Behavioral and pharmacologic treatment of transformed migraine with analgesic overuse: outcome at 3 yearsLicia Grazzi
Headache Center, National Neurological Institute C. Besta, Milan, Italy
Headache 42:483-90. 2002
..Confirmation of these findings, as well as extension to other forms of behavioral and cognitive-behavioral treatment, is required...
Headache with medication overuse: treatment strategies and proposals of relapse preventionLicia Grazzi
Headaches and Cerebrovascular Disorders Unit, C Besta National Neurological Institute, Via Celoria 11, 20133, Milan, Italy
Neurol Sci 29:93-8. 2008
..This article reviews current clinical experiences of MOH patients treated with different approaches. Moreover, initial outcomes and long-term durability of treatments are discussed...
Behavioural approach to the "difficult" patientLicia Grazzi
Department of Clinical Neurosciences, C Besta Neurological Institute, Via Celoria 11, 20133 Milan, Italy
Neurol Sci 29:S96-8. 2008
..The purpose of this article is to highlight behavioural/psychological factors important to consider for clinicians managing this particular category of patients...
Disability in young patients suffering from primary headachesL Grazzi
Headache Centre, National Neurological Institute C Besta, Via Celoria 11, I 20123 Milan, Italy
Neurol Sci 25:S111-2. 2004
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Headache in children and adolescents: conventional and unconventional approaches to treatmentL Grazzi
Headache Centre, National Neurological Institute C Besta, Via Celoria 11, I 20133 Milan, Italy
Neurol Sci 25:S223-5. 2004
..The diagnostic criteria for adults were adopted for use in young patients. Since that time a burgeoning number of studies on headache in young people have been published...
Primary headaches in children and adolescentsL Grazzi
Headache Centre, National Neurological Institute C Besta, Via Celoria 11, I 20133 Milan, Italy
Neurol Sci 25:S232-3. 2004
..The diagnostic criteria for adults were adopted for use in young patients. Since that time a burgeoning number of studies on headache in young people have been published...
MIDAS questionnaire modification for a new MIDAS junior questionnaire: a clinical experience at the Neurological Institute "C. Besta"L Grazzi
Headache Centre, National Neurological Institute C Besta, Via Celoria 11, I 20133 Milan, Italy
Neurol Sci 25:S261-2. 2004
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Pharmacological behavioural treatment for children and adolescents with tension-type headache: preliminary dataL Grazzi
National Neurological Institute C Besta, Via Celoria 11, I 20133 Milan, Italy
Neurol Sci 25:S270-1. 2004
..These data, however, are preliminary and the sample sizes are small, so these conclusions are tentative. We will continue our data collection for 12 months...
In-patient vs. day-hospital withdrawal treatment for chronic migraine with medication overuse and disability assessment: results at one-year follow-upLicia Grazzi
Department of Clinical Neurosciences, National Neurological Institute C Besta, Via Celoria 11, 20133 Milan, Italy
Neurol Sci 29:S161-3. 2008
..The possibility of withdrawal within a day-hospital setting is considered a therapeutic alternative for these patients and compared to in-patient withdrawal. Long-term results are discussed...
Magnesium as a treatment for paediatric tension-type headache: a clinical replication seriesL Grazzi
Headache Center, National Neurological Institute C Besta, Via Celoria 11, I 20133, Milan, Italy
Neurol Sci 25:338-41. 2005
..Although uncontrolled, the initial findings are encouraging and suggest that further, better controlled research is warranted...
Facial pain in children and adolescentsL Grazzi
C Besta National Neurological Institute, Via Celoria 11, I 20133, Milan, Italy
Neurol Sci 26:s101-3. 2005
..Some of the most common forms of facial pain will be considered and some considerations concerning the problem of atypical facial pain in young age and its treatment will be discussed...
