Stylianos E Orfanos

Summary

Affiliation: University of Athens
Country: Greece

Publications

  1. ncbi Pulmonary endothelium in acute lung injury: from basic science to the critically ill
    S E Orfanos
    Department of Critical Care and Pulmonary Medicine, M Simou Laboratory, Medical School, University of Athens, Evangelismos Hospital, 45 47 Ipsilandou St, 10675, Athens, Greece
    Intensive Care Med 30:1702-14. 2004
  2. ncbi Diagnostic and prognostic value of procalcitonin among febrile critically ill patients with prolonged ICU stay
    Iraklis Tsangaris
    The 2nd Critical Care Department, Attikon University General Hospital, Medical School, University of Athens, 1 Rimini Str, 12462, Athens, Greece
    BMC Infect Dis 9:213. 2009
  3. ncbi Angiopoietin-2 is increased in severe sepsis: correlation with inflammatory mediators
    Stylianos E Orfanos
    Second Department of Critical Care, Attikon University Hospital, University of Athens Medical School, 1 Rimini Street, Haidari, Athens 124 62, Greece
    Crit Care Med 35:199-206. 2007
  4. ncbi Microdialysis-assessed interstitium alterations during sepsis: relationship to stage, infection, and pathogen
    Petros Kopterides
    Second Department of Critical Care Medicine, Attiko University Hospital, Medical School, National and Kapodistrian University of Athens, 1 Rimini Street, Haidari, 12462, Athens, Greece
    Intensive Care Med 37:1756-64. 2011
  5. ncbi Soluble guanylyl cyclase expression is reduced in LPS-induced lung injury
    Constantinos Glynos
    George P Livanos and Marianthi Simou Laboratories, Evangelismos Hospital, 1st Department of Pulmonary and Critical Care, University of Athens, Athens, Greece 10675
    Am J Physiol Regul Integr Comp Physiol 292:R1448-55. 2007
  6. ncbi Ex-vivo effect of dexamethasone on cytokine production from whole blood of septic patients: correlation with disease severity
    Evangelos J Giamarellos-Bourboulis
    4th Department of Internal Medicine, University of Athens, Medical School, Greece
    Cytokine 49:89-94. 2010
  7. ncbi A critical role for gelsolin in ventilator-induced lung injury
    Nikolaos A Maniatis
    Marianthi Simou Lab, Evaggelismos Hospital, University of Athens Medical School, Athens, Greece
    Am J Respir Cell Mol Biol 41:426-32. 2009
  8. ncbi Inhaled activated protein C protects mice from ventilator-induced lung injury
    Nikolaos A Maniatis
    2nd Dept, of Critical Care, Attikon Hospital, National and Kapodistrian University of Athens Medical School, Rimini 1, Haidari, Greece
    Crit Care 14:R70. 2010
  9. ncbi Exhaled breath condensate in mechanically ventilated brain-injured patients with no lung injury or sepsis
    Ioanna Korovesi
    First Critical Care Department, Evangelismos Hospital and M Simou Laboratory, Athens, Greece
    Anesthesiology 114:1118-29. 2011
  10. ncbi Angiopoietin-2 is increased in septic shock: evidence for the existence of a circulating factor stimulating its release from human monocytes
    Hariklia Kranidioti
    4th Department of Internal Medicine, University of Athens, Medical School, Greece
    Immunol Lett 125:65-71. 2009

