Research Topics
Species | Georg von Samson-HimmelstjernaSummaryAffiliation: University of Veterinary Medicine Country: Germany Publications
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Detail Information
Publications
Allele-specific PCR for the beta-tubulin codon 200 TTC/TAC polymorphism using single adult and larval small strongyle (Cyathostominae) stagesG von Samson-Himmelstjerna
Institute of Parasitology, School of Veterinary Medicine Hannover, Germany
J Parasitol 88:254-7. 2002..This method might be applied for the future assessment of allele frequencies in susceptible and resistant populations to further investigate the mechanism of BZ-resistance in small strongyles...- Feasibility of genus-specific real-time PCR for the differentiation of larvae from gastrointestinal nematodes of naturally infected sheepElisabeth M Siedek
Pfizer Ltd, Sandwich, UK
Berl Munch Tierarztl Wochenschr 119:303-7. 2006..Thus, real-time PCR was found to be suitable as a speedy and reliable diagnostic tool for the assessment of gastrointestinal nematode infections of ruminants in the field... - Differential gene expression in hypobiosis-induced and non-induced third-stage larvae of the bovine lungworm Dictyocaulus viviparusChristina Strube
Institute for Parasitology, Centre for Infectious Diseases, University of Veterinary Medicine Hannover, Buenteweg 17, 30559 Hannover, Germany
Int J Parasitol 37:221-31. 2007..The expression patterns of these genes were validated by quantitative real-time PCR. This revealed differential gene expression, particularly for the N-methyltransferase... - Development and evaluation of a recombinant antigen-based ELISA for serodiagnosis of cattle lungwormChristian von Holtum
Institute for Parasitology, University of Veterinary Medicine Hannover, Buenteweg 17, 30559 Hannover, Germany
Vet Parasitol 151:218-26. 2008..Thus, we conclude that the ELISA using the recombinant MSP-fusion protein appears to be a suitable method for routine diagnosis and epidemiological studies of cattle lungworm... - Anthelmintic resistance in cyathostomin populations from horse yards in Italy, United Kingdom and GermanyDonato Traversa
Faculty of Veterinary Medicine, University of Teramo, Italy
Parasit Vectors 2:S2. 2009.... - Faecal Cyathostomin Egg Count distribution and efficacy of anthelmintics against cyathostomins in Italy: a matter of geography?Piermarino Milillo
Faculty of Veterinary Medicine, University of Teramo, Italy
Parasit Vectors 2:S4. 2009.... - Will technology provide solutions for drug resistance in veterinary helminths?Georg von Samson-Himmelstjerna
University of Veterinary Medicine Hannover, Buenteweg 17, 30559 Hannover, Germany
Vet Parasitol 132:223-39. 2005..New classes of anthelmintics are needed, but until they are developed and available to the producers, technology can assist to achieve the goal of better sustainability in anthelmintic usage... - Putative G protein-coupled receptors in parasitic nematodes--potential targets for the new anthelmintic class cyclooctadepsipeptides?C Welz
Institute for Parasitology, University of Veterinary Medicine, Buenteweg 17, Hannover, Germany
Parasitol Res 97:S22-32. 2005..Therefore it seems reasonable to allocate the depsiphilins to the previously described latrophilins and latrophilin-like proteins... - Clinical and epidemiological characteristics of Eimeria infections in first-year grazing cattleG von Samson-Himmelstjerna
Institute of Parasitology, University of Veterinary Medicine, Hannover, Germany
Vet Parasitol 136:215-21. 2006..39; p = 0.0001). These data indicate that in endemic areas first-year grazing calves must be considered at risk to develop clinical coccidiosis due to E. alabamensis infection during the first 2-3 weeks post turnout... - Molecular diagnosis of anthelmintic resistanceGeorg von Samson-Himmelstjerna
Institute of Parasitology, University of Veterinary Medicine Hannover, Bunteweg 17, 30559 Hannover, Germany
Vet Parasitol 136:99-107. 2006..It is argued that a prerequisite for future molecular diagnosis will be tests providing reliable and exact quantification of resistance related alleles in DNA extracted from representative pools of parasites... - Cases of reduced cyathostomin egg-reappearance period and failure of Parascaris equorum egg count reduction following ivermectin treatment as well as survey on pyrantel efficacy on German horse farmsG von Samson-Himmelstjerna
Institute for Parasitology, University of Veterinary Medicine, Buenteweg 17, 30559 Hannover, Germany
Vet Parasitol 144:74-80. 2007..On one farm in 2 consecutive years, IVM treatment did not lead to a significant reduction in P. equorum faecal egg counts in one and five young horses, respectively... - Standardization of the egg hatch test for the detection of benzimidazole resistance in parasitic nematodesGeorg von Samson-Himmelstjerna
Institute for Parasitology, University of Veterinary Medicine, Hannover, Germany
