W Stremmel

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. ncbi Alterations of lipid metabolism in Wilson disease
    Jessica Seessle
    Department of Gastroenterology, University Hospital Heidelberg, Heidelberg, Germany
    Lipids Health Dis 10:83. 2011
  2. ncbi Myocardial late gadolinium enhancement cardiovascular magnetic resonance in patients with cirrhosis
    Dirk Lossnitzer
    Department of Internal Medicine III, University Hospital of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    J Cardiovasc Magn Reson 12:47. 2010
  3. ncbi Early treatment of imported falciparum malaria in the intermediate and intensive care unit setting: an 8-year single-center retrospective study
    Lukas Schwake
    Department of Internal Medicine IV Gastroenterology, Infectious Diseases and Intensive Care Medicine, University Hospital Heidelberg, Im Neuenheimer Feld, D 69120 Heidelberg, Germany
    Crit Care 12:R22. 2008
  4. ncbi Truncating mutations in the Wilson disease gene ATP7B are associated with very low serum ceruloplasmin oxidase activity and an early onset of Wilson disease
    Uta Merle
    Department of Gastroenterology and Hepatology, University Hospital, Heidelberg, Germany
    BMC Gastroenterol 10:8. 2010
  5. ncbi Limitations of the MELD score in predicting mortality or need for removal from waiting list in patients awaiting liver transplantation
    Daniel Gotthardt
    Department of Internal Medicine IV, University Hospital of Heidelberg, Heidelberg, Germany
    BMC Gastroenterol 9:72. 2009
  6. ncbi Sensitivity and specificity of plasma disappearance rate of indocyanine green as a prognostic indicator in acute liver failure
    Uta Merle
    Department of Gastroenterology, University Hospital Heidelberg, Heidelberg, Germany
    BMC Gastroenterol 9:91. 2009
  7. ncbi Wilson protein expression, copper excretion and sweat production in sweat glands of Wilson disease patients and controls
    Mark Schaefer
    Department of Gastroenterology and Infections Diseases, University of Heidelberg Medical School, INF 410, D 69120 Heidelberg, Germany
    BMC Gastroenterol 8:29. 2008
  8. ncbi TNF-alpha-induced up-regulation of pro-inflammatory cytokines is reduced by phosphatidylcholine in intestinal epithelial cells
    Irina Treede
    Department of Gastroenterology, University of Heidelberg, Heidelberg, Germany
    BMC Gastroenterol 9:53. 2009
  9. ncbi Uptake of long chain fatty acids is regulated by dynamic interaction of FAT/CD36 with cholesterol/sphingolipid enriched microdomains (lipid rafts)
    Robert Ehehalt
    Department of Gastroenterology, University Hospital Heidelberg, INF 410, 69120 Heidelberg, Germany
    BMC Cell Biol 9:45. 2008
  10. ncbi Retarded release phosphatidylcholine benefits patients with chronic active ulcerative colitis
    W Stremmel
    Department of Gastroenterology, University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    Gut 54:966-71. 2005

Collaborators

Detail Information

Publications83

  1. ncbi Alterations of lipid metabolism in Wilson disease
    Jessica Seessle
    Department of Gastroenterology, University Hospital Heidelberg, Heidelberg, Germany
    Lipids Health Dis 10:83. 2011
    ..However, serum lipid profile has not been investigated in large human WD patient cohorts to date...
  2. ncbi Myocardial late gadolinium enhancement cardiovascular magnetic resonance in patients with cirrhosis
    Dirk Lossnitzer
    Department of Internal Medicine III, University Hospital of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    J Cardiovasc Magn Reson 12:47. 2010
    ..We sought to identify myocardial tissue characterization and evaluate cardiovascular magnetic resonance (CMR) for diagnosis of cardiac impairment...
