Heinz Wiendl

Summary

Country: Germany

Publications

  1. ncbi Two pore domain potassium channels in cerebral ischemia: a focus on K2P9.1 (TASK3, KCNK9)
    Petra Ehling
    University of Wuerzburg, Department of Neurology, Josef Schneider Str, 11, 97080 Wuerzburg, Germany
    Exp Transl Stroke Med 2:14. 2010
  2. ncbi Safety and clinical outcomes of rituximab therapy in patients with different autoimmune diseases: experience from a national registry (GRAID)
    Hans Peter Tony
    Medizinische Klinik und Poliklinik II, Universitatsklinikum Wurzburg, Klinikstr 6 8, 97070 Wurzburg, Germany
    Arthritis Res Ther 13:R75. 2011
  3. ncbi HLA-G in the nervous system
    Heinz Wiendl
    Department of Neurology, Bayerische Julius Maximilians Universität Würzburg, Wurzburg, Germany
    Hum Immunol 68:286-93. 2007
  4. ncbi Multiple sclerosis therapeutics: unexpected outcomes clouding undisputed successes
    Heinz Wiendl
    Department of Neurology, Julius Maximilians University Würzburg, Wurzburg, Germany
    Neurology 72:1008-15. 2009
  5. ncbi Immunobiology of muscle: advances in understanding an immunological microenvironment
    Heinz Wiendl
    Department of Neurology, Julius Maximilians University, Josef Schneider Strasse 11, D 97080 Wuerzburg, Germany
    Trends Immunol 26:373-80. 2005
  6. ncbi Idiopathic inflammatory myopathies: current and future therapeutic options
    Heinz Wiendl
    Department of Neurology, University of Wuerzburg, Wuerzburg, Germany
    Neurotherapeutics 5:548-57. 2008
  7. ncbi Expression of the immune-tolerogenic major histocompatibility molecule HLA-G in multiple sclerosis: implications for CNS immunity
    Heinz Wiendl
    Department of General Neurology, Hertie Institute for Clinical Brain Research, University of Tubingen, Tubingen, Germany
    Brain 128:2689-704. 2005
  8. ncbi Muscle-derived positive and negative regulators of the immune response
    Heinz Wiendl
    Department of Neurology, Julius Maximilians University of Wuerzburg, Wuerzburg, Germany
    Curr Opin Rheumatol 17:714-9. 2005
  9. ncbi Basic and escalating immunomodulatory treatments in multiple sclerosis: current therapeutic recommendations
    H Wiendl
    Department of Neurology and Clinical Research, Unit for MS and Neuroimmunology, University of Wurzburg, Wurzburg, Germany
    J Neurol 255:1449-63. 2008
  10. ncbi Interferon-beta enhances monocyte and dendritic cell expression of B7-H1 (PD-L1), a strong inhibitor of autologous T-cell activation: relevance for the immune modulatory effect in multiple sclerosis
    Bettina Schreiner
    Department of General Neurology, Hertie Institute for Clinical Brain Research, University of Tubingen, Hoppe Seyler Strasse 3, 72076 Tubingen, Germany
    J Neuroimmunol 155:172-82. 2004

Detail Information

Publications94

  1. ncbi Two pore domain potassium channels in cerebral ischemia: a focus on K2P9.1 (TASK3, KCNK9)
    Petra Ehling
    University of Wuerzburg, Department of Neurology, Josef Schneider Str, 11, 97080 Wuerzburg, Germany
    Exp Transl Stroke Med 2:14. 2010
    ..K2P3.1-/- animals showed larger infarct volumes and a worse functional outcome following experimentally induced ischemic stroke. Here, we question the role of the closely related K2P channel K2P9.1...
  2. ncbi Safety and clinical outcomes of rituximab therapy in patients with different autoimmune diseases: experience from a national registry (GRAID)
    Hans Peter Tony
    Medizinische Klinik und Poliklinik II, Universitatsklinikum Wurzburg, Klinikstr 6 8, 97070 Wurzburg, Germany
    Arthritis Res Ther 13:R75. 2011
    ....
  3. ncbi HLA-G in the nervous system
    Heinz Wiendl
    Department of Neurology, Bayerische Julius Maximilians Universität Würzburg, Wurzburg, Germany
    Hum Immunol 68:286-93. 2007
    ..These findings are relevant both from a pathogenetic as well as from a therapeutic viewpoint...
  4. ncbi Multiple sclerosis therapeutics: unexpected outcomes clouding undisputed successes
    Heinz Wiendl
    Department of Neurology, Julius Maximilians University Würzburg, Wurzburg, Germany
    Neurology 72:1008-15. 2009
    ....
  5. ncbi Immunobiology of muscle: advances in understanding an immunological microenvironment
    Heinz Wiendl
    Department of Neurology, Julius Maximilians University, Josef Schneider Strasse 11, D 97080 Wuerzburg, Germany
    Trends Immunol 26:373-80. 2005
    ....
  6. ncbi Idiopathic inflammatory myopathies: current and future therapeutic options
    Heinz Wiendl
    Department of Neurology, University of Wuerzburg, Wuerzburg, Germany
    Neurotherapeutics 5:548-57. 2008
    ..Possible future therapeutic options are presented and discussed...
