Pharmacological assessment of netobimin as a potential anthelmintic for use in horses: plasma disposition, faecal excretion and efficacyC Gokbulut
Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Adnan Menderes, Aydin, Turkey
Res Vet Sci 86:514-20. 2009
..Considering the pharmacokinetic and efficacy parameters NTB could be used as an anthelmintic in horses...
- Sex-related plasma disposition of ivermectin following pour-on administration in goats
Cengiz Gokbulut
Department of Pharmacology and Toxicology, University of Adnan Menderes, Isikli Koyu, Aydin, Turkey
Vet Parasitol 162:342-5. 2009
..78 days, respectively) were significantly longer compared with female animals (1.42 days and 3.55 days, respectively) and this suggesting that the excretion patterns of IVM in male and female animals are probably different each other...
- Comparative plasma disposition, bioavailability and efficacy of ivermectin following oral and pour-on administrations in horses
Cengiz Gokbulut
Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Adnan Menderes University, Isikli Koyu, 09100 Aydin, Turkey
Vet Parasitol 170:120-6. 2010
..In conclusion, the poor plasma availability observed after pour-on administration could result in subtherapeutic plasma concentrations, which may promote the development of drug resistance in parasites...
- The effect of fasting on the plasma disposition of triclabendazole following oral administration in goats
Cengiz Gokbulut
Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Adnan Menderes, Isikli Kampusu, Aydin, Turkey
Res Vet Sci 89:415-7. 2010
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- The effect of sesame and sunflower oils on the plasma disposition of ivermectin in goats
C Gokbulut
Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Adnan Menderes, Isikli Koyu, Aydin, Turkey
J Vet Pharmacol Ther 31:472-8. 2008
..v. administration. Longer terminal elimination half-lives and resultant longer mean resident time were observed after s.c. administration of the both combinations compared with i.v. administration...
- Comparison of plasma pharmacokinetic profile of ivermectin following administration of subcutaneous injection (Baymec) and oral tablet (Efektin) in goats
C Gokbulut
Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Adnan Menderes, Isikli Koyu, Aydin, Turkey
J Vet Pharmacol Ther 30:489-91. 2007
- Comparative plasma disposition of fenbendazole, oxfendazole and albendazole in dogs
C Gokbulut
Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine and Research and Development Laboratory, University of Adnan Menderes, Aydin, Turkey
Vet Parasitol 148:279-87. 2007
..The data on the pharmacokinetic profile of OFZ presented here may contribute to evaluate its potential as an anthelmintic drug for parasite control in dogs...
- The effect of diet type on the plasma disposition of triclabendazole in goats
Cengiz Gokbulut
Department of Pharmacology and Toxicology, University of Adnan Menderes, Isikli Koyu, Aydin, Turkey
Res Vet Sci 82:388-91. 2007
..48+/-4.40 h). It is concluded that anthelmintically more active sulphoxide metabolite has higher plasma concentration when triclabendazole is administered to goats fed with concentrate feed + hay compared to grazing goats...
- Plasma disposition and faecal excretion of netobimin metabolites and enantiospecific disposition of albendazole sulphoxide produced in ewes
C Gokbulut
Department of Pharmacology and Toxicology, Research and Development Laboratory, University of Adnan Menderes, Aydin, Turkey
Vet Res Commun 30:791-805. 2006
..The specific behaviour of the two enantiomers probably reflects different enantioselectivity of the enzymatic systems of the liver that are responsible for sulphoxidation and sulphonation of ABZ...
- The effects of different ages and dosages on the plasma disposition and hair concentration profile of ivermectin following pour-on administration in goats
C Gokbulut
Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Adnan Menderes University, Aydin, Turkey
J Vet Pharmacol Ther 34:70-5. 2011
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- Comparative plasma dispositions of ivermectin and doramectin following subcutaneous and oral administration in dogs
Cengiz Gokbulut
Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Adnan Menderes, Isikli Koyu, Aydin, Turkey
Vet Parasitol 135:347-54. 2006
..Considering the pharmacokinetic parameters, IVM and DRM could be used by the oral or subcutaneous route for the control of parasitic infection in dogs...
- Breed-related plasma disposition of ivermectin following subcutaneous administration in Kilis and Damascus goats
Cengiz Gokbulut
Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Adnan Menderes, Isikli Koyu, 09100 Aydin, Turkey
Res Vet Sci 87:445-8. 2009
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- Plasma disposition, concentration in the hair, and anthelmintic efficacy of eprinomectin after topical administration in donkeys
Cengiz Gokbulut
Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Adnan Menderes, Isikli Koyu 09100 Aydin, Turkey
Am J Vet Res 72:1639-45. 2011
..To investigate plasma disposition, concentration in the hair, and anthelmintic efficacy of eprinomectin after topical administration in donkeys...
- Plasma disposition and faecal excretion of oxfendazole, fenbendazole and albendazole following oral administration to donkeys
Cengiz Gokbulut
Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Adnan Menderes, Isikli Koyu, Aydin, Turkey
Vet J 172:166-72. 2006
..A higher metabolic capacity, first-pass effects and lower absorption of benzimidazoles in donkeys decrease bioavailability and efficacy compared to ruminants...
- Plasma dispositions of ivermectin, doramectin and moxidectin following subcutaneous administration in rabbits
C Gokbulut
Department of Pharmacology and Toxicology, University of Adnan Menderes, Isikli Koyu, Aydin, Turkey
Lab Anim 44:138-42. 2010
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- Plasma pharmacokinetics and faecal excretion of ivermectin (Eqvalan paste) and doramectin (Dectomax, 1%) following oral administration in donkeys
C Gokbulut
Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Adnan Menderes, Isikli Koyu, Aydin, Turkey
Res Vet Sci 79:233-8. 2005
..33 microgg(-1) - IVM, 12.12 microgg(-1) - DRM) were detected at 55.9 and 48.0 h, respectively and each compound was detected (0.05 microgg(-1)) in faeces between 11h and 9 days following oral administration in donkeys...
- Contents and sources of DDT impurities in dicofol formulations in Turkey
Cafer Turgut
Faculty of Agriculture, Adnan Menderes University, 09100, Aydin, Turkey
Environ Sci Pollut Res Int 16:214-7. 2009
..Specifically, DDT content in a dicofol formulation cannot exceed 0.1%. The goal of this project was to determine the DDT content in dicofol formulations used in Turkey...
