Christos C Zouboulis

Summary

Country: Germany

Publications

  1. ncbi Treating acne with antibiotic-resistant bacterial colonization
    Thrasivoulos Tzellos
    Dessau Medical Center, Departments of Dermatology, Venereology, Allergology and Immunology, Auenweg Dessau, Germany
    Expert Opin Pharmacother 12:1233-47. 2011
  2. ncbi Clinical aspects and molecular diagnostics of skin aging
    Christos C Zouboulis
    Departments of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center, Auenweg 38, 06847 Dessau, Germany
    Clin Dermatol 29:3-14. 2011
  3. ncbi [The sebaceous gland]
    C C Zouboulis
    Klinik fur Dermatologie, Venerologie und Allergologie Immunologisches Zentrum, Städtisches Klinikum Dessau, Auenweg 38, 06847, Dessau, Germany
    Hautarzt 61:467-8, 4704, 476-7. 2010
  4. ncbi Human skin stem cells and the ageing process
    Christos C Zouboulis
    Department of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center, Dessau, Germany
    Exp Gerontol 43:986-97. 2008
  5. ncbi The sebocyte culture: a model to study the pathophysiology of the sebaceous gland in sebostasis, seborrhoea and acne
    Christos C Zouboulis
    Department of Dermatology, Dessau Medical Center, Dessau, Germany
    Arch Dermatol Res 300:397-413. 2008
  6. ncbi [Epidemiology and clinical manifestations of Adamantiades-Behçet disease in Germany -- current pathogenetic concepts and therapeutic possibilities]
    Andreas Altenburg
    Clinic for Dermatology, Venerology and Allergology, , Campus Benjamin Franklin, Berlin
    J Dtsch Dermatol Ges 4:49-64; quiz 65-6. 2006
  7. ncbi Isotretinoin revisited: pluripotent effects on human sebaceous gland cells
    Christos C Zouboulis
    Department of Dermatology, Dessau Medical Center, Dessau, Germany
    J Invest Dermatol 126:2154-6. 2006
  8. ncbi HLA-independent antibacterial host response toward Th1 immunity mediated by IL-12: a new concept for the pathogenesis of Adamantiades-Behçet's disease
    Christos C Zouboulis
    Department of Dermatology and Immunology, Dessau Medical Center, Dessau, Germany
    J Invest Dermatol 126:1444-7. 2006
  9. ncbi Frontiers in sebaceous gland biology and pathology
    Christos C Zouboulis
    Department of Dermatology, Dessau Medical Center, Dessau, Germany
    Exp Dermatol 17:542-51. 2008
  10. ncbi [Acne vulgaris. The role of hormones]
    C C Zouboulis
    Klinik fur Dermatologie, Venerologie und Allergologie Immunologisches Zentrum, Städtisches Klinikum Dessau, Auenweg 38, 06847 Dessau Rosslau
    Hautarzt 61:107-8, 110-4. 2010

Detail Information

Publications119 found, 100 shown here

  1. ncbi Treating acne with antibiotic-resistant bacterial colonization
    Thrasivoulos Tzellos
    Dessau Medical Center, Departments of Dermatology, Venereology, Allergology and Immunology, Auenweg Dessau, Germany
    Expert Opin Pharmacother 12:1233-47. 2011
    ..Benzoyl-peroxide-based treatment is the most evidence-based approach. Oral isotretinoin remains the most efficacious option for severe acne...
  2. ncbi Clinical aspects and molecular diagnostics of skin aging
    Christos C Zouboulis
    Departments of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center, Auenweg 38, 06847 Dessau, Germany
    Clin Dermatol 29:3-14. 2011
    ..Understanding the molecular mechanisms of aging may open new strategies to deal with the various diseases accompanying high age, including cancer...
  3. ncbi [The sebaceous gland]
    C C Zouboulis
    Klinik fur Dermatologie, Venerologie und Allergologie Immunologisches Zentrum, Städtisches Klinikum Dessau, Auenweg 38, 06847, Dessau, Germany
    Hautarzt 61:467-8, 4704, 476-7. 2010
    ..Atopic dermatitis, seborrheic dermatitis, psoriasis and acne vulgaris are some of the disease on which pathogenesis and severity sebaceous lipids may or are surely involved...
  4. ncbi Human skin stem cells and the ageing process
    Christos C Zouboulis
    Department of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center, Dessau, Germany
    Exp Gerontol 43:986-97. 2008
    ..In addition, they provide in vitro models to study epidermal lineage selection and its role in the ageing process...
  5. ncbi The sebocyte culture: a model to study the pathophysiology of the sebaceous gland in sebostasis, seborrhoea and acne
    Christos C Zouboulis
    Department of Dermatology, Dessau Medical Center, Dessau, Germany
    Arch Dermatol Res 300:397-413. 2008
    ..This article summarizes the data of newest research of sebostasis, seborrhoea and acne made possible through the development of human and animal sebocyte culture models...
  6. ncbi [Epidemiology and clinical manifestations of Adamantiades-Behçet disease in Germany -- current pathogenetic concepts and therapeutic possibilities]
    Andreas Altenburg
    Clinic for Dermatology, Venerology and Allergology, , Campus Benjamin Franklin, Berlin
    J Dtsch Dermatol Ges 4:49-64; quiz 65-6. 2006
  7. ncbi Isotretinoin revisited: pluripotent effects on human sebaceous gland cells
    Christos C Zouboulis
    Department of Dermatology, Dessau Medical Center, Dessau, Germany
    J Invest Dermatol 126:2154-6. 2006
    ..These events were specific to sebocytes, as isotretinoin failed to induce apoptosis in keratinocytes. Isotretinoin-induced apoptosis was shown to be an RAR-independent mechanism...
