Dimitrios Paraskevis

Summary

Affiliation: University of Athens
Country: Greece

Publications

  1. ncbi Mutations associated with genotypic resistance to antiretroviral therapy in treatment naïve HIV-1 infected patients in Greece
    E Magiorkinis
    Department of Hygiene and Epidemiology, National Retrovirus Reference Center, Athens School of Medicine, University of Athens, Alexanfroupoles 25, GR-115 27, Greece
    Virus Res 85:109-15. 2002
  2. ncbi Analysis of the evolutionary relationships of HIV-1 and SIVcpz sequences using bayesian inference: implications for the origin of HIV-1
    D Paraskevis
    Rega Institute for Medical Research, Katholieke Universiteit Leuven, Belgium
    Mol Biol Evol 20:1986-96. 2003
  3. ncbi Analysis of complex HIV-1 intersubtype recombinants using a Bayesian scanning method
    D Paraskevis
    Laboratory for Clinical and Epidemiological Virology, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B 3000 Leuven, Belgium
    Infect Genet Evol 5:219-24. 2005
  4. ncbi SlidingBayes: exploring recombination using a sliding window approach based on Bayesian phylogenetic inference
    D Paraskevis
    Laboratory for Clinical and Epidemiological Virology, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B 3000 Leuven, Belgium
    Bioinformatics 21:1274-5. 2005
  5. ncbi Tracing the HIV-1 subtype B mobility in Europe: a phylogeographic approach
    Dimitrios Paraskevis
    Katholieke Universiteit Leuven, Rega Institute for Medical Research, Minderbroederstraat 10, B 3000 Leuven, Belgium
    Retrovirology 6:49. 2009
  6. ncbi Prevalence of resistance-associated mutations in newly diagnosed HIV-1 patients in Greece
    D Paraskevis
    Department of Hygiene and Epidemiology, Athens University Medical School, Mikras Asias 75, GR 11527 Athens, Greece
    Virus Res 112:115-22. 2005
  7. ncbi Phylogenetic reconstruction of a known HIV-1 CRF04_cpx transmission network using maximum likelihood and Bayesian methods
    Dimitrios Paraskevis
    National Retrovirus Reference Center, Department of Hygiene and Epidemiology, Athens University Medical School, Athens, Greece
    J Mol Evol 59:709-17. 2004
  8. ncbi Emergence of an NNRTI resistance mutation Y181C in an HIV-infected NNRTI-naive patient
    Emmanouil Magiorkinis
    Department of Hygiene and Epidemiology, University of Athens Medical School, GR 11527 Athens, Greece
    AIDS Res Hum Retroviruses 24:413-5. 2008
  9. ncbi The effect of antiretroviral treatment of different durations in primary HIV infection
    Nikos Pantazis
    Department of Hygiene, Epidemiology and Medical Statistics, Athens University Medical School, Athens, Greece
    AIDS 22:2441-50. 2008
  10. ncbi Increasing prevalence of HIV-1 subtype A in Greece: estimating epidemic history and origin
    Dimitrios Paraskevis
    Department of Hygiene and Epidemiology, National Retrovirus Reference Center, Athens, Greece
    J Infect Dis 196:1167-76. 2007

