H Wiendl

Summary

Country: Germany

Publications

  1. ncbi Muscle-derived positive and negative regulators of the immune response
    Heinz Wiendl
    Department of Neurology, Julius Maximilians University of Wuerzburg, Wuerzburg, Germany
    Curr Opin Rheumatol 17:714-9. 2005
  2. ncbi Immunobiology of muscle: advances in understanding an immunological microenvironment
    Heinz Wiendl
    Department of Neurology, Julius Maximilians University, Josef Schneider Strasse 11, D 97080 Wuerzburg, Germany
    Trends Immunol 26:373-80. 2005
  3. ncbi Immune circuitry in the peripheral nervous system
    Bernd C Kieseier
    Department of Neurology, Heinrich-Heine-University, , Germany
    Curr Opin Neurol 19:437-45. 2006
  4. ncbi The cell-specific expression of metalloproteinase-disintegrins (ADAMs) in inflammatory myopathies
    Thomas Dehmel
    Department of Neurology, Heinrich Heine University, Moorenstrasse 5, 40225 Duesseldorf, Germany
    Neurobiol Dis 25:665-74. 2007
  5. ncbi B7-H1 restricts neuroantigen-specific T cell responses and confines inflammatory CNS damage: implications for the lesion pathogenesis of multiple sclerosis
    Sonja Ortler
    Clinical Research Group for Multiple Sclerosis and Neuroimmunology, Department of Neurology, University of Wurzburg, Wurzburg, Germany
    Eur J Immunol 38:1734-44. 2008
  6. ncbi GluR3 antibodies: prevalence in focal epilepsy but no specificity for Rasmussen's encephalitis
    H Wiendl
    Department of Neurology, University of Tubingen, Germany
    Neurology 57:1511-4. 2001
  7. ncbi [Multiple sclerosis: potential therapeutic options and update of ongoing studies]
    H Wiendl
    Abteilung für Allgemeine Neurologie und Hertie Institut für Klinische Hirnforschung, Neurologische Klinik der Eberhard Karls Universität Tübingen
    Nervenarzt 75:536-52. 2004
  8. ncbi Hide-and-seek in the brain: a role for HLA-G mediating immune privilege for glioma cells
    Heinz Wiendl
    Department of Neurology, University of Tubingen, Hoppe Seyler Strasse 3, D 72076 Tubingen, Germany
    Semin Cancer Biol 13:343-51. 2003
  9. ncbi Express and protect yourself: the potential role of HLA-G on muscle cells and in inflammatory myopathies
    Heinz Wiendl
    Department of Neurology, University of Tubingen, Tubingen, Germany
    Hum Immunol 64:1050-6. 2003
  10. ncbi Human muscle cells express a B7-related molecule, B7-H1, with strong negative immune regulatory potential: a novel mechanism of counterbalancing the immune attack in idiopathic inflammatory myopathies
    Heinz Wiendl
    Department of Neurology, University of Tubingen, Medical School, D 72076 Tubingen, Germany
    FASEB J 17:1892-4. 2003

Detail Information

Publications98

  1. ncbi Muscle-derived positive and negative regulators of the immune response
    Heinz Wiendl
    Department of Neurology, Julius Maximilians University of Wuerzburg, Wuerzburg, Germany
    Curr Opin Rheumatol 17:714-9. 2005
    ....
  2. ncbi Immunobiology of muscle: advances in understanding an immunological microenvironment
    Heinz Wiendl
    Department of Neurology, Julius Maximilians University, Josef Schneider Strasse 11, D 97080 Wuerzburg, Germany
    Trends Immunol 26:373-80. 2005
    ....
  3. ncbi Immune circuitry in the peripheral nervous system
    Bernd C Kieseier
    Department of Neurology, Heinrich-Heine-University, , Germany
    Curr Opin Neurol 19:437-45. 2006
    ..This may foster the development of specific and highly effective therapies for immune-mediated disorders of the peripheral nerve...
  4. ncbi The cell-specific expression of metalloproteinase-disintegrins (ADAMs) in inflammatory myopathies
    Thomas Dehmel
    Department of Neurology, Heinrich Heine University, Moorenstrasse 5, 40225 Duesseldorf, Germany
    Neurobiol Dis 25:665-74. 2007
    ..Our results suggest that certain ADAMs are expressed by specific cell populations during the genesis of immune-mediated diseases of human muscle...
  5. ncbi B7-H1 restricts neuroantigen-specific T cell responses and confines inflammatory CNS damage: implications for the lesion pathogenesis of multiple sclerosis
    Sonja Ortler
    Clinical Research Group for Multiple Sclerosis and Neuroimmunology, Department of Neurology, University of Wurzburg, Wurzburg, Germany
    Eur J Immunol 38:1734-44. 2008
    ..Our findings demonstrate the critical importance of B7-H1 as an immune-inhibitory molecule capable of down-regulating T cell responses thus contributing to the confinement of immunopathological damage...
  6. ncbi GluR3 antibodies: prevalence in focal epilepsy but no specificity for Rasmussen's encephalitis
    H Wiendl
    Department of Neurology, University of Tubingen, Germany
    Neurology 57:1511-4. 2001
    ....