  8. ncbi HLA-independent antibacterial host response toward Th1 immunity mediated by IL-12: a new concept for the pathogenesis of Adamantiades-Behçet's disease
    Christos C Zouboulis
    Department of Dermatology and Immunology, Dessau Medical Center, Dessau, Germany
    J Invest Dermatol 126:1444-7. 2006
    ..The authors provide evidence for an antibacterial host response toward T-helper type 1 immunity mediated by IL-12 in patients with ABD, which is HLA independent...
  9. ncbi Frontiers in sebaceous gland biology and pathology
    Christos C Zouboulis
    Department of Dermatology, Dessau Medical Center, Dessau, Germany
    Exp Dermatol 17:542-51. 2008
    ..These multiple homeostatic functions award the sebaceous gland the role 'brain of the skin' and the most important cutaneous endocrine gland...
  10. ncbi [Acne vulgaris. The role of hormones]
    C C Zouboulis
    Klinik fur Dermatologie, Venerologie und Allergologie Immunologisches Zentrum, Städtisches Klinikum Dessau, Auenweg 38, 06847 Dessau Rosslau
    Hautarzt 61:107-8, 110-4. 2010
    ..Hormone-like active lipids, hormones in diet and neuropeptides may also play a role in the development of acne lesions. The target of antiandrogen treatment of the skin is mainly the sebaceous gland and the primary effect is sebostasis...
  11. ncbi Study of the efficacy, tolerability, and safety of 2 fixed-dose combination gels in the management of acne vulgaris
    Christos C Zouboulis
    Department of Dermatology, Dessau Medical Center, Auenweg 38, 06847 Dessau, Germany
    Cutis 84:223-9. 2009
    ....
  12. ncbi Regulation of stearoyl-coenzyme A desaturase and fatty acid delta-6 desaturase-2 expression by linoleic acid and arachidonic acid in human sebocytes leads to enhancement of proinflammatory activity but does not affect lipogenesis
    C C Zouboulis
    Department of Dermatology, Dessau Medical Center, Auenweg 38, 06847 Dessau, Germany
    Br J Dermatol 165:269-76. 2011
    ..On the other hand, fatty acid delta-6 desaturase-2 (FADS2) catalyses the conversion of LA to AA...
  13. ncbi Sexual hormones in human skin
    C C Zouboulis
    Department of Dermatology, Dessau Medical Center, Dessau, Germany
    Horm Metab Res 39:85-95. 2007
    ..However, they reliably reduce acne. Cyproterone acetate and spironolactone are similarly effective as anti-androgens in reducing hirsutism, although there is wide variability in individual responses...
  14. ncbi Aging of human sebocytes in vitro induced by exposure to a defined hormone environment
    Evgenia Makrantonaki
    Laboratory for Biogerontology, Dermato-Pharmacology and Dermato-Endocrinology, Institute of Clinical Pharmacology and Toxicology, , Campus Benjamin Franklin, Berlin, Germany
    Dermatology 213:262-3. 2006
  15. ncbi Longterm visual prognosis of patients with ocular Adamantiades-Behçet's disease treated with interferon-alpha-2a
    Lothar Krause
    Department of Ophthalmology, Charite Universitaetsmedizin Berlin, Berlin, Germany
    J Rheumatol 35:896-903. 2008
    ..Interferon-alpha (IFN-alpha) has proven to be effective in mucocutaneous ABD and has been reported to improve ocular lesions. We examined the longterm effects of IFN-alpha-2a in a case series of 45 patients with ocular involvement...
  16. ncbi Ocular involvement in Adamantiades-Behçet's disease in Berlin, Germany
    Lothar Krause
    Department of Ophthalmology, Charite Campus Benjamin Franklin, Hindenburgdamm 30, 12200, Berlin, Germany
    Graefes Arch Clin Exp Ophthalmol 247:661-6. 2009
    ..Berlin is the city with the highest number of non-native German inhabitants, and its multi-ethnic character renders it uniquely appropriate for epidemiological studies on ABD...
  17. ncbi Cyproterone acetate loading to lipid nanoparticles for topical acne treatment: particle characterisation and skin uptake
    Jana Stecová
    Institut fur Pharmazie, Freie Universitat Berlin, Konigin Luise Strasse 2 4, D 14195, Berlin, Germany
    Pharm Res 24:991-1000. 2007
    ..To improve skin penetration of the poorly absorbed drug, we intended to identify the active moiety and to load it to particulate carrier systems...
  18. ncbi Interplay of IGF-I and 17beta-estradiol at age-specific levels in human sebocytes and fibroblasts in vitro
    Evgenia Makrantonaki
    Laboratory for Biogerontology, Dermato Pharmacology and Dermato Endocrinology, Institute of Clinical Pharmacology and Toxicology, Charite Universitaetsmedizin Berlin, Berlin, Germany
    Exp Gerontol 43:939-46. 2008
    ..In conclusion, IGF-I is a key regulator of human skin aging and declining IGF-I levels with age may play a significant role in the reduction of skin surface lipids and thickness...