  3. ncbi Early treatment of imported falciparum malaria in the intermediate and intensive care unit setting: an 8-year single-center retrospective study
    Lukas Schwake
    Department of Internal Medicine IV Gastroenterology, Infectious Diseases and Intensive Care Medicine, University Hospital Heidelberg, Im Neuenheimer Feld, D 69120 Heidelberg, Germany
    Crit Care 12:R22. 2008
    ..The present study was undertaken to evaluate critically the benefit of this strategy, which includes daily consultation with senior specialists in tropical medicine...
  4. ncbi Truncating mutations in the Wilson disease gene ATP7B are associated with very low serum ceruloplasmin oxidase activity and an early onset of Wilson disease
    Uta Merle
    Department of Gastroenterology and Hepatology, University Hospital, Heidelberg, Germany
    BMC Gastroenterol 10:8. 2010
    ..We aimed to evaluate whether 'severe' protein-truncating ATP7B mutations (SMs) are associated with low serum ceruloplasmin oxidase activities and an early age of onset when compared to missense mutations (MMs)...
  5. ncbi Limitations of the MELD score in predicting mortality or need for removal from waiting list in patients awaiting liver transplantation
    Daniel Gotthardt
    Department of Internal Medicine IV, University Hospital of Heidelberg, Heidelberg, Germany
    BMC Gastroenterol 9:72. 2009
    ..The relative shortage of organ donors renders the allocation algorithms of organs essential. The optimal strategy based on scoring systems and/or waiting time is still under debate...
  6. ncbi Sensitivity and specificity of plasma disappearance rate of indocyanine green as a prognostic indicator in acute liver failure
    Uta Merle
    Department of Gastroenterology, University Hospital Heidelberg, Heidelberg, Germany
    BMC Gastroenterol 9:91. 2009
    ....
  7. ncbi Wilson protein expression, copper excretion and sweat production in sweat glands of Wilson disease patients and controls
    Mark Schaefer
    Department of Gastroenterology and Infections Diseases, University of Heidelberg Medical School, INF 410, D 69120 Heidelberg, Germany
    BMC Gastroenterol 8:29. 2008
    ..It is the aim of this study to investigate Wilson protein expression in sweat glands and analysing its effects on copper excretion into sweat in controls and patients with Wilson disease...
  8. ncbi TNF-alpha-induced up-regulation of pro-inflammatory cytokines is reduced by phosphatidylcholine in intestinal epithelial cells
    Irina Treede
    Department of Gastroenterology, University of Heidelberg, Heidelberg, Germany
    BMC Gastroenterol 9:53. 2009
    ..We investigate here in more detail the hypothesis that the exogenous application of PC has anti-inflammatory properties...
  9. ncbi Uptake of long chain fatty acids is regulated by dynamic interaction of FAT/CD36 with cholesterol/sphingolipid enriched microdomains (lipid rafts)
    Robert Ehehalt
    Department of Gastroenterology, University Hospital Heidelberg, INF 410, 69120 Heidelberg, Germany
    BMC Cell Biol 9:45. 2008
    ..However, we now can provide further evidence that not only proteins but also lipid microdomains play an important part in the regulation of the facilitated uptake process...
  10. ncbi Retarded release phosphatidylcholine benefits patients with chronic active ulcerative colitis
    W Stremmel
    Department of Gastroenterology, University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    Gut 54:966-71. 2005
    ..We examined the hypothesis of an anti-inflammatory effect of phosphatidylcholine in ulcerative colitis...
  11. ncbi Mice with targeted disruption of the fatty acid transport protein 4 (Fatp 4, Slc27a4) gene show features of lethal restrictive dermopathy
    Thomas Herrmann
    Dept of Internal Medicine IV, University of Heidelberg, Bergheimer Str 58, 69115 Heidelberg, Germany
    J Cell Biol 161:1105-15. 2003
    ..These findings reveal a previously unknown, essential function of Fatp4 in the formation of the epidermal barrier...
  12. ncbi Phosphatidylcholine (lecithin) and the mucus layer: Evidence of therapeutic efficacy in ulcerative colitis?