Detail Information

Publications31

  1. ncbi Mutations associated with genotypic resistance to antiretroviral therapy in treatment naïve HIV-1 infected patients in Greece
    E Magiorkinis
    Department of Hygiene and Epidemiology, National Retrovirus Reference Center, Athens School of Medicine, University of Athens, Alexanfroupoles 25, GR-115 27, Greece
    Virus Res 85:109-15. 2002
    ..The clinical significance of the polymorphisms associated with reduced susceptibility to NNRTIs remains to be clarified...
  2. ncbi Analysis of the evolutionary relationships of HIV-1 and SIVcpz sequences using bayesian inference: implications for the origin of HIV-1
    D Paraskevis
    Rega Institute for Medical Research, Katholieke Universiteit Leuven, Belgium
    Mol Biol Evol 20:1986-96. 2003
    ..The discordant phylogenetic relationships between the HIV-1/SIVcpz sequences may have been caused by ancient recombination events, but they are also due, at least in part, to altered rates of evolution between parental SIVcpz lineages...
  3. ncbi Analysis of complex HIV-1 intersubtype recombinants using a Bayesian scanning method
    D Paraskevis
    Laboratory for Clinical and Epidemiological Virology, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B 3000 Leuven, Belgium
    Infect Genet Evol 5:219-24. 2005
    ..Thus, a recently developed Bayesian scanning tool can facilitate the analysis and classification of HIV-1 mosaic sequences...
  4. ncbi SlidingBayes: exploring recombination using a sliding window approach based on Bayesian phylogenetic inference
    D Paraskevis
    Laboratory for Clinical and Epidemiological Virology, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B 3000 Leuven, Belgium
    Bioinformatics 21:1274-5. 2005
    ..The tool can be used for nucleotide and amino acid sequences and combines all the modeling possibilities of MrBayes with the ability to plot the posterior probability support for clustering of various combinations of taxa...
  5. ncbi Tracing the HIV-1 subtype B mobility in Europe: a phylogeographic approach
    Dimitrios Paraskevis
    Katholieke Universiteit Leuven, Rega Institute for Medical Research, Minderbroederstraat 10, B 3000 Leuven, Belgium
    Retrovirology 6:49. 2009
    ..However the spatial diffusion of the epidemic from the perspective of the virus has not previously been traced...
  6. ncbi Prevalence of resistance-associated mutations in newly diagnosed HIV-1 patients in Greece
    D Paraskevis
    Department of Hygiene and Epidemiology, Athens University Medical School, Mikras Asias 75, GR 11527 Athens, Greece
    Virus Res 112:115-22. 2005
    ..For two individuals, there was clear evidence for transmitted resistance based on epidemiological information for a known source of HIV-1 transmission. The prevalence of the HIV-1 non-B subtypes and recombinants was 52%...
  7. ncbi Phylogenetic reconstruction of a known HIV-1 CRF04_cpx transmission network using maximum likelihood and Bayesian methods
    Dimitrios Paraskevis
    National Retrovirus Reference Center, Department of Hygiene and Epidemiology, Athens University Medical School, Athens, Greece
    J Mol Evol 59:709-17. 2004
    ..For patients with known infection dates, the estimated dates of the coalescent events obtained using molecular clock calculations based on a newly developed Bayesian method in gag + env were in agreement with the actual infection dates...
  8. ncbi Emergence of an NNRTI resistance mutation Y181C in an HIV-infected NNRTI-naive patient
    Emmanouil Magiorkinis
    Department of Hygiene and Epidemiology, University of Athens Medical School, GR 11527 Athens, Greece
    AIDS Res Hum Retroviruses 24:413-5. 2008
    ..The genetic barrier against resistance of this combination may be lower than previously thought...
  9. ncbi The effect of antiretroviral treatment of different durations in primary HIV infection
    Nikos Pantazis
    Department of Hygiene, Epidemiology and Medical Statistics, Athens University Medical School, Athens, Greece
    AIDS 22:2441-50. 2008
    ....
  10. ncbi Increasing prevalence of HIV-1 subtype A in Greece: estimating epidemic history and origin
    Dimitrios Paraskevis
    Department of Hygiene and Epidemiology, National Retrovirus Reference Center, Athens, Greece
    J Infect Dis 196:1167-76. 2007
    ..In North America and Europe, human immunodeficiency virus (HIV)-1 infection has typically been dominated by subtype B transmission. More recently, however, non-B subtypes have been increasingly reported in Europe...
  11. ncbi Transmission of drug-resistant HIV-1 is stabilizing in Europe
