Research Topics
| Sophia G AntimisiarisSummaryAffiliation: University of Patras Country: Greece Publications
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Detail Information
Publications
In-vitro antileishmanial and trypanocidal activities of arsonoliposomes and preliminary in-vivo distribution in BALB/c miceSophia G Antimisiaris
Department of Pharmacy, Laboratory of Pharmaceutical Technology, University of Patras, Rio 26500, Greece
J Pharm Pharmacol 55:647-52. 2003....- In vivo distribution of arsonoliposomes: effect of vesicle lipid compositionParaskevi Zagana
Laboratory of Pharmaceutical Technology, Department of Pharmacy, University of Patras, 26500 Rio, Greece
Int J Pharm 347:86-92. 2008..This proves that arsonoliposome lipid composition (and consequently their integrity) influences their pharmacokinetic profile. Thus, the proper arsonoliposome composition should be used according to the intended application... - PLGA, chitosan or chitosan-coated PLGA microparticles for alveolar delivery? A comparative study of particle stability during nebulizationMaria Letizia Manca
Laboratory of Pharmaceutical Technology, Department of Pharmacy, University of Patras, Rio 26510, Greece
Colloids Surf B Biointerfaces 62:220-31. 2008..50% or 0.75% CHT exhibited highest EE% for RIF and also best nebulization ability and stability, compared to all other MP formulations studied. Additionally they had good mucoadhesive properties and comparably low cytotoxicity... - Liposomes for drug delivery to the lungs by nebulizationMarco Zaru
Department of Pharmacy, University of Patras, Rio, Greece
Eur J Pharm Biopharm 67:655-66. 2007..Mucoadhesion and A549 cell toxicity studies were in line with this conclusion, however if mucoadhesion is required, improvement may be needed... - Release of rifampicin from chitosan, PLGA and chitosan-coated PLGA microparticlesMaria Letizia Manca
Laboratory of Pharmaceutical Technology, Department of Pharmacy, University of Patras, Rio 26510, Greece
Colloids Surf B Biointerfaces 67:166-70. 2008..40 the release was faster from the CHT-coated particles. Concluding, it is proven that when PLGA MPs are coated with CHT, in addition to increased particle mucoadhesive properties, the release kinetics of RIF are modified... - Chitosan-coated liposomes for delivery to lungs by nebulisationMarco Zaru
Laboratory of Pharmaceutical Technology, Department of Pharmacy, University of Patras, Rio 26510, Greece
Colloids Surf B Biointerfaces 71:88-95. 2009..Thereby, it is concluded that CHT-coated liposomes have advantages (compared to non-coated) when the delivery of drugs to the lungs by nebulisation is considered... - Complex hydrogel systems composed of polymers, liposomes, and cyclodextrins: implications of composition on rheological properties and agingSpyridon Mourtas
Laboratory of Pharmaceutical Technology, Department of Pharmacy, School of Health Sciences, University of Patras, 26510 Rio, Greece
Langmuir 25:8480-8. 2009..Gels with a high CD concentration (400 mg/mL) are almost insensitive to aging, whereas all other gels become slightly more elastic and less viscous as aging proceeds... - Dexamethasone incorporating liposomes: effect of lipid composition on drug trapping efficiency and vesicle stabilityVassilios Athanassios Tsotas
Laboratory of Pharmaceutical Technology, Department of Pharmacy, School of Health Sciences, University of Patras, Rio, Greece
Drug Deliv 14:441-5. 2007.... - Liposomal drugs dispersed in hydrogels. Effect of liposome, drug and gel properties on drug release kineticsSpyridon Mourtas
Laboratory of Pharmaceutical Technology, Department of Pharmacy, School of Health Sciences, University of Patras, 26510 Rio, Greece
Colloids Surf B Biointerfaces 55:212-21. 2007..The same is true for calcein in liposomal gels. Carbopol gel rheological properties were found to be significantly different (compared to the other gels), implying that these characteristics are important for drug diffusion from gels... - Integrity of liposomes in presence of various formulation excipients, when dispersed in aqueous media and in hydrogelsSpyridon Mourtas
Laboratory of Pharmaceutical Technology, Department of Pharmacy, School of Health Sciences, University of Patras, 26510 Rio, Greece
Colloids Surf B Biointerfaces 61:270-6. 2008..Conclusively, the results of this study suggest that liposomes are protected from excipients when dispersed in gels compared to aqueous media. This should be taken into account when liposomal drug formulations are designed... - Integrity of liposomes in presence of cyclodextrins: effect of liposome type and lipid compositionPanayiota Hatzi
