Research Topics
Genomes and GenesSpecies | S WalitzaSummaryCountry: Germany Publications
| Collaborators
|
Detail Information
Publications
Tetrahydroisoquinoline derivatives: a new perspective on monoaminergic dysfunction in children with ADHD?Veit Roessner
Department of Child and Adolescent Psychiatry, University of Goettingen, Goettingen, Germany
Behav Brain Funct 3:64. 2007..abstract:..- Transmission disequilibrium studies in children and adolescents with obsessive-compulsive disorders pertaining to polymorphisms of genes of the serotonergic pathwayS Walitza
Department of Child and Adolescent Psychiatry, Julius Maximilians University, Wurzburg, Germany
J Neural Transm 111:817-25. 2004..We did not detect transmission disequilibrium of the investigated polymorphisms in OCD. Hence, these polymorphisms do not play a major role in the genetic predisposition to early onset OCD... - [Genetic findings in obsessive-compulsive disorder in childhood and adolescence and in adulthood]Susanne Walitza
Klinik für Kinder und Jugendpsychiatrie und Psychotherapie der Universität Würzburg
Z Kinder Jugendpsychiatr Psychother 36:45-52. 2008..The phenotypic and genetic heterogeneity of OCD complicate the identification of specific genetic factors. Further studies have to be designed in consideration of subtypes, e.g. age at onset, symptom dimensions, or comorbid disorders... - Transmission disequilibrium of polymorphic variants in the tryptophan hydroxylase-2 gene in attention-deficit/hyperactivity disorderS Walitza
Department of Child and Adolescent Psychiatry and Psychotherapy, Julius Maximilians University, Wurzburg, Germany
Mol Psychiatry 10:1126-32. 2005..064). Our results link potentially functional TPH2 variations to the pathophysiology of ADHD, and further support the relevance of 5-HT in disorders related to altered motor activity and cognitive processes... - Transmission disequilibrium studies in early onset of obsessive-compulsive disorder for polymorphisms in genes of the dopaminergic systemSusanne Walitza
Department of Child and Adolescent Psychiatry and Psychotherapy, University of Wurzburg, Fuchsleinstr 15, 97080 Wurzburg, Germany
J Neural Transm 115:1071-8. 2008..No evidence of transmission disequilibrium was detected for alleles of the DAT1 and COMT polymorphisms. These polymorphisms do not appear to play a major role in the genetic predisposition to early onset OCD in our study group... - Children and adolescents with obsessive-compulsive disorder and comorbid attention-deficit/hyperactivity disorder: preliminary results of a prospective follow-up studyS Walitza
Department of Child and Adolescent Psychiatry and Psychotherapy, University of Wurzburg, Wurzburg, Germany
J Neural Transm 115:187-90. 2008..Both groups appear to develop different patterns of comorbid disorders... - Genome-wide linkage analysis of ADHD using high-density SNP arrays: novel loci at 5q13.1 and 14q12M Romanos
ADHD Clinical Research Program, Department of Child and Adolescent Psychiatry and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany
Mol Psychiatry 13:522-30. 2008..Our study provides further evidence for common gene effects throughout different populations despite the complex multifactorial etiology of ADHD... - Allelic variants of SNAP25 in a family-based sample of ADHDT J Renner
Department of Child and Adolescent Psychiatry and Psychotherapy, University of Wurzburg, Wurzburg, Germany
J Neural Transm 115:317-21. 2008..In our German ADHD sample no preferential transmission of either variant could be observed. Further investigation considering sub-sample analysis regarding response to D-amphetamine could enlight the role of SNAP25 in ADHD... - Association and linkage of allelic variants of the dopamine transporter gene in ADHDS Friedel
Department of Child and Adolescent Psychiatry, University of Duisburg Essen, Essen, Germany
Mol Psychiatry 12:923-33. 2007..Future studies are required to assess if variation at this locus also explains other positive linkage results obtained for chromosome 5p... - No evidence for preferential transmission of common valine allele of the Val66Met polymorphism of the brain-derived neurotrophic factor gene (BDNF) in ADHDB G Schimmelmann
Department of Child and Adolescent Psychiatry, Rheinische Kliniken Essen, University of Duisburg Essen, Essen, Germany