Parasitol Res 105:825-34. 2009..The protocols for the test and preparation of solutions of thiabendazole are described... - Effects of worm control practices examined by a combined faecal egg count and questionnaire survey on horse farms in Germany, Italy and the UKGeorg von Samson-Himmelstjerna
University of Veterinary Medicine, Hannover, Germany
Parasit Vectors 2:S3. 2009.... - Efficacy of two cyclooctadepsipeptides, PF1022A and emodepside, against anthelmintic-resistant nematodes in sheep and cattleG von Samson-Himmelstjerna
Institute for Parasitology, Hannover School of Veterinary Medicine, Bunteweg 17, D 30559 Hannover, Germany
Parasitology 130:343-7. 2005..Both, PF1022A and emodepside were found to be fully effective against these parasite populations. These findings confirm that this new class of compounds acts by a different mode of action compared to the above-mentioned anthelmintics... - Comparative use of faecal egg count reduction test, egg hatch assay and beta-tubulin codon 200 genotyping in small strongyles (cyathostominae) before and after benzimidazole treatmentGeorg von Samson-Himmelstjerna
Institute of Parasitology, Hannover School of Veterinary Medicine, Buenteweg 17, 30559 Hannover, Germany
Vet Parasitol 108:227-35. 2002..Thus, there seems to be a difference in the significance of the codon 200 polymorphism in the mechanisms of BZ resistance in small strongyles of the horse and sheep trichostrongyles... - Quantitative analysis of ITS2 sequences in trichostrongyle parasitesG von Samson-Himmelstjerna
Institute of Parasitology, Hannover School of Veterinary Medicine, Buenteweg 17, D 30559, Hannover, Germany
Int J Parasitol 32:1529-35. 2002..This technique provides means for a rapid, reliable and quantitative detection and differentiation of the most important parasitic nematodes of sheep and cattle... - TaqMan minor groove binder real-time PCR analysis of beta-tubulin codon 200 polymorphism in small strongyles (Cyathostomin) indicates that the TAC allele is only moderately selected in benzimidazole-resistant populationsG von Samson-Himmelstjerna
Institute of Parasitology, Hannover School of Veterinary Medicine, Buenteweg 17, D 30559 Hannover, Germany
Parasitology 127:489-96. 2003..It is concluded that the beta-tubulin codon 200 polymorphism is not the sole mechanism involved in the process of BZ resistance in cyathostomins... - Analysis of codon usage in beta-tubulin sequences of helminthsG von Samson-Himmelstjerna
Institute of Parasitology, Hannover School of Veterinary Medicine, Buenteweg 17, 30559 Hannover, Germany
Parasitol Res 90:294-300. 2003..Finally, using the cu patterns of the sequences studied, a phylogenetic tree was constructed. The topology of this tree was very much in concordance with that of a phylogeny based on small subunit ribosomal DNA sequence alignments... - Effect of repeated benzimidazole treatments with increasing dosages on the phenotype of resistance and the beta-tubulin codon 200 genotype distribution in a benzimidazole-resistant cyathostomin populationMichaela Drogemuller
Hannover School of Veterinary Medicine, Institute of Parasitology, Buenteweg 17, D-30559 Hannover, Germany
Vet Parasitol 123:201-13. 2004..Furthermore, it may also be concluded that, in contrast to sheep trichostrongyles, such a selection regime does not result in beta-tubulin codon 200 TAC allele autocracy... - Expression of recombinant beta-tubulin alleles from Cylicocyclus nassatus (Cyathostominae)William J Blackhall
Institute for Parasitology, University of Veterinary Medicine Hannover, Buenteweg 17, 30559 Hannover, Germany
Parasitol Res 99:687-93. 2006..In this work, we describe the construction of expression vectors containing these alleles and their expression in Escherichia coli... - Amplification of ribosomal DNA of Anoplocephalidae: Anoplocephala perfoliata diagnosis by PCR as a possible alternative to coprological methodsMichaela Drogemuller
Institute of Parasitology, School of Veterinary Medicine Hannover, Buenteweg 17, D-30559 Hannover, Germany
Vet Parasitol 124:205-15. 2004..The ITS-2 PCR enabled the detection of genomic DNA as low as 0.5 pgs. First efforts on the practical application of the PCR-based approach were made. A 6-mg fragment of a tapeworm proglottid was detected in 0.5 and 1g of faeces... - Investigation of diversity and isotypes of the beta-tubulin cDNA in several small strongyle (Cyathostominae) speciesMichaela Pape
Institute of Parasitology, School of Veterinary Medicine, Buenteweg 17, D 30559 Hannover, Germany
J Parasitol 88:673-7. 2002..The variation in size was caused by a length polymorphism within the 3' untranslated region, and 2 functional mRNAs seem to be transcribed from the same gene... - SLO-1-channels of parasitic nematodes reconstitute locomotor behaviour and emodepside sensitivity in Caenorhabditis elegans slo-1 loss of function mutantsClaudia Welz
Institute for Parasitology, University of Veterinary Medicine Hannover, Hannover, Germany
PLoS Pathog 7:e1001330. 2011.... - Genetic regulation of arrested development in nematodes: are age-1 and daf-gene orthologs present in Dictyocaulus viviparus?Christina Strube
Institute for Parasitology, University of Veterinary Medicine Hannover, Buenteweg, 17, 30559 Hannover, Germany