  7. ncbi Expression of the immune-tolerogenic major histocompatibility molecule HLA-G in multiple sclerosis: implications for CNS immunity
    Heinz Wiendl
    Department of General Neurology, Hertie Institute for Clinical Brain Research, University of Tubingen, Tubingen, Germany
    Brain 128:2689-704. 2005
    ..This pathway may act as an inhibitory feedback aimed to downregulate the deleterious effects of T-cell infiltration in neuroinflammation...
  8. ncbi Muscle-derived positive and negative regulators of the immune response
    Heinz Wiendl
    Department of Neurology, Julius Maximilians University of Wuerzburg, Wuerzburg, Germany
    Curr Opin Rheumatol 17:714-9. 2005
    ....
  9. ncbi Basic and escalating immunomodulatory treatments in multiple sclerosis: current therapeutic recommendations
    H Wiendl
    Department of Neurology and Clinical Research, Unit for MS and Neuroimmunology, University of Wurzburg, Wurzburg, Germany
    J Neurol 255:1449-63. 2008
    ..The review also outlines a few areas of controversy and delineates the need for future research...
  10. ncbi Interferon-beta enhances monocyte and dendritic cell expression of B7-H1 (PD-L1), a strong inhibitor of autologous T-cell activation: relevance for the immune modulatory effect in multiple sclerosis
    Bettina Schreiner
    Department of General Neurology, Hertie Institute for Clinical Brain Research, University of Tubingen, Hoppe Seyler Strasse 3, 72076 Tubingen, Germany
    J Neuroimmunol 155:172-82. 2004
    ..IFN-beta up-regulates B7-H1 in vitro and in MS patients in vivo and might represent a novel mechanism how IFN-beta acts as a negative modulator on APC T-cell interactions in the periphery...
  11. ncbi B7-H1 restricts neuroantigen-specific T cell responses and confines inflammatory CNS damage: implications for the lesion pathogenesis of multiple sclerosis
    Sonja Ortler
    Clinical Research Group for Multiple Sclerosis and Neuroimmunology, Department of Neurology, University of Wurzburg, Wurzburg, Germany
    Eur J Immunol 38:1734-44. 2008
    ..Our findings demonstrate the critical importance of B7-H1 as an immune-inhibitory molecule capable of down-regulating T cell responses thus contributing to the confinement of immunopathological damage...
  12. ncbi Mouse Schwann cells activate MHC class I and II restricted T-cell responses, but require external peptide processing for MHC class II presentation
    Gerd Meyer zu Horste
    Department of Neurology, Heinrich Heine University, Dusseldorf, Germany
    Neurobiol Dis 37:483-90. 2010
    ..Thus, antigen presentation may be a pathological function of Schwann cells exacerbating nerve damage in inflammatory neuropathies...
  13. ncbi PD-1 regulates neural damage in oligodendroglia-induced inflammation
    Antje Kroner
    Department of Neurology, University of Wuerzburg, Wuerzburg, Germany
    PLoS ONE 4:e4405. 2009
    ..Our finding may have implications for understanding the mechanisms leading to the high clinical variability of polygenic or even monogenic disorders of the nervous system...
  14. ncbi Monocyte-derived HLA-G acts as a strong inhibitor of autologous CD4 T cell activation and is upregulated by interferon-beta in vitro and in vivo: rationale for the therapy of multiple sclerosis
    Meike Mitsdoerffer
    Department of Neurology, University of Tubingen, Hoppe Seyler Strasse 3, D 72076 Tubingen, Germany
    J Neuroimmunol 159:155-64. 2005
    ..We conclude that some desirable immune-modulatory effects of INF-beta might be accomplished via the upregulation of the immune-tolerogenic molecule HLA-G...
  15. ncbi The level of B7 homologue 1 expression on brain DC is decisive for CD8 Treg cell recruitment into the CNS during EAE
    Alla L Zozulya
    University of Wuerzburg, Department of Neurology, Wuerzburg, Germany
    Eur J Immunol 39:1536-43. 2009
    ..The recruitment of regulatory-type CD8(+) T cells into the CNS and the role of brain DC expressing B7-homologue 1 molecules in this process open up the possibility of DC-targeted therapeutic manipulation of neuroinflammatory diseases...
  16. ncbi Human muscle cells express a B7-related molecule, B7-H1, with strong negative immune regulatory potential: a novel mechanism of counterbalancing the immune attack in idiopathic inflammatory myopathies
    Heinz Wiendl
    Department of Neurology, University of Tubingen, Medical School, D 72076 Tubingen, Germany
    FASEB J 17:1892-4. 2003
    ..These data highlight the immune regulatory properties of muscle cells and suggest that B7-H1 expression represents an inhibitory mechanism induced upon inflammatory stimuli and aimed at protecting muscle fibers from immune aggression...
  17. ncbi Altered neuronal expression of TASK1 and TASK3 potassium channels in rodent and human autoimmune CNS inflammation
    Sven G Meuth
    Department of Neurology, University of Wurzburg, Josef Schneider Strafe 11, 97080 Wurzburg, Germany
    Neurosci Lett 446:133-8. 2008
    ..Thus, regulated expression of TASK channels might contribute to a molecular switch between death and survival of neurons in autoimmune CNS inflammation...