  7. ncbi [Multiple sclerosis: potential therapeutic options and update of ongoing studies]
    H Wiendl
    Abteilung für Allgemeine Neurologie und Hertie Institut für Klinische Hirnforschung, Neurologische Klinik der Eberhard Karls Universität Tübingen
    Nervenarzt 75:536-52. 2004
    ..Based on current concepts of the MS pathogenesis, this article summarizes new therapeutic approaches. Substances and strategies currently tested in clinical trials are reviewed...
  8. ncbi Hide-and-seek in the brain: a role for HLA-G mediating immune privilege for glioma cells
    Heinz Wiendl
    Department of Neurology, University of Tubingen, Hoppe Seyler Strasse 3, D 72076 Tubingen, Germany
    Semin Cancer Biol 13:343-51. 2003
    ..Possible therapeutic implications derived from these observations include the targeting of HLA-G expression within the framework of inducing glioma-specific immunity...
  9. ncbi Express and protect yourself: the potential role of HLA-G on muscle cells and in inflammatory myopathies
    Heinz Wiendl
    Department of Neurology, University of Tubingen, Tubingen, Germany
    Hum Immunol 64:1050-6. 2003
    ..We further speculate on the potential therapeutic implications of HLA-G that relate to special approaches such as myoblast transplantation or strategies against inflammatory aggression in general...
  10. ncbi Human muscle cells express a B7-related molecule, B7-H1, with strong negative immune regulatory potential: a novel mechanism of counterbalancing the immune attack in idiopathic inflammatory myopathies
    Heinz Wiendl
    Department of Neurology, University of Tubingen, Medical School, D 72076 Tubingen, Germany
    FASEB J 17:1892-4. 2003
    ..These data highlight the immune regulatory properties of muscle cells and suggest that B7-H1 expression represents an inhibitory mechanism induced upon inflammatory stimuli and aimed at protecting muscle fibers from immune aggression...
  11. ncbi The CD28 related molecule ICOS: T cell modulation in the presence and absence of B7.1/2 and regulational expression in multiple sclerosis
    Heinz Wiendl
    Department of Neurology, University of Tubingen, Hoppe Seyler Strasse 3, Tubingen, D 72076, Germany
    J Neuroimmunol 140:177-87. 2003
    ..In MS patients we demonstrate the functionality of the ICOS costimulatory pathway. Potential implications of ICOSL/ICOS interactions for MS immunopathogenesis are discussed...
  12. ncbi Antigen processing and presentation in human muscle: cathepsin S is critical for MHC class II expression and upregulated in inflammatory myopathies
    Heinz Wiendl
    Department of Neurology, University of Tubingen, Hoppe Seyler Strasse 3, D 72076 Tubingen, Germany
    J Neuroimmunol 138:132-43. 2003
    ..We therefore conclude that CatS is involved in the regulation of class II expression in human myoblasts independently from Ii processing...
  13. ncbi Muscle fibres and cultured muscle cells express the B7.1/2-related inducible co-stimulatory molecule, ICOSL: implications for the pathogenesis of inflammatory myopathies
    Heinz Wiendl
    Department of Neurology, University of Tubingen, Medical School, Tubingen, Germany
    Brain 126:1026-35. 2003
    ..1 and B7.2. ICOSL-ICOS interactions may play an important role in inflammatory myopathies, providing further evidence for the antigen-presenting capacity of muscle cells...
  14. ncbi Disease-modifying therapies in multiple sclerosis: an update on recent and ongoing trials and future strategies
    Heinz Wiendl
    Department of Neurology, University of Tubingen, Hoppe Seyler Strasse 3, D 72076 Tubingen, Germany
    Expert Opin Investig Drugs 12:689-712. 2003
    ..This review summarises recent progress with currently available disease-modifying therapies and - on the basis of present immunopathogenetic concepts - outlines ongoing studies as well as future treatment strategies...
  15. ncbi The non-classical MHC molecule HLA-G protects human muscle cells from immune-mediated lysis: implications for myoblast transplantation and gene therapy
    Heinz Wiendl
    Department of Neurology, University of Tubingen, Medical School, Tubingen, Germany
    Brain 126:176-85. 2003
    ..Further, HLA-G could represent a novel self-derived anti-inflammatory principle applicable in strategies against inflammatory aggression...
  16. ncbi Therapeutic approaches in multiple sclerosis: lessons from failed and interrupted treatment trials
    Heinz Wiendl
    Department of Neurology, School of Medicine, University of Tuebingen, Tuebingen, Germany
    BioDrugs 16:183-200. 2002
    ..Since failed trials add to our growing understanding of multiple sclerosis, 'misses' are nearly as important to the scientific process as the 'hits'...
  17. ncbi Very bright dorsal columns: spinal magnetic resonance imaging in funicular myelosis
    H Wiendl
    Department of Neurology, , Hoppe-Seyler-Strasse 3, D-72076, , Germany
    Arch Neurol 59:147-8. 2002
  18. ncbi A functional role of HLA-G expression in human gliomas: an alternative strategy of immune escape
    Heinz Wiendl
    Department of Neurology, Medical School, University of Tubingen, Tubingen, Germany
    J Immunol 168:4772-80. 2002
    ..We conclude that the aberrant expression of HLA-G may contribute to immune escape in human glioblastoma...
  19. ncbi Interferon-beta enhances monocyte and dendritic cell expression of B7-H1 (PD-L1), a strong inhibitor of autologous T-cell activation: relevance for the immune modulatory effect in multiple sclerosis
    Bettina Schreiner
    Department of General Neurology, Hertie Institute for Clinical Brain Research, University of Tubingen, Hoppe Seyler Strasse 3, 72076 Tubingen, Germany
    J Neuroimmunol 155:172-82. 2004
    ..IFN-beta up-regulates B7-H1 in vitro and in MS patients in vivo and might represent a novel mechanism how IFN-beta acts as a negative modulator on APC T-cell interactions in the periphery...