Laboratory of Pharmaceutical Technology, Department of Pharmacy, School of Health Sciences, University of Patras, Rio 26500, Patras, Greece
Int J Pharm 333:167-76. 2007..Turbidity measurements confirm that DRV liposomes are affected more than SUV... - Arsenic trioxide liposomes: encapsulation efficiency and in vitro stabilityParaskevi Kallinteri
Laboratory of Pharmaceutical Technology, Department of Pharmacy, University of Patras, Rio, Greece
J Liposome Res 14:27-38. 2004.... - Does the lipid membrane composition of arsonoliposomes affect their anticancer activity? A cell culture studyParaskevi Zagana
Laboratory of Pharmaceutical Technology, Department of Pharmacy, University of Patras, Patras, Greece
Mol Nutr Food Res 53:592-9. 2009..Thereby it is concluded that arsonoliposome composition should be adjusted in accordance to their in vivo kinetics and the desired, for each specific application, biodistribution of As and/or encapsulated drug... - Arsonoliposomes: effect of arsonolipid acyl chain length and vesicle composition on their toxicity towards cancer and normal cells in cultureOlga Gortzi
Department of Pharmacy, University of Patras, Rio 26500, Patras, Greece
Eur J Pharm Sci 18:175-83. 2003.... - The effect of added liposomes on the rheological properties of a hydrogel: a systematic studySpyridon Mourtas
Laboratory of Pharmaceutical Technology, Department of Pharmacy, School of Health Sciences, University of Patras, 26510 Rio, Greece
J Colloid Interface Sci 317:611-9. 2008..Concluding, liposome composition (membrane rigidity) and lipid concentration, but not liposome size, seem to be very important factors that determine the rheological modulations caused by liposome addition in gels... - Incorporation of PEG-lipids in arsonoliposomes results in formation of highly stable arsenic-containing vesiclesSophia Piperoudi
Laboratory of Pharmaceutical Technology, Department of Pharmacy, School of Health Sciences, University of Patras, Rio 26500, Patras, Greece
Chem Phys Lipids 139:96-106. 2006..In addition to high membrane integrity, the high content pegylated arsonoliposomes are morphologically perfect round-shaped vesicles without the sharp edges typically observed with non-pegylated DSPC-containing arsonoliposomes... - Arsonoliposomes: preparation and physicochemical characterizationSophia G Antimisiaris
Laboratory of Pharmaceutical Technology, Department of Pharmacy, University of Patras, and FORTH Institute of Chemical Engineering, Patras, Greece
Methods Mol Biol 605:147-62. 2010..Herein, we describe in detail the preparation and physicochemical characterization of ARSL... - Arsonoliposome interaction with thiols: effect of pegylation and arsonolipid content of arsonoliposomes on their integrity during incubation in glutathioneMaria N Haikou
Laboratory of Pharmaceutical Technology, Department of Pharmacy, University of Patras, Rio 26500, Patras, Greece
J Nanosci Nanotechnol 6:2974-8. 2006.... - Arsonoliposomes: effect of lipid composition on their stability and morphologySophia Piperoudi
Laboratory of Pharmaceutical Technology, Department of Pharmacy, University of Patras, Patras, Greece
J Liposome Res 15:187-97. 2005..The latter arsonoliposomes provide a system that may be used for combining arsonolipid activity with the activity of other drugs... - Haemolytic activity of liposomes: effect of vesicle size, lipid concentration and polyethylene glycol-lipid or arsonolipid incorporationSpyridon Mourtas
Laboratory of Pharmaceutical Technology, Department of Pharmacy, School of Health Sciences, University of Patras, 26510 Rio, Greece
J Biomed Nanotechnol 5:409-15. 2009..Nevertheless, at concentrations which are relevant with liposomal drug administration in humans, all formulations tested demonstrated negligible haemolysis... - Stability of protein-encapsulating DRV liposomes after freeze-drying: A study with BSA and t-PAVassiliki Ntimenou
Laboratory of Pharmaceutical Technology, Dept. of Pharmacy, University of Patras, Rio, 26510, Greece
J Liposome Res 16:403-16. 2006..Thereby, interactions between proteins and membranes determine not only the encapsulation efficiency but also the need for cryopreservation of liposomal protein formulations... - In vivo distribution of arsenic after i.p. injection of arsonoliposomes in balb-c miceSophia G Antimisiaris
Laboratory of Pharmaceutical Technology, Department of Pharmacy, Rio 26500, Greece
Int J Pharm 289:151-8. 2005..No acute toxicity, or effect on the body or organ weight of the mice was observed... - Uptake and permeability studies of BBB-targeting immunoliposomes using the hCMEC/D3 cell lineEleni Markoutsa
Laboratory of Pharmaceutical Technology, Department of Pharmacy, University of Patras, Rio, Greece
