Cell cycle arrest and autoschizis in a human bladder carcinoma cell line following Vitamin C and Vitamin K3 treatmentJames M Jamison
Department of Urology, College of Medicine, Northeastern Ohio Universities, Summa Health System NEOUCOM, Akron, OH 44304, USA
Biochem Pharmacol 67:337-51. 2004
..These results suggest that Ca(2+) disregulation activates at least one DNase which degrades tumor cell DNA and induces tumor cell death...
- The gallbladder of Uranoscopus scaber L. (teleost perciform fish) is lined by specialized cholecystocytes
J Gilloteaux
Department of Anatomical Sciences, St George s International School of Medicine, Newcastle upon Tyne, United Kingdom
Anat Rec (Hoboken) 294:1890-903. 2011
..In addition, aggregations of mitochondria and anomalous mitochondrial morphologies were found that resemble oncocytoma-like changes...
- Intracellular liposomes and cholesterol deposits in chronic cholecystitis and biliary sludge
Jacques Gilloteaux
Departments of Pathology and Surgery, Summa Health System, Summa Research Foundation, Akron, Ohio, USA
Ultrastruct Pathol 28:123-36. 2004
..Based on the aforementioned data, a comprehensive sequence for cholecystocyte ultrastructural alterations and pathologies is proposed, as a result of chronic cholecystitis...
- Microscopic aspects of autoschizic cell death in human ovarian carcinoma (2774) cells following vitamin C, vitamin K3 or vitamin C:K3 treatment
Jacques Gilloteaux
Department of Urology, Summa Health System, Akron, OH 44304, USA
Microsc Microanal 9:311-29. 2003
..These results also suggest that the vitamin combination may find clinical use in the treatment of ovarian cancer...
- Autoschizis of human ovarian carcinoma cells: scanning electron and light microscopy of a new cell death induced by sodium ascorbate: menadione treatment
J Gilloteaux
M E I O Inc, Coral Gables, Florida 33135, USA
Scanning 25:137-49. 2003
..9% by oncosis. These results confirm that autoschizis is the principal form of cell death that results from the in vitro treatment of human ovarian carcinoma cells with the vitamin combination...
- Carcinoma in situ of the cystic duct
Jacques Gilloteaux
Department of Surgery, Summa Health System, Summa Research Foundation, Akron, Ohio, USA
Ultrastruct Pathol 29:79-84. 2005
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- Cell death by autoschizis in TRAMP prostate carcinoma cells as a result of treatment by ascorbate: menadione combination
Jacques Gilloteaux
American University of the Caribbean School of Medicine, Campus St Maarten, M E I O, Inc, Coral Gables, Florida 33134, USA
Ultrastruct Pathol 29:221-35. 2005
..The organelle-free self-excisions caused an extreme reduction in cell size as well as chromatolysis and karyolysis that were consistent with cell death by autoschizis, but not with apoptosis...
- Morphology and DNA degeneration during autoschizic cell death in bladder carcinoma T24 cells induced by ascorbate and menadione treatment
Jacques Gilloteaux
Department of Anatomy, American University of the Caribbean, School of Medicine, Coral Gables, Florida 33134, USA
Anat Rec A Discov Mol Cell Evol Biol 288:58-83. 2006
..In addition, gel electrophoresis and Feulgen staining demonstrate that autoschizis is accompanied by random DNA degeneration...
- The perinuclear space of pancreatic acinar cells and the synthetic pathway of zymogen in Scorpaena scrofa L.: ultrastructural aspects
Jacques Gilloteaux
Department of Anatomy, American University of the Caribbean School of Medicine, Coral Gables, FL 33134, USA
Tissue Cell 40:7-20. 2008
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- Cell damage and death by autoschizis in human bladder (RT4) carcinoma cells resulting from treatment with ascorbate and menadione
Jacques Gilloteaux
Department of Anatomical Sciences, St Georges University School of Medicine, Newcastle upon Tyne, UK
Ultrastruct Pathol 34:140-60. 2010
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- Autoschizis: a new form of cell death for human ovarian carcinoma cells following ascorbate:menadione treatment. Nuclear and DNA degradation
Jacques Gilloteaux
Department of Anatomy, American University of the Caribbean, School of Medicine, Campus St Maarten, M E I O Inc, Ponce de Leon Boulevard 901, Suite 401, Coral Gables, FL 33135, USA
Tissue Cell 36:197-209. 2004
..Histochem. Cytochem. 49 (2001) 109] which demonstrated that the VC:VK3 combination induced autoschizic cell death by a series of cytoplasmic excisions without organelles along with specific nuclear ultrastructural damage...
- Autoschizis: another cell death for cancer cells induced by oxidative stress
J Gilloteaux
Department of Urology, Summa Health System, Akron, Ohio 44304, USA
Ital J Anat Embryol 106:79-92. 2001
..From our morphological studies and previous biochemical reports on the topic, we are able to propose that this autoschizic cell death found is induced by oxidative stress...
