Research Topics
| Spilios ManolakopoulosSummaryAffiliation: University of Athens Country: Greece Publications
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Detail Information
Publications
Interferon-alpha plus lamivudine vs lamivudine reduces breakthroughs, but does not affect sustained response in HBeAg negative chronic hepatitis BMichalis Economou
Department of Gastroenterology, Polyclinic General Hospital, Athens, Greece
World J Gastroenterol 11:5882-7. 2005..Our aim was to investigate the efficacy of combination treatment of IFN-alpha and lamivudine compared to lamivudine monotherapy, after 24 mo of administration in HBeAg-negative hepatitis B patients...- Long-term therapy with adefovir dipivoxil in hepatitis B e antigen-negative patients developing resistance to lamivudineS Manolakopoulos
Department of Gastroenterology, Polyclinic General Hospital, Athens, Greece
Aliment Pharmacol Ther 27:266-73. 2008..The efficacy of long-term adefovir dipivoxil monotherapy or combination of adefovir and lamivudine in hepatitis B e antigen (HBe-Ag)-negative lamivudine-resistant chronic hepatitis B (CHB) patients is still under investigation... - Ultrasound-guided liver biopsy in real life: comparison of same-day prebiopsy versus real-time ultrasound approachSpilios Manolakopoulos
Gastroenterology Department, Polykliniki General Hospital, Athens, Greece
J Gastroenterol Hepatol 22:1490-3. 2007..The aim of this study was to compare ultrasound assessment of the puncture site before performing percutaneous liver biopsy with real-time ultrasound liver biopsy for suspected diffuse liver disease... - A single alcohol ingestion does not affect serum hepatitis C virus RNA in patients with chronic hepatitis CSpilios Manolakopoulos
Department of Gastroenterology, Polyclinic General Hospital, Athens, Greece
Liver Int 26:1196-200. 2006..Our aim was to evaluate the effect of a single moderate alcohol intake on serum HCV RNA concentrations and hepatic function in patients with chronic HCV infection... - Lamivudine monotherapy in HBeAg-negative chronic hepatitis B: prediction of response-breakthrough and long-term clinical outcomeS Manolakopoulos
Department of Gastroenterology, Polyclinic General Hospital, Athens, Greece
Aliment Pharmacol Ther 23:787-95. 2006..Factors that predict response and breakthrough phenomenon to lamivudine monotherapy in patients with HBeAg-negative chronic hepatitis B have not been well defined... - An assessment of serum leptin levels in patients with chronic viral hepatitis: a prospective studySpilios Manolakopoulos
Department of Gastroenterology, Polyclinic General Hospital, Athens, Greece
BMC Gastroenterol 7:17. 2007.... - Toxic hepatitis after sequential administration of flutamide and cyproterone acetateSpilios Manolakopoulos
Department of Gastroenterology, Polyclinic General Hospital, Athens, Greece
Dig Dis Sci 49:462-5. 2004 - Antiviral therapy reduces portal pressure in patients with cirrhosis due to HBeAg-negative chronic hepatitis B and significant portal hypertensionSpilios Manolakopoulos
Department of Gastroenterology, Polyclinic General Hospital, Athens, Greece
J Hepatol 51:468-74. 2009..We evaluated the effect of lamivudine monotherapy on hepatic venous pressure gradient (HVPG) in CHB-related cirrhosis with significant portal hypertension... - Clinical course of lamivudine monotherapy in patients with decompensated cirrhosis due to HBeAg negative chronic HBV infectionSpilios Manolakopoulos
2nd Department of Gastroenterology, Evangelismos General Hospital, Athens, Greece
Am J Gastroenterol 99:57-63. 2004..001). CONCLUSIONS: Lamivudine significantly improves liver function in HBeAg-negative decompensated cirrhosis. However, the development of the biochemical breakthrough due to YMDD mutants is associated with fatal outcome... - Is there a meaningful serum hepatitis B virus DNA cutoff level for therapeutic decisions in hepatitis B e antigen-negative chronic hepatitis B virus infection?George V Papatheodoridis
2nd Department of Internal Medicine, Athens University Medical School, Hippokration General Hospital of Athens, Athens, Greece
Hepatology 48:1451-9. 2008..In contrast, minimal histological lesions are observed in the majority of HBeAg-negative patients with persistently normal ALT and HBV DNA >2,000 IU/mL, who may not require immediate liver biopsy and treatment but only close follow-up... - Sustained rise of portal pressure after sclerotherapy, but not band ligation, in acute variceal bleeding in cirrhosisAlec Avgerinos
2nd Department of Gastroenterology, Athens University, Evangelismos Hospital, Athens, Greece