Collaborators

Detail Information

Publications21

  1. ncbi Pulmonary endothelium in acute lung injury: from basic science to the critically ill
    S E Orfanos
    Department of Critical Care and Pulmonary Medicine, M Simou Laboratory, Medical School, University of Athens, Evangelismos Hospital, 45 47 Ipsilandou St, 10675, Athens, Greece
    Intensive Care Med 30:1702-14. 2004
    ..OBJECTIVE: We highlight pathogenic mechanisms of pulmonary endothelial injury and their clinical implications in ALI/ARDS patients...
  2. ncbi Diagnostic and prognostic value of procalcitonin among febrile critically ill patients with prolonged ICU stay
    Iraklis Tsangaris
    The 2nd Critical Care Department, Attikon University General Hospital, Medical School, University of Athens, 1 Rimini Str, 12462, Athens, Greece
    BMC Infect Dis 9:213. 2009
    ..Procalcitonin (PCT) has been proposed as a diagnostic and prognostic sepsis marker, but has never been validated in febrile patients with prolonged ICU stay...
  3. ncbi Angiopoietin-2 is increased in severe sepsis: correlation with inflammatory mediators
    Stylianos E Orfanos
    Second Department of Critical Care, Attikon University Hospital, University of Athens Medical School, 1 Rimini Street, Haidari, Athens 124 62, Greece
    Crit Care Med 35:199-206. 2007
    ....
  4. ncbi Microdialysis-assessed interstitium alterations during sepsis: relationship to stage, infection, and pathogen
    Petros Kopterides
    Second Department of Critical Care Medicine, Attiko University Hospital, Medical School, National and Kapodistrian University of Athens, 1 Rimini Street, Haidari, 12462, Athens, Greece
    Intensive Care Med 37:1756-64. 2011
    ....
  5. ncbi Soluble guanylyl cyclase expression is reduced in LPS-induced lung injury
    Constantinos Glynos
    George P Livanos and Marianthi Simou Laboratories, Evangelismos Hospital, 1st Department of Pulmonary and Critical Care, University of Athens, Athens, Greece 10675
    Am J Physiol Regul Integr Comp Physiol 292:R1448-55. 2007
    ..We conclude that sGC expression is reduced in LPS-induced lung injury, while inhibition of the enzyme with ODQ worsens lung inflammation, suggesting that sGC exerts a protective role in ALI...
  6. ncbi Ex-vivo effect of dexamethasone on cytokine production from whole blood of septic patients: correlation with disease severity
    Evangelos J Giamarellos-Bourboulis
    4th Department of Internal Medicine, University of Athens, Medical School, Greece
    Cytokine 49:89-94. 2010
    ....
  7. ncbi A critical role for gelsolin in ventilator-induced lung injury
    Nikolaos A Maniatis
    Marianthi Simou Lab, Evaggelismos Hospital, University of Athens Medical School, Athens, Greece
    Am J Respir Cell Mol Biol 41:426-32. 2009
    ..Therefore, intracellular GSN and GSN-mediated responses were shown to be an important player in the pathogenesis of VILI...
  8. ncbi Inhaled activated protein C protects mice from ventilator-induced lung injury
    Nikolaos A Maniatis
    2nd Dept, of Critical Care, Attikon Hospital, National and Kapodistrian University of Athens Medical School, Rimini 1, Haidari, Greece
    Crit Care 14:R70. 2010
    ..We also assessed the effects of APC on the activation status of Extracellular- Regulated Kinase 1/2 (ERK) pathway, which has been shown to be involved in regulating pulmonary responses to mechanical stretch...
  9. ncbi Exhaled breath condensate in mechanically ventilated brain-injured patients with no lung injury or sepsis
    Ioanna Korovesi
    First Critical Care Department, Evangelismos Hospital and M Simou Laboratory, Athens, Greece
    Anesthesiology 114:1118-29. 2011
    ....
  10. ncbi Angiopoietin-2 is increased in septic shock: evidence for the existence of a circulating factor stimulating its release from human monocytes
    Hariklia Kranidioti
    4th Department of Internal Medicine, University of Athens, Medical School, Greece
    Immunol Lett 125:65-71. 2009
    ..It seems that a circulating factor may exist in the serum of patients with septic shock that stimulates gene expression and subsequent release of Ang-2 from monocytes. TLR4 and TNFalpha modulate release of Ang-2...
  11. ncbi Neutrophil CD64 expression and serum IL-8: sensitive early markers of severity and outcome in sepsis
    Olga Livaditi