  19. ncbi Enzymes involved in the biosynthesis of leukotriene B4 and prostaglandin E2 are active in sebaceous glands
    Theodosios Alestas
    Department of Dermatology, , Campus Benjamin Franklin, Fabeckstrasse 60-62, 14195 Berlin, Germany
    J Mol Med 84:75-87. 2006
    ..In conclusion, human sebocytes possess the enzyme machinery for functional leukotriene and prostaglandin pathways. A comprehensive link between inflammation and sebaceous lipid synthesis is provided...
  20. ncbi Characterization of the vitamin D endocrine system in human sebocytes in vitro
    Christina Krämer
    Department of Dermatology, The Saarland University Hospital, 66421 Homburg Saar, Germany
    J Steroid Biochem Mol Biol 113:9-16. 2009
    ..We conclude that sebaceous glands represent potential targets for therapy with vitamin D analogues or for pharmacological modulation of 1,25(OH)(2)D(3) synthesis/metabolism...
  21. ncbi KdPT, a tripeptide derivative of alpha-melanocyte-stimulating hormone, suppresses IL-1 beta-mediated cytokine expression and signaling in human sebocytes
    Arianna Mastrofrancesco
    Department of Dermatology, University of Munster, Munster, Germany
    J Immunol 185:1903-11. 2010
    ..Our data demonstrate a promising anti-inflammatory potential of KdPT and point toward novel future directions in the treatment of acne-as well as of various other IL-1-mediated inflammatory diseases-with this small molecule...
  22. ncbi Nicotine and biochanin A, but not cigarette smoke, induce anti-inflammatory effects on keratinocytes and endothelial cells in patients with Behçet's disease
    Aylin Kalayciyan
    Department of Dermatology, Charite Universitaetsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    J Invest Dermatol 127:81-9. 2007
    ..Moreover, biochanin A is likely to exhibit similar and even more profound results than nicotine...
  23. ncbi [Modern aspects of acne pathogenesis]
    Christos C Zouboulis
    Klinik fur Dermatologie, Venerologie und Allergologie Immunologisches Zentrum, Städtisches Klinikum Dessau, Dessau Rosslau
    J Dtsch Dermatol Ges 8:S7-14. 2010
    ..Acne is worldwide the most common skin disease...
  24. ncbi A historical review of Adamantiades-Behçet's disease
    Christos C Zouboulis
    Department of Dermatology, University Medical Center Benjamin Franklin, The Free University of Berlin, Germany
    Adv Exp Med Biol 528:7-14. 2003
  25. ncbi Age-specific hormonal decline is accompanied by transcriptional changes in human sebocytes in vitro
    Evgenia Makrantonaki
    Laboratory for Biogerontology, Dermato-Pharmacology and Dermato-Endocrinology, Institute of Clinical Pharmacology and Toxicology, , Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    Aging Cell 5:331-44. 2006
    ....
  26. ncbi Anti-acne agents attenuate FGFR2 signal transduction in acne
    Bodo C Melnik
    Department of Dermatology, Environmental Medicine and Health Theory, University of Osnabruck, Osnabruck, Germany
    J Invest Dermatol 129:1868-77. 2009
    ....
  27. ncbi Differential regulation of Toll-like receptor and CD14 pathways by retinoids and corticosteroids in human sebocytes
    Marina K Oeff
    Department of Dermatology, , Campus Benjamin Franklin, Berlin, Germany
    Dermatology 213:266. 2006
  28. ncbi Intraocular surgery under systemic interferon-alpha therapy in ocular Adamantiades-Behçet's disease
    Lothar Krause
    Department of Ophthalmology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    Graefes Arch Clin Exp Ophthalmol 245:1617-21. 2007
    ..In some cases, such as tractional retinal detachment, secondary glaucoma or secondary cataract formation, intraocular surgery is required...
  29. ncbi The skin as a mirror of the aging process in the human organism--state of the art and results of the aging research in the German National Genome Research Network 2 (NGFN-2)
    Evgenia Makrantonaki
    Departments of Dermatology and Immunology, Dessau Medical Center, Auenweg 38, 06847 Dessau, Germany
    Exp Gerontol 42:879-86. 2007
    ..Thus, these results could be a basis for an integrated and interdisciplinary approach to the analysis of the aging process...
  30. ncbi Propionibacterium acnes and sebaceous lipogenesis: a love-hate relationship?
    Christos C Zouboulis
    Departments of Dermatology, Venereology, Allergology, and Immunology, Dessau Medical Center, Dessau, Germany
    J Invest Dermatol 129:2093-6. 2009
    ..acnes with sebaceous lipogenesis, inflammation, and innate immunity, and points out the concurrent evidence that P. acnes-induced lipids may represent a recruitment of allies and/or enemies of the human skin...
  31. ncbi Update and future of systemic acne treatment
    Christos C Zouboulis
    Department of Dermatology, University Medical Center Benjamin Franklin, The Free University of Berlin, Berlin, Germany
    Dermatology 206:37-53. 2003
    ....
  32. ncbi Mitochondrial-associated cell death mechanisms are reset to an embryonic-like state in aged donor-derived iPS cells harboring chromosomal aberrations
    Alessandro Prigione
    Molecular Embryology and Aging Group, Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany
    PLoS ONE 6:e27352. 2011
    ..Nevertheless, we believe it will be essential to develop reprogramming protocols capable of safeguarding the integrity of the genome of aged somatic cells, before employing iPSC-based therapy for age-associated disorders...
  33. ncbi High albumin levels restrict the kinetics of 13-cis retinoic acid uptake and intracellular isomerization to all-trans retinoic acid and inhibit its anti-proliferative effect on SZ95 sebocytes
    Miki Tsukada
    Department of Dermatology, University Medical Center Benjamin Franklin, The Free University of Berlin, Fabeckstrasse 60-62, 14195 Berlin, Germany
    J Invest Dermatol 119:182-5. 2002
    ..These results indicate a critical function of serum albumin as retinoid-binding protein in reducing the concentration of active retinoids and restricting their biologic effects on human sebocytes...
  34. ncbi [Hormonal antiandrogens in acne treatment]
    Christos C Zouboulis
    Klinik fur Dermatologie, Venerologie und Allergologie Immunologisches Zentrum, Städtisches Klinikum Dessau, Dessau Rosslau
    J Dtsch Dermatol Ges 8:S60-74. 2010
    ....
  35. ncbi Skin and brain age together: The role of hormones in the ageing process
    Evgenia Makrantonaki
    Department of Dermatology, Dessau Medical Center, Germany
    Exp Gerontol 45:801-13. 2010
    ....
  36. ncbi Intralesional cryosurgery enhances the involution of recalcitrant auricular keloids: a new clinical approach supported by experimental studies
    Yaron Har-Shai
    Department of Dermatology, , Campus Benjamin Franklin, Berlin, Germany
    Wound Repair Regen 14:18-27. 2006
    ....
  37. ncbi Androgens and ageing of the skin
    Evgenia Makrantonaki
    Departments of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center, Dessau, Germany
    Curr Opin Endocrinol Diabetes Obes 16:240-5. 2009
    ..This study reviews current advances in our understanding of the role of androgens in the initiation of skin ageing...
  38. ncbi Acne and sebaceous gland function
    Christos C Zouboulis
    Department of Dermatology, Charite University Medicine Berlin, Campus Benjamin Franklin, Fabeckstrasse 60 62, 14195 Berlin, Germany
    Clin Dermatol 22:360-6. 2004
    ..They should also influence peroxisome proliferator-activated receptor regulation. Isotretinoin is still the most active available drug for the treatment of severe acne...
  39. ncbi Vitamins as hormones
    J Reichrath
    Department of Dermatology, The Saarland University Hospital, Homburg, Germany
    Horm Metab Res 39:71-84. 2007
    ..This review summarizes existing knowledge on vitamins A and D, the major vitamin-hormones of the skin...
  40. ncbi Benediktos Adamantiades and his forgotten contributions to medicine
    Christos C Zouboulis
    Department of Dermatology, University Medical Center Benjamin Franklin, The Free University of Berlin, Fabeckstrasse 60 62, 14195 Berlin, Germany
    Eur J Dermatol 12:471-4. 2002
    ..Adamantiades compiled over 150 scientific papers many of which marked a new stage in his field. He died in 1962 in Athens...
  41. ncbi Association of Mycoplasma fermentans with Adamantiades-Behçet's disease
    Christos C Zouboulis
    Department of Dermatology, University Medical Center Benjamin Franklin, The Free University of Berlin, Berlin, Germany
    Adv Exp Med Biol 528:191-4. 2003
  42. ncbi Pathogenesis of Adamantiades-Behçet's disease
    Christos C Zouboulis
    Department of Dermatology, University Medical Center Benjamin Franklin, The Free University of Berlin, Berlin, Germany
    Adv Exp Med Biol 528:161-71. 2003
  43. ncbi 2,3,7,8-Tetrachlorodibenzo-p-dioxin alters sebaceous gland cell differentiation in vitro
    Qiang Ju
    Laboratory of Biogerontology, Dermato Pharmacology and Dermato Endocrinology, Institute of Clinical Pharmacology and Toxicology, Charite Universitaetsmedizin Berlin, Berlin, Germany
    Exp Dermatol 20:320-5. 2011
    ..In addition and together with the results of a parallel study (J Dermatol Sci 58, 2010, 211), we provide evidence that TCDD effects on human sebocytes are mediated through the AhR signalling pathway...
  44. ncbi Psychophysiological reactivity under mental stress in atopic dermatitis
    Kristina Seiffert
    Department of Psychosomatics and Psychotherapy, Charite University Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany
    Dermatology 210:286-93. 2005
    ..An association of mental stress with atopic dermatitis is widely accepted. However, no long-term evaluation of psychophysiological reactivity over the course of disease has yet been performed...
  45. ncbi Interferon alfa-2a in the treatment of ocular Adamantiades-Behçet's disease
    Lothar Krause
    Department of Ophthalmology, University Medical Center Benjamin Franklin, , Berlin, Germany
    Adv Exp Med Biol 528:511-9. 2003
  46. ncbi Androgen action on human skin -- from basic research to clinical significance
    Christos C Zouboulis
    Department of Dermatology, Charite University Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany
    Exp Dermatol 13:5-10. 2004
    ..Partial effectiveness has only been achieved either by androgen depletion, inhibition of androgen metabolism or blockade of the androgen receptor...
  47. ncbi Oral alitretinoin (9-cis-retinoic acid) therapy for chronic hand dermatitis in patients refractory to standard therapy: results of a randomized, double-blind, placebo-controlled, multicenter trial
    Thomas Ruzicka
    Department of Dermatology, Heinrich Heine University Hospital, Dusseldorf, Germany
    Arch Dermatol 140:1453-9. 2004
    ..To assess the efficacy and safety of oral alitretinoin (9-cis-retinoic acid), 10 mg/d, 20 mg/d, and 40 mg/d, compared with placebo control, in the treatment of chronic hand dermatitis...
  48. ncbi Extended venous thrombosis in Adamantiades-Behçet's disease
    Christos C Zouboulis
    Department of Dermatology, Charite University Medicine Berlin, Campus Benjamin Franklin, Fabeckstrasse 60 62 14195 Berlin, Germany
    Eur J Dermatol 14:268-71. 2004
    ..During the 52-month follow-up single oral aphthous ulcers were occasionally observed and erythema nodosum-like lesions and skin pustules occurred at the lower extremities two weeks after a temporary discontinuation of treatment...
  49. ncbi Neuroendocrine regulation of sebocytes -- a pathogenetic link between stress and acne
    Christos C Zouboulis
    Department of Dermatology, Charite University Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany
    Exp Dermatol 13:31-5. 2004
    ..By means of their autocrine, paracrine and endocrine actions, these neuroendocrine factors appear to mediate centrally and topically induced stress towards the sebaceous gland, ultimately affecting the clinical course of acne...
  50. ncbi William J. Cunliffe Scientific Awards. Characteristics and pathomechanisms of endogenously aged skin
    Evgenia Makrantonaki
    Laboratory for Biogerontology, Dermato Pharmacology and Dermato Endocrinology, Institute of Clinical Pharmacology and Toxicology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    Dermatology 214:352-60. 2007
    ..In conclusion, among other factors the hormone environment plays a distinct role in the generation of aged skin...
  51. ncbi [Dermatoendocrinology. Skin aging]
    E Makrantonaki
    Klinik fur Dermatologie, Venerologie und Allergologie Immunologisches Zentrum, Städtisches Klinikum Dessau, Auenweg 38, 06847, Dessau, Germany
    Hautarzt 61:505-10. 2010
    ....
  52. ncbi Inhibition of the androgen receptor by antisense oligonucleotides regulates the biological activity of androgens in SZ95 sebocytes
    S Fimmel
    Laboratory of Biogerontology, Dermato Pharmacology and Dermato Endocrinology, Institute of Clinical Pharmacology and Toxicology, Campus Benjamin Franklin, Charite Universitatsmedizin Berlin, Berlin, Germany
    Horm Metab Res 39:149-56. 2007
    ....
  53. ncbi Zileuton prevents the activation of the leukotriene pathway and reduces sebaceous lipogenesis
    Christos C Zouboulis
    Departments of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center, Dessau, Germany
    Exp Dermatol 19:148-50. 2010
    ..IL-6 release and neutral lipid content were also reduced under long-term zileuton treatment. In conclusion, zileuton prevents the activation of the leukotriene pathway and enhancement of lipogenesis by AA in human sebocytes in vitro...
  54. ncbi [S2k-guideline for therapy of acne]
    Alexander Nast
    Division of Evidence Based Medicine, Klinik fur Dermatologie, Venerologie und Allergologie, Charite Universitatsmedizin Berlin, Berlin
    J Dtsch Dermatol Ges 8:s1-59. 2010
    ..For maintenance treatment: topical retinoid or its combination with BPO. Particular attention should be paid to compliance and quality of life. Additional treatment options are discussed in the main body of the text...
  55. ncbi Pathogenesis of Adamantiades-Behçet's disease
    Christos C Zouboulis
    Department of Dermatology, University Medical Center Benjamin Franklin, The Free University of Berlin, Germany
    Med Microbiol Immunol 192:149-55. 2003
    ..Endothelial activation leading to a chronic local inflammation process together with platelet and serum factors enhance coagulation and thrombosis...
  56. ncbi Univariate and multivariate analyses comparing demographic, genetic, clinical, and serological risk factors for severe Adamantiades-Behçet's disease
    Christos C Zouboulis
    Department of Dermatology, University Medical Center Benjamin Franklin, The Free University of Berlin, Berlin, Germany
    Adv Exp Med Biol 528:123-6. 2003
  57. ncbi Corticotropin-releasing hormone: an autocrine hormone that promotes lipogenesis in human sebocytes
    Christos C Zouboulis
    Department of Dermatology, University Medical Center Benjamin Franklin, The Free University of Berlin, 14195 Berlin, Germany
    Proc Natl Acad Sci U S A 99:7148-53. 2002
    ..The findings implicate CRH in the clinical development of acne, seborrhea, androgenetic alopecia, skin aging, xerosis, and other skin disorders associated with alterations in lipid formation of sebaceous origin...
  58. ncbi Chronological ageing and photoageing of the human sebaceous gland
    C C Zouboulis
    Department of Dermatology, University Medical Center Benjamin Franklin, The Free University of Berlin, Berlin, Germany
    Clin Exp Dermatol 26:600-7. 2001
    ..Topical and systemic oestrogens offer treatment options for skin xerosis in menopausal females. A combination of isotretinoin and interferon-alpha may prevent tumour development in patients with Muir-Torre syndrome...
  59. ncbi Corticotropin-releasing hormone skin signaling is receptor-mediated and is predominant in the sebaceous glands
    K Krause
    Department of Dermatology, Charite Universitaetsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    Horm Metab Res 39:166-70. 2007
    ..However, further investigations into the downstream effects of CRH and Uct are required to elucidate the mechanism by which these neuropeptides could establish a stress-related pathophysiological condition in the skin...
