Gouda K Helal

Summary

Publications

  1. ncbi Systemic administration of Zn2+ during the reperfusion phase of transient cerebral ischaemia protects rat hippocampus against iron-catalysed postischaemic injury
    Gouda K Helal
    Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al Azhar University, Cairo, Egypt
    Clin Exp Pharmacol Physiol 35:775-81. 2008
  2. ncbi Metallothionein attenuates carmustine-induced oxidative stress and protects against pulmonary fibrosis in rats
    Gouda Kamel Helal
    Department of Pharmacology, College of Pharmacy, King Saud University, P O Box 2457, Riyadh 11451, Saudi Arabia
    Arch Toxicol 83:87-94. 2009
  3. ncbi Metallothionein induction reduces caspase-3 activity and TNFalpha levels with preservation of cognitive function and intact hippocampal neurons in carmustine-treated rats
    Gouda K Helal
    Department of Pharmacology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia
    Oxid Med Cell Longev 2:26-35. 2009
  4. ncbi Thymoquinone supplementation ameliorates acute endotoxemia-induced liver dysfunction in rats
    Gouda K Helal
    Department of Pharmacology, College of Pharmacy, King Saud University, Saudi Arabia
    Pak J Pharm Sci 23:131-7. 2010
  5. ncbi Pro-inflammatory and oxidative stress pathways which compromise sperm motility and survival may be altered by L-carnitine
    Adel R A Abd-Allah
    Department of Pharmacology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia
    Oxid Med Cell Longev 2:73-81. 2009
  6. ncbi Protective effect of N-acetylcysteine against carmustine-induced myelotoxicity in rats
    El Sayed M El-Sayed
    Pharmacology and Toxicology Department, Faculty of Pharmacy, Al Azhar University, Cairo, Egypt
    Food Chem Toxicol 48:1576-80. 2010

Detail Information

Publications6

  1. ncbi Systemic administration of Zn2+ during the reperfusion phase of transient cerebral ischaemia protects rat hippocampus against iron-catalysed postischaemic injury
    Gouda K Helal
    Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al Azhar University, Cairo, Egypt
    Clin Exp Pharmacol Physiol 35:775-81. 2008
    ..injected ZnCl(2), which can induce expression of brain MT, increase the anti-oxidant capacity and diminish iron-catalysed lipid peroxidation and apoptosis. This may give new insights as to how to improve the outcome for stroke patients...
  2. ncbi Metallothionein attenuates carmustine-induced oxidative stress and protects against pulmonary fibrosis in rats
    Gouda Kamel Helal
    Department of Pharmacology, College of Pharmacy, King Saud University, P O Box 2457, Riyadh 11451, Saudi Arabia
    Arch Toxicol 83:87-94. 2009
    ..Based on our results, it is possible to postulate that exogenous MT can act against BCNU-induced lung toxicity by a mechanism related, at least in part, to its ability to decrease oxidative stress and fibrosis...
  3. ncbi Metallothionein induction reduces caspase-3 activity and TNFalpha levels with preservation of cognitive function and intact hippocampal neurons in carmustine-treated rats
    Gouda K Helal
    Department of Pharmacology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia
    Oxid Med Cell Longev 2:26-35. 2009
    ..In conclusion, MT induction halts BCNU-induced hippocampal toxicity as it prevented GR inhibition and GSH depletion and counteracted the increased levels of TNFalpha, MDA and caspase-3 activity with subsequent preservation of cognition...
  4. ncbi Thymoquinone supplementation ameliorates acute endotoxemia-induced liver dysfunction in rats
    Gouda K Helal
    Department of Pharmacology, College of Pharmacy, King Saud University, Saudi Arabia
    Pak J Pharm Sci 23:131-7. 2010
    ..The present study conclude that TQ reduced acute endoxemia-induced liver dysfunction at least in part by its anti-inflammatory, antiapoptotic and antioxidant activities...
  5. ncbi Pro-inflammatory and oxidative stress pathways which compromise sperm motility and survival may be altered by L-carnitine
    Adel R A Abd-Allah
    Department of Pharmacology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia
    Oxid Med Cell Longev 2:73-81. 2009
    ..L-carnitine administration ameliorates these effects by antioxidant and/or anti-inflammatory mechanisms suggesting a protective role against male infertility in severely infected or septic patients...
  6. ncbi Protective effect of N-acetylcysteine against carmustine-induced myelotoxicity in rats
    El Sayed M El-Sayed
    Pharmacology and Toxicology Department, Faculty of Pharmacy, Al Azhar University, Cairo, Egypt
    Food Chem Toxicol 48:1576-80. 2010
    ..Conclusively, NAC could have a potential protective effect against BCNU-induced myelotoxicity; an effect that is mainly attributed to the antioxidant property...