    Wolfgang Stremmel
    Department of Gastroenterology, University Hospital Heidelberg, Heidelberg, Germany
    Dig Dis 28:490-6. 2010
    ..Topical supplement of PC by a delayed-released oral PC preparation is effective in resolving inflammatory activity of UC and may develop to a first-choice therapy for this disease...
  13. ncbi Delayed release phosphatidylcholine in chronic-active ulcerative colitis: a randomized, double-blinded, dose finding study
    Wolfgang Stremmel
    Department of Gastroenterology, University Hospital Heidelberg, Heidelberg, Germany
    J Clin Gastroenterol 44:e101-7. 2010
    ..In 2 preceding studies, delayed release phosphatidylcholine (rPC) was found to (a) improve disease activity and (b) withdraw steroids in patients with chronic-active ulcerative colitis...
  14. ncbi A new concept of cellular uptake and intracellular trafficking of long-chain fatty acids
    W Stremmel
    Department of Gastroenterology, Ruprecht Karls University, 69115 Heidelberg, Germany
    Lipids 36:981-9. 2001
    ..The uptake process is terminated after activation to acyl-CoA by the members of the FATP family targeted intracellularly to different organelles...
  15. ncbi Liver and iron metabolism--a comprehensive hypothesis for the pathogenesis of genetic hemochromatosis
    W Stremmel
    Department of Gastroenterology, University Hospital Heidelberg, Germany
    Z Gastroenterol 45:71-5. 2007
    ..Therefore, a high erythron requirement for iron can utilize excess iron and may represent the rationale of phlebotomy therapy in this disease...
  16. ncbi Regulatory CD4+ CD25+ T cells prevent thymic dysfunction in experimental chronic colitis
    C Veltkamp
    Department of Gastroenterology, Ruprecht Karls University, Heidelberg, Germany
    Scand J Immunol 66:636-44. 2007
    ..In conclusion, early CD4+ CD25+ cotransfer prevents thymic dysfunction which underlies immune-mediated bowel inflammation in BM-->Tg epsilon26 mice...
  17. ncbi Mouse fatty acid transport protein 4 (FATP4): characterization of the gene and functional assessment as a very long chain acyl-CoA synthetase
    T Herrmann
    Department of Internal Medicine IV, University of Heidelberg, Bergheimer Strasse 58, 69115, Heidelberg, Germany
    Gene 270:31-40. 2001
    ....
  18. ncbi Long-chain fatty acid uptake by skeletal myocytes: a confocal laser scanning microscopy study
    C Elsing
    Department of Medicine, University of Heidelberg, Germany
    Cell Mol Life Sci 54:744-50. 1998
    ..Membrane hyper- and depolarization decreased uptake rates. This study demonstrates for the first time kinetic data from isolated myocytes with evidence for a carrier-mediated transport mechanism for long-chain fatty acids...
  19. ncbi The iron-regulatory peptide hormone hepcidin: expression and cellular localization in the mammalian kidney
    H Kulaksiz
    Department of Internal Medicine, Division of Gastroenterology, Im Neuenheimer Feld 410, University Hospital Heidelberg, D 69121 Heidelberg, Germany
    J Endocrinol 184:361-70. 2005
    ..Localization of hepcidin in the kidney implicates an iron-regulatory role of this peptide hormone in the renal tubular system, possibly in connection with the iron transporter divalent metal transporter-1...
  20. ncbi Cytomegalovirus infection after liver transplantation incidence, risks, and benefits of prophylaxis
    K Weigand
    Department of Gastroenterology and Hepatology, University Hospital Heidelberg, Germany
    Transplant Proc 42:2634-41. 2010
    ..Antiviral prophylaxis is recommended in clinical practice guidelines depending on the CMV status of both donor and recipient as well as the individual risk profile...
  21. ncbi Development of a heterologous, multigenotype vaccine against hepatitis C virus infection
    J Encke
    University of Heidelberg, Heidelberg, Germany
    Eur J Clin Invest 37:396-406. 2007
    ....