  18. ncbi TASK1 modulates inflammation and neurodegeneration in autoimmune inflammation of the central nervous system
    Stefan Bittner
    University of Wuerzburg, Department of Neurology, Josef Schneider Str 11, 97080 Wuerzburg, Germany
    Brain 132:2501-16. 2009
    ..These data support the identification and characterization of TASK1 as potential molecular target for the therapy of inflammatory and degenerative central nervous system disorders...
  19. ncbi Expression of the B7-related molecule B7-H1 by glioma cells: a potential mechanism of immune paralysis
    Sabine Wintterle
    Department of Neurology, Medical School, , Hoppe-Seyler-Strasse 3, , Germany
    Cancer Res 63:7462-7. 2003
    ..B7-H1 expression may thus significantly influence the outcome of T-cell tumor cell interactions and represents a novel mechanism by which glioma cells evade immune recognition and destruction...
  20. ncbi Human myoblasts modulate the function of antigen-presenting cells
    Nicholas Schwab
    Department of Neurology, University of Wuerzburg, Germany
    J Neuroimmunol 200:62-70. 2008
    ..MB-lysates strongly stimulated MPh phagocytosis. Hypothetically, MB might modulate APC, counterbalancing immune-mediated damage...
  21. ncbi Upregulation of K2P5.1 potassium channels in multiple sclerosis
    Stefan Bittner
    Department of Neurology, University of Wurzburg, Wurzburg, Munster, Germany
    Ann Neurol 68:58-69. 2010
    ..1 (KCNK5; TASK2), a member of the 2-pore domain family of potassium channels, on T-cell function and demonstrate its putative relevance in a T-cell-mediated autoimmune disorder, multiple sclerosis (MS)...
  22. ncbi Human muscle cells express the costimulatory molecule B7-H3, which modulates muscle-immune interactions
    Anne Waschbisch
    University of Wuerzburg, Wuerzburg, Germany, and University of Erlangen, Erlangen, Germany
    Arthritis Rheum 58:3600-8. 2008
    ..The present study was undertaken to examine the expression and functional relevance of B7 homolog 3 (B7-H3), a novel B7 homolog attributed significant immunoregulatory functions, in human muscle cells in vivo and in vitro...
  23. ncbi Collateral neuronal apoptosis in CNS gray matter during an oligodendrocyte-directed CD8(+) T cell attack
    Kerstin Göbel
    Department of Neurology, University of Wurzburg, Germany
    Glia 58:469-80. 2010
    ..Collateral neuronal apoptosis could contribute to substantial neuronal loss in gray matter lesions and cause persistent neurological impairment in both acute and chronic gray matter lesions in various inflammatory CNS disorders...
  24. ncbi Cytotoxic CD8+ T cell-neuron interactions: perforin-dependent electrical silencing precedes but is not causally linked to neuronal cell death
    Sven G Meuth
    Department of Neurology, University of Wurzburg, D 97070 Wurzburg, Germany
    J Neurosci 29:15397-409. 2009
    ..Thus, electrical silencing is an immediate consequence of MHC I-restricted interaction of CD8(+) T cells with neurons. This mechanism is clearly perforin-dependent and precedes, but is not causally linked, to neuronal cell death...
  25. ncbi Deficiency of the negative immune regulator B7-H1 enhances inflammation and neuropathic pain after chronic constriction injury of mouse sciatic nerve
    Nurcan Uceyler
    Department of Neurology, University of Wurzburg, Josef Schneider Str 11, 97080 Wurzburg, Germany
    Exp Neurol 222:153-60. 2010
    ..Interestingly, mechanical hyperalgesia was more pronounced in the absence of B7-H1. Our study identifies B7-H1 as an important suppressor of the inflammatory response and neuropathic pain occurring after peripheral nerve injury...
  26. ncbi The co-inhibitory molecule PD-1 modulates disease severity in a model for an inherited, demyelinating neuropathy
    Antje Kroner
    Department of Neurology, University of Wuerzburg, Wuerzburg
    Neurobiol Dis 33:96-103. 2009
    ....
  27. ncbi Antigen-specific blockade of lethal CD8 T-cell mediated autoimmunity in a mouse model of multiple sclerosis
    Shin Young Na
    Institute for Virology and Immunobiology, University of Wurzburg, Wurzburg, Germany
    J Immunol 182:6569-75. 2009
    ..Mechanistic studies performed in vitro and in vivo indicate that it is the low expression of MHC class I on oligodendrocytes, which makes this form of Ag-specific intervention possible...
  28. ncbi Multiple sclerosis: Mitoxantrone promotes differential effects on immunocompetent cells in vitro
    Oliver Neuhaus
    Department of Neurology, Heinrich Heine Universitat, Moorenstr 5, 40225 Dusseldorf, Germany
    J Neuroimmunol 168:128-37. 2005
    ....
  29. ncbi HLA-G expression defines a novel regulatory T-cell subset present in human peripheral blood and sites of inflammation
    Ute Feger
    Department of General Neurology, Hertie Institute for Clinical Brain Research, Eberhard Karls University Tuebingen, Tuebingen, Germany
    Blood 110:568-77. 2007
    ....
  30. ncbi Lack of evidence for a pathogenic role of T-lymphocytes in an animal model for Charcot-Marie-Tooth disease 1A
    Bianca Kohl
    Department of Neurology, Section of Developmental Neurobiology, University of Wuerzburg, Josef Schneider Strasse 11, D 97080 Wuerzburg, Germany
    Neurobiol Dis 38:78-84. 2010
    ..We suggest that - in contrast to myelin phagocytosing macrophages - T-lymphocytes are not a promising target for treatment of CMT1A...
  31. ncbi Early detrimental T-cell effects in experimental cerebral ischemia are neither related to adaptive immunity nor thrombus formation
    Christoph Kleinschnitz
    Department of Neurology, University of Wuerzburg, D 97080 Wuerzburg, Germany
    Blood 115:3835-42. 2010
    ..Our data demonstrate that T cells critically contribute to cerebral ischemia, but their detrimental effect neither depends on antigen recognition nor TCR costimulation or thrombus formation...
  32. ncbi Intracerebral dendritic cells critically modulate encephalitogenic versus regulatory immune responses in the CNS
    Alla L Zozulya
    Department of Neurology, University of Wurzburg, 97080 Wurzburg, Germany
    J Neurosci 29:140-52. 2009
    ..Our findings suggest that DCs are a rate-limiting factor for neuroinflammation...
  33. ncbi Intercellular exchanges of membrane fragments (trogocytosis) between human muscle cells and immune cells: a potential mechanism for the modulation of muscular immune responses
    Anne Waschbisch
    Clinical Research Group for Multiple Sclerosis and Neuroimmunology, Department of Neurology, University of Wuerzburg, Wuerzburg, Germany
    J Neuroimmunol 209:131-8. 2009
    ..Our observations raise the hypothesis that trogocytosis may modulate the outcome of T-T interactions within the micromilieu of skeletal muscle...
  34. ncbi CNS inflammation and neuronal degeneration is aggravated by impaired CD200-CD200R-mediated macrophage silencing
    Sven G Meuth
    University of Wuerzburg, Department of Neurology, Josef Schneider Strasse 11, 97080 Wuerzburg, Germany
    J Neuroimmunol 194:62-9. 2008
    ..CD200 and its receptor could also be detected on neurons and macrophages in human MS plaques. Therefore the CD200-CD200R pathway seems of critical relevance for macrophage-mediated damage in autoimmune inflammation of the CNS...
  35. ncbi B7-H1-deficiency enhances the potential of tolerogenic dendritic cells by activating CD1d-restricted type II NKT cells
    Carolin Brandl
    Institute of Virology and Immunobiology, University of Wuerzburg, Wuerzburg, Germany
    PLoS ONE 5:e10800. 2010
    ..Dendritic cells (DC) can act tolerogenic at a semi-mature stage by induction of protective CD4(+) T cell and NKT cell responses...
  36. ncbi Blockade of the kinin receptor B1 protects from autoimmune CNS disease by reducing leukocyte trafficking
    Kerstin Göbel
    Department of Neurology, University of Wuerzburg, Josef Schneider Strasse 11, 97080 Wuerzburg, Germany
    J Autoimmun 36:106-14. 2011
    ..In contrast, blocking B2R had no significant impact on EAE. We conclude that B1R inhibition can reduce BBB damage and cell invasion during autoimmune CNS disease and may offer a novel anti-inflammatory strategy for the treatment of MS...
  37. ncbi Accelerated course of experimental autoimmune encephalomyelitis in PD-1-deficient central nervous system myelin mutants
    Antje Kroner
    Clinical Research Group for MS and Neuroimmunology, Department of Neurology, University of Wuerzburg, Josef Schneider Strasse 11, 97080 Wuerzburg, Germany
    Am J Pathol 174:2290-9. 2009
    ....
  38. ncbi Expression of the B7-related molecule ICOSL by human glioma cells in vitro and in vivo
    Bettina Schreiner
    Department of Neurology, University of Tubingen, Medical School, Tubingen, Germany
    Glia 44:296-301. 2003
    ..However, ICOSL gene transfer into glioma cells does not alter their immunogenicity under primary or secondary alloreactive coculture assays...
  39. ncbi The CD28 related molecule ICOS: T cell modulation in the presence and absence of B7.1/2 and regulational expression in multiple sclerosis
    Heinz Wiendl
    Department of Neurology, University of Tubingen, Hoppe Seyler Strasse 3, Tubingen, D 72076, Germany
    J Neuroimmunol 140:177-87. 2003
    ..In MS patients we demonstrate the functionality of the ICOS costimulatory pathway. Potential implications of ICOSL/ICOS interactions for MS immunopathogenesis are discussed...
  40. ncbi Expression of antigen processing and presenting molecules by Schwann cells in inflammatory neuropathies
    Gerd Meyer zu Horste
    Department of Neurology, Heinrich Heine University, Dusseldorf, Germany
    Glia 58:80-92. 2010
    ..Taken together, our data suggest antigen processing and presentation as a possible function of Schwann cells that may contribute to (auto)immune responses within peripheral nerves...
  41. ncbi Express and protect yourself: the potential role of HLA-G on muscle cells and in inflammatory myopathies
    Heinz Wiendl
    Department of Neurology, University of Tubingen, Tubingen, Germany
    Hum Immunol 64:1050-6. 2003
    ..We further speculate on the potential therapeutic implications of HLA-G that relate to special approaches such as myoblast transplantation or strategies against inflammatory aggression in general...
  42. ncbi Muscle fibres and cultured muscle cells express the B7.1/2-related inducible co-stimulatory molecule, ICOSL: implications for the pathogenesis of inflammatory myopathies
    Heinz Wiendl
    Department of Neurology, University of Tubingen, Medical School, Tubingen, Germany
    Brain 126:1026-35. 2003
    ..1 and B7.2. ICOSL-ICOS interactions may play an important role in inflammatory myopathies, providing further evidence for the antigen-presenting capacity of muscle cells...
  43. ncbi WHO grade associated downregulation of MHC class I antigen-processing machinery components in human astrocytomas: does it reflect a potential immune escape mechanism?
    Matthias Mehling
    Department of General Neurology, Hertie Institute for Clinical Brain Research, University of Tubingen, Hoppe Seyler Strasse 3, 72076, Tubingen, Germany
    Acta Neuropathol 114:111-9. 2007
    ....
  44. ncbi Therapeutic approaches to multiple sclerosis: an update on failed, interrupted, or inconclusive trials of immunomodulatory treatment strategies
    Jochen C Ulzheimer
    Department of Neurology, University of Wuerzburg, Wuerzburg, Germany
    BioDrugs 24:249-74. 2010
    ..Neuroprotective and alternative treatment strategies are presented elsewhere...
  45. ncbi Treatment and treatment trials in multiple sclerosis
    Bernd C Kieseier
    Department of Neurology, Heinrich Heine University, Duesseldorf, Germany
    Curr Opin Neurol 20:286-93. 2007
    ..This review focuses on advances in current and novel treatment approaches in multiple sclerosis...
  46. ncbi Stromal interaction molecules 1 and 2 are key regulators of autoreactive T cell activation in murine autoimmune central nervous system inflammation
    Michael K Schuhmann
    Department of Neurology, University of Wurzburg, Wurzburg, Germany
    J Immunol 184:1536-42. 2010
    ....
  47. ncbi The non-classical MHC molecule HLA-G protects human muscle cells from immune-mediated lysis: implications for myoblast transplantation and gene therapy
    Heinz Wiendl
    Department of Neurology, University of Tubingen, Medical School, Tubingen, Germany
    Brain 126:176-85. 2003
    ..Further, HLA-G could represent a novel self-derived anti-inflammatory principle applicable in strategies against inflammatory aggression...
  48. ncbi Identification of targets and new developments in the treatment of multiple sclerosis--focus on cladribine
    Clemens Warnke
    Department of Neurology, Heinrich Heine University Dusseldorf, Germany
    Drug Des Devel Ther 4:117-26. 2010
    ....
  49. ncbi The neuroprotective impact of the leak potassium channel TASK1 on stroke development in mice
    Sven G Meuth
    University of Wurzburg, Department of Neurology, Wurzburg, Germany
    Neurobiol Dis 33:1-11. 2009
    ..In conclusion, our data provide evidence for an important role of functional TASK channels in limiting tissue damage during cerebral ischemia...
  50. ncbi CD8+ T cells and neuronal damage: direct and collateral mechanisms of cytotoxicity and impaired electrical excitability
    Nico Melzer
    Department of Neurology, University of Wurzburg, Josef Schneider Strasse 11, 97080 Wurzburg, Germany
    FASEB J 23:3659-73. 2009
    ..Moreover, we discuss mechanisms of impaired electrical signaling and cell death of neurons as direct and collateral targets of CD8(+) T cells in the CNS...
  51. ncbi Action of treosulfan in myelin-oligodendrocyte-glycoprotein-induced experimental autoimmune encephalomyelitis and human lymphocytes
    Robert Weissert
    Experimental Neuroimmunology Laboratory, Department of General Neurology, Hertie Institute for Clinical Brain Research, University of Tubingen, Hoppe Seyler Strasse 3, 72076 Tubingen, Germany
    J Neuroimmunol 144:28-37. 2003
    ....
  52. ncbi T cell suppression by naturally occurring HLA-G-expressing regulatory CD4+ T cells is IL-10-dependent and reversible
    Yu Hwa Huang
    Department of Neurology, University of Wuerzburg, Wuerzburg, Germany
    J Leukoc Biol 86:273-81. 2009
    ..Further, HLA-G(pos) T(reg)-mediated suppression critically depends on the secretion of IL-10 but not TGF-beta...
  53. ncbi The genetic influence of the nonclassical MHC molecule HLA-G on multiple sclerosis
    Antje Kroner
    Clinical Research Group for Multiple Sclerosis and Neuroimmunology, Department of Neurology, University of Wurzburg, Wurzburg, Germany
    Hum Immunol 68:422-5. 2007
    ..Although HLA-G is assumed to play an important role in the immunoregulatory processes of MS, our results do not support a role of genetic factors influencing disease susceptibility of the disease course...
  54. ncbi An imbalance of two functionally and phenotypically different subsets of plasmacytoid dendritic cells characterizes the dysfunctional immune regulation in multiple sclerosis
    Nicholas Schwab
    Department of Neurology, Clinical Research Group for Multiple Sclerosis and Neuroimmunology, University of Wuerzburg, Wuerzburg, Germany
    J Immunol 184:5368-74. 2010
    ....
  55. ncbi Specific central nervous system recruitment of HLA-G(+) regulatory T cells in multiple sclerosis
    Yu Hwa Huang
    Department of Neurology, University of Wurzburg, Wurzburg, Germany
    Ann Neurol 66:171-83. 2009
    ..Here we studied the role of these cells in multiple sclerosis (MS), a prototypic autoimmune inflammatory disorder of the central nervous system (CNS)...
  56. ncbi Microglial expression of the B7 family member B7 homolog 1 confers strong immune inhibition: implications for immune responses and autoimmunity in the CNS
    Tim Magnus
    Department of Neurology, University of Homburg, D 66424 Homburg, Germany
    J Neurosci 25:2537-46. 2005
    ..Together, our data propose microglial B7-H1 as an important immune inhibitory molecule capable of downregulating T-cell activation in the CNS and thus confining immunopathological damage...
  57. ncbi Expression of K2P5.1 potassium channels on CD4+ T lymphocytes correlates with disease activity in rheumatoid arthritis patients
    Stefan Bittner
    Department of Neurology, University of Wuerzburg, Josef Schneider Str 11, Wuerzburg 97080, Germany
    Arthritis Res Ther 13:R21. 2011
    ..1 is upregulated upon (autoimmune) T cell stimulation. The aim of this study was to correlate expression levels of K(2P)5.1 on T cells from patients with rheumatoid arthritis (RA) to disease activity in these patients...
  58. ncbi TWIK-related acid-sensitive K+ channel 1 (TASK1) and TASK3 critically influence T lymphocyte effector functions
    Sven G Meuth
    Department of Neurology, University of Wuerzburg, Wuerzburg, Germany
    J Biol Chem 283:14559-70. 2008
    ..These data introduce K(2)P channels as novel potassium conductance on T lymphocytes critically influencing T cell effector function and identify a possible molecular target for immunomodulation in T cell-mediated autoimmune disorders...
  59. ncbi A beta-lactam antibiotic dampens excitotoxic inflammatory CNS damage in a mouse model of multiple sclerosis
    Nico Melzer
    Department of Neurology, University of Wurzburg, Wurzburg, Germany
    PLoS ONE 3:e3149. 2008
    ..The mechanisms are reduction of T cell activation by modulation of cellular antigen-presentation and impairment of antigen-specific T cell migration into the CNS rather than or modulation of central glutamate homeostasis...
  60. ncbi Therapeutic approaches to multiple sclerosis: an update on failed, interrupted, or inconclusive trials of neuroprotective and alternative treatment strategies
    Sven G Meuth
    Department of Neurology, University of Wuerzburg, Wuerzburg, Germany
    BioDrugs 24:317-30. 2010
    ..In order to maintain clarity, this review focuses on neuroprotective and various other treatment strategies. Clinical trials addressing anti-inflammatory research strategies are presented elsewhere...
  61. ncbi Therapeutic approaches in multiple sclerosis: lessons from failed and interrupted treatment trials
    Heinz Wiendl
    Department of Neurology, School of Medicine, University of Tuebingen, Tuebingen, Germany
    BioDrugs 16:183-200. 2002
    ..Since failed trials add to our growing understanding of multiple sclerosis, 'misses' are nearly as important to the scientific process as the 'hits'...
  62. ncbi Antigen processing and presentation in human muscle: cathepsin S is critical for MHC class II expression and upregulated in inflammatory myopathies
    Heinz Wiendl
    Department of Neurology, University of Tubingen, Hoppe Seyler Strasse 3, D 72076 Tubingen, Germany
    J Neuroimmunol 138:132-43. 2003
    ..We therefore conclude that CatS is involved in the regulation of class II expression in human myoblasts independently from Ii processing...
  63. ncbi Expression of toll-like receptors by human muscle cells in vitro and in vivo: TLR3 is highly expressed in inflammatory and HIV myopathies, mediates IL-8 release and up-regulation of NKG2D-ligands
    Bettina Schreiner
    Department of General Neurology, Hertie Institute for Clinical Brain Research, Eberhard Karls University Tuebingen, Tuebingen, Germany
    FASEB J 20:118-20. 2006
    ....
  64. ncbi Active immunization induces toxicity of diphtheria toxin in diphtheria resistant mice--implications for neuroinflammatory models
    Gerd Meyer zu Horste
    Department of Neurology, Heinrich Heine University, Moorenstrasse 5, 40225 Dusseldorf, Germany
    J Immunol Methods 354:80-4. 2010
    ....
  65. ncbi Collateral bystander damage by myelin-directed CD8+ T cells causes axonal loss
    Bettina Sobottka
    Department of Neurology, Heinrich Heine University, Moorenstrasse 5, Duesseldorf, Germany
    Am J Pathol 175:1160-6. 2009
    ....
  66. ncbi Hide-and-seek in the brain: a role for HLA-G mediating immune privilege for glioma cells
    Heinz Wiendl
    Department of Neurology, University of Tubingen, Hoppe Seyler Strasse 3, D 72076 Tubingen, Germany
    Semin Cancer Biol 13:343-51. 2003
    ..Possible therapeutic implications derived from these observations include the targeting of HLA-G expression within the framework of inducing glioma-specific immunity...
  67. ncbi A functional role of HLA-G expression in human gliomas: an alternative strategy of immune escape
    Heinz Wiendl
    Department of Neurology, Medical School, University of Tubingen, Tubingen, Germany
    J Immunol 168:4772-80. 2002
    ..We conclude that the aberrant expression of HLA-G may contribute to immune escape in human glioblastoma...