Parasitol Res 101:1111-5. 2007..No orthologs of the age-1 or daf-genes could be identified in D. viviparus. The possible differences in the role of the daf-genes concerning arrested development in parasitic and free-living nematodes will be discussed... - Evaluation of a milk ELISA for the serodiagnosis of Dictyocaulus viviparus in dairy cowsChristiane Fiedor
Institute for Parasitology, University of Veterinary Medicine Hannover, Buenteweg 17, 30559 Hannover, Germany
Vet Parasitol 166:255-61. 2009.... - Microchip capillary electrophoresis-based genetic comparison of closely related cyathostomin nematode parasites of horses using randomly amplified polymorphic DNA polymerase chain reactionJanez Posedi
Institute of Parasitology, Hannover School of Veterinary Medicine, Buenteweg 17, 30559 Hannover, Germany
Parasitol Res 92:421-9. 2004..Furthermore, by determining the second internal transcribed spacer region of three and nine individual worms for C. elongatus and C. insigne, respectively, low intraspecific variations of only up to 0.3% were demonstrated... - The putative cyclooctadepsipeptide receptor depsiphilin of the canine hookworm Ancylostoma caninumNina Krüger
Institute for Parasitology, University of Veterinary Medicine, Hannover, Germany
Parasitol Res 105:S91-100. 2009..Depsiphilin is transcribed in all five examined stages, but we found a significantly lower transcript level in third-stage larvae. A correlation between these findings and a reduced emodepside activity remains to be investigated... - A comparison of immune responses to infection with virulent infectious bursal disease virus (IBDV) between specific-pathogen-free chickens infected at 12 and 28 days of ageSilke Rautenschlein
Clinic for Poultry, University of Veterinary Medicine Hannover, Bunteweg 17, 30559 Hannover, Germany
Vet Immunol Immunopathol 115:251-60. 2007..Under these experimental conditions, age-related differences were found only for the cytokine patterns but interestingly this did not influence the outcome of the disease with IBDV-IM... - In silico analysis of the cyclophilin repertoire of apicomplexan parasitesJurgen Krucken
Institute for Parasitology, University of Veterinary Medicine Foundation, Bunteweg 17, 30559 Hannover, Germany
Parasit Vectors 2:27. 2009..abstract:.. - Real-time RT-PCR quantitation of mCLCA1 and mCLCA2 reveals differentially regulated expression in pre- and postnatal murine tissuesIna Leverkoehne
Department of Pathology, School of Veterinary Medicine Hannover, Buenteweg 17, 30559 Hannover, Germany
Histochem Cell Biol 118:11-7. 2002..These results indicate that, in spite of their extremely close sequence homology, mCLCA1 and mCLCA2 are involved in different, yet unidentified pathways... - P-glycoprotein in helminths: function and perspectives for anthelmintic treatment and reversal of resistanceDominique Kerboeuf
UR086 BioAgresseurs, , INRA, 37380 Nouzilly, France
Int J Antimicrob Agents 22:332-46. 2003..In contrast to earlier data, most recent observations, based on experimentally overexpressed Pgp in Trypanosoma brucei, indicate a possible involvement in the mechanism of drug resistance in this parasite... - Impact of formalin-fixation and paraffin-embedding on the ratio between mRNA copy numbers of differently expressed genesDorthe von Smolinski
Department of Veterinary Pathology, Free University Berlin, Robert von Ostertag Str. 15, 14163, Berlin
Histochem Cell Biol 124:177-88. 2005..In contrast, tissue autolysis of up to 24 h and long-term storage of embedded tissues of up to 20 years had no additional effects... - Drug resistance in veterinary helminthsAdrian J Wolstenholme
Department of Biology and Biochemistry, University of Bath, Bath, BA2 7AY, UK
Trends Parasitol 20:469-76. 2004..This review summarizes some of the recent findings on resistance mechanisms, puts forward some recommendations for limiting its impact and suggests some priorities for research in this area... - Cyclooctadepsipeptides--a new class of anthelmintically active compoundsAchim Harder
Bayer AG, Business Group Animal Health, Biological and Chemical Evaluation, Alfred-Nobel-Strasse 50, 40789 Monheim, Germany
Parasitol Res 88:481-8. 2002 - Synthesis of anthelmintically active N-methylated amidoxime analogues of the cyclic octadepsipeptide PF1022APeter Jeschke
Bayer AG, Bayer CropScience, Research Global Chemistry Insecticides, Alfred Nobel Str 50, D 40789 Monheim, Germany
Pest Manag Sci 58:1205-15. 2002..Here we report on a specific modification at the N-methyl amide linkage by using the mono-thionated PF1022A, resulting in novel anthelmintically active backbone analogues of PF 1022A... - Rapid identification of isometamidium-resistant stocks of Trypanosoma b. brucei by PCR-RFLPYohannes Afework
Institute for Parasitology and Tropical Veterinary Medicine, , , 14163, Berlin, Germany
Parasitol Res 99:253-61. 2006..Thus, the isometamidium-sensitive and isometamidium-resistant T. b. brucei could be successfully distinguished by digestion with the restriction endonuclease Sfa NI...