Jin Li Zhang

Summary

Country: Germany

Publications

  1. ncbi Human IL-21 and IL-4 bind to partially overlapping epitopes of common gamma-chain
    Jin Li Zhang
    Theodor Boveri Institut für Biowissenschaften, Biozentrum, Physiologische Chemie II, Universitat Wurzburg, Am Hubland, D 97074 Wurzburg, Germany
    Biochem Biophys Res Commun 300:291-6. 2003
  2. ncbi von Willebrand factor type C domain-containing proteins regulate bone morphogenetic protein signaling through different recognition mechanisms
    Jin Li Zhang
    Department of Physiological Chemistry II, Biocenter, University of Wuerzburg, Am Hubland, 97074 Wuerzburg, Germany
    J Biol Chem 282:20002-14. 2007
  3. ncbi Crystallization and preliminary X-ray analysis of the complex of the first von Willebrand type C domain bound to bone morphogenetic protein 2
    Li Yan Qiu
    Lehrstuhl für Physiologische Chemie II, Theodor Boveri Institut Biozentrum der Universität Würzburg, Am Hubland, D 97074 Wurzburg, Germany
    Acta Crystallogr Sect F Struct Biol Cryst Commun 64:307-12. 2008
  4. ncbi The high-affinity interaction of human IL-4 and the receptor alpha chain is constituted by two independent binding clusters
    Jin Li Zhang
    Department of Physiological Chemistry II, Biocenter, University of Wuerzburg, Am Hubland, 97074 Wuerzburg, Germany
    J Mol Biol 315:399-407. 2002
  5. ncbi Molecular recognition of BMP-2 and BMP receptor IA
    Sascha Keller
    Lehrstuhl für Physiologische Chemie II, Theodor Boveri Institut für Biowissenschaften Biozentrum, Universitat Wurzburg, Am Hubland, D 97074 Wuerzburg, Germany
    Nat Struct Mol Biol 11:481-8. 2004
  6. ncbi Crystal structure analysis reveals how the Chordin family member crossveinless 2 blocks BMP-2 receptor binding
    Jin Li Zhang
    Department of Physiological Chemistry II, Biocenter, University of Wuerzburg, Am Hubland, 97074 Wuerzburg, Germany
    Dev Cell 14:739-50. 2008
  7. ncbi The binding of von Willebrand factor type C domains of Chordin family proteins to BMP-2 and Tsg is mediated by their SD1 subdomain
    Takuo Fujisawa
    Department of Physiological Chemistry II, University of Wuerzburg, Am Hubland, Wuerzburg, Germany
    Biochem Biophys Res Commun 385:215-9. 2009
  8. ncbi Structure, binding, and antagonists in the IL-4/IL-13 receptor system
    Thomas D Mueller
    Physiological Chemistry II, Biocenter, University of Wuerzburg, Am Hubland, Germany
    Biochim Biophys Acta 1592:237-50. 2002
  9. ncbi Molecular recognition in bone morphogenetic protein (BMP)/receptor interaction
    Walter Sebald
    Physiologische Chemie II, Theodor Boveri Institut für Biowissenschaften Biozentrum der Universität Würzburg, D 97074 Wurzburg, Germany
    Biol Chem 385:697-710. 2004
  10. ncbi Molecular basis of cytokine signalling--theme and variations
    Walter Sebald
    Department of Physiological Chemistry II, Theodor Boveri Institute for Life Sciences Biocenter, University of Wuerzburg, 97074 Wuerzburg, Germany
    FEBS J 277:106-18. 2010