  20. ncbi Clonal expansions of pathogenic CD8+ effector cells in the CNS of myelin mutant mice
    C Leder
    Department of Neurology, University of Wuerzburg, D 97080 Wuerzburg, Germany
    Mol Cell Neurosci 36:416-24. 2007
    ..The association of primary oligodendrocyte damage with secondary expansions of pathogenic cells underlines the role of adaptive immune reactions in neurodegenerative and neuroinflammatory diseases...
  21. ncbi Monocyte-derived HLA-G acts as a strong inhibitor of autologous CD4 T cell activation and is upregulated by interferon-beta in vitro and in vivo: rationale for the therapy of multiple sclerosis
    Meike Mitsdoerffer
    Department of Neurology, University of Tubingen, Hoppe Seyler Strasse 3, D 72076 Tubingen, Germany
    J Neuroimmunol 159:155-64. 2005
    ..We conclude that some desirable immune-modulatory effects of INF-beta might be accomplished via the upregulation of the immune-tolerogenic molecule HLA-G...
  22. ncbi HLA-G expression defines a novel regulatory T-cell subset present in human peripheral blood and sites of inflammation
    Ute Feger
    Department of General Neurology, Hertie Institute for Clinical Brain Research, Eberhard Karls University Tuebingen, Tuebingen, Germany
    Blood 110:568-77. 2007
    ....
  23. ncbi Expression of the B7-related molecule B7-H1 by glioma cells: a potential mechanism of immune paralysis
    Sabine Wintterle
    Department of Neurology, Medical School, , Hoppe-Seyler-Strasse 3, , Germany
    Cancer Res 63:7462-7. 2003
    ..B7-H1 expression may thus significantly influence the outcome of T-cell tumor cell interactions and represents a novel mechanism by which glioma cells evade immune recognition and destruction...
  24. ncbi Mouse Schwann cells activate MHC class I and II restricted T-cell responses, but require external peptide processing for MHC class II presentation
    Gerd Meyer zu Horste
    Department of Neurology, Heinrich Heine University, Dusseldorf, Germany
    Neurobiol Dis 37:483-90. 2010
    ..Thus, antigen presentation may be a pathological function of Schwann cells exacerbating nerve damage in inflammatory neuropathies...
  25. ncbi Expression of CD28-related costimulatory molecule and its ligand in inflammatory neuropathies
    W Hu
    Department of Neurology, Heinrich Heine University, Dusseldorf, Germany
    Neurology 68:277-82. 2007
    ..Activation of effector T lymphocytes, mediated in part by costimulatory molecules, is an important mechanism in the pathogenesis of immune-mediated diseases of the peripheral nervous system (PNS)...
  26. ncbi Immunotherapeutic approaches in MS: update on pathophysiology and emerging agents or strategies 2006
    C Kleinschnitz
    Department of Neurology, Bayerische Julius Maximilians Universität Würzburg, Wurzburg, Germany
    Endocr Metab Immune Disord Drug Targets 7:35-63. 2007
    ..The pathogenetic rationale of these novel drug targets for the treatment of MS as well as accompanying preclinical and clinical data are highlighted...
  27. ncbi CNS inflammation and neuronal degeneration is aggravated by impaired CD200-CD200R-mediated macrophage silencing
    Sven G Meuth
    University of Wuerzburg, Department of Neurology, Josef Schneider Strasse 11, 97080 Wuerzburg, Germany
    J Neuroimmunol 194:62-9. 2008
    ..CD200 and its receptor could also be detected on neurons and macrophages in human MS plaques. Therefore the CD200-CD200R pathway seems of critical relevance for macrophage-mediated damage in autoimmune inflammation of the CNS...
  28. ncbi Human myoblasts modulate the function of antigen-presenting cells
    Nicholas Schwab
    Department of Neurology, University of Wuerzburg, Germany
    J Neuroimmunol 200:62-70. 2008
    ..MB-lysates strongly stimulated MPh phagocytosis. Hypothetically, MB might modulate APC, counterbalancing immune-mediated damage...
  29. ncbi Multiple sclerosis: Mitoxantrone promotes differential effects on immunocompetent cells in vitro
    Oliver Neuhaus
    Department of Neurology, Heinrich Heine Universitat, Moorenstr 5, 40225 Dusseldorf, Germany
    J Neuroimmunol 168:128-37. 2005
    ....
  30. ncbi Intercellular exchanges of membrane fragments (trogocytosis) between human muscle cells and immune cells: a potential mechanism for the modulation of muscular immune responses
    Anne Waschbisch
    Clinical Research Group for Multiple Sclerosis and Neuroimmunology, Department of Neurology, University of Wuerzburg, Wuerzburg, Germany
    J Neuroimmunol 209:131-8. 2009
    ..Our observations raise the hypothesis that trogocytosis may modulate the outcome of T-T interactions within the micromilieu of skeletal muscle...