  68. ncbi A PD-1 polymorphism is associated with disease progression in multiple sclerosis
    Antje Kroner
    Clinical Research Group for Multiple Sclerosis and Neuroimmunology, Department of Neurology, Bayerische Julius Maximilians Universität, Wurzburg, Germany
    Ann Neurol 58:50-7. 2005
    ..In conclusion, our data suggest that PD-1 polymorphism is a genetic modifier of the progression of MS, possibly through inducing a partial defect in PD-1-mediated inhibition of T-cell activation...
  69. ncbi The two-pore domain potassium channel TASK3 functionally impacts glioma cell death
    Sven G Meuth
    Department of Neurology, University of Wurzburg, Josef Schneider Str 11, 97080 Wurzburg, Germany
    J Neurooncol 87:263-70. 2008
    ..This implies that TASK3 channels may possibly represent a novel molecular target for the treatment of this type of cancer...
  70. ncbi Recent clinical trials and future therapies
    Sven G Meuth
    Universitat Wurzburg, Klinik und Poliklinik fur Neurologie, Josef Schneider Str 11, 97080 Wurzburg, Germany
    J Neurol 255:93-6. 2008
    ..Here we describe examples of monoclonal antibodies, a novel immunosuppressant and interesting neuroprotective strategies...
  71. ncbi Oral disease-modifying treatments for multiple sclerosis: the story so far
    Bernd C Kieseier
    Department of Neurology, Heinrich Heine University, Dusseldorf, Germany
    CNS Drugs 21:483-502. 2007
    ..It is hoped that these trials will advance the development of oral therapies for MS...
  72. ncbi A novel homozygous missense mutation in the GNE gene of a patient with quadriceps-sparing hereditary inclusion body myopathy associated with muscle inflammation
    Sabine Krause
    Department of Neurology, Friedrich-Baur-Institute, Ludwig-Maximilians University, Munich, Germany
    Neuromuscul Disord 13:830-4. 2003
    ..We conclude that muscle inflammation is not sufficient to exclude the diagnosis of hereditary inclusion body myopathy...
  73. ncbi Modulation of T-effector function by imatinib at the level of cytokine secretion
    Christoph Leder
    Department of Neurology, University of Wuerzburg, Wuerzburg, Germany
    Exp Hematol 35:1266-71. 2007
    ..However, the discussion about imatinib's influence on immune cells is still controversial. The aim of this study was to clarify the effect of imatinib on CD8+ and CD4+ T-cell effector functions...
  74. ncbi Detrimental contribution of the immuno-inhibitor B7-H1 to rabies virus encephalitis
    Monique Lafon
    Viral Neuroimmunology, Institut Pasteur, Paris, France
    J Immunol 180:7506-15. 2008
    ..They show that the B7-H1/PD-1 pathway can be exploited locally and in an organ specific manner--here the nervous system--by a neurotropic virus to promote successful host invasion...
  75. ncbi Modulation of neuronal activity by the endogenous pentapeptide QYNAD
    Sven G Meuth
    Institute of Physiology, Otto-von-Guericke University, Magdeburg, Germany
    Eur J Neurosci 18:2697-706. 2003
    ....
  76. ncbi Postpartum-activation of multiple sclerosis is associated with down-regulation of tolerogenic HLA-G
    Laura Airas
    Department of Neurology and MediCity Research Laboratory, University of Turku, PO Box 52, 20521Turku, Finland
    J Neuroimmunol 187:205-11. 2007
    ..The results delineate an important role for the immune-tolerogenic molecule HLA-G in modulating disease activity and pregnancy-related changes in MS patients...
  77. ncbi The contribution of TWIK-related acid-sensitive K+-containing channels to the function of dorsal lateral geniculate thalamocortical relay neurons
    Sven G Meuth
    Institut für Experimentelle Epilepsieforschung, Westfalische Wilhelms Universitat Munster, Hüfferstr 68, D 48149 Munster, Germany
    Mol Pharmacol 69:1468-76. 2006
    ..In conclusion, our findings demonstrate a significant contribution of TASK-1 channels to ISO in DLG TC neurons, although the genetic knockout of TASK-1 did not produce severe deficits in the thalamocortical system...
  78. ncbi The cell-specific expression of metalloproteinase-disintegrins (ADAMs) in inflammatory myopathies
    Thomas Dehmel
    Department of Neurology, Heinrich Heine University, Moorenstrasse 5, 40225 Duesseldorf, Germany
    Neurobiol Dis 25:665-74. 2007
    ..Our results suggest that certain ADAMs are expressed by specific cell populations during the genesis of immune-mediated diseases of human muscle...
  79. ncbi Cytoplasmic translocation of Olig2 in adult glial progenitors marks the generation of reactive astrocytes following autoimmune inflammation
    Riccardo Cassiani-Ingoni
    Cellular Immunology Section, Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Exp Neurol 201:349-58. 2006
    ..Together, these data ascribe a pivotal role to Olig2+ glial precursor cells in the adult CNS, linking autoimmune inflammation and glial scar formation...