J Neural Transm 114:523-6. 2007..We did not find support for an involvement of the Val66 allele of the Val66Met polymorphism of BDNF in the pathogenesis of ADHD in our sample... - Exploring the genetic link between RLS and ADHDB G Schimmelmann
Department of Child and Adolescent Psychiatry and Psychotherapy, University of Duisburg Essen, LVR Klinikun Essen, Virchowstr 174, 45147 Essen, Germany
J Psychiatr Res 43:941-5. 2009..Genes relevant to RLS remain interesting candidates for ADHD; particularly BTBD9 needs further study, as it has been related to iron storage, a potential pathophysiological link between RLS and certain subtypes of ADHD... - No evidence for association between a functional promoter variant of the Norepinephrine Transporter gene SLC6A2 and ADHD in a family-based sampleT J Renner
Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Wurzburg, Germany
Atten Defic Hyperact Disord 3:285-9. 2011..5%, P = 0.55). We conclude that A-3081T is not a major risk variant in our ADHD sample, though SLC6A2 remains an interesting candidate gene in ADHD, especially for the inattentive subtype... - Family-based association study of serotonergic candidate genes and attention-deficit/hyperactivity disorder in a German sampleP Heiser
Department of Child and Adolescent Psychiatry and Psychotherapy, Philipps University, Marburg, Germany
J Neural Transm 114:513-21. 2007..We cannot rule out the possibility that other variations in the investigated genes contribute to the etiology of ADHD... - 5-HT2A promoter polymorphism -1438G/A in children and adolescents with obsessive-compulsive disordersS Walitza
Department of Child and Adolescent Psychiatry, Julius Maximilians University, Wurzburg, Germany
Mol Psychiatry 7:1054-7. 2002..05) between individuals with OCD and controls. In this, to our knowledge, first association study based on children and adolescents with OCD, we confirm an association of the A-allele of the 5-HT2A receptor gene with OCD... - Brief review of available evidence concerning the potential induction of genomic damage by methylphenidateH Stopper
Department of Toxicology, University of Wuerzburg, Wuerzburg, Germany
J Neural Transm 115:331-4. 2008..In conclusion, changes in treatment strategies do not seem justified currently. Larger studies are under way and will hopefully eliminate any remaining doubt about potential genotoxic or carcinogenic consequences of MPH treatment... - [Diagnosis of attention-deficit hyperactivity disorder in childhood and adolescence]M Romanos
Klinik und Poliklinik für Kinder und Jugendpsychiatrie, Psychosomatik und Psychotherapie, Klinische Forschergruppe ADHS KFO 125, Universitat Wurzburg, Fuchsleinstrasse 15, 97080 Wurzburg
Nervenarzt 79:782-90. 2008..Diagnosis of comorbid disorders is obligatory due to their high prevalence rates. In some cases successful treatment of a child suffering from ADHD requires the additional diagnosis and treatment of ADHD in further family members... - [Obsessive-compulsive disorder in children and adolescents]Thomas Jans
Klinik und Poliklinik für Kinder und Jugendpsychiatrie, Psychosomatik und Psychotherapie des Universtätsklinikums Würzburg
Prax Kinderpsychol Kinderpsychiatr 57:429-56. 2008..This paper gives a review on juvenile obsessive-compulsive disorder and addresses issues of classification, epidemiology, symptoms, co-morbidity, diagnostics, aetiology, treatment strategies and the course of the disorder... - Transmission disequilibrium of polymorphic variants in the tryptophan hydroxylase-2 gene in children and adolescents with obsessive-compulsive disorderRainald Mossner
Clinical and Molecular Psychobiology, Department of Psychiatry and Psychotherapy, University of Wurzburg, Fuchsleinstrasse 15, 97080 Wurzburg, Germany
Int J Neuropsychopharmacol 9:437-42. 2006..58 (95% CI 0.98-6.82). In conclusion, the results link TPH2 variations to the pathogenesis of early-onset OCD and further support the aetiological relevance of 5-HT signalling in OCD... - Genotoxicity of the neurotransmitter dopamine in vitroHelga Stopper
Department of Toxicology, University of Wuerzburg, Versbacher Strasse 9, D 97078 Wuerzburg, Germany
Toxicol In Vitro 23:640-6. 2009.... - Reduced NoGo-anteriorisation during continuous performance test in deletion syndrome 22q11.2Marcel Romanos
Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Clinic of Wuerzburg, Fuechsleinstrasse 15, 97074 Wuerzburg, Germany
J Psychiatr Res 44:768-74. 2010..Despite recent reports of structural alterations of the ACC in DS22q11.2 our findings suggest that response-inhibition mediated by the ACC is not impaired in DS22q11.2... - [Severe early-childhood obsessive-compulsive disorder--case report on a 4-year-old girl]Renner Tobias
Klinik für Kinder und Jugendpsychiatrie und Psychotherapie der Universität Würzburg
Z Kinder Jugendpsychiatr Psychother 34:287-93. 2006..OCD is seldom diagnosed in children younger than six years of age. The present report deals with the diagnosis and therapy of OCD at a very early onset in childhood... - Co-morbidity of adult attention-deficit/hyperactivity disorder with focus on personality traits and related disorders in a tertiary referral centerChristian P Jacob
Department of Psychiatry and Psychotherapy, University of Wuerzburg, Fuechsleinstr 15, 97080, Wuerzburg, Germany
Eur Arch Psychiatry Clin Neurosci 257:309-17. 2007..The prevalence and consequences of co-morbid axis-I and axis-II disorders as well as personality traits were examined in a large cohort of adult attention-deficit/hyperactivity disorder (AADHD) at a tertiary referral center... - Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studiesKlaus Peter Lesch
ADHD Clinical Research Program, Molecular and Clinical Psychobiology, Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wuerzburg, Fuechsleinstr 15, 97080, Wuerzburg, Germany
J Neural Transm 115:1573-85. 2008..g., CDH13, ASTN2) and regulators of synaptic plasticity (e.g., CTNNA2, KALRN) despite the complex multifactorial etiologies of adult ADHD and addiction vulnerability... - No elevated genomic damage in children and adolescents with attention deficit/hyperactivity disorder after methylphenidate therapySusanne Walitza
Department of Child and Adolescent Psychiatry and Psychotherapy, University of Wuerzburg, Fuechsleinstr 15, 97080 Wuerzburg, Germany
Toxicol Lett 184:38-43. 2009..Furthermore, micronuclei were analyzed in a second tissue, buccal mucosa... - Does methylphenidate cause a cytogenetic effect in children with attention deficit hyperactivity disorder?Susanne Walitza
Department of Child and Adolescent Psychiatry and Psychotherapy, University of Wurzburg, Wurzburg, Germany
Environ Health Perspect 115:936-40. 2007..Assessment and treatment of patients were performed during inpatient or outpatient health care. The measure for genomic damage was the frequency of micronuclei, a subset of chromosomal aberrations, in peripheral lymphocytes... - Transmission disequilibrium analysis of the functional 5-HT3A receptor variant C178T in early-onset obsessive compulsive-disorderRainald Mossner
Department of Psychiatry and Psychotherapy, University of Wurzburg, Wurzburg, Germany
J Psychopharmacol 21:833-6. 2007..51 (95% CI 0.36-0.65). This argues against an involvement of the 5-HT(3A) receptor in the polygenic aetiology of early-onset OCD... - [Validation of the German version of the Australian Scale of Asperger's Syndrome (ASAS)]Siebke Melfsen
,
Z Kinder Jugendpsychiatr Psychother 33:27-34. 2005..CONCLUSIONS: The scale appears to be an adequate tool for screening purposes in that it correctly discriminates children and adolescents with Asperger's Syndrome... - The extent of social anxiety in combination with mental disordersSiebke Melfsen
Dept. of Psychiatry for Children and Adolescents, University of Wuerzburg, Fuechsleinstr. 15, 97080, Wuerzburg, Germany
Eur Child Adolesc Psychiatry 15:111-7. 2006..In none of these disorders, however, did the mean total score exceed the cut-off of 20... - Novel mutations of the extraneuronal monoamine transporter gene in children and adolescents with obsessive-compulsive disorderAndreas Lazar
Department of Pharmacology, University of Cologne, Cologne, Germany
Int J Neuropsychopharmacol 11:35-48. 2008..Heterologous expression of mutant cDNA revealed a 40% decline of transport capacity for norepinephrine. Rare mutations in the EMT gene suggest a causative or modulating role in genetic subtypes of OCD... - Effects of methylphenidate on multiple components of attention in children with attention deficit hyperactivity disorderOliver Tucha
Department of Experimental Psychology, University of Regensburg, 93040 Regensburg, Germany
Psychopharmacology (Berl) 185:315-26. 2006..Although MPH-induced improvements were observed in a broad range of attention measures, children with ADHD who were on MPH treatment nevertheless displayed serious deficits in a number of components of attention...