exacerbates pancreatic beta-cell function, growth and survival after Western-style diet feeding in weaning male ratsSunmin Park
Department of Food and Nutrition, College of Natural Science, Hoseo University, ChungNam Do 336 795, South Korea
J Nutr Biochem 17:307-18. 2006..These findings suggest that the antecedent consumption of AD possibly accelerates and augments the development of glucose dysregulation via decreased insulin secretion capacity and pancreatic beta-cell mass when the diets switch to WD... - Exercise enhances insulin and leptin signaling in the cerebral cortex and hypothalamus during dexamethasone-induced stress in diabetic ratsSunmin Park
Department of Food and Nutrition, College of Natural Science, Hoseo University, Asan Si, Korea
Neuroendocrinology 82:282-93. 2005..In conclusion, exercise improves insulin and leptin signaling in the cerebral cortex and hypothalamus of diabetic rats exacerbated with HDEX, contributing to the regulation of body weight and glucose homeostasis... - Long-term consumption of caffeine improves glucose homeostasis by enhancing insulinotropic action through islet insulin/insulin-like growth factor 1 signaling in diabetic ratsSunmin Park
Department of Food and Nutrition, College of Natural Science and Institute of Basic Sciences, Hoseo University, Asan Si, South Korea
Metabolism 56:599-607. 2007.... - Ginsenosides Rb1 and Rg1 suppress triglyceride accumulation in 3T3-L1 adipocytes and enhance beta-cell insulin secretion and viability in Min6 cells via PKA-dependent pathwaysSunmin Park
Department of Food and Nutrition, Institutes of Basic Science, Hoseo University, South Korea
Biosci Biotechnol Biochem 72:2815-23. 2008..These results suggest that Rb1 and Rg1 improved glucose homeostasis through the activation of a PKA like glucagon-like peptide-1 receptor agonist... - Induction of long-term normoglycemia without medication in Korean type 2 diabetes patients after continuous subcutaneous insulin infusion therapySunmin Park
Food and Nutrition, Hoseo University, Sechul-Ri, Asan-Si, Chungnam-Do, 336-795, Korea
Diabetes Metab Res Rev 19:124-30. 2003..The possibility of remission is higher if the severity of glucose toxicity is lower at the initiation stage of the therapy. It is suggested that CSII therapy might be considered as an early treatment for type 2 diabetic patients... - Does fluoxetine administration influence insulin resistance in 90% pancreatectomized rats?Sunmin Park
Department of Food and Nutrition, Hoseo University, Chungnam-Do, Korea
Metabolism 51:38-43. 2002.... - Effects of alpha-tocopherol supplementation and continuous subcutaneous insulin infusion on oxidative stress in Korean patients with type 2 diabetesSunmin Park
Department of Food and Nutrition, Hoseo University, Asan Si, Korea
Am J Clin Nutr 75:728-33. 2002..Our previous study showed, however, that CSII does not reduce oxidative stress even though it normalizes blood glucose concentrations... - Irs1 and Irs2 signaling is essential for hepatic glucose homeostasis and systemic growthXiaocheng Dong
Howard Hughes Medical Institute, Division of Endocrinology, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
J Clin Invest 116:101-14. 2006..Thus, signals delivered by Irs1 or Irs2 regulate hepatic gene expression that coordinates glucose homeostasis and systemic growth... - A steroidal glycoside from Polygonatum odoratum (Mill.) Druce. improves insulin resistance but does not alter insulin secretion in 90% pancreatectomized ratsSoo Bong Choi
Department of Internal Medicine, Konkuk University, Kyohyun dong, Chungioo Si, Chungbuk Do, Korea
Biosci Biotechnol Biochem 66:2036-43. 2002..In conclusion, SG-100 has an antihyperglycemic effect by promoting peripheral insulin sensitivity without changing insulin secretion... - Long-term consumption of fermented soybean-derived Chungkookjang enhances insulinotropic action unlike soybeans in 90% pancreatectomized diabetic ratsDae Young Kwon
Food Functional Research Division, Korean Food Research Institutes, Seoul, Korea
Eur J Nutr 46:44-52. 2007..We previously reported that Chungkookjang (CKJ), fermented unsalted soybeans, exhibited better anti-diabetic action than cooked soybeans (CSB) in vitro, but its effectiveness and mechanism have not been studied in vivo... - Upregulation of insulin receptor substrate-2 in pancreatic beta cells prevents diabetesAnita M Hennige
Howard Hughes Medical Institute, Joslin Diabetes Center, Boston, Massachusetts 02215, USA
J Clin Invest 112:1521-32. 2003..Thus, pharmacological approaches that promote Irs2 expression in beta cells, especially specific cAMP agonists, could be rational treatments for beta cell failure and diabetes... - Estrogen and exercise may enhance beta-cell function and mass via insulin receptor substrate 2 induction in ovariectomized diabetic ratsSoo Bong Choi
Department of Internal Medicine, College of Medicine, Konkuk University, Chung Ju, Korea
Endocrinology 146:4786-94. 2005..Regular moderate exercise eliminates the risk factors of contracting diabetes in the postmenopausal state... - Changes in components, glycyrrhizin and glycyrrhetinic acid, in raw Glycyrrhiza uralensis Fisch, modify insulin sensitizing and insulinotropic actionsByoung Seob Ko
