Spindle orientation, asymmetric division and tumour suppression in Drosophila stem cellsCayetano Gonzalez
Cell Division Group, Institute for Research in Biomedicine, Barcelona, Spain
Nat Rev Genet 8:462-72. 2007
..In parallel, the machinery that drives asymmetry in stem cells has been further characterized, identifying new components and uncovering the unique, highly sophisticated behaviour of centrosomes in these cells...
- Centrosome function during stem cell division: the devil is in the details
Cayetano Gonzalez
Cell Division Group, Institute for Research in Biomedicine IRB Barcelona, PCB, C Josep Samitier 1 5, Barcelona, Spain
Curr Opin Cell Biol 20:694-8. 2008
..Animal development without centrosomes would therefore seem inconceivable. The claim of flies without centrosomes may appear to challenge this notion. Does it?..
- The interphase microtubule aster is a determinant of asymmetric division orientation in Drosophila neuroblasts
Jens Januschke
Cell Division Group, Institute for Research in Biomedicine Barcelona, 08028 Barcelona, Spain
J Cell Biol 188:693-706. 2010
..We have also found that the span of such memory is limited to the last mitosis. Furthermore, the orientation of the NB axis of polarity can be reset to any angle with respect to the surrounding tissue and is, therefore, cell autonomous...
- Neural stem cells: the need for a proper orientation
Bart Lesage
Cell Division Group, IRB Barcelona, PCB, c Baldiri Reixac 10 12, Barcelona, Spain
Curr Opin Genet Dev 20:438-42. 2010
..Although still fragmentary, the emerging picture suggests that both notable parallelisms and striking differences apply...
- Centrosome dysfunction in Drosophila neural stem cells causes tumors that are not due to genome instability
Elisabeth Castellanos
Cell Division Group, IRB Barcelona, PCB, c Baldiri Reixac 10 12, 08028 Barcelona, Spain
Curr Biol 18:1209-14. 2008
..We propose that such tumors might be caused by impaired asymmetric division of neural stem cells [4]. These results show that centrosome loss, far from being innocuous, is a potentially dangerous condition in flies...
- Spindle alignment is achieved without rotation after the first cell cycle in Drosophila embryonic neuroblasts
Elena Rebollo
Cell Division Group, IRB Barcelona, PCB, Barcelona, Spain
Development 136:3393-7. 2009
..Therefore, predetermined spindle orientation is not restricted to larval NBs. On the contrary, it actually applies to all but the first cell cycle of embryonic NBs...
- Drosophila neuroblasts retain the daughter centrosome
Jens Januschke
Cell Division Group, IRB Barcelona, Institute for Research in Biomedicine IRB Barcelona, Barcelona, Spain
Nat Commun 2:243. 2011
..Our results demonstrate maturation-dependent centrosome fate in Drosophila NBs and that the stemness properties of these cells are not linked to mother centrosome inheritance...
- Functionally unequal centrosomes drive spindle orientation in asymmetrically dividing Drosophila neural stem cells
Elena Rebollo
Cell Division Group, Institute for Research in Biomedicine, Parc Científic Barcelona, C Josep Samitier 1 5, 08028 Barcelona, Spain
Dev Cell 12:467-74. 2007
..Apical aster maintenance requires the function of Pins. These results reveal that spindle orientation in Drosophila larval NBs is determined very early in the cell cycle, and is mediated by asymmetric centrosome function...
- Time-lapse imaging of embryonic neural stem cell division in Drosophila by two-photon microscopy
Elena Rebollo
Cell Division Group, IRB Barcelona, Barcelona, Spain
Curr Protoc Stem Cell Biol . 2010
..It is ideally suited to following embryonic neuroblasts located underneath the neuroepithelial cell layer for several rounds of cell division...
- Ectopic expression of germline genes drives malignant brain tumor growth in Drosophila
Ana Janic
Cell Division Group, Institute for Research in Biomedicine IRB Barcelona, PCB, c Baldiri Reixac 10 12, Barcelona, Spain
Science 330:1824-7. 2010
..Our results demonstrate that germline traits are necessary for tumor growth in this Drosophila model and suggest that inactivation of germline genes might have tumor-suppressing effects in other species...
- Induction of tumor growth by altered stem-cell asymmetric division in Drosophila melanogaster
Emmanuel Caussinus
Cell Biology and Biophysics Program, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
Nat Genet 37:1125-9. 2005
....
- Asterless is a centriolar protein required for centrosome function and embryo development in Drosophila
Hanne Varmark
Cell Biology and Biophysics Programme, European Molecular Biology Laboratory, Meyerhofstrasse, D 69117 Heidelberg, Germany
Curr Biol 17:1735-45. 2007
..Only a few centriolar proteins have been identified so far in Drosophila, most related to centriole duplication...
- Connecting cancer to the asymmetric division of stem cells
Andreas Wodarz
Department of Stem Cell Biology, DFG Research Center for Molecular Physiology of the Brain CMPB, University of Gottingen, Justus von Liebig Weg 11, 37077 Gottingen, Germany
Cell 124:1121-3. 2006
..This work suggests a mechanism by which loss of polarity in stem cells may lead to tumorigenesis...
- Contribution of noncentrosomal microtubules to spindle assembly in Drosophila spermatocytes
Elena Rebollo
Cell Biology and Biophysics Programme, European Molecular Biology Laboratory, Heidelberg, Germany
PLoS Biol 2:E8. 2004
..These observations are consistent with a model in which centrosomal and noncentrosomal microtubules contribute to the assembly and are required for the robustness of the cell division spindle in cells that contain centrosomes...
- Dispatch. Cell division: the place and time of cytokinesis
Cayetano Gonzalez
European Molecular Biology Laboratory, Cell Biology and Biophysics Programme, Meyerhofstrasse 1, 69117 Heidelberg, Germany
Curr Biol 13:R363-5. 2003
....
- Drosophila dd4 mutants reveal that gammaTuRC is required to maintain juxtaposed half spindles in spermatocytes
Vitor Barbosa
University of Cambridge, Department of Genetics, Downing Street, Cambridge CB2 3EH, UK
J Cell Sci 116:929-41. 2003
..We conclude that spermatocytes do not need astral microtubules nucleated by opposite poles to intersect in order to form a central spindle and a cleavage furrow...