  31. ncbi The level of B7 homologue 1 expression on brain DC is decisive for CD8 Treg cell recruitment into the CNS during EAE
    Alla L Zozulya
    University of Wuerzburg, Department of Neurology, Wuerzburg, Germany
    Eur J Immunol 39:1536-43. 2009
    ..The recruitment of regulatory-type CD8(+) T cells into the CNS and the role of brain DC expressing B7-homologue 1 molecules in this process open up the possibility of DC-targeted therapeutic manipulation of neuroinflammatory diseases...
  32. ncbi Expression of the B7-related molecule ICOSL by human glioma cells in vitro and in vivo
    Bettina Schreiner
    Department of Neurology, University of Tubingen, Medical School, Tubingen, Germany
    Glia 44:296-301. 2003
    ..However, ICOSL gene transfer into glioma cells does not alter their immunogenicity under primary or secondary alloreactive coculture assays...
  33. ncbi Treatment and treatment trials in multiple sclerosis
    Bernd C Kieseier
    Department of Neurology, Heinrich Heine University, Duesseldorf, Germany
    Curr Opin Neurol 20:286-93. 2007
    ..This review focuses on advances in current and novel treatment approaches in multiple sclerosis...
  34. ncbi Microglial expression of the B7 family member B7 homolog 1 confers strong immune inhibition: implications for immune responses and autoimmunity in the CNS
    Tim Magnus
    Department of Neurology, University of Homburg, D 66424 Homburg, Germany
    J Neurosci 25:2537-46. 2005
    ..Together, our data propose microglial B7-H1 as an important immune inhibitory molecule capable of downregulating T-cell activation in the CNS and thus confining immunopathological damage...
  35. ncbi A PD-1 polymorphism is associated with disease progression in multiple sclerosis
    Antje Kroner
    Clinical Research Group for Multiple Sclerosis and Neuroimmunology, Department of Neurology, Bayerische Julius Maximilians Universität, Wurzburg, Germany
    Ann Neurol 58:50-7. 2005
    ..In conclusion, our data suggest that PD-1 polymorphism is a genetic modifier of the progression of MS, possibly through inducing a partial defect in PD-1-mediated inhibition of T-cell activation...
  36. ncbi Human muscle cells express the costimulatory molecule B7-H3, which modulates muscle-immune interactions
    Anne Waschbisch
    University of Wuerzburg, Wuerzburg, Germany, and University of Erlangen, Erlangen, Germany
    Arthritis Rheum 58:3600-8. 2008
    ..The present study was undertaken to examine the expression and functional relevance of B7 homolog 3 (B7-H3), a novel B7 homolog attributed significant immunoregulatory functions, in human muscle cells in vivo and in vitro...
  37. ncbi T cell suppression by naturally occurring HLA-G-expressing regulatory CD4+ T cells is IL-10-dependent and reversible
    Yu Hwa Huang
    Department of Neurology, University of Wuerzburg, Wuerzburg, Germany
    J Leukoc Biol 86:273-81. 2009
    ..Further, HLA-G(pos) T(reg)-mediated suppression critically depends on the secretion of IL-10 but not TGF-beta...
  38. ncbi Expression of the immune-tolerogenic major histocompatibility molecule HLA-G in multiple sclerosis: implications for CNS immunity
    Heinz Wiendl
    Department of General Neurology, Hertie Institute for Clinical Brain Research, University of Tubingen, Tubingen, Germany
    Brain 128:2689-704. 2005
    ..This pathway may act as an inhibitory feedback aimed to downregulate the deleterious effects of T-cell infiltration in neuroinflammation...
  39. ncbi Combined therapy of cerebral arteriovenous malformations: histological differences between a non-adhesive liquid embolic agent and n-butyl 2-cyanoacrylate (NBCA)
    F Duffner
    Department of Neurosurgery, University Hospital, Eberhard Karls University, Tubingen, Germany
    Clin Neuropathol 21:13-7. 2002
    ..Inc., Irvine, CA, USA) are to be compared to those of n-butyl 2-cyanoacrylate (NBCA) with regard to the histopathological results after preoperative embolization of a cerebral arteriovenous malformation (AVM)...
  40. ncbi [Dementia as a primary symptom in late onset multiple sclerosis. Case series and review of the literature]
    T Leyhe
    Klinik für Psychiatrie und Psychotherapie der Universität Tübingen
    Nervenarzt 76:748-55. 2005
    ..Until now dementia as the primary symptomatology has not been described in patients older than 60 years. Possibly MS as a differential diagnosis in dementia as well as cognitive impairment as an initial symptom of MS is under-recognized...
  41. ncbi CADASIL: underdiagnosed in psychiatric patients?
    T Leyhe
    Department of Psychiatry and Psychotherapy, University of Tubingen, Germany
    Acta Psychiatr Scand 111:392-6; discussion 396-7. 2005
    ..Retrospectively in up to 15% the initial presentation is psychiatric disturbances. In these cases the diagnosis often is delayed or missed...
  42. ncbi Intracerebral dendritic cells critically modulate encephalitogenic versus regulatory immune responses in the CNS
    Alla L Zozulya
    Department of Neurology, University of Wurzburg, 97080 Wurzburg, Germany
    J Neurosci 29:140-52. 2009
    ..Our findings suggest that DCs are a rate-limiting factor for neuroinflammation...
  43. ncbi Action of treosulfan in myelin-oligodendrocyte-glycoprotein-induced experimental autoimmune encephalomyelitis and human lymphocytes
    Robert Weissert
    Experimental Neuroimmunology Laboratory, Department of General Neurology, Hertie Institute for Clinical Brain Research, University of Tubingen, Hoppe Seyler Strasse 3, 72076 Tubingen, Germany
    J Neuroimmunol 144:28-37. 2003
    ....
  44. ncbi The role of CD8 suppressors versus destructors in autoimmune central nervous system inflammation
    Alla L Zozulya
    University of Wurzburg, Department of Neurology, Wurzburg, Germany
    Hum Immunol 69:797-804. 2008
    ..This knowledge may help to further develop concepts of reconstituting or enhancing endogenous mechanisms of immune tolerance in future therapeutic concepts for MS...
  45. ncbi WHO grade associated downregulation of MHC class I antigen-processing machinery components in human astrocytomas: does it reflect a potential immune escape mechanism?
    Matthias Mehling
    Department of General Neurology, Hertie Institute for Clinical Brain Research, University of Tubingen, Hoppe Seyler Strasse 3, 72076, Tubingen, Germany
    Acta Neuropathol 114:111-9. 2007
    ....
  46. ncbi Upregulation of K2P5.1 potassium channels in multiple sclerosis
    Stefan Bittner
    Department of Neurology, University of Wurzburg, Wurzburg, Munster, Germany
    Ann Neurol 68:58-69. 2010
    ..1 (KCNK5; TASK2), a member of the 2-pore domain family of potassium channels, on T-cell function and demonstrate its putative relevance in a T-cell-mediated autoimmune disorder, multiple sclerosis (MS)...
  47. ncbi Therapeutic approaches to multiple sclerosis: an update on failed, interrupted, or inconclusive trials of immunomodulatory treatment strategies
    Jochen C Ulzheimer
    Department of Neurology, University of Wuerzburg, Wuerzburg, Germany
    BioDrugs 24:249-74. 2010
    ..Neuroprotective and alternative treatment strategies are presented elsewhere...
  48. ncbi Collateral bystander damage by myelin-directed CD8+ T cells causes axonal loss
    Bettina Sobottka
    Department of Neurology, Heinrich Heine University, Moorenstrasse 5, Duesseldorf, Germany
    Am J Pathol 175:1160-6. 2009
    ....
  49. ncbi Increased frequency of CD4+ CD25+ regulatory T cells in the cerebrospinal fluid but not in the blood of multiple sclerosis patients
    U Feger
    Department of General Neurology, Hertie Institute for Clinical Brain Research, University of Tubingen, Germany
    Clin Exp Immunol 147:412-8. 2007
    ..The frequency of nTreg in the periphery did not differ between MS patients and healthy donors; however, nTreg from MS patients showed reduced suppressive capacity...
  50. ncbi The role of leukemia-derived B7-H1 (PD-L1) in tumor-T-cell interactions in humans
    Helmut Rainer Salih
    Department of Hematology Oncology II, University of Tuebingen, Germany
    Exp Hematol 34:888-94. 2006
    ..Recently, B7-H1 on murine leukemia cells was reported to mediate resistance to cytolytic T-cell destruction. We here investigate the expression and function of the B7 homolog B7-H1 in human leukemia...
  51. ncbi Deficiency of the negative immune regulator B7-H1 enhances inflammation and neuropathic pain after chronic constriction injury of mouse sciatic nerve
    Nurcan Uceyler
    Department of Neurology, University of Wurzburg, Josef Schneider Str 11, 97080 Wurzburg, Germany
    Exp Neurol 222:153-60. 2010
    ..Interestingly, mechanical hyperalgesia was more pronounced in the absence of B7-H1. Our study identifies B7-H1 as an important suppressor of the inflammatory response and neuropathic pain occurring after peripheral nerve injury...
  52. ncbi The genetic influence of the nonclassical MHC molecule HLA-G on multiple sclerosis
    Antje Kroner
    Clinical Research Group for Multiple Sclerosis and Neuroimmunology, Department of Neurology, University of Wurzburg, Wurzburg, Germany
    Hum Immunol 68:422-5. 2007
    ..Although HLA-G is assumed to play an important role in the immunoregulatory processes of MS, our results do not support a role of genetic factors influencing disease susceptibility of the disease course...
  53. ncbi A novel homozygous missense mutation in the GNE gene of a patient with quadriceps-sparing hereditary inclusion body myopathy associated with muscle inflammation
    Sabine Krause
    Department of Neurology, Friedrich-Baur-Institute, Ludwig-Maximilians University, Munich, Germany
    Neuromuscul Disord 13:830-4. 2003
    ..We conclude that muscle inflammation is not sufficient to exclude the diagnosis of hereditary inclusion body myopathy...
  54. ncbi TASK1 modulates inflammation and neurodegeneration in autoimmune inflammation of the central nervous system
    Stefan Bittner
    University of Wuerzburg, Department of Neurology, Josef Schneider Str 11, 97080 Wuerzburg, Germany
    Brain 132:2501-16. 2009
    ..These data support the identification and characterization of TASK1 as potential molecular target for the therapy of inflammatory and degenerative central nervous system disorders...
  55. ncbi Specific central nervous system recruitment of HLA-G(+) regulatory T cells in multiple sclerosis
    Yu Hwa Huang
    Department of Neurology, University of Wurzburg, Wurzburg, Germany
    Ann Neurol 66:171-83. 2009
    ..Here we studied the role of these cells in multiple sclerosis (MS), a prototypic autoimmune inflammatory disorder of the central nervous system (CNS)...