Hepatology 39:1623-30. 2004..024) and overall failure (P =.037) [correction]. In conclusion, during acute variceal bleeding EIS, but not EBL, causes a sustained increase in HVPG, which is followed by a higher rebleeding rate... - Fibrous ring formation in cirrhotics treated with band ligationChristos Triantos
2nd Department of Gastroenterology, Evangelismos General Hospital, Athens, Greece
Hepatogastroenterology 55:108-11. 2008..We observed that the formation of a fibrous ring following variceal eradication appeared to be associated with less variceal recurrence. We aimed to evaluate this formally... - Long-term adefovir plus lamivudine therapy does not decrease creatinine clearance in HBeAg-negative chronic hepatitis B patientsSpilios Manolakopoulos
2nd Academic Department of Internal Medicine, Hippokration Hospital of Athens, Athens, Greece
Liver Int 31:1525-32. 2011..As there are concerns about potential nephrotoxicity of nucleotide analogues, we evaluated renal function parameters during long-term adefovir and lamivudine combination therapy... - Pegylated interferon alfa-2b pen device and ribavirin treatment for patients with chronic hepatitis C: an evaluation of patient satisfactionParaskevi Aggelopoulou-Tiga
First Internal Medicine Department, General Hospital of West Attica St Varvara, 12351, Athens, Greece
Eur J Gastroenterol Hepatol 22:1058-65. 2010..The aim of this study was to evaluate the satisfaction of patients with chronic hepatitis C who used the pegylated interferon ?-2b pen device... - Insulin resistance and metabolic syndrome in chronic liver diseases: old entities with new implicationsEmmanuel A Tsochatzis
Second Department of Internal Medicine, Athens University Medical School, Hippokration General Hospital, Athens, Greece
Scand J Gastroenterol 44:6-14. 2009..As specific therapies do not exist, patients with metabolic syndrome and CHC and NAFLD should be counseled to lose weight and ameliorate their glycemic control and lipid profile... - Substitution treatment or active intravenous drug use should not be contraindications for antiviral treatment in drug users with chronic hepatitis CSpilios Manolakopoulos
2nd Academic Department of Internal Medicine, Hippokration General Hospital, Agia Paraskevi, Athens, Greece
Liver Int 30:1454-60. 2010..We analysed the effect of IDU and/or substitution therapy on chronic hepatitis C (CHC) treatment adherence and response... - Virological suppression does not prevent the development of hepatocellular carcinoma in HBeAg-negative chronic hepatitis B patients with cirrhosis receiving oral antiviral(s) starting with lamivudine monotherapy: results of the nationwide HEPNET. Greece cGeorge V Papatheodoridis
2nd Department of Internal Medicine, Athens University Medical School, Hippokration General Hospital, Athens, Greece
Gut 60:1109-16. 2011..To evaluate the risk and predictors of hepatocellular carcinoma (HCC) in HBeAg-negative chronic hepatitis B patients of the large HEPNET.Greece cohort study who received long-term oral antivirals starting with lamivudine monotherapy... - Smoking is associated with steatosis and severe fibrosis in chronic hepatitis C but not BEmmanuel Tsochatzis
Second Department of Internal Medicine, Athens University Medical School, Hippokration General Hospital, Athens, Greece
Scand J Gastroenterol 44:752-9. 2009..The purpose of this study was to evaluate the relationship, if any, of such factors on liver fibrosis in a cohort of patients with CHB and CHC... - Quantitative analysis of hepatitis D virus RNA and hepatitis B surface antigen serum levels in chronic delta hepatitis improves treatment monitoringEmanuel K Manesis
Academic Department of Medicine, Hippokration General Hospital, Athens, Greece
Antivir Ther 12:381-8. 2007..Treatment of chronic delta hepatitis is long and difficult and better monitoring is needed... - Peginterferon/ribavirin treatment achieves a higher compliance rate than interferon/ribavirin combination in patients chronically infected with HCV on methadone maintenanceDimitrios Dimitroulopoulos
Department of Gastroenterology, Agios Savvas Hospital, Athens, Greece
Eur J Gastroenterol Hepatol 21:1407-12. 2009..Chronic hepatitis C virus infection (HCV) is the most common infectious disease among intravenous drug users... - Therapeutic strategies in the management of patients with chronic hepatitis B virus infectionGeorge V Papatheodoridis
2nd Department of Internal Medicine, Athens University School of Medicine, Hippokration General Hospital of Athens, Athens, Greece