  60. ncbi The human sebocyte culture model provides new insights into development and management of seborrhoea and acne
    C C Zouboulis
    Department of Dermatology, University Medical Center Benjamin Franklin, Free University of Berlin, Germany
    Dermatology 196:21-31. 1998
    ....
  61. ncbi Sebocytes are the key regulators of androgen homeostasis in human skin
    M Fritsch
    Department of Dermatology, University Medical Center Benjamin Franklin, The Free University of Berlin, Berlin, Germany
    J Invest Dermatol 116:793-800. 2001
    ..Sebocytes are able to synthesize testosterone from adrenal precursors and to inactivate it in order to maintain androgen homeostasis, whereas keratinocytes are responsible for androgen degradation...
  62. ncbi Non-infectious ulcerating oral mucous membrane diseases
    Andreas Altenburg
    Department of Dermatology, Venerology and Allergology Immunological Center, Dessau Medical Center, Germany
    J Dtsch Dermatol Ges 7:242-57. 2009
    ....
  63. ncbi Acrodermatitis enteropathica: an uncommon differential diagnosis in childhood - first description of a new sequence variant
    Anja G Jung
    Department of Dermatology, Dessau Hospital, Dessau, Germany
    J Dtsch Dermatol Ges 9:999-1002. 2011
    ..Lifelong zinc substitution is recommended. A differential diagnosis can be difficult because bacterial and fungal superinfection is common in zinc deficiency. Precise diagnosis requires testing family members for the gene...
  64. ncbi Current developments and uses of cryosurgery in the treatment of keloids and hypertrophic scars
    Christos C Zouboulis
    Department of Dermatology, University Medical Center Benjamin Franklin, The Free University of Berlin, Berlin, Germany
    Wound Repair Regen 10:98-102. 2002
  65. ncbi [Severe erythrodermic psoriasis in a patient with 22q11 deletion syndrome]
    Jan C Preiss
    Medizinische Klinik I (Gastroenterologie, Infektiologie, Rheumatologie, , Campus Benjamin Franklin, Berlin
    Med Klin (Munich) 100:275-8. 2005
    ..This case report suggests that calcium can be involved in psoriasis pathogenesis at least in a subgroup of patients and that systemic retinoids exhibit insufficient effectiveness under low serum albumin levels...
  66. ncbi Isotretinoin: state of the art treatment for acne vulgaris
    Ruta Ganceviciene
    Department of Dermatology, Dessau Medical Center, Dessau, Germany
    J Dtsch Dermatol Ges 8:S47-59. 2010
    ....
  67. ncbi Medium-dose prednisolone pulse therapy in alopecia areata
    Pinelopi Efentaki
    Departments of Dermatology, Venereology, Allergology and Immunology Dessau Medical Center Dessau, Germany
    Dermatoendocrinol 1:310-3. 2009
    ..Although the exact etiology of alopecia areata is still unknown, systemic prednisolone treatment seem to be effective in early stages but significant side effects may occur leading to discontinuation of treatment...
  68. ncbi The William J. Cunliffe Scientific Awards
    Christos C Zouboulis
    Department of Dermatology, , Germany
    Dermatology 211:191-2. 2005
  69. ncbi Sebaceous glands and the prostaglandin pathway--key stones of an exciting mosaic
    Christos C Zouboulis
    Department of Dermatology, , Campus Benjamin Franklin, Berlin, Germany
    J Invest Dermatol 125:x-xi. 2005
  70. ncbi A historical review of early descriptions of Adamantiades-Behçet's disease
    Christos C Zouboulis
    Department of Dermatology, University Medical Center Benjamin Franklin, The Free University of Berlin, Fabeckstrasse 60-62, 14195 Berlin, Germany
    J Invest Dermatol 119:201-5. 2002
  71. ncbi Responsiveness to androgens and effectiveness of antisense oligonucleotides against the androgen receptor on human epidermal keratinocytes is dependent on the age of the donor and the location of cell origin
    S Fimmel
    Laboratory of Biogerontology, Dermato Pharmacology and Dermato Endocrinology, Institute of Clinical Pharmacology and Toxicology, Campus Benjamin Franklin, Charite Universitaetsmedizin Berlin, Berlin, Germany
    Horm Metab Res 39:157-65. 2007
    ..Our results demonstrate an enhanced androgen sensitivity of keratinocytes from aged individuals associated with an origin-specific type of response...
  72. ncbi Impressive skin manifestation of systemic sarcoidosis
    A M H A Janitha P Chandani
    Department of Dermatology, University Medical Center Benjamin Franklin, The Free University of Berlin, Fabeckstrasse 60-62, 14195 Berlin, Germany
    Int J Dermatol 41:232-6. 2002
  73. ncbi Clindamycin phosphate/tretinoin gel formulation in the treatment of acne vulgaris
    M Badawy Abdel-Naser
    Dessau Medical Center, Departments of Dermatology, Venereology, Allergology and Immunology, Auenweg 38, 06847 Dessau, Germany
    Expert Opin Pharmacother 9:2931-7. 2008
    ..The once daily use of CTG, its rapid and dual effect and good tolerability have a positive impact on the duration of disease, patients' compliance and overall costs of therapy...
  74. ncbi Ulerythema ophryogenes and keratosis pilaris in a child with monosomy 18p
    C C Zouboulis
    Department of Dermatology, University Medical Center Steglitz, Germany
    Pediatr Dermatol 11:172-5. 1994
    ..The association of chromosome 18p deletion defect and ulerythema ophryogenes may be helpful in future attempts to localize the gene defect responsible for follicular genokeratoses...