- Cancer cell necrosis by autoschizis: synergism of antitumor activity of vitamin C: vitamin K3 on human bladder carcinoma T24 cells
J Gilloteaux
Department of Anatomy, Lake Erie College of Osteopathic Medicine, Pennsylvania 16509 1025, USA
Scanning 20:564-75. 1998
..This process of cell death induced by oxidative stress was named autoschizis because it showed both apoptotic and necrotic morphologic characteristics...
- Effect of ethidium on the morphology, antiviral activity and subcellular distribution of poly r(A-U)
J M Jamison
Department of Microbiology and Immunology, Summa Health System, Akron, Ohio 44304
Cell Biol Int 17:1091-105. 1993
..These results suggest the elevated antiviral activity may be related to the altered uptake and subcellular distribution of the EB/poly r(A-U) complex...
- Ultrastructural aspects of autoschizis: a new cancer cell death induced by the synergistic action of ascorbate/menadione on human bladder carcinoma cells
J Gilloteaux
Department of Anatomy, Lake Erie College of Osteopathic Medicine, Pennsylvania 16509 1025, USA
Ultrastruct Pathol 25:183-92. 2001
..1998; 20: 564-575). This morphological characterization of autoschizic cell death confirms and extends the authors previous reports and demonstrates that this cell death is distinct from apoptosis...
- The in vitro antitumor activity of vitamins C and K3 against ovarian carcinoma
Vivian E von Gruenigen
Department of Obstetrics and Gynecology, Summa Health System, 525 E Market Street, Akron, OH 44309, USA
Anticancer Res 23:3279-87. 2003
..The objective was to evaluate the cytotoxic effect and mechanism of action of vitamins C (VC) and K3 (VK3) on ovarian carcinoma...
- Ultrastructural nucleolar alterations induced by an ametantrone--poly r(A-U) complex
J M Jamison
Department of Urology, Summa Health System Northeastern Ohio Universities College of Medicine, Rootstown 44272, USA
Tissue Cell 30:475-84. 1998
..These results are consistent with a model in which the poly r(A-U) and/or the AMT inhibit DNA transcription and rRNA processing as well as the release of nascent preribosomes from the nucleolus...
- Transmission electron microscopy and scanning force microscopy of poly r(A-U) and poly r(A-U)-ethidium bromide
J Gilloteaux
Department of Anatomy, Lake Erie College of Osteopathic Medicine, PA 16509 1025, USA
Scanning 19:523-32. 1997
..These conformational changes are due to a number of factors, including the displacement of ordered water surrounding the poly r(A-U) and charge shielding of the phosphate groups of the poly r(A-U) upon the binding of the ethidium...
- Lipid deposits and lipo-mucosomes in human cholecystitis and epithelial metaplasia in chronic cholecystitis
Jacques Gilloteaux
Department of Anatomy, American University of the Caribbean, School of Medicine, Cupecoy-Lowlands, St. Maarten, NA, West Indies
Ultrastruct Pathol 27:313-21. 2003
..In addition to lipid deposition in macrophages, lipid is also incorporated in other cells and tissues of the gallbladder wall (endothelium of capillaries, smooth muscles and fibrocytes)...
- Nucleolar changes and fibrillarin redistribution following apatone treatment of human bladder carcinoma cells
James M Jamison
St Thomas Hospital, Akron, Ohio 44310, USA
J Histochem Cytochem 58:635-51. 2010
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- Autoschizis: a novel cell death
James M Jamison
Department of Urology, Summa Health System Northeastern Ohio Universities College of Medicine, 2209 State Route 44, PO Box 95, Rootstown, OH 44272 0095, USA
Biochem Pharmacol 63:1773-83. 2002
..This report discusses the mechanisms of action employed by these vitamins to induce tumor-specific death by autoschizis...
- Unusual circular annulate lamellae in hepatocytes of Torpedo marmorata
A Haggag
Department of Anatomy, American University of the Caribbean School of Medicine, M.E.I.O. Inc, St Maarten Campus, Netherland Antilles, West Indies
Histol Histopathol 20:785-9. 2005
..These findings can concur and support other authors' observations suggesting that these adult hepatocytes transient changes reflect that this species could be exposed to local, natural or likely human coastal seabed pollutants...
- The association of vitamins C and K3 kills cancer cells mainly by autoschizis, a novel form of cell death. Basis for their potential use as coadjuvants in anticancer therapy
Julien Verrax
, , Nutrition et Toxicologie, , , Brussels, Belgium
Eur J Med Chem 38:451-7. 2003
..The aim is to prepare the introduction of the association of vitamins C and K(3) into human clinics as a new, non-toxic adjuvant cancer therapy...
- Inhibition of the development of metastases by dietary vitamin C:K3 combination
Henryk S Taper
Unité de Pharmacocinétique, Metabolisme, Nutrition, et Toxicologie, Universite Catholique de Louvain, avenue E Mounier, 73, B 1200 Bruxelles, Belgium
Life Sci 75:955-67. 2004
..These results demonstrate that oral vitamin C and K(3) significantly inhibited the metastases of T.L.T. tumors in C3H mice. At least a portion of this inhibition was due to tumor cell death by autoschizis...