  22. ncbi Risk of infection with Helicobacter pylori and hepatitis A virus in different groups of hospital workers
    J Rudi
    Department of Medicine, University of Heidelberg, Germany
    Am J Gastroenterol 92:258-62. 1997
    ..The purpose of this study was to determine whether different staff groups in an acute care hospital are at increased risk of acquiring Helicobacter pylori and hepatitis A virus infection...
  23. ncbi Establishment of persistent hepatitis C virus infection and replication in vitro
    S Seipp
    Department of Internal Medicine, University of Heidelberg, Germany
    J Gen Virol 78:2467-76. 1997
    ..These data support the hypothesis of an LDL-receptor mediated uptake of HCV into cells in vitro...
  24. ncbi Spontaneous regression of intrahepatic lesions mimicking metastatic disease
    J Pohl
    Department of Medicine, Ruprecht Karls University, Heidelberg, Germany
    Z Gastroenterol 38:803-6. 2000
    ..The exact diagnosis remained elusive but the rare case of reversible focal fibrosis is the most likely cause of these spontaneously regressive lesions...
  25. ncbi Can monovalent hepatitis A and B vaccines be replaced by a combined hepatitis A/B vaccine during the primary immunization course?
    B Kallinowski
    Department of Internal Medicine IV, University Hospital of Heidelberg, Bergheimer Strasse 58, D 69115, Heidelberg, Germany
    Vaccine 19:16-22. 2000
    ..This study demonstrated for the first time that switching from monovalent hepatitis A and B vaccinations to the combined hepatitis A and B vaccination has no negative influence on the tolerability and improves the immunogenicity...
  26. ncbi HJV gene mutations in European patients with juvenile hemochromatosis
    S G Gehrke
    Department of Internal Medicine IV, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    Clin Genet 67:425-8. 2005
    ..Therefore, detection of the G320V mutation could identify the majority of JH cases from these regions non-invasively...
  27. ncbi Helicobacter pylori-induced apoptosis in T cells is mediated by the mitochondrial pathway independent of death receptors
    T M Ganten
    University of Heidelberg, Germany
    Eur J Clin Invest 37:117-25. 2007
    ..In this study we investigated the mechanisms of H. pylori-induced apoptosis in T lymphocytes, which could explain a mechanism of immune evasion facilitating chronic inflammation of the mucosa and gastric carcinogenesis...
  28. ncbi IL-1beta and IL-10 have dual effects on enteric glial cell proliferation
    A Ruhl
    Department of Gastroenterology, Ruprecht Karls University, Heidelberg, Germany
    Neurogastroenterol Motil 13:89-94. 2001
    ..The differential effects of IL-1beta and IL-10 suggest that during intestinal inflammation there may be a regulatory interplay between different classes of cytokines modulating EGC proliferation...
  29. ncbi Prospective validation of a simple laboratory score to predict outcome after orthotopic liver transplantation
    L Schneider
    Department General Surgery, University of Heidelberg, Heidelberg, Germany
    Transplant Proc 43:1747-50. 2011
    ..To establish a score to predict 30-day mortality and graft loss retrospectively and to validate the score prospectively...
  30. ncbi TAp73/Delta Np73 influences apoptotic response, chemosensitivity and prognosis in hepatocellular carcinoma
    M Muller
    Department of Internal Medicine IV, Hepatology and Gastroenterology, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    Cell Death Differ 12:1564-77. 2005
    ..Our data indicate that Delta Np73 is an important gene in hepatocarcinogenesis and a relevant prognostic factor...
  31. ncbi Isolation of enteric glia and establishment of transformed enteroglial cell lines from the myenteric plexus of adult rat
    A Ruhl
    Department of Gastroenterology, Ruprecht Karls University, Heidelberg, Germany
    Neurogastroenterol Motil 13:95-106. 2001
    ..Such cell lines are now available for physiological studies of the functional properties of enteric glia in vitro...