Medication-overuse headache: description, treatment, and relapse preventionLicia Grazzi
Headache Center, Neurological Institute C Besta, Milan, Italy
Curr Pain Headache Rep 10:71-7. 2006
..The problem regarding the diagnosis, the classification, and clinical aspects of MOH is reviewed in this article. The different therapeutic approaches, initial outcomes, and long-term durability of treatment also are discussed...
Chronic headaches: pharmacological and non-pharmacological treatmentL Grazzi
Headache Center, C Besta National Neurological Institute, Via Celoria 11, I 20133, Milan, Italy
Neurol Sci 27:S174-8. 2006
..Also the different therapeutical approaches, pharmacological and non-pharmacological, initial outcomes and long-term durability of treatment are discussed...
Chronic headaches: pharmacological and non-pharmacological treatmentL Grazzi
Centro Cefalee, National Neurological Institute C Besta, Via Celoria 11, I 20133 Milan, Italy
Neurol Sci 28:S134-7. 2007
..The different therapeutical approaches, pharmacological and nonpharmacological, initial outcomes and long-term durability of treatment are discussed...
Behavioural treatments: rationale and overview of the most common therapeutic protocolsL Grazzi
Neurological Institute C Besta, Via Celoria 11, I 20133 Milan, Italy
Neurol Sci 28:S67-9. 2007
..As side effects and complications are minimal, these approaches are optimal options for young patients or for patients where the medications remain contraindicated...
Magnesium as a preventive treatment for paediatric episodic tension-type headache: results at 1-year follow-upL Grazzi
Headache Center, National Neurological Institute C Besta, Via Celoria 11, I 20133, Milan, Italy
Neurol Sci 28:148-50. 2007
..7%. MIDAS subscores improved as well (question A=58.0%; question B=22.5%). Although uncontrolled, these findings are encouraging and suggest that further, better controlled research investigations are warranted...
Behavioral plus pharmacological treatment versus pharmacological treatment only for chronic migraine with medication overuse after day-hospital withdrawalLicia Grazzi
National Neurological Institute C Besta, Via Celoria 11, 20133, Milan, Italy
Neurol Sci 30:S117-9. 2009
..In this study, a clinical experience where day-hospital withdrawal is followed by pharmacological treatment and on the other side pharmacological treatment is combined with behavioral approach is discussed...
Psychological variables in chronic migraine with medication overuse before and after inpatient withdrawal: results at 1-year follow-upSusanna Usai
Headache Center, National Neurological Institute C Besta, Via Celoria 11, 20133, Milan, Italy
Neurol Sci 30:S125-7. 2009
..The changes of clinical indexes and of psychological parameters are discussed and analyzed in order to address the most adequate therapeutic strategy for this kind of patients...
Disability in chronic migraine patients with medication overuse: treatment effects at 1-year follow-upLicia Grazzi
Neurological Institute C.Besta, Milan, Italy
Headache 44:678-83. 2004
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Reduction in the impact of chronic migraine with medication overuse after day-hospital withdrawal therapySusanna Usai
National Neurological Institute C Besta, Headache Center, Via Celoria 11, 20133 Milan, Italy
Neurol Sci 29:S176-8. 2008
..4 (median 65) to 59.4+/-8.5 (median 62) (Student's t-test p<0.00001) and with a reduction in the percentage of patients with very severe headache-related impact one year after withdrawal therapy...
Treatment of chronic migraine with medication overuse: is drug withdrawal crucial?Licia Grazzi
Neurological Institute C Besta, Via Celoria 11, 20133, Milan, Italy
Neurol Sci 30:S85-8. 2009
..The necessity of withdrawal performed by different treatment schedules, outcomes, and the long-term durability of treatment are discussed...
Chronic migraine with medication overuse pre-post withdrawal of symptomatic medication: clinical results and FMRI correlationsLicia Grazzi
National Neurological Institute C Besta Headache Centre, Milan, Italy
Headache 50:998-1004. 2010
..Functional magnetic resonance imaging (fMRI) may be a useful technique for obtaining information on particular neuronal changes in the pain network involved in this condition...
Pain processing in medication overuse headache: a functional magnetic resonance imaging (FMRI) studyStefania Ferraro
Neuroradiology Department Headache Centre, Carlo Besta Neurological Institute IRCCS Foundation, Milan, Italy
Pain Med 13:255-62. 2012
..The secondary aim was to investigate whether activations in MOH patients normalize after medication withdrawal, which would suggest a possible role of the pain matrix in headache chronification...
Therapeutic neurostimulation in chronic headaches: problems of patient selectionMassimo Leone
Headache Centre, National Neurological Institute IRCCS Foundation C Besta, Via Celoria 11, 20133 Milan, Italy
Neurol Sci 29:S59-61. 2008
..We also propose that only completely drug-resistant (as opposed to partially drug-resistant) patients be considered for neurostimulation unless there are other indications...
Microembolic air load during contrast-transcranial Doppler: a trigger for migraine with aura?Luigi Caputi
Department of Cerebrovascular Diseases, Neurological Institute C Besta, Milan, Italy
Headache 50:1320-7. 2010
..The occurrence of MA attacks after microbubble (MB) injection during contrast-enhanced transcranial Doppler (ce-TCD) has been recently described...
Gingkolide B as migraine preventive treatment in young age: results at 1-year follow-upSusanna Usai
Department of Neurological Sciences, Headache Unit, Neurological Institute C Besta IRCCS Foundation, Via Celoria, 11, 20133 Milan, Italy
Neurol Sci 32:S197-9. 2011
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Disability pattern in chronic migraine with medication overuse: a comparison with migraine without auraLicia Grazzi
National Neurological Institute C. Besta, Milan, Italy
Headache 45:553-60. 2005
..These results are consistent with the fact that CMO may be an evolution of episodic migraine, characterized by increase in headache frequency and more evident disability in performing different daily duties...
When should "chronic migraine" patients be considered "refractory" to pharmacological prophylaxis?Domenico D'Amico
Department of Clinical Neurosciences, C Besta Neurological Institute, Via Celoria 11, 20133 Milan, Italy
Neurol Sci 29:S55-8. 2008
..However before a definition of "refractory" chronic migraine can become established, generally accepted diagnostic criteria and treatment guidelines for this condition need to be developed...
Disability and quality of life in different primary headaches: results from Italian studiesG Bussone
National Neurological Institute C Besta, Via Celoria 11, I 20133 Milan, Italy
Neurol Sci 25:S105-7. 2004
..Our results confirmed a marked personal and social burden in patients with migraine without aura, and also in the less well-studied forms of primary headaches, cluster headache and chronic migraine...
Non-pharmacological approaches in migraine prophylaxis: behavioral medicineLicia Grazzi
Headache Center, Neurological Institute C Besta, Via Celoria 11, 20135, Milan, Italy
Neurol Sci 31:S133-5. 2010
..The different therapeutical approaches, initial outcomes are discussed...
An innovative approach for migraine prevention in young age: a preliminary studySusanna Usai
Headache Center, National Neurological Institute C Besta, Via Celoria, 11, 20133, Milan, Italy
Neurol Sci 31:S181-3. 2010
..These preliminary data show that Ginkgolide B seems to be effective as preventive treatment in reducing migraine attack frequency and in attenuating the use of symptomatic medication in our small series of children with primary headache...
What future for treatment of chronic migraine with medication overuse?Licia Grazzi
Department of Neurological Sciences, Headache Unit, Neurological Institute C Besta IRCCS Foundation, Via Celoria 11, 20133 Milan, Italy
Neurol Sci 32:S19-22. 2011
..The clinical experience performed at our Headache Unit, the necessity of withdrawal, different treatment schedules, and different treatment strategies of our center were discussed...
Quality of life and disability in primary chronic daily headachesS Usai
C. Besta National Neurological Institute, Via Celoria 11, I-20133 Milan, Italy
Neurol Sci 24:S97-100. 2003
..We also found that MIDAS and SF-36 were sensitive to clinical changes in a group of 84 patients with chronic migraine and medication overuse who completed the both questionnaires before and after treatment...
Strategies for the treatment of autonomic trigeminal cephalalgiasM Leone
Headache Centre, National Neurological Institute C Besta, Via Celoria 11, I 20133 Milan, Italy
Neurol Sci 25:S167-70. 2004
..SUNCT is commonly described as drug resistant. Recent studies report that lamotrigin may be the drug of choice for SUNCT...
Neuroimaging in chronic migraineLuisa Chiapparini
Department of Neuroradiology, Foundation IRCCS Neurological Institute Carlo Besta, Milan, Italy
Neurol Sci 31:S19-22. 2010
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Caliber fluctuations of cervical internal carotid artery and migraine with aura: a possible vasospasm detected by ultrasonographic examinationsSusanna Usai
Headache Center, National Neurological Institute C Besta, Via Celoria, Milan 11 20133, Italy
Headache 49:1068-72. 2009
..We report a case of a 33-year-old woman affected by migraine with and without aura who exhibited a possible cervical internal carotid artery vasospasm, detected by ultrasound, before a typical migraine aura...
Italian experience of electromyographic-biofeedback treatment of episodic common migraine: preliminary resultsL Grazzi
Headache Center, National Neurological Institute C. Besta, Milan, Italy
Headache 33:439-41. 1993
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Electromyographic biofeedback-assisted relaxation training in juvenile episodic tension-type headache: clinical outcome at three-year follow-upL Grazzi
Neurological Institute C Besta, Milan, Italy
Cephalalgia 21:798-803. 2001
..Further investigation is warranted...
Measuring responses to therapy in headache patients: new and traditional end-pointsD D'Amico
National Neurological Institute C Besta, Via Celoria 11, I 20123 Milan, Italy
Neurol Sci 25:S108-10. 2004
..However, further studies to determine the suitability of these instruments as outcome measures in clinical practice are necessary...
Treatment of chronic daily headache with medication overuseL Grazzi
C. Besta National Neurological Institute, Via Celoria 11, I-20133 Milan, Italy
Neurol Sci 24:S125-7. 2003
..Clinical aspects and different therapeutic strategies for chronic daily headache patients with medication overuse are considered...
Use of the Migraine Disability Assessment Questionnaire in children and adolescents with headache: an Italian pilot studyL Grazzi
Headache Center, C. Besta National Neurological Institute, Via Celoria 11, 20133 Milan, Italy
Headache 43:767-73. 2003
..Minimal changes in the phrasing and content of the items would be sufficient to render the MIDAS specific for the younger population with headache...
Headache and Chiari malformation in young age: clinical aspects and differential diagnosisLicia Grazzi
Neurological Institute C Besta, Milan, Italy
Neurol Sci 32:S299-301. 2011
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Headache in young age: classification of primary formsLicia Grazzi
Headache Center, Foundation IRCCS Neurological Institute C Besta, Via Celoria 11, 20133, Milan, Italy
Neurol Sci 31:S77-9. 2010
..The article reviews the most important diagnostic categories of headache in young age and the limitations of the classification criteria for this group of patients...
Health-related quality of life in patients with cluster headache during active periodsA Rigamonti
C. Besta National Neurological Institute, Milan, Italy
Cephalalgia 22:818-21. 2002
..For most scales the difference was significant (P < 0.0001, Student's t-test, Bonferroni correction). Our findings suggest that cluster headache has marked functional consequences even when appropriate treatments are used...
Increased familial risk of cluster headacheM Leone
Carlo Besta National Neurological Institute, Milan, Italy
Neurology 56:1233-6. 2001
..Second-degree relatives had an eightfold significantly increased risk. The increased familial risk strongly supports the hypothesis that cluster headache has a genetic component in some families...
Functional-MRI evaluation of pain processing in chronic migraine with medication overuseLuisa Chiapparini
Department of Radiology, Neurological Institute C Besta, Milan, Italy
Neurol Sci 30:S71-4. 2009
..The activated areas are congruent with some data of the literature and the data emerged are discussed according to preceding reports...
Chronic migraine with medication overuse: treatment outcome and disability at 3 years follow-upS Usai
Headache Centre, National Neurological Institute C Besta, Via Celoria 11, I 20133 Milan, Italy
Neurol Sci 25:S272-3. 2004
..To our knowledge, this is the first investigation where the MIDAS questionnaire has been used as an outcome measure in patients with chronic headache to assess disability during such a long follow-up period...
Sumatriptan in the acute treatment of migraine without aura: efficacy of 50-mg doseF Moschiano
Headache Centre, Neurological Institute C Besta, Milano, Italy
Headache 37:421-3. 1997
..If, however, sumatriptan is ineffective at that dose it can be increased to a maximum of 100 mg...
Alpha-dihydroergocryptine in the prophylaxis of migraine: a multicenter double-blind study versus flunarizineG Bussone
Headache Centre, C Besta Neurological Institute, Via Celoria, 11, Milan, Italy
Headache 39:426-31. 1999
..Based on the overall improvement in migraine parameters, alpha-dihydroergocryptine can be recommended for use in migraine prophylaxis...
Coexistence of migraine and cluster headache: report of 10 cases and possible pathogenetic implicationsV Centonze
Neurological Institute C. Besta, Milan, Italy
Headache 37:21-5. 1997
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Transdermal clonidine in the prophylaxis of episodic cluster headache: an open studyM Leone
Headache Center, Istituto Neurologico Carlo Besta, Milano, Italy
Headache 37:559-60. 1997
..Further studies are necessary to clarify the effectiveness of transdermal clonidine in the prophylaxis of episodic cluster headache...
Chronic headache in young patients: clinical aspects and treatment suggestionsL Grazzi
C. Besta National Neurological Institute, Via Celoria 11, I-20133 Milan, Italy
Neurol Sci 24:S112-4. 2003
..CDH may be associated with comorbid anxiety or depression, resulting in a tremendous amount of dysfunction for the youngster and the family...
Increased plasma nitrites in migraine and cluster headache patients in interictal period: basal hyperactivity of L-arginine-NO pathway?A Ferraris
Neurological Institute C. Besta, Milan, Italy
Cephalalgia 22:33-6. 2002
..These findings suggest that a basal dysfunction in the L-arginine-NO pathway may be involved in the peripheral mechanisms predisposing subjects with neurovascular headaches to individual attacks...
Prevalence and characteristics of right-to-left shunt in migraine with aura: a survey on 120 Italian patientsL Caputi
Cerebrovascular Diseases Unit, C Besta Neurological Institute, Milan, Italy
Neurol Sci 30:S109-11. 2009
..We found RLS in 61 of them. A latent RLS was found in 28%, a permanent RLS in 72%, a shower-curtain pattern was detected in 52% of the studied patients...
Selective vs. complete family interview for detecting those affected by familial cluster headacheM Leone
Istituto Nazionale Neurologico Carlo Besta, Via Celoria 11, 20133 Milan, Italy
Cephalalgia 24:938-9. 2004
..We found only one new first-degree relative with cluster headache (1/40 = 2.5%). The selective interview may be used with confidence as a means of investigating the hereditary component of cluster headache...
Disability in chronic migraine with medication overuse: treatment effects at 3 yearsFrank Andrasik
Department of Psychology, University of West Florida, Pensacola, FL 32514, USA
Headache 47:1277-81. 2007
..To determine the clinical status, with respect to pain indices and disability level, of chronic migraine patients with medication overuse who were treated 3 years previously...