  56. ncbi An imbalance of two functionally and phenotypically different subsets of plasmacytoid dendritic cells characterizes the dysfunctional immune regulation in multiple sclerosis
    Nicholas Schwab
    Department of Neurology, Clinical Research Group for Multiple Sclerosis and Neuroimmunology, University of Wuerzburg, Wuerzburg, Germany
    J Immunol 184:5368-74. 2010
    ....
  57. ncbi Immune-refractory cancers and their little helpers--an extended role for immunetolerogenic MHC molecules HLA-G and HLA-E?
    Jörg Wischhusen
    Department for Obstetrics and Gynecology, Julius Maximilians University Würzburg, School of Medicine, Josef Schneider Strasse 4, 97080 Wurzburg, Germany
    Semin Cancer Biol 17:459-68. 2007
    ..It is suggested that various cell types within a tumour cooperate in order to inhibit anti-tumour immunity-and that immunetolerogenic HLA-G may play a major role in this context...
  58. ncbi Multiple sclerosis therapeutics: unexpected outcomes clouding undisputed successes
    Heinz Wiendl
    Department of Neurology, Julius Maximilians University Würzburg, Wurzburg, Germany
    Neurology 72:1008-15. 2009
    ....
  59. ncbi Expression of antigen processing and presenting molecules by Schwann cells in inflammatory neuropathies
    Gerd Meyer zu Horste
    Department of Neurology, Heinrich Heine University, Dusseldorf, Germany
    Glia 58:80-92. 2010
    ..Taken together, our data suggest antigen processing and presentation as a possible function of Schwann cells that may contribute to (auto)immune responses within peripheral nerves...
  60. ncbi Oral disease-modifying treatments for multiple sclerosis: the story so far
    Bernd C Kieseier
    Department of Neurology, Heinrich Heine University, Dusseldorf, Germany
    CNS Drugs 21:483-502. 2007
    ..It is hoped that these trials will advance the development of oral therapies for MS...
  61. ncbi Dose-dependent melanonychia by mitoxantrone
    C Reinsberger
    Department of Neurology, University Hospital, Julius Maximilians University, Wuerzburg, Germany
    Mult Scler 15:1131-2. 2009
    ..Albeit speculative, pathogenesis of selective melanonychia by mitoxantrone could involve selective activation of nail matrix melanocytes or endocrine disturbances involving melanocyte stimulating hormone...
  62. ncbi Idiopathic inflammatory myopathies: current and future therapeutic options
    Heinz Wiendl
    Department of Neurology, University of Wuerzburg, Wuerzburg, Germany
    Neurotherapeutics 5:548-57. 2008
    ..Possible future therapeutic options are presented and discussed...
  63. ncbi FOXP3+ T regulatory cells in idiopathic inflammatory myopathies
    Anne Waschbisch
    Department of Neurology, Julius Maximilians University, Wuerzburg, Germany
    J Neuroimmunol 225:137-42. 2010
    ..Our data suggest that FOXP3 Tregs serve to counterbalance muscle destruction by cytotoxic T cells in myositis...
  64. ncbi PD-1 regulates neural damage in oligodendroglia-induced inflammation
    Antje Kroner
    Department of Neurology, University of Wuerzburg, Wuerzburg, Germany
    PLoS ONE 4:e4405. 2009
    ..Our finding may have implications for understanding the mechanisms leading to the high clinical variability of polygenic or even monogenic disorders of the nervous system...
  65. ncbi Early detrimental T-cell effects in experimental cerebral ischemia are neither related to adaptive immunity nor thrombus formation
    Christoph Kleinschnitz
    Department of Neurology, University of Wuerzburg, D 97080 Wuerzburg, Germany
    Blood 115:3835-42. 2010
    ..Our data demonstrate that T cells critically contribute to cerebral ischemia, but their detrimental effect neither depends on antigen recognition nor TCR costimulation or thrombus formation...
  66. ncbi CD8+ T cells and neuronal damage: direct and collateral mechanisms of cytotoxicity and impaired electrical excitability
    Nico Melzer
    Department of Neurology, University of Wurzburg, Josef Schneider Strasse 11, 97080 Wurzburg, Germany
    FASEB J 23:3659-73. 2009
    ..Moreover, we discuss mechanisms of impaired electrical signaling and cell death of neurons as direct and collateral targets of CD8(+) T cells in the CNS...
  67. ncbi Stromal interaction molecules 1 and 2 are key regulators of autoreactive T cell activation in murine autoimmune central nervous system inflammation
    Michael K Schuhmann
    Department of Neurology, University of Wurzburg, Wurzburg, Germany
    J Immunol 184:1536-42. 2010
    ....
  68. ncbi The future of multiple sclerosis therapy
    Bernd C Kieseier
    Department of Neurology, Heinrich Heine University, Moorenstrasse 5, 40225 Duesseldorf, Germany
    Pharmacol Res 60:207-11. 2009
    ..These agents are potentially more effective, but may carry more serious side effects. Finally, drugs with a known good safety profile are being developed further. These advances are critically reviewed and put into perspective...
  69. ncbi The two-pore domain potassium channel TASK3 functionally impacts glioma cell death
    Sven G Meuth
    Department of Neurology, University of Wurzburg, Josef Schneider Str 11, 97080 Wurzburg, Germany
    J Neurooncol 87:263-70. 2008
    ..This implies that TASK3 channels may possibly represent a novel molecular target for the treatment of this type of cancer...