    3rd (Evgenidion Hospital, Department of Critical Care, University of Athens Medical School, 20 Papadiamantopoulou St, Athens, 115 28, Greece
    Cytokine 36:283-90. 2006
    ..Based on this single measurement it is possible to reliably assess the stage, detect the severity and predict the 28-day mortality of sepsis...
  12. ncbi TREM-1 expression on neutrophils and monocytes of septic patients: relation to the underlying infection and the implicated pathogen
    Thekla Poukoulidou
    4th Department of Internal Medicine, University of Athens, Medical School, Attikon General Hospital, 1 Rimini Str, 12462 Athens, Greece
    BMC Infect Dis 11:309. 2011
    ..Current knowledge on the exact ligand causing expression of TREM-1 on neutrophils and monocytes is limited. The present study aimed at the role of underlying infection and of the causative pathogen in the expression of TREM-1 in sepsis...
  13. ncbi Endothelial pathomechanisms in acute lung injury
    Nikolaos A Maniatis
    M Simou Laboratory, University of Athens Medical School, Athens, Greece
    Vascul Pharmacol 49:119-33. 2008
    ....
  14. ncbi Prognostic importance of increased plasma amino-terminal pro-brain natriuretic peptide levels in a large noncardiac, general intensive care unit population
    Anastasia Kotanidou
    First Department of Critical Care Medicine, Evangelismos Hospital, Athens, Greece
    Shock 31:342-7. 2009
    ..Elevated admission NT-pro-BNP represents an independent predictor for poor ICU outcome in the presence of clinical severity scores...
  15. ncbi Kinetics of adipose tissue microdialysis-derived metabolites in critically ill septic patients: associations with sepsis severity and clinical outcome
    Ioanna Dimopoulou
    Second Department of Critical Care Medicine, Attikon Hospital, Medical School, University of Athens, Athens, Greece
    Shock 35:343-8. 2011
    ..Elevated tissue lactate, pyruvate, and glycerol levels are related to poor clinical outcome, with the latter constituting an independent predictor...
  16. ncbi Tumour necrosis factor-alpha (TNFalpha) and interleukin-10 are crucial mediators in post-operative systemic inflammatory response and determine the occurrence of complications after major abdominal surgery
    Ioanna Dimopoulou
    2nd Department of Critical Care Medicine, Attikon Hospital, University of Athens, Medical School, Greece
    Cytokine 37:55-61. 2007
    ..The course of serum cytokine levels in patients with postoperative systemic inflammatory response syndrome (SIRS) after major abdominal surgery remains currently unclear...
  17. ncbi Inhaled activated protein C attenuates lung injury induced by aerosolized endotoxin in mice
    Anastasia Kotanidou
    1st Department of Critical Care Medicine Pulmonary Services, Evangelismos Hospital, University of Athens Medical School, Athens, Greece
    Vascul Pharmacol 45:134-40. 2006
    ..This effect may be associated with leukocyte trafficking modifications, related, at least in part, to VCAM-1 reduction...
  18. ncbi Hypoxemic resuscitation prevents pulmonary capillary endothelial dysfunction induced by normoxemic resuscitation from hemorrhagic shock
    Emmanuel E Douzinas
    3rd Department of Critical Care, Metaxa Cancer Hospital, Piraeus, Greece
    Crit Care Med 37:869-75. 2009
    ..In this study, we sought to investigate the effect of hypoxemic resuscitation on pulmonary endothelium...
  19. ncbi History of mechanical ventilation may affect respiratory mechanics evolution in acute respiratory distress syndrome
    Antonia Koutsoukou
    Critical Care Department and Pulmonary Services, Evangelismos General Hospital, University of Athens Medical School, GR 10675 Athens, Greece
    J Crit Care 24:626.e1-6. 2009
    ....
  20. ncbi The endothelium in acute lung injury/acute respiratory distress syndrome
    Nikolaos A Maniatis
    M Simou Laboratory, University of Athens Medical School, Athens, Greece
    Curr Opin Crit Care 14:22-30. 2008
    ....
  21. ncbi Pulmonary capillary endothelial metabolic dysfunction: severity in pulmonary arterial hypertension related to connective tissue disease versus idiopathic pulmonary arterial hypertension
    David Langleben
    Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    Arthritis Rheum 58:1156-64. 2008
    ..e., PAH related to connective tissue disease (PAH-CTD) versus idiopathic PAH (IPAH)...