Grit Zahn

Summary

Country: Germany

Publications

  1. ncbi Preclinical evaluation of the novel small-molecule integrin alpha5beta1 inhibitor JSM6427 in monkey and rabbit models of choroidal neovascularization
    Grit Zahn
    Jerini AG, Invalidenstrasse 130, 10115 Berlin, Germany
    Arch Ophthalmol 127:1329-35. 2009
  2. ncbi Assessment of the integrin alpha5beta1 antagonist JSM6427 in proliferative vitreoretinopathy using in vitro assays and a rabbit model of retinal detachment
    Grit Zahn
    Jerini AG, Berlin, Germany
    Invest Ophthalmol Vis Sci 51:1028-35. 2010
  3. ncbi SAR of N-phenyl piperidine based oral integrin alpha5beta1 antagonists
    Gunther Zischinsky
    Jerini AG, Invalidenstrasse 130, Berlin D 10115, Germany
    Bioorg Med Chem Lett 20:65-8. 2010
  4. ncbi Discovery of orally available integrin alpha5beta1 antagonists
    Gunther Zischinsky
    Jerini AG, Invalidenstrasse 130, Berlin D 10115, Germany
    Bioorg Med Chem Lett 20:380-2. 2010
  5. ncbi Design and synthesis of a new class of selective integrin alpha5beta1 antagonists
    Roland Stragies
    Jerini AG, Invalidenstrasse 130, D 10115 Berlin, Germany
    J Med Chem 50:3786-94. 2007

Collaborators

Detail Information

Publications5

  1. ncbi Preclinical evaluation of the novel small-molecule integrin alpha5beta1 inhibitor JSM6427 in monkey and rabbit models of choroidal neovascularization
    Grit Zahn
    Jerini AG, Invalidenstrasse 130, 10115 Berlin, Germany
    Arch Ophthalmol 127:1329-35. 2009
    ..To evaluate the pharmacologic activity and tolerability of JSM6427, a potent and first selective small-molecule inhibitor of integrin alpha5beta1, in monkey and rabbit models of choroidal neovascularization (CNV)...
  2. ncbi Assessment of the integrin alpha5beta1 antagonist JSM6427 in proliferative vitreoretinopathy using in vitro assays and a rabbit model of retinal detachment
    Grit Zahn
    Jerini AG, Berlin, Germany
    Invest Ophthalmol Vis Sci 51:1028-35. 2010
    ....
  3. ncbi SAR of N-phenyl piperidine based oral integrin alpha5beta1 antagonists
    Gunther Zischinsky
    Jerini AG, Invalidenstrasse 130, Berlin D 10115, Germany
    Bioorg Med Chem Lett 20:65-8. 2010
    ..Recently, a new class of selective integrin alpha5beta1inhibitors consisting of a heterocyclic based scaffold was published. Herein the SAR and pharmacokinetic profiles of N-phenyl piperidine derivatives are described...
  4. ncbi Discovery of orally available integrin alpha5beta1 antagonists
    Gunther Zischinsky
    Jerini AG, Invalidenstrasse 130, Berlin D 10115, Germany
    Bioorg Med Chem Lett 20:380-2. 2010
    ..Herein the discovery of new orally available integrin alpha5beta1 inhibitor scaffolds for potential systemic treatment is described...
  5. ncbi Design and synthesis of a new class of selective integrin alpha5beta1 antagonists
    Roland Stragies
    Jerini AG, Invalidenstrasse 130, D 10115 Berlin, Germany
    J Med Chem 50:3786-94. 2007
    ..On the basis of the encouraging results from various in vitro studies, the most active compounds were selected for further in vivo studies in animal models and preclinical development...