    Jurgen Vercauteren
    Katholieke Universiteit Leuven, Leuven, Belgium
    J Infect Dis 200:1503-8. 2009
    ..02). We found that TDR appears to be stabilizing in Europe, consistent with recent reports of decreasing drug resistance and improved viral suppression in patients treated for HIV-1 infection...
  12. ncbi In vivo characteristics of human immunodeficiency virus type 1 intersubtype recombination: determination of hot spots and correlation with sequence similarity
    Gkikas Magiorkinis
    National Retrovirus Reference Center, Department of Hygiene and Epidemiology, Athens University Medical School, Mikras Asias 75, 11527 Athens, Greece
    J Gen Virol 84:2715-22. 2003
    ..This finding suggests that recombination in vivo may occur preferentially during reverse transcription through the strand displacement-assimilation model rather than the copy-choice model...
  13. ncbi Comparative evaluation of the performance of the Abbott RealTime HIV-1 assay for measurement of HIV-1 plasma viral load on genetically diverse samples from Greece
    Antigoni Katsoulidou
    National Retrovirus Reference Center, Department of Hygiene and Epidemiology and Medical Statistics, Athens University Medical School, Goudi, Greece
    Virol J 8:10. 2011
    ..HIV-1 is characterized by increased genetic heterogeneity which tends to hinder the reliability of detection and accuracy of HIV-1 RNA quantitation assays...
  14. ncbi Molecular characterization of occult hepatitis B cases in Greek blood donors
    Antigoni Katsoulidou
    Department of Hygiene and Epidemiology, Athens University Medical School, Athens, Greece
    J Med Virol 81:815-25. 2009
    ..HBsAg diagnostic failure and low viral replication in occult HBV infection carriers could possibly be attributed to multiple changes in envelope and polymerase regions, respectively...
  15. ncbi Molecular analysis of the full-length genome of HIV type 1 subtype I: evidence of A/G/I recombination
    G Nasioulas
    National Retrovirus Reference Center, Department of Hygiene and Epidemiology, Athens University Medical School, Greece
    AIDS Res Hum Retroviruses 15:745-58. 1999
    ..Our results indicate that subtype I, which was probably circulating in Greece in the early 1980s, is a triple mosaic consisting of A, G, and I sequences...
  16. ncbi European recommendations for the clinical use of HIV drug resistance testing: 2011 update
    Anne Mieke Vandamme
    Rega Institute for Medical Research, Katholieke Universiteit Leuven, Leuven, Belgium
    AIDS Rev 13:77-108. 2011
    ..Indeed, resistance test results should be used in the context of all other clinically relevant information for predicting therapy response...
  17. ncbi Genetic evolution of human immunodeficiency virus type 1 in two spouses responding successfully to highly active antiretroviral therapy
    Cleo G Anastassopoulou
    National Retrovirus Reference Center, Department of Hygiene and Epidemiology, Athens University Medical School, Greece
    AIDS Res Hum Retroviruses 19:65-71. 2003
    ..These findings reinforce the evidence of a crucial role for host-selective constraints on HIV-1 env evolution in vivo...
  18. ncbi Re-analysis of 34 full-length HIV-1 intersubtype recombinant sequences
    G Magiorkinis
    National Retrovirus Reference Center, Department of Hygiene and Epidemiology, Athens University Medical School, Mikras Asias 75, 11527 Athens, Greece
    Infect Genet Evol 5:225-9. 2005
    ..These findings indicate that the complexity of the HIV-1 recombinants is much greater than previously estimated...
  19. ncbi Low-dose IFN-alpha monotherapy in treatment-naive individuals with HIV-1 infection: evidence of potent suppression of viral replication
    A Hatzakis
    Department of Hygiene and Epidemiology, Athens University Medical School, Athens, Greece
    J Interferon Cytokine Res 21:861-9. 2001
    ..Thus, low daily IFN-alpha exhibits potent anti-HIV-1 activity in vivo without serious adverse effects. These properties render IFN-alpha an attractive candidate for further assessment as a constituent of HAART...
  20. ncbi Rates and determinants of virologic and immunological response to HAART resumption after treatment interruption in HIV-1 clinical practice
    Giota Touloumi
    Department of Hygiene, Epidemiology, and Medical Statistics, Athens University Medical School, Athens, Greece
    J Acquir Immune Defic Syndr 49:492-8. 2008
    ..To describe CD4 and HIV RNA changes during treatment resumption (TR) after treatment interruption (TI) compared with response to first highly active antiretroviral therapy (HAART) and to investigate predictors...