  80. ncbi The role of leukemia-derived B7-H1 (PD-L1) in tumor-T-cell interactions in humans
    Helmut Rainer Salih
    Department of Hematology Oncology II, University of Tuebingen, Germany
    Exp Hematol 34:888-94. 2006
    ..Recently, B7-H1 on murine leukemia cells was reported to mediate resistance to cytolytic T-cell destruction. We here investigate the expression and function of the B7 homolog B7-H1 in human leukemia...
  81. ncbi Blockade of PD-L1 (B7-H1) augments human tumor-specific T cell responses in vitro
    Christian Blank
    Department of Hematology and Oncology, University of Regensburg, Regensburg, Germany
    Int J Cancer 119:317-27. 2006
    ..In summary, our data suggest that PD-L1/PD-1 interactions negatively regulate T cell effector functions predominantly in the absence of exogenous cytokine support, indicating an important role for this pathway in tumor evasion...
  82. ncbi Immune-refractory cancers and their little helpers--an extended role for immunetolerogenic MHC molecules HLA-G and HLA-E?
    Jörg Wischhusen
    Department for Obstetrics and Gynecology, Julius Maximilians University Würzburg, School of Medicine, Josef Schneider Strasse 4, 97080 Wurzburg, Germany
    Semin Cancer Biol 17:459-68. 2007
    ..It is suggested that various cell types within a tumour cooperate in order to inhibit anti-tumour immunity-and that immunetolerogenic HLA-G may play a major role in this context...
  83. ncbi Multiple sclerosis therapy: an update on recently finished trials
    Christoph Kleinschnitz
    Department of Neurology, Bayerische Julius Maximilians Universität Würzburg, Josef Schneider Str 11, 97080, Wurzburg, Germany
    J Neurol 254:1473-90. 2007
    ..Pharmacotherapies include agents that target chemoattraction, cell migration, chemotherapies, and antigen-based therapies...
  84. ncbi Acute disseminated encephalomyelitis: an update
    Til Menge
    Department of Neurology, University of San Francisco, San Francisco, Calif, USA
    Arch Neurol 62:1673-80. 2005
    ....
  85. ncbi An autoreactive gamma delta TCR derived from a polymyositis lesion
    Heinz Wiendl
    Max Planck Institute of Neurobiology, Martinsried, Germany
    J Immunol 169:515-21. 2002
    ..To our knowledge, this is the first example of a molecularly defined gammadelta TCR directly derived from an autoimmune tissue lesion. The strategy used in this study may be applicable to other autoimmune diseases...
  86. ncbi Immune circuitry in the peripheral nervous system
    Bernd C Kieseier
    Department of Neurology, Heinrich-Heine-University, , Germany
    Curr Opin Neurol 19:437-45. 2006
    ..This may foster the development of specific and highly effective therapies for immune-mediated disorders of the peripheral nerve...
  87. ncbi Immune cells contribute to myelin degeneration and axonopathic changes in mice overexpressing proteolipid protein in oligodendrocytes
    Chi Wang Ip
    Department of Neurology, University of Wuerzburg, D 97080 Wuerzburg, Germany
    J Neurosci 26:8206-16. 2006
    ..These findings provide strong evidence that a primary glial damage can cause secondary immune reactions of pathological significance as it has been suggested for some forms of multiple sclerosis and other leukodystrophies...
  88. ncbi Disease-modifying therapies in multiple sclerosis: an update on recent and ongoing trials and future strategies
    Heinz Wiendl
    Department of Neurology, University of Tubingen, Hoppe Seyler Strasse 3, D 72076 Tubingen, Germany
    Expert Opin Investig Drugs 12:689-712. 2003
    ..This review summarises recent progress with currently available disease-modifying therapies and - on the basis of present immunopathogenetic concepts - outlines ongoing studies as well as future treatment strategies...
  89. ncbi Human herpesvirus 6 in serum and spinal fluid of patients with multiple sclerosis?
    Robert Beck
    Arch Neurol 60:639; author reply 639-40. 2003
  90. ncbi Multiple sclerosis: advances, excitements, disenchantments
    Bernd C Kieseier
    Department of Neurology, Heinrich-Heine-University, Moorenstrasse 5, 40225 Duesseldorf, Germany
    Lancet Neurol 5:2-3. 2006
  91. ncbi Destruction of neurons by cytotoxic T cells: a new pathogenic mechanism in Rasmussen's encephalitis
    Christian G Bien
    Department of Epileptology, University of Bonn, Bonn, Germany
    Ann Neurol 51:311-8. 2002
    ..This study directly shows, for what we believe is the first time, that a cytotoxic T-cell mechanism contributes to loss of neurons in human brain disease...
  92. ncbi Localization of UDP-GlcNAc 2-epimerase/ManAc kinase (GNE) in the Golgi complex and the nucleus of mammalian cells
    Sabine Krause
    Friedrich Baur Institute, Department of Neurology and Gene Center, Ludwig Maximilians University, Genzentrum München, Feodor Lynen Str 25, 81377 Munchen, Germany
    Exp Cell Res 304:365-79. 2005
    ..A regulatory role for GNE shifting between the nuclear and the Golgi compartment is proposed. Further insight into GNE regulation may promote the understanding of HIBM pathogenesis...
  93. ncbi Pharmacological treatment of early multiple sclerosis
    Olaf Stuve
    Neurology Section, VA North Texas Health Care System, Medical Service, Dallas, Texas 75216, USA
    Drugs 68:73-83. 2008
    ....