Collaborators

Detail Information

Publications12

  1. ncbi Human IL-21 and IL-4 bind to partially overlapping epitopes of common gamma-chain
    Jin Li Zhang
    Theodor Boveri Institut für Biowissenschaften, Biozentrum, Physiologische Chemie II, Universitat Wurzburg, Am Hubland, D 97074 Wurzburg, Germany
    Biochem Biophys Res Commun 300:291-6. 2003
    ..These results open the way to understand the molecular recognition mechanism in the IL-21 receptor system and also the promiscuous binding properties of gamma(c)...
  2. ncbi von Willebrand factor type C domain-containing proteins regulate bone morphogenetic protein signaling through different recognition mechanisms
    Jin Li Zhang
    Department of Physiological Chemistry II, Biocenter, University of Wuerzburg, Am Hubland, 97074 Wuerzburg, Germany
    J Biol Chem 282:20002-14. 2007
    ..The VWCs of CV2, however, do not interact with Tsg. The present results show that chordin, CHL2, and CV2 regulate BMP-2 signaling by different recognition mechanisms...
  3. ncbi Crystallization and preliminary X-ray analysis of the complex of the first von Willebrand type C domain bound to bone morphogenetic protein 2
    Li Yan Qiu
    Lehrstuhl für Physiologische Chemie II, Theodor Boveri Institut Biozentrum der Universität Würzburg, Am Hubland, D 97074 Wurzburg, Germany
    Acta Crystallogr Sect F Struct Biol Cryst Commun 64:307-12. 2008
    ..7, c = 139.2 A and a = b = 83.7, c = 139.6 A, respectively. Initial analysis suggests that a complete binary complex consisting of one BMP2 dimer bound to two CV2 VWC1 domains is present in the asymmetric unit...
  4. ncbi The high-affinity interaction of human IL-4 and the receptor alpha chain is constituted by two independent binding clusters
    Jin Li Zhang
    Department of Physiological Chemistry II, Biocenter, University of Wuerzburg, Am Hubland, 97074 Wuerzburg, Germany
    J Mol Biol 315:399-407. 2002
    ..These results show that the high-affinity IL-4/IL4-BP contact is constituted by two independent binding units, each containing a central polar or charged side-chain surrounded by hydrophobic groups (avocado cluster)...
  5. ncbi Molecular recognition of BMP-2 and BMP receptor IA
    Sascha Keller
    Lehrstuhl für Physiologische Chemie II, Theodor Boveri Institut für Biowissenschaften Biozentrum, Universitat Wurzburg, Am Hubland, D 97074 Wuerzburg, Germany
    Nat Struct Mol Biol 11:481-8. 2004
    ..Thus, the L51P substitution converts BMP-2 into a receptor-inactive inhibitor of noggin. These results are relevant for other proteins of the TGF-beta superfamily and provide useful clues for structure-based drug design...
  6. ncbi Crystal structure analysis reveals how the Chordin family member crossveinless 2 blocks BMP-2 receptor binding
    Jin Li Zhang
    Department of Physiological Chemistry II, Biocenter, University of Wuerzburg, Am Hubland, 97074 Wuerzburg, Germany
    Dev Cell 14:739-50. 2008
    ..In vivo experiments reveal that the BMP-enhancing (pro-BMP) activity of CV-2 is independent of BMP-2 binding by VWC1, showing that pro- and anti-BMP activities are structurally separated in CV-2...
  7. ncbi The binding of von Willebrand factor type C domains of Chordin family proteins to BMP-2 and Tsg is mediated by their SD1 subdomain
    Takuo Fujisawa
    Department of Physiological Chemistry II, University of Wuerzburg, Am Hubland, Wuerzburg, Germany
    Biochem Biophys Res Commun 385:215-9. 2009
    ..These results together provide strong evidence that the SD1 subdomain module of about 40 residues represents the crucial binding partner for BMPs and Tsg in these Chordin family proteins and likely in other BMP-binding VWC domains also...
  8. ncbi Structure, binding, and antagonists in the IL-4/IL-13 receptor system
    Thomas D Mueller
    Physiological Chemistry II, Biocenter, University of Wuerzburg, Am Hubland, Germany
    Biochim Biophys Acta 1592:237-50. 2002
    ..Based on these new data, the hitherto elusive goal of designing small molecular mimetics may be feasible...
  9. ncbi Molecular recognition in bone morphogenetic protein (BMP)/receptor interaction
    Walter Sebald
    Physiologische Chemie II, Theodor Boveri Institut für Biowissenschaften Biozentrum der Universität Würzburg, D 97074 Wurzburg, Germany
    Biol Chem 385:697-710. 2004
    ..BMP muteins with disrupted epitopes for receptor chains or modulator proteins provide clues for drug design and development...
  10. ncbi Molecular basis of cytokine signalling--theme and variations
    Walter Sebald
    Department of Physiological Chemistry II, Theodor Boveri Institute for Life Sciences Biocenter, University of Wuerzburg, 97074 Wuerzburg, Germany
    FEBS J 277:106-18. 2010
    ..Possible indications exist in the areas of haematology, immunology, inflammation, cancer and tissue regeneration...
  11. ncbi Functional epitope of common gamma chain for interleukin-4 binding
    Jin-Li Zhang
    , Physiologische Chemie II, , Germany
    Eur J Biochem 269:1490-9. 2002
    ..These results provide a basis for elucidating the molecular recognition mechanism in the IL-4 receptor system and a paradigm for other gamma(c)-dependent cytokine receptor systems...
  12. ncbi Interactions of daidzin with intramolecular G-quadruplex
    Wei Li
    Department of Chemical Technology, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China
    FEBS Lett 580:4905-10. 2006
    ..This work provides guidance not only on exploring the molecular anti-cancer mechanism of dietary isoflavones, but also searching small natural products as promising anticancer candidates that can inhibit telomerase activity...