  70. ncbi Cathepsin G, and not the asparagine-specific endoprotease, controls the processing of myelin basic protein in lysosomes from human B lymphocytes
    Timo Burster
    Department of Medicine II, University of Tubingen, Tubingen, Germany
    J Immunol 172:5495-503. 2004
    ..Internalization of exogenous CatG represents a novel mechanism of professional APC to acquire functionally dominant proteolytic activity that complements the panel of endogenous lysosomal enzymes...
  71. ncbi Modulation of T-effector function by imatinib at the level of cytokine secretion
    Christoph Leder
    Department of Neurology, University of Wuerzburg, Wuerzburg, Germany
    Exp Hematol 35:1266-71. 2007
    ..However, the discussion about imatinib's influence on immune cells is still controversial. The aim of this study was to clarify the effect of imatinib on CD8+ and CD4+ T-cell effector functions...
  72. ncbi HLA-G in the nervous system
    Heinz Wiendl
    Department of Neurology, Bayerische Julius Maximilians Universität Würzburg, Wurzburg, Germany
    Hum Immunol 68:286-93. 2007
    ..These findings are relevant both from a pathogenetic as well as from a therapeutic viewpoint...
  73. ncbi Effects of natalizumab treatment on Foxp3+ T regulatory cells
    Max Philipp Stenner
    Department of Neurology, Julius Maximilians University, Wuerzburg, Germany
    PLoS ONE 3:e3319. 2008
    ..Our objective was to study impacts of Natalizumab therapy on Foxp3+ T regulatory cells (Tregs) in multiple sclerosis (MS) patients...
  74. ncbi CD8+ T-cell immunity in chronic inflammatory demyelinating polyradiculoneuropathy
    T Schneider-Hohendorf
    Department of Neurology, University ofMunster, Munster, Germany
    Neurology 78:402-8. 2012
    ..Thus, we asked whether nervous tissue infiltrating and blood-derived lymphocytes in CIDP are clonally expanded to evaluate the involvement of T cells in the pathogenesis of the disease...
  75. ncbi Vascular endothelial growth factor (VEGF) in leptomeningeal metastasis: diagnostic and prognostic value
    U Herrlinger
    Department of General Neurology, Hertie Institute for Clinical Brain Research, University of Tubingen, Hoppe Seyler Str 3, D 72076 Tuebingen, Germany
    Br J Cancer 91:219-24. 2004
    ..High VEGF levels have a very high specificity for LM and may help to establish the diagnosis. The role of VEGF as a predictor of outcome should be substantiated in prospective studies...
  76. ncbi Analysis of the C/T(-1) single nucleotide polymorphism in the CD40 gene in multiple sclerosis
    D Buck
    Clinical Research Group for Multiple Sclerosis and Neuroimmunology, Department of Neurology, Bayerische Julius Maximilians Universität, Wurzburg, Germany
    Tissue Antigens 68:335-8. 2006
    ....
  77. ncbi Blockade of PD-L1 (B7-H1) augments human tumor-specific T cell responses in vitro
    Christian Blank
    Department of Hematology and Oncology, University of Regensburg, Regensburg, Germany
    Int J Cancer 119:317-27. 2006
    ..In summary, our data suggest that PD-L1/PD-1 interactions negatively regulate T cell effector functions predominantly in the absence of exogenous cytokine support, indicating an important role for this pathway in tumor evasion...
  78. ncbi Localization of UDP-GlcNAc 2-epimerase/ManAc kinase (GNE) in the Golgi complex and the nucleus of mammalian cells
    Sabine Krause
    Friedrich Baur Institute, Department of Neurology and Gene Center, Ludwig Maximilians University, Genzentrum München, Feodor Lynen Str 25, 81377 Munchen, Germany
    Exp Cell Res 304:365-79. 2005
    ..A regulatory role for GNE shifting between the nuclear and the Golgi compartment is proposed. Further insight into GNE regulation may promote the understanding of HIBM pathogenesis...
  79. ncbi An autoreactive gamma delta TCR derived from a polymyositis lesion
    Heinz Wiendl
    Max Planck Institute of Neurobiology, Martinsried, Germany
    J Immunol 169:515-21. 2002
    ..To our knowledge, this is the first example of a molecularly defined gammadelta TCR directly derived from an autoimmune tissue lesion. The strategy used in this study may be applicable to other autoimmune diseases...
  80. ncbi Cytoplasmic translocation of Olig2 in adult glial progenitors marks the generation of reactive astrocytes following autoimmune inflammation
    Riccardo Cassiani-Ingoni
    Cellular Immunology Section, Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Exp Neurol 201:349-58. 2006
    ..Together, these data ascribe a pivotal role to Olig2+ glial precursor cells in the adult CNS, linking autoimmune inflammation and glial scar formation...
  81. ncbi Pharmacological treatment of early multiple sclerosis
    Olaf Stuve
    Neurology Section, VA North Texas Health Care System, Medical Service, Dallas, Texas 75216, USA
    Drugs 68:73-83. 2008
    ....
  82. ncbi Detrimental contribution of the immuno-inhibitor B7-H1 to rabies virus encephalitis
    Monique Lafon
    Viral Neuroimmunology, Institut Pasteur, Paris, France
    J Immunol 180:7506-15. 2008
    ..They show that the B7-H1/PD-1 pathway can be exploited locally and in an organ specific manner--here the nervous system--by a neurotropic virus to promote successful host invasion...
