On the action of cyclosporine A, rapamycin and tacrolimus on M. avium including subspecies paratuberculosisRobert J Greenstein
Department of Surgery, Veterans Affairs Medical Center, Bronx, New York, United States of America
PLoS ONE 3:e2496. 2008
..Rapamycin and Tacrolimus are macrolides. We hypothesized that their mode of action may simply be to inhibit MAP growth...
- Vitamins A & D inhibit the growth of mycobacteria in radiometric culture
Robert J Greenstein
Department of Surgery, James J Peters Veterans Affairs Medical Center, Bronx, New York, United States of America
PLoS ONE 7:e29631. 2012
..We hypothesized that some vitamins may directly influence the growth of prokaryotes, particularly mycobacteria...
- Growth of M. avium subspecies paratuberculosis in culture is enhanced by nicotinic acid, nicotinamide, and ? and ? nicotinamide adenine dinucleotide
Robert J Greenstein
Department of Surgery, James J Peters VAMC, Bronx, NY 10468, USA
Dig Dis Sci 56:368-75. 2011
..Mycobacterium avium subspecies paratuberculosis (MAP) may be zoonotic. We hypothesized that tobacco components might alter the growth kinetics of MAP, explaining these divergent clinical observations...
- The thioamides methimazole and thiourea inhibit growth of M. avium Subspecies paratuberculosis in culture
Robert J Greenstein
Department of Surgery, James J Peters VA Medical Center, Bronx, New York, United States of America
PLoS ONE 5:e11099. 2010
..Because other thioamides treat tuberculosis, leprosy and M. avium complex, we hypothesized that a mode of action of some thioamide anti-thyrotoxicosis medications may include MAP growth inhibition...
- Monensin causes dose dependent inhibition of Mycobacterium avium subspecies paratuberculosis in radiometric culture
Robert J Greenstein
Laboratory of Molecular Surgical Research, VAMC Bronx, NY 112, 130 West Kingsbridge Road, Bronx, NY 10468, USA
Gut Pathog 1:4. 2009
..We posit that the "Growth Enhancer" effect of Monensin may, at least in part, be due to inhibition of MAP in clinical or sub-clinical Johne's disease...
- On the effect of thalidomide on Mycobacterium avium subspecies paratuberculosis in culture
Robert J Greenstein
VAMC Bronx NY 112, 130 West Kingsbridge Rd, Bronx, NY 10468, USA
Int J Infect Dis 13:e254-63. 2009
..We herein test the hypothesis that thalidomide may inhibit MAP growth...
- On the action of 5-amino-salicylic acid and sulfapyridine on M. avium including subspecies paratuberculosis
Robert J Greenstein
Departments of Surgery and Laboratory of Molecular Surgical Research, VA Medical Center, Bronx, New York, United States of America
PLoS ONE 2:e516. 2007
..We concluded that their most plausible mechanism of action is as antiMAP antibiotics. We herein hypothesize that the mechanism of action of 5-ASA and/or sulfapyridine may also simply be to inhibit MAP growth...
- On the action of methotrexate and 6-mercaptopurine on M. avium subspecies paratuberculosis
Robert J Greenstein
Laboratory of Molecular Surgical Research, VA Medical Center, Bronx, New York, United States of America
PLoS ONE 2:e161. 2007
..We hypothesized that the clinical efficacy of methotrexate and 6-MP in IBD may be to simply inhibit the growth of MAP...
- Emerging pathogens: is Mycobacterium avium subspecies paratuberculosis zoonotic?
Robert J Greenstein
Department of Surgery, VAMC Bronx (112, New York, NY 10468, USA
Lancet 364:396-7. 2004
- Is Crohn's disease caused by a mycobacterium? Comparisons with leprosy, tuberculosis, and Johne's disease
Robert J Greenstein
Department of Surgery and Director of the Laboratory of Molecular Surgical Research, VA Medical Center, Bronx, NY, USA
Lancet Infect Dis 3:507-14. 2003
..Rational studies to evaluate appropriate therapies to cure Crohn's disease are proposed...
- Esophageal anatomy and function in laparoscopic gastric restrictive bariatric surgery: implications for patient selection
R J Greenstein
Surgery, VAMC, Bronx, NY, USA
Obes Surg 8:199-206. 1998
..The purpose of this study was to assess factors of clinical importance in morbidly obese patients having a laparoscopically adjustable gastric band (LAP-BAND) implanted in order to achieve weight loss...
- Is there clinical, epidemiological and molecular evidence for two forms of Crohn's disease?
R J Greenstein
Laboratory of Molecular Surgical Research, VAMC Bronx, NY 10468, USA
Mol Med Today 1:343-8. 1995
..If correct, this subclassification may provide key insights into the pathogenesis and differing host immune responses in Crohn's disease and also allow the development of more rational therapies...
