Michael Zeschnigk

Summary

Affiliation: University of Duisburg-Essen
Country: Germany

Publications

  1. ncbi IGF2/H19 hypomethylation in Silver-Russell syndrome and isolated hemihypoplasia
    Michael Zeschnigk
    Institut fur Humangenetik, Universitatsklinikum Essen, Essen, Germany
    Eur J Hum Genet 16:328-34. 2008
  2. ncbi Massive parallel bisulfite sequencing of CG-rich DNA fragments reveals that methylation of many X-chromosomal CpG islands in female blood DNA is incomplete
    Michael Zeschnigk
    Institut fur Humangenetik, Universitatsklinikum Essen, Essen, Germany
    Hum Mol Genet 18:1439-48. 2009
  3. ncbi EFS shows biallelic methylation in uveal melanoma with poor prognosis as well as tissue-specific methylation
    Lisa C Neumann
    Institut fur Humangenetik, Universitatsklinikum Essen, Hufelandstr, 55, 45157 Essen, Germany
    BMC Cancer 11:380. 2011
  4. ncbi Low frequency of imprinting defects in ICSI children born small for gestational age
    Deniz Kanber
    Institut fur Humangenetik, Universitatsklinikum Essen, Essen, Germany
    Eur J Hum Genet 17:22-9. 2009
  5. ncbi Novel cell lines derived by long-term culture of primary uveal melanomas
    Gordon Nareyeck
    Department of Ophthalmology, Universitatsklinikum Essen, Essen, Germany
    Ophthalmologica 223:196-201. 2009
  6. ncbi Expression of MCSP and PRAME in conjunctival melanoma
    Henrike Westekemper
    Department of Ophthalmology, University Hospital of Essen, Hufelandstrasse 55, Essen, Germany
    Br J Ophthalmol 94:1322-7. 2010
  7. ncbi Combining DNA expression with positional information to detect functional silencing of chromosomal regions
    Johannes Husing
    Institut für Medizinische Informatik, Biometrie und Epidemiologie, Universitatsklinikum Essen, Hufelandstrasse 55, D 45122 Essen, Germany
    Bioinformatics 19:2335-42. 2003
  8. ncbi A novel real-time PCR assay for quantitative analysis of methylated alleles (QAMA): analysis of the retinoblastoma locus
    Michael Zeschnigk
    Institut fur Humangenetik, Hufelandstrasse 55, D 45122 Essen, Germany
    Nucleic Acids Res 32:e125. 2004
  9. ncbi Differential expression of tissue inhibitor of matrix metalloproteinases 3 in uveal melanoma
    Gordon Nareyeck
    Department of Ophthalmology, Universitatsklinikum Essen, Essen, Germany
    Ophthalmic Res 37:23-8. 2005
  10. ncbi Tumor classification based on gene expression profiling shows that uveal melanomas with and without monosomy 3 represent two distinct entities
    Frank Tschentscher
    , , 45122 Essen, Germany
    Cancer Res 63:2578-84. 2003