Lancet Infect Dis 8:167-78. 2008..Entecavir resistance is rare in naive individuals (year 4, <1%), but increases over time in lamivudine-resistant patients (year 4, 43%). The best strategy for long-term therapy in chronic HBV infection has yet to be established... - Incidence of hepatocellular carcinoma in chronic hepatitis B patients receiving nucleos(t)ide therapy: a systematic reviewGeorge V Papatheodoridis
2nd Department of Internal Medicine, Athens University Medical School, Athens, Greece
J Hepatol 53:348-56. 2010..The effect of medium-term nucleos(t)ide analogue therapy on HCC incidence is unclear; therefore, we systematically reviewed all the data on HCC incidence from studies in chronic hepatitis B patients treated with nucleos(t)ide analogues... - Effects of endoscopic variceal treatment on oesophageal function: a prospective, randomized studyNikos Viazis
Second Departments of Gastroenterology, Athens University, Athens, Greece
Eur J Gastroenterol Hepatol 14:263-9. 2002..CONCLUSION : Our data define the advantages of ligation over sclerotherapy with respect to post-treatment oesophageal dysmotility and associated gastro-oesophageal reflux... - A prospective cross-over study using a sphincterotome and a guidewire to increase the success rate of common bile duct cannulationGeorgios Karamanolis
Department of Gastroenterology, Athens Naval Hospital and Veterans, Athens, Greece
World J Gastroenterol 11:1649-52. 2005..CONCLUSION: The use of a sphincterotome and a guidewire increases the success rate of selective bile duct cannulation in cases that this has not been accomplished with a standard catheter... - Elastography for hepatic fibrosis severity in chronic hepatitis B or CMaria Vasiliki Papageorgiou
2nd Department of Internal Medicine, Medical School of Athens University, Athens, Greece
Case Rep Gastroenterol 5:63-72. 2011..To assess the value of transient elastography for predicting significant fibrosis or cirrhosis in chronic hepatitis B or C (CHB or CHC) patients... - High prevalence of elevated liver enzymes in blood donors: associations with male gender and central adiposityGeorge V Papatheodoridis
Hellenic Foundation for Gastroenterology and Nutrition, Athens, Greece
Eur J Gastroenterol Hepatol 19:281-7. 2007.... - Rheumatic manifestations of hepatitisDimitrios Vassilopoulos
2nd Department of Medicine, Athens University School of Medicine, Hippokration General Hospital, Athens, Greece
Curr Opin Rheumatol 22:91-6. 2010..In this review the most common clinical rheumatic manifestations of HBV or HCV infection and their management will be critically presented with a special emphasis on the efficacy and safety of the new biologic agents... - Unusual combination of paraneoplastic manifestations in a patient with metastatic gastrointestinal stromal tumor (GIST)Spyridon Tsikrikas
2nd Academic Department of Internal Medicine, University of Athens, Hippokration General Hospital, Athens, Greece
Scand J Gastroenterol 43:1012-5. 2008..We present the case of a 54-year-old patient with metastatic GIST at diagnosis and the emergence of paraneoplastic manifestations during follow-up... - Octreotide versus hydrocortisone versus placebo in the prevention of post-ERCP pancreatitis: a multicenter randomized controlled trialSpilios Manolakopoulos
2nd Department of Gastroenterology, Evangelismos General Hospital, University of Athens, Athens, Greece
Gastrointest Endosc 55:470-5. 2002..CONCLUSIONS: The results of this trial indicate that octreotide and hydrocortisone do not prevent ERCP-induced pancreatitis... - Outcome of hepatitis B e antigen-negative chronic hepatitis B on long-term nucleos(t)ide analog therapy starting with lamivudineGeorge V Papatheodoridis
2nd Academic Department of Internal Medicine, Hippokration General Hospital of Athens, Greece
Hepatology 42:121-9. 2005..In such patients with advanced fibrosis, close follow-up for lamivudine resistance and prompt onset of additional antiviral therapy is required or the ab initio use of agent(s) with low resistance rates should be considered... - Serum hepatitis B virus-DNA cutoff levels in hepatitis B e antigen-negative chronic hepatitis B virus infectionGeorge V Papatheodoridis
Hepatology 46:606-7; author reply 607. 2007 - Drug evaluation: LB-80380--a novel phosphonate nucleoside for the potential treatment of HBV infectionGeorge V Papatheodoridis
2nd Department of Internal Medicine, Athens University Medical School, Hippokration General Hospital of Athens, 114 Vas Sofias Avenue, Athens 11527, Greece
Curr Opin Mol Ther 8:352-7. 2006..In April 2003, phase II trials were initiated, the results of which were reported in February 2006. LB-80380 is the prodrug of LB-80317 (PMCDG), another compound from this series...