  83. ncbi Postpartum-activation of multiple sclerosis is associated with down-regulation of tolerogenic HLA-G
    Laura Airas
    Department of Neurology and MediCity Research Laboratory, University of Turku, PO Box 52, 20521Turku, Finland
    J Neuroimmunol 187:205-11. 2007
    ..The results delineate an important role for the immune-tolerogenic molecule HLA-G in modulating disease activity and pregnancy-related changes in MS patients...
  84. ncbi Immune cells contribute to myelin degeneration and axonopathic changes in mice overexpressing proteolipid protein in oligodendrocytes
    Chi Wang Ip
    Department of Neurology, University of Wuerzburg, D 97080 Wuerzburg, Germany
    J Neurosci 26:8206-16. 2006
    ..These findings provide strong evidence that a primary glial damage can cause secondary immune reactions of pathological significance as it has been suggested for some forms of multiple sclerosis and other leukodystrophies...
  85. ncbi Destruction of neurons by cytotoxic T cells: a new pathogenic mechanism in Rasmussen's encephalitis
    Christian G Bien
    Department of Epileptology, University of Bonn, Bonn, Germany
    Ann Neurol 51:311-8. 2002
    ..This study directly shows, for what we believe is the first time, that a cytotoxic T-cell mechanism contributes to loss of neurons in human brain disease...
  86. ncbi Advances in pathogenic concepts and therapeutic agents in Rasmussen's encephalitis
    Christian G Bien
    University of Bonn, Department of Epileptology, Germany
    Expert Opin Investig Drugs 11:981-9. 2002
    ..An opinion on symptomatic treatment with anticonvulsive drugs is included...
  87. ncbi Human herpesvirus 6 in serum and spinal fluid of patients with multiple sclerosis?
    Robert Beck
    Arch Neurol 60:639; author reply 639-40. 2003
  88. ncbi Modulation of neuronal activity by the endogenous pentapeptide QYNAD
    Sven G Meuth
    Institute of Physiology, Otto-von-Guericke University, Magdeburg, Germany
    Eur J Neurosci 18:2697-706. 2003
    ....
  89. ncbi Multiple sclerosis therapy: an update on recently finished trials
    Christoph Kleinschnitz
    Department of Neurology, Bayerische Julius Maximilians Universität Würzburg, Josef Schneider Str 11, 97080, Wurzburg, Germany
    J Neurol 254:1473-90. 2007
    ..Pharmacotherapies include agents that target chemoattraction, cell migration, chemotherapies, and antigen-based therapies...
  90. ncbi Antigen recognition properties of a Vgamma1.3Vdelta2-T-cell receptor from a rare variant of polymyositis
    Klaus Dornmair
    Max Planck Institute of Neurobiology, Am Klopferspitz 18a, D 82152 Martinsried, Germany
    J Neuroimmunol 152:168-75. 2004
    ..These results (a) provide further insight into the molecular properties of this unusual TCR, and (b) should help in future attempts to identify the elusive target antigen(s)...
  91. ncbi Acute disseminated encephalomyelitis: an update
    Til Menge
    Department of Neurology, University of San Francisco, San Francisco, Calif, USA
    Arch Neurol 62:1673-80. 2005
    ....
  92. ncbi Expression of toll-like receptors by human muscle cells in vitro and in vivo: TLR3 is highly expressed in inflammatory and HIV myopathies, mediates IL-8 release and up-regulation of NKG2D-ligands
    Bettina Schreiner
    Department of General Neurology, Hertie Institute for Clinical Brain Research, Eberhard Karls University Tuebingen, Tuebingen, Germany
    FASEB J 20:118-20. 2006
    ....
  93. ncbi Treatment of active secondary progressive multiple sclerosis with treosulfan
    Heinz Wiendl
    Department of Neurology, University of Wuerzburg, Josef Schneider Str 11, D 97080 Wuerzburg, Germany
    J Neurol 254:884-9. 2007
    ..To study the safety and efficacy of treosulfan, a cytotoxic alkylating agent, in patients with active secondary progressive multiple sclerosis...
  94. ncbi Multiple sclerosis: advances, excitements, disenchantments
    Bernd C Kieseier
    Department of Neurology, Heinrich-Heine-University, Moorenstrasse 5, 40225 Duesseldorf, Germany
    Lancet Neurol 5:2-3. 2006
  95. ncbi The inflamed peripheral nervous system: update on immune therapies
    Bernd C Kieseier
    Curr Opin Neurol 19:433-6. 2006
  96. ncbi No effect of immunomodulatory therapy in focal epilepsy with positive glutamate receptor type 3--antibodies
    Michael Feichtinger
    Department of Neurology, Medical University of Graz, Auenbruggerplatz 22, A 8036 Graz, Austria
    Seizure 15:350-4. 2006
    ..Interestingly, GluR3 serum levels remained positive after successful surgical intervention leading to patient's seizure freedom...
  97. ncbi TWIK-related acid-sensitive K+ channel 1 (TASK1) and TASK3 critically influence T lymphocyte effector functions
    Sven G Meuth
    Department of Neurology, University of Wuerzburg, Wuerzburg, Germany
    J Biol Chem 283:14559-70. 2008
    ..These data introduce K(2)P channels as novel potassium conductance on T lymphocytes critically influencing T cell effector function and identify a possible molecular target for immunomodulation in T cell-mediated autoimmune disorders...