Collaborators

Detail Information

Publications15

  1. ncbi IGF2/H19 hypomethylation in Silver-Russell syndrome and isolated hemihypoplasia
    Michael Zeschnigk
    Institut fur Humangenetik, Universitatsklinikum Essen, Essen, Germany
    Eur J Hum Genet 16:328-34. 2008
    ..Furthermore, we show that methylation analysis by QAMA and MLPA is more sensitive in detecting ICR1 hypomethylation than Southern blot analysis of CTS3...
  2. ncbi Massive parallel bisulfite sequencing of CG-rich DNA fragments reveals that methylation of many X-chromosomal CpG islands in female blood DNA is incomplete
    Michael Zeschnigk
    Institut fur Humangenetik, Universitatsklinikum Essen, Essen, Germany
    Hum Mol Genet 18:1439-48. 2009
    ..Remarkably, methylation of X-chromosomal CGIs in female blood cells was most often incomplete (25-75%). Such incomplete methylation was mainly found on the X-chromosome, suggesting that it is linked to X-chromosome inactivation...
  3. ncbi EFS shows biallelic methylation in uveal melanoma with poor prognosis as well as tissue-specific methylation
    Lisa C Neumann
    Institut fur Humangenetik, Universitatsklinikum Essen, Hufelandstr, 55, 45157 Essen, Germany
    BMC Cancer 11:380. 2011
    ....
  4. ncbi Low frequency of imprinting defects in ICSI children born small for gestational age
    Deniz Kanber
    Institut fur Humangenetik, Universitatsklinikum Essen, Essen, Germany
    Eur J Hum Genet 17:22-9. 2009
    ....
  5. ncbi Novel cell lines derived by long-term culture of primary uveal melanomas
    Gordon Nareyeck
    Department of Ophthalmology, Universitatsklinikum Essen, Essen, Germany
    Ophthalmologica 223:196-201. 2009
    ..Uveal melanomas with or without monosomy 3 have different metastatic potentials. Therefore, it would be of great experimental importance to obtain cell lines of both groups - established and characterized under the same conditions...
  6. ncbi Expression of MCSP and PRAME in conjunctival melanoma
    Henrike Westekemper
    Department of Ophthalmology, University Hospital of Essen, Hufelandstrasse 55, Essen, Germany
    Br J Ophthalmol 94:1322-7. 2010
    ....
  7. ncbi Combining DNA expression with positional information to detect functional silencing of chromosomal regions
    Johannes Husing
    Institut für Medizinische Informatik, Biometrie und Epidemiologie, Universitatsklinikum Essen, Hufelandstrasse 55, D 45122 Essen, Germany
    Bioinformatics 19:2335-42. 2003
    ..Epigenetic phenomena may also silence several genes in the same region of a chromosome. While cytogenetic or other molecular genetic methods spot changes of DNA copy number, they cannot detect other causes of silencing...
  8. ncbi A novel real-time PCR assay for quantitative analysis of methylated alleles (QAMA): analysis of the retinoblastoma locus
    Michael Zeschnigk
    Institut fur Humangenetik, Hufelandstrasse 55, D 45122 Essen, Germany
    Nucleic Acids Res 32:e125. 2004
    ..Because the high sequence specificity inherent to the MGB technology is widely used to discriminate single nucleotide polymorphisms, QAMA potentially can be used to discriminate the methylation status of single CpG dinucleotides...
  9. ncbi Differential expression of tissue inhibitor of matrix metalloproteinases 3 in uveal melanoma
    Gordon Nareyeck
    Department of Ophthalmology, Universitatsklinikum Essen, Essen, Germany
    Ophthalmic Res 37:23-8. 2005
    ..There was a trend between TIMP-3 protein expression and both cell type (p = 0.11) and presence of loops and/or networks (p = 0.06) in tumour which may indicate a role of TIMP-3 in the biology of uveal melanoma...
  10. ncbi Tumor classification based on gene expression profiling shows that uveal melanomas with and without monosomy 3 represent two distinct entities
    Frank Tschentscher
    , , 45122 Essen, Germany
    Cancer Res 63:2578-84. 2003
    ..Our findings suggest that there are two distinct entities of uveal melanoma that were previously unrecognized because they are not obviously distinguishable by clinicopathological features...
  11. ncbi Aberrant hypomethylation of the cancer-testis antigen PRAME correlates with PRAME expression in acute myeloid leukemia
    Christina A Ortmann
    Klinik für Hämatologie, Zentrum für Konservative Onkologie, Universitatsklinikum Essen, Hufelandstrasse 55, 45122, Essen, Germany
    Ann Hematol 87:809-18. 2008
    ..Such a role is further supported by the observation that treatment of PRAME-negative cell lines U-937 and THP-1 with the demethylating agent 5'-Aza-2'dC resulted in a dose-related upregulation of PRAME expression...
  12. ncbi DNA methylation in promoter regions of red cell membrane protein genes in healthy individuals and patients with hereditary membrane disorders
    Ralph Remus
    Institute of Genetics, University of Cologne, Cologne, Germany
    Int J Hematol 81:385-95. 2005
    ..In disease states, the DNA methylation profiles of these red cell membrane protein genes were essentially not different from those in healthy individuals (statistically not significant)...
  13. ncbi Relationships between DNA methylation and expression in erythrocyte membrane protein (band 3, protein 4.2, and beta-spectrin) genes during human erythroid development and differentiation
    Ralph Remus
    Institute of Genetics, University of Cologne, Cologne, Germany
    Int J Hematol 82:422-9. 2005
    ....