  32. ncbi Expression of a bile acid transporter in biliary epithelial cells from normal and cholestatic rat livers
    C Elsing
    Gastroenterology, Department of Medicine, University of Heidelberg, Bergheimerstrasse 58, D 69115 Heidelberg, Germany
    Eur J Med Res 4:165-8. 1999
    ..These observations indicate that biliary epithelial cells are involved in bile acid transport across the biliary tree. In addition the carrier could also play a role in the signal transduction of bile acid induced ductular secretion...
  33. ncbi Diversity of Helicobacter pylori vacA and cagA genes and relationship to VacA and CagA protein expression, cytotoxin production, and associated diseases
    J Rudi
    Department of Medicine, University of Heidelberg, Germany
    J Clin Microbiol 36:944-8. 1998
    ..pylori isolates are identical to those previously reported. H. pylori strains of vacA type s1 are associated with the occurrence of peptic ulceration and the presence of cagA, cytotoxin activity, and VacA expression...
  34. ncbi Pro-hepcidin: expression and cell specific localisation in the liver and its regulation in hereditary haemochromatosis, chronic renal insufficiency, and renal anaemia
    H Kulaksiz
    Department of Internal Medicine, Division of Gastroenterology, University Hospital Heidelberg, Heidelberg, Germany
    Gut 53:735-43. 2004
    ....
  35. ncbi Temporary placement of fully covered self-expandable metal stents in biliary complications after liver transplantation
    P Sauer
    Department of Gastroenterology, University of Heidelberg, Germany
    Endoscopy 44:536-8. 2012
    ....
  36. ncbi [Combined liver-kidney and kidney after liver transplantation: indications and experiences from a nephrological perspective at a single center]
    J Seckinger
    Klinik fur Innere Medizin I, Sektion Nephrologie, Medizinische Universitatsklinik Heidelberg, Heidelberg, Germany
    Dtsch Med Wochenschr 135:1973-8. 2010
    ..In CLKT, there appears to be a certain immunological protection for the kidney transplant by the liver transplant...
  37. ncbi Fatal varicella in an immunocompromised adult associated with a European genotype E2 variant of varicella zoster virus
    C Springfeld
    Department of Internal Medicine IV, University of Heidelberg, Heidelberg, Germany
    J Clin Virol 44:70-3. 2009
    ..The most effective method to prevent severe varicella in immunocompromised patients is active immunization prior to immunosuppressive therapy...
  38. ncbi Prophylactic and therapeutic vaccination with dendritic cells against hepatitis C virus infection
    J Encke
    Department of Internal Medicine IV, University of Heidelberg, Germany
    Clin Exp Immunol 142:362-9. 2005
    ..Our results indicate that HCV core pulsed DC may serve as a new modality for immunotherapy of HCV especially in chronically infected patients...
  39. ncbi Combination therapy with interferon-alpha 2b and ribavirin for the treatment of relapse patients and non-responders with chronic HCV infection
    B Kallinowski
    Dept of Internal Medicine, University of Heidelberg, Germany
    Z Gastroenterol 39:199-204, 206. 2001
    ....
  40. ncbi Immunogenicity of two accelerated hepatitis B vaccination protocols in liver transplant candidates
    S H Engler
    Department of Medicine, Division of Gastroenterology, University of Heidelberg, Bergheimerstrasse 58, 69115 Heidelberg, Germany
    Eur J Gastroenterol Hepatol 13:363-7. 2001
    ....
  41. ncbi Vacuolating cytotoxin of Helicobacter pylori induces apoptosis in the human gastric epithelial cell line AGS
    D Kuck
    Department of Medicine, University of Heidelberg, 69115 Heidelberg, Germany
    Infect Immun 69:5080-7. 2001
    ..These findings demonstrate that the vacuolating cytototoxin of H. pylori is a bacterial factor capable of inducing apoptosis in gastric epithelial cells...
  42. ncbi An early increase in gamma glutamyltranspeptidase and low aspartