Seth J Goldenberg

Summary

Publications

  1. ncbi Strategies for the identification of novel inhibitors of deubiquitinating enzymes
    Seth J Goldenberg
    Progenra Inc, 271A Great Valley Parkway, Malvern, PA 19355, USA
    Biochem Soc Trans 36:828-32. 2008
  2. ncbi Strategies for the identification of ubiquitin ligase inhibitors
    Seth J Goldenberg
    Progenra Inc, 271A Great Valley Parkway, Malvern, PA 19355, USA
    Biochem Soc Trans 38:132-6. 2010
  3. ncbi Characterization of selective ubiquitin and ubiquitin-like protease inhibitors using a fluorescence-based multiplex assay format
    Xufan Tian
    Division of Research and Development, Progenra, Inc, Malvern, Pennsylvania 19355, USA
    Assay Drug Dev Technol 9:165-73. 2011
  4. ncbi Characterization of ubiquitin and ubiquitin-like-protein isopeptidase activities
    Benjamin Nicholson
    Division of Research and Development, Progenra, Inc, Malvern, Pennsylvania 19355, USA
    Protein Sci 17:1035-43. 2008
  5. ncbi Structure of the Cand1-Cul1-Roc1 complex reveals regulatory mechanisms for the assembly of the multisubunit cullin-dependent ubiquitin ligases
    Seth J Goldenberg
    Department of Pharmacology, Box 357280, University of Washington, Seattle, WA 98195, USA
    Cell 119:517-28. 2004
  6. ncbi The KLHL12-Cullin-3 ubiquitin ligase negatively regulates the Wnt-beta-catenin pathway by targeting Dishevelled for degradation
    Stephane Angers
    Howard Hughes Medical Institute, University of Washington School of Medicine, Box 357370, Seattle, WA 98195, USA
    Nat Cell Biol 8:348-57. 2006
  7. ncbi Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling
    Michael B Major
    Howard Hughes Medical Institute, University of Washington School of Medicine, Box 357370, Seattle, WA 98195, USA
    Science 316:1043-6. 2007

Collaborators

  • Benjamin Nicholson
  • Keith D Wilkinson
  • Jeffrey G Marblestone
  • Stephane Angers
  • Xufan Tian
  • Michael B Major
  • Travis L Biechele
  • Randall T Moon
  • Michael J MacCoss
  • Ning Zheng
  • Michael R Mattern
  • Craig Leach
  • Nigora S Isamiddinova
  • Raymond J Peroutka
  • Anne Claude Gingras
  • Jason D Berndt
  • Anne-Claude Gingras
  • Nathan D Camp
  • Xianhua Yi
  • Charlotte Hubbert
  • Chris J Thorpe

Detail Information

Publications7

  1. ncbi Strategies for the identification of novel inhibitors of deubiquitinating enzymes
    Seth J Goldenberg
    Progenra Inc, 271A Great Valley Parkway, Malvern, PA 19355, USA
    Biochem Soc Trans 36:828-32. 2008
    ..In this review, current platforms for detecting DUB inhibitors are discussed and the advantages and disadvantages of the approaches are underlined...
  2. ncbi Strategies for the identification of ubiquitin ligase inhibitors
    Seth J Goldenberg
    Progenra Inc, 271A Great Valley Parkway, Malvern, PA 19355, USA
    Biochem Soc Trans 38:132-6. 2010
    ..In this paper, we will discuss current platforms that report on E3 ligase activity and can detect E3 inhibitors, and underline the advantages and disadvantages of each approach...
  3. ncbi Characterization of selective ubiquitin and ubiquitin-like protease inhibitors using a fluorescence-based multiplex assay format
    Xufan Tian
    Division of Research and Development, Progenra, Inc, Malvern, Pennsylvania 19355, USA
    Assay Drug Dev Technol 9:165-73. 2011
    ..Specifically, we have used this assay format to characterize P022077, a selective ubiquitin-specific protease 7 inhibitor discovered at Progenra...
  4. ncbi Characterization of ubiquitin and ubiquitin-like-protein isopeptidase activities
    Benjamin Nicholson
    Division of Research and Development, Progenra, Inc, Malvern, Pennsylvania 19355, USA
    Protein Sci 17:1035-43. 2008
    ..Taken together, these studies illustrate the utility of the reporter-based approach to measuring isopeptidase activity...
  5. ncbi Structure of the Cand1-Cul1-Roc1 complex reveals regulatory mechanisms for the assembly of the multisubunit cullin-dependent ubiquitin ligases
    Seth J Goldenberg
    Department of Pharmacology, Box 357280, University of Washington, Seattle, WA 98195, USA
    Cell 119:517-28. 2004
    ..Together with biochemical evidence, these structural results elucidate the mechanisms by which Cand1 and Nedd8 regulate the assembly-disassembly cycles of SCF and other cullin-dependent E3 complexes...
  6. ncbi The KLHL12-Cullin-3 ubiquitin ligase negatively regulates the Wnt-beta-catenin pathway by targeting Dishevelled for degradation
    Stephane Angers
    Howard Hughes Medical Institute, University of Washington School of Medicine, Box 357370, Seattle, WA 98195, USA
    Nat Cell Biol 8:348-57. 2006
    ....
  7. ncbi Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling
    Michael B Major
    Howard Hughes Medical Institute, University of Washington School of Medicine, Box 357370, Seattle, WA 98195, USA
    Science 316:1043-6. 2007
    ..These data provide a possible mechanistic explanation for the tumor suppressor activity of WTX...