  21. ncbi Comparative evaluation of the QUANTIPLEX HIV-1 RNA 2.0 and 3.0 (bDNA) assays and the AMPLICOR HIV-1 MONITOR v1.5 test for the quantitation of human immunodeficiency virus type 1 RNA in plasma
    C G Anastassopoulou
    Department of Hygiene and Epidemiology, National Retrovirus Reference Center, Athens University Medical School, 75 Mikras Asias Street, GR-11527 (Goudi, Athens, Greece
    J Virol Methods 91:67-74. 2001
    ..5) were found at frequencies of 80% for bDNA 2.0 and bDNA 3.0 and only at 58.5% for bDNA 2.0 and Monitor v1.5. In contrast, bDNA 3.0 and Monitor v1.5 measurements were highly correlated (r=0.96) and in good agreement (92.7%)...
  22. ncbi Re-analysis of human immunodeficiency virus type 1 isolates from Cyprus and Greece, initially designated 'subtype I', reveals a unique complex A/G/H/K/? mosaic pattern
    D Paraskevis
    National Retrovirus Reference Center, Department of Hygiene and Epidemiology, Athens University Medical School, M. Asias 75, Athens 115 27, Greece
    J Gen Virol 82:575-80. 2001
    ....
  23. ncbi Genetic variants in immunoregulatory genes and risk for childhood lymphomas
    Elisabeth Andrie
    Department of Hygiene, Epidemiology and Medical Statistics, Athens University Medical School, 75 Mikras Asias Str, Goudi, Athens, Greece
    Eur J Haematol 83:334-42. 2009
    ....
  24. ncbi Phylogenetic analysis of the full-length SARS-CoV sequences: evidence for phylogenetic discordance in three genomic regions
    G Magiorkinis
    National Retrovirus Reference Center, Department of Hygiene and Epidemiology, Athens University Medical School, Athens, Greece
    J Med Virol 74:369-72. 2004
    ....
  25. ncbi Prevalence and genotypic distribution of TT virus in Athens, Greece
    A Katsoulidou
    Department of Hygiene and Epidemiology, Athens University Medical School, Athens, Greece
    J Med Virol 65:423-9. 2001
    ..Further studies will shed light on the role of this highly prevalent virus...
  26. ncbi Molecular characterization of a complex, recombinant human immunodeficiency virus type 1 (HIV-1) isolate (A/G/J/K/?): evidence to support the existence of a novel HIV-1 subtype
    D Paraskevis
    National Retrovirus Reference Center, Department of Hygiene and Epidemiology, Athens University Medical School, 75 Mikras Asias Street, GR-115 27 Athens, Greece
    J Gen Virol 82:2509-14. 2001
    ..Thus, novel recombinants embody partial genomic regions which may have originated either from subtypes that existed in the past and became extinct or from contemporary subtypes that are extremely rare...
  27. ncbi Development and assessment of a novel real-time PCR assay for quantitation of HBV DNA
    D Paraskevis
    Department of Hygiene and Epidemiology, Athens University Medical School, Greece
    J Virol Methods 103:201-12. 2002
    ..These findings suggest that our RTD-PCR assay combines high sensitivity and reproducibility for HBV DNA quantitation in an incomparable high dynamic range of quantitation...
  28. ncbi HIV-1 genetic variants circulation in the North of Angola
    A Abecasis
    Laboratorio de Virologia, Serviço de Imuno Hemoterapia, Hospital de Egas Moniz, Rua da Junqueira, 126, 1349 019 Lisboa, Portugal
    Infect Genet Evol 5:231-7. 2005
    ..Three sequences were untypable and may possibly belong to new subtypes or recombinants of unknown subtypes. Moreover, 13 recombinant sequences were found, most of them with very complex patterns including untypable fragments...
  29. ncbi The phylogenetic information profile of HIV-1 and the degradation effect of recombination
    G Magiorkinis
    Medical School, National and Kapodistrian University of Athens, Greece
    Infect Genet Evol 8:139-45. 2008
    ..Moreover, we provide evidence that phylogenetic information is correlated to the sequence similarity of the dataset used and is degraded by the effect of recombination...
  30. ncbi HIV epidemiology in Greece
    G Nikolopoulos
    National Retrovirus Reference Center, Department of Hygiene Epidemiology and Medical Statistics, Medical School, University of Athens, Greece
    Future Microbiol 3:507-16. 2008
    ..HIV requires an effective and sustained response meeting the needs of vulnerable subpopulations...
  31. ncbi Analysing the evolutionary history of HCV: puzzle of ancient phylogenetic discordance
    G Magiorkinis
    National Retrovirus Reference Center Department of Hygiene and Epidemiology University of Athens, School of Medicine Alexandroupoleos 25, 11527 Goudi, Athens, Greece
    Infect Genet Evol 7:354-60. 2007
    ....