  75. ncbi Molecular mechanisms of skin aging: state of the art
    E Makrantonaki
    Laboratory for Biogerontology, Dermato Pharmacology and Dermato Endocrinology, Institute Clinical Pharmacology and Toxiology, Berlin, Berlin, Germany
    Ann N Y Acad Sci 1119:40-50. 2007
    ..Understanding the molecular mechanisms of aging may open new strategies in dealing with the various diseases accompanying aging, including cancer...
  76. ncbi Exploration of retinoid activity and the role of inflammation in acne: issues affecting future directions for acne therapy
    C C Zouboulis
    Department of Dermatology, University Medical Center Benjamin Franklin, The Free University of Berlin, Germany
    J Eur Acad Dermatol Venereol 15:63-7. 2001
    ..Therefore, future compounds targeting acne have to inhibit pro-inflammatory lipids in sebum, and thus down-regulate acne-related inflammatory signals and reduce the LTB4-induced migration of inflammatory cells...
  77. ncbi Influence of physiological androgen levels on wound healing and immune status in men
    S Fimmel
    Department of Dermatology, , Berlin, Germany
    Aging Male 8:166-74. 2005
    ....
  78. ncbi Retinoids--which dermatological indications will benefit in the near future?
    C C Zouboulis
    Department of Dermatology, University Medical Center Benjamin Franklin, The Free University of Berlin, Berlin, Germany
    Skin Pharmacol Appl Skin Physiol 14:303-15. 2001
    ....
  79. ncbi Testosterone metabolism to 5alpha-dihydrotestosterone and synthesis of sebaceous lipids is regulated by the peroxisome proliferator-activated receptor ligand linoleic acid in human sebocytes
    E Makrantonaki
    Laboratory of Biogerontology, Dermatopharmacology and Dermatoendocrinology, Institute of Clinical Pharmacology and Toxicology, Charite University Medicine Berlin, Berlin, Germany
    Br J Dermatol 156:428-32. 2007
    ..This contradiction led to the assumption that cofactors may be required for lipid regulation and peroxisome proliferator-activated receptor (PPAR) ligands were suggested to be adequate candidates...
  80. ncbi Establishment and characterization of an immortalized human sebaceous gland cell line (SZ95)
    C C Zouboulis
    Department of Dermatology, University Medical Center Benjamin Franklin, The Free University of Berlin, Germany
    J Invest Dermatol 113:1011-20. 1999
    ..Thus SZ95 is an immortalized human sebaceous gland cell line that shows the morphologic, phenotypic and functional characteristics of normal human sebocytes...
  81. ncbi Effect of 5alpha-dihydrotestosterone and testosterone on apoptosis in human dermal papilla cells
    A Winiarska
    Department of Dermatology and Allergy, , Berlin, Germany
    Skin Pharmacol Physiol 19:311-21. 2006
    ..These data suggest that DPC from nonbalding scalp regions do have the capacity to undergo apoptosis, but need a high androgen stimulus. The present study provides an interesting new pathogenetic approach in androgenetic alopecia...
  82. ncbi Human skin: an independent peripheral endocrine organ
    C C Zouboulis
    Department of Dermatology, University Medical Center Benjamin Franklin, The Free University of Berlin, Berlin, Germany
    Horm Res 54:230-42. 2000
    ..Therefore, the human skin fulfils all requirements for being the largest, independent peripheral endocrine organ...
  83. ncbi All-trans-retinoic acid and 13-cis-retinoic acid: pharmacokinetics and biological activity in different cell culture models of human keratinocytes
    M Schroeder
    Department of Dermatology, Charite Universitaetsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    Horm Metab Res 39:136-40. 2007
    ..On the other hand, induced keratinocyte proliferation in low seeding densities may provide an explanation for the acanthosis induced by topical retinoids in aged and steroid-damaged skin...
  84. ncbi Cryosurgery in dermatology
    C C Zouboulis
    Department of Dermatology, University Medical Center Benjamin Franklin, The Free University of Berlin, Hindenburgdamm 30, D 12 200, Berlin, Germany
    Eur J Dermatol 8:466-74. 1998
    ..Pain during and/or shortly after treatment, bulla formation and local oedema are the major, temporary adverse effects; lesional hypopigmentation and/or peripheral hyperpigmentation is the most common by occurring long-term complication...
  85. ncbi Topical all-trans retinoic acid (RA) induces an early, coordinated increase in RA-inducible skin-specific gene/psoriasin and cellular RA-binding protein II mRNA levels which precedes skin erythema
    C C Zouboulis
    Department of Dermatology, University Medical Center, Benjamin Franklin, Free University of Berlin, Germany
    Arch Dermatol Res 288:664-9. 1996
    ..We conclude, therefore, that induction of RIS-1 and CRABP II mRNA levels by topical RA in human skin are early, coordinated molecular events which precede the clinical cutaneous erythematous response to RA...
  86. ncbi Possible role of DP IV inhibitors in acne therapy
    Anja Thielitz
    Department of Dermatology and Venereology, Otto-von-Guericke University, Leipziger Str. 44, D-39120 Magdeburg, Germany
    Adv Exp Med Biol 575:163-7. 2006
  87. ncbi Activation of platelet-activating factor receptor in SZ95 sebocytes results in inflammatory cytokine and prostaglandin E2 production
    Qiwei Zhang
    Department of Dermatology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Exp Dermatol 15:769-74. 2006
    ..These studies suggest that SZ95 sebocytes express functional PAF-Rs and PAF-Rs are involved in regulating the expression of inflammatory mediators, including COX-2, PGE(2) and IL-8...