Eur J Pharm Biopharm 77:265-74. 2011..Co-decoration with a second ligand slightly decreases OX-26-decorated vesicle uptake, but not transcytosis, proving that the biotin-streptavidin technique can be applied for the generation of dual-targeting nanoliposomes... - Heparin incorporating liposomes as a delivery system of heparin from PET-covered metallic stents: effect on haemocompatibilityGeorgia Koromila
Laboratory of Pharmaceutical Technology, Department of Pharmacy, School of Health Sciences, University of Patras, Rio 26510, Greece
Biomaterials 27:2525-33. 2006.... - Preparation of DRV liposomesSophia G Antimisiaris
Laboratory of Pharmaceutical Technology, Department of Pharmacy, University of Patras, and ICE HT FORTH, Patras, Greece
Methods Mol Biol 605:51-75. 2010.... - Stability and aggregation studies of non-sonicated arsonolipid-containing vesiclesDimitrios G Fatouros
Laboratory of Pharmaceutical Technology, Department of Pharmacy, University of Patras, 26504, Greece
Cell Mol Biol Lett 10:173-83. 2005..Aggregation could not be always explained on the basis of zeta potential changes, indicating that the process is complex... - Curcumin-decorated nanoliposomes with very high affinity for amyloid-?1-42 peptideSpyridon Mourtas
Laboratory of Pharmaceutical Technology, Department of Pharmacy, University of Patras, Rio 26510, Patras, Greece
Biomaterials 32:1635-45. 2011..In summary, we describe here the preparation and characterization of new nanoparticles with a very high affinity for A?1-42 fibrils, to be exploited as vectors for the targeted delivery of new diagnostic and therapeutic molecules for AD... - Release of liposome-encapsulated calcein from liposome entrapping gelatin-carboxymethylcellulose films: a presentation of different possibilitiesCatalina Peptu
Laboratory of Pharmaceutical Technology, Department of Pharmacy, University of Patras, Rio 26510, Greece
J Nanosci Nanotechnol 8:2249-58. 2008..Film composition also affects the integrity of the film-entrapped liposomes during the crosslinking process, possibly due its effect on the density of the polymeric network of the film... - Arsonoliposomes, a novel class of arsenic-containing liposomes: effect of palmitoyl-arsonolipid-containing liposomes on the viability of cancer and normal cells in cultureOlga Gortzi
Laboratory of Pharmaceutical Technology, University of Patras, Greece
Pharm Res 19:79-86. 2002..CONCLUSIONS: Considering the numerous advantages of liposomal systems in therapeutics, it is concluded that the arsonoliposome system is very interesting and future applications should be exploited by further studies... - Effect of amphiphilic drugs on the stability and zeta-potential of their liposome formulations: a study with prednisolone, diazepam, and griseofulvinDimitrios G Fatouros
Laboratory of Pharmaceutical Technology, Department of Pharmacy, School of Health Sciences, University of Patras, Rio, 26500, Greece
J Colloid Interface Sci 251:271-7. 2002..Thereby, we may conclude that the previously demonstrated effects of the thiazides on liposome properties are not solely related to their structure... - Magnetoliposomes with high USPIO entrapping efficiency, stability and magnetic propertiesAthanasios Skouras
Laboratory of Pharmaceutical Technology, Dept of Pharmacy, School of Health Sciences, University of Patras, Patras, Greece
Nanomedicine 7:572-9. 2011..Targeted MLs retained their nanosize and integrity during storage for 1 month at 4 °C and up to 2 weeks at 37 °C... - Dexamethasone incorporating liposomes: an in vitro study of their applicability as a slow releasing delivery system of dexamethasone from covered metallic stentsParaskevi Kallinteri
Department of Pharmacy, Laboratory of Pharmaceutical Technology, University of Patras, Patras 26500, Greece
Biomaterials 23:4819-26. 2002..Further in vitro and in vivo studies are needed in order to exploit the possible applications of this methodology... - Arsonoliposomes: novel nanosized arsenic-containing vesicles for drug deliveryDimitris G Fatouros
Department of Pharmaceutics and Analytical Chemistry, The Danish University of Pharmaceutical Sciences, Universitetsparken 2, 2100, Copenhagen, Denmark
J Nanosci Nanotechnol 6:2618-37. 2006..From studies performed thus far it is concluded that arsonoliposomes are nanosized-vesicles with interesting properties that justify further exploitation towards the development of therapeutic systems for cancer or parasitic diseases... - Thermal behavior of novel non-sonicated arsonolipid-containing liposomesSotirios Koutsopoulos
Center for Biomedical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, 02139-4307, USA
Biophys Chem 121:150-4. 2006....