Deptartment of Quality Control and Inspection, Korea Institute of Oriental Medicine, Korea
Biosci Biotechnol Biochem 71:1452-61. 2007..In conclusion, GRP extract containing glycyrrhetinic acid improved glucose tolerance better than GR extract by enhancing insulinotropic action. Thus, GRP had better anti-diabetic action than GR... - Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetesXueying Lin
Howard Hughes Medical Institute Children s Hospital, Division of Endocrinology, Harvard Medical School, Boston, Massachusetts 02115, USA
J Clin Invest 114:908-16. 2004..Thus, Irs2 signaling promotes regeneration of adult beta cells and central control of nutrient homeostasis, which can prevent obesity and diabetes in mice... - Improvement of insulin resistance and insulin secretion by water extracts of Cordyceps militaris, Phellinus linteus, and Paecilomyces tenuipes in 90% pancreatectomized ratsSoo Bong Choi
Internal Medicine, Konkuk University, Chungbuk-Do, Korea
Biosci Biotechnol Biochem 68:2257-64. 2004..militaris, but P. tenuipes decreased both. In sum, a water extract of C. militaris ameliorates insulin resistance by enhancing glucose utilization in skeletal muscles... - Insulin sensitizing and alpha-glucoamylase inhibitory action of sennosides, rheins and rhaponticin in Rhei RhizomaSoo Bong Choi
Department of Internal Medicine, Konkuk University, Chungjoo, Chungbuk, Korea
Life Sci 78:934-42. 2006..Rhein and rhaponticin are potential candidates for hypoglycemic agents... - Effects of okchun-san, a herbal formulation, on blood glucose levels and body weight in a model of Type 2 diabetesMun Seog Chang
Department of Prescriptionology, College of Oriental Medicine, Kyung Hee University, 1 Hoegi-Dong, Dongdaemun-gu, Seoul 130-701, Republic of Korea
J Ethnopharmacol 103:491-5. 2006..These results suggest that OCS-C can be useful as an anti-diabetic therapy for Type 2 diabetic patients by lowering the blood glucose level... - Exercise and dexamethasone oppositely modulate beta-cell function and survival via independent pathways in 90% pancreatectomized ratsSoo Bong Choi
Department of Internal Medicine, College of Medicine, Konkuk University, Chung Ju 380-704, South Korea
J Endocrinol 190:471-82. 2006..In conclusion, the improvement of beta-cell function and survival via the activation of an insulin/IGF-I signaling cascade due to exercise has a crucial role in preventing the development and progression of type 2 diabetes... - Exendin-4 uses Irs2 signaling to mediate pancreatic beta cell growth and functionSunmin Park
Howard Hughes Medical Institute, Division of Endocrinology, Department of Medicine, Children s Hospital Boston, MA 02215, USA
J Biol Chem 281:1159-68. 2006.... - Tramadol enhances hepatic insulin sensitivity via enhancing insulin signaling cascade in the cerebral cortex and hypothalamus of 90% pancreatectomized ratsSoo Bong Choi
Department of Internal Medicine, College of Medicine, Konkuk University, Republic of Korea
Brain Res Bull 67:77-86. 2005..The data suggest that tramadol ameliorates peripheral glucose metabolism through central activation of MOR, and that central and peripheral glucose metabolism are therefore likely to be interrelated... - In vitro and short-term in vivo characteristics of a Kel-F thin film modified glucose sensorSun Kil Kang
Department of Biomedical Engineering, College of Medicine and Institute of Medical and Biological Engineering, Medical Research Center, Seoul National University, Seoul 110-744, Korea
Anal Sci 19:1481-6. 2003..The in vivo characteristics of the glucose sensor described show great promise for one-point in vivo calibration... - The insulin sensitizing effect of homoisoflavone-enriched fraction in Liriope platyphylla Wang et Tang via PI3-kinase pathwaySoo Bong Choi
Department of Internal Medicine, Konkuk University, Kyohyun dong, Chungjoo Si, Chungbuk Do, South Korea
Life Sci 75:2653-64. 2004..GLUT4 translocation was increased through insulin receptor substrate 1 (IRS1)-PI3 kinase-Akt signaling mechanism. Thus, homoisoflavone-enriched fraction in LPWT extract played an important role as an insulin sensitizer in adipocytes... - Insulin sensitizing and insulinotropic action of berberine from Cortidis rhizomaByoung-Seob Ko
Department of Quality Inspection and Examination, Korea Institute of Oriental Medicine, Daejun 305-390, Korea
Biol Pharm Bull 28:1431-7. 2005..Data suggested that berberine can act as an effective insulin sensitizing and insulinotropic agent. Therefore, berberine can be used as anti-diabetic agent for obese diabetic patients... - The isoflavonoid aglycone-rich fractions of Chungkookjang, fermented unsalted soybeans, enhance insulin signaling and peroxisome proliferator-activated receptor-gamma activity in vitroDae Young Kwon
Food Functional Research Division, Korean Food Research Institutes, Korea
Biofactors 26:245-58. 2006..In addition, CKJ contains small peptides improving glucose-stimulated insulin secretion in insulinoma cells. Overall, CKJ is superior to CSB in anti-diabetic action...