Holger K Ulbrich

Summary

Affiliation: University of Mainz
Country: Germany

Publications

  1. ncbi Characterization of a computerized assay for rapid and easy determination of leukocyte adhesion to endothelial cells
    Holger Ulbrich
    Johannes Gutenberg University of Mainz, Institute of Pharmacy, Mainz, Germany
    Biol Pharm Bull 28:718-24. 2005
  2. ncbi Licofelone, a novel 5-LOX/COX-inhibitor, attenuates leukocyte rolling and adhesion on endothelium under flow
    H Ulbrich
    Karolinska Institute, Department of Physiology and Pharmacology, Von Eulers Vag 8, SE 171 77 Stockholm, Sweden
    Biochem Pharmacol 70:30-6. 2005
  3. ncbi A novel class of potent nonglycosidic and nonpeptidic pan-selectin inhibitors
    Holger K Ulbrich
    Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, Johannes Gutenberg University, Staudingerweg 5, DE 55099 Mainz, Germany
    J Med Chem 49:5988-99. 2006
  4. ncbi Diaryl-dithiolanes and -isothiazoles: COX-1/COX-2 and 5-LOX-inhibitory, *OH scavenging and anti-adhesive activities
    Michael Scholz
    Institute of Pharmacy, Department of Pharmaceutical and Medicinal Chemistry, Johannes Gutenberg University, Staudingerweg 5, DE 55128 Mainz, Germany
    Bioorg Med Chem 17:558-68. 2009
  5. ncbi In-vitro test system for the evaluation of cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) inhibitors based on a single HPLC run with UV detection using bovine aortic coronary endothelial cells (BAECs)
    G Dannhardt
    Institute of Pharmacy, University of Mainz, Germany
    Inflamm Res 50:262-9. 2001
  6. ncbi Investigations concerning the COX/5-LOX inhibiting and hydroxyl radical scavenging potencies of novel 4,5-diaryl isoselenazoles
    Michael Scholz
    Institute of Pharmacy, Department of Pharmaceutical and Medicinal Chemistry, Johannes Gutenberg University, Staudingerweg 5, DE 55128 Mainz, Germany
    Eur J Med Chem 43:1152-9. 2008

Detail Information

Publications6

  1. ncbi Characterization of a computerized assay for rapid and easy determination of leukocyte adhesion to endothelial cells
    Holger Ulbrich
    Johannes Gutenberg University of Mainz, Institute of Pharmacy, Mainz, Germany
    Biol Pharm Bull 28:718-24. 2005
    ..This assay lends itself to the screening of pharmacological substances with different mechanism of action that might act on either leukocytes or endothelial cells...
  2. ncbi Licofelone, a novel 5-LOX/COX-inhibitor, attenuates leukocyte rolling and adhesion on endothelium under flow
    H Ulbrich
    Karolinska Institute, Department of Physiology and Pharmacology, Von Eulers Vag 8, SE 171 77 Stockholm, Sweden
    Biochem Pharmacol 70:30-6. 2005
    ..Thus, the novel 5-LOX/COX inhibitor licofelone possesses anti-inflammatory activity that, in addition to COX/LOX inhibition, involves effects on leukocyte-endothelial interactions...
  3. ncbi A novel class of potent nonglycosidic and nonpeptidic pan-selectin inhibitors
    Holger K Ulbrich
    Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, Johannes Gutenberg University, Staudingerweg 5, DE 55099 Mainz, Germany
    J Med Chem 49:5988-99. 2006
    ..The assays used are predictive for the in vivo efficacy of test compounds as shown for 2a in a proteose peptone induced peritonitis model of acute inflammation in mice...
  4. ncbi Diaryl-dithiolanes and -isothiazoles: COX-1/COX-2 and 5-LOX-inhibitory, *OH scavenging and anti-adhesive activities
    Michael Scholz
    Institute of Pharmacy, Department of Pharmaceutical and Medicinal Chemistry, Johannes Gutenberg University, Staudingerweg 5, DE 55128 Mainz, Germany
    Bioorg Med Chem 17:558-68. 2009
    ..Thus, the novel 5-LOX/COX and (*)OH inhibitor 11a possesses anti-inflammatory activity that, in addition to COX/5-LOX inhibition, implicates effects on leukocyte-endothelial interactions...
  5. ncbi In-vitro test system for the evaluation of cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) inhibitors based on a single HPLC run with UV detection using bovine aortic coronary endothelial cells (BAECs)
    G Dannhardt
    Institute of Pharmacy, University of Mainz, Germany
    Inflamm Res 50:262-9. 2001
    ..The aim of this study was to develop a new, whole-cell test system which is easy to handle and requires a standard equipment for the parallel screening of COX-1 and COX-2 inhibitors...
  6. ncbi Investigations concerning the COX/5-LOX inhibiting and hydroxyl radical scavenging potencies of novel 4,5-diaryl isoselenazoles
    Michael Scholz
    Institute of Pharmacy, Department of Pharmaceutical and Medicinal Chemistry, Johannes Gutenberg University, Staudingerweg 5, DE 55128 Mainz, Germany
    Eur J Med Chem 43:1152-9. 2008
    ....