  88. ncbi [Malignant melanoma -- a medical students' viewpoint]
    Moritz Felcht
    Benjamin-Franklin-Kolleg, Fachbereich Humanmedizin, Berlin
    J Dtsch Dermatol Ges 3:421-30. 2005
    ..Thus early recognition is of utmost importance. Experimental approaches, such as dendritic cell vaccination, have shown some effectiveness which must be confirmed in multicenter, randomised trials...
  89. ncbi Investigation of micronized titanium dioxide penetration in human skin xenografts and its effect on cellular functions of human skin-derived cells
    Borbala Kiss
    Department of Dermatology, University of Debrecen, Medical and Health Science Center, Debrecen, Hungary
    Exp Dermatol 17:659-67. 2008
    ....
  90. ncbi Matrix metalloproteinases of epithelial origin in facial sebum of patients with acne and their regulation by isotretinoin
    Eleni Papakonstantinou
    Department of Pharmacology, School of Medicine, Aristotle University, Thessaloniki, Greece
    J Invest Dermatol 125:673-84. 2005
    ..These data indicate that MMP and TIMP of epithelial origin may be involved in acne pathogenesis, and that isotretinoin-induced reduction in MMP-9 and -13 may contribute to the therapeutic effects of the agent in acne...
  91. ncbi LXRalpha enhances lipid synthesis in SZ95 sebocytes
    Il Hong
    College of Pharmacy and Bio MAX Institute, Seoul National University, Seoul, Korea
    J Invest Dermatol 128:1266-72. 2008
    ..Thus, we suggest that LXR ligands could provide a new class of therapeutic agents for sebaceous gland-associated disorders such as seborrhea and acne...
  92. ncbi Inhibitors of dipeptidyl peptidase IV and aminopeptidase N target major pathogenetic steps in acne initiation
    Anja Thielitz
    Department of Dermatology and Venereology, Otto von Guericke University Magdeburg, Magdeburg, Germany
    J Invest Dermatol 127:1042-51. 2007
    ....
  93. ncbi Characterization of liver X receptor expression and function in human skin and the pilosebaceous unit
    Louise E Russell
    Centre for Cutaneous Research and Centre for Endocrinology, Bart s and the London Queen Mary s School of Medicine and Dentistry, Queen Mary College, University of London, London, UK
    Exp Dermatol 16:844-52. 2007
    ..In addition, we showed that the synthetic agonist TO901317 significantly reduced hair growth, in vitro...
  94. ncbi Peroxidated squalene induces the production of inflammatory mediators in HaCaT keratinocytes: a possible role in acne vulgaris
    Monica Ottaviani
    San Gallicano Dermatological Institute IRCCS, Rome, Italy
    J Invest Dermatol 126:2430-7. 2006
    ....
  95. ncbi The renal retinoid system: time-dependent activation in experimental glomerulonephritis
    Sabine Liebler
    Department of Nephrology, University Hospital, University of Heidelberg, Bergheimer Strasse 56a, D-69115 Heidelberg, Germany
    Am J Physiol Renal Physiol 286:F458-65. 2004
    ..Our data document a stimulation of glomerular retinoid-synthesizing enzymes and expression of retinoid receptors in the early repair phase of THY-GN, suggesting activation of this system in acute renal disease...
  96. ncbi Vitrectomy and trabeculectomy combined with interferon alpha treatment in Adamantiades-Behçet's disease: a case report
    Lothar Krause
    Department of Ophthalmology, Universitatsklinikum Benjamin Franklin, Freie Universitat Berlin, Hindenburgdamm 30, 12200 Berlin, Germany
    Graefes Arch Clin Exp Ophthalmol 241:871-4. 2003
    ..Left untreated, it leads to blindness and often to loss of the eye through secondary complications such as phthisis or painful glaucoma...
  97. ncbi Expression of peroxisome proliferator-activated receptor and CCAAT/enhancer binding protein transcription factors in cultured human sebocytes
    WenChieh Chen
    Department of Dermatology, College of Medicine, National Cheng Kung University, Sheng Li Road 138, 704 Tainan, Taiwan
    J Invest Dermatol 121:441-7. 2003
    ..Treatment with linoleic acid for 48 h induced further differentiation of sebocytes leading to abundant lipid synthesis...
  98. ncbi Cutaneous androgen metabolism: basic research and clinical perspectives
    WenChieh Chen
    Department of Dermatology, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    J Invest Dermatol 119:992-1007. 2002
    ..Pharmacologic development of more potent specific isoenzyme antagonists may lead to better clinical treatment or even prevention of androgen-dependent dermatoses...
  99. ncbi Identification of platelet-activating factor acetylhydrolase II in human skin
    Mariangela Marques
    Department of Dermatology, Indiana University School of Medicine, Indianapolis, Indiana 46202, U S A
    J Invest Dermatol 119:913-9. 2002
    ....
  100. ncbi Evidence for expression of melanocortin-1 receptor in human sebocytes in vitro and in situ
    Markus Bohm
    Department of Dermatology and Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, University of Munster, Munster, Germany
    J Invest Dermatol 118:533-9. 2002
    ..By modulating interleukin-8 secretion, alpha-melanocyte-stimulating hormone may act as a modulator of inflammatory responses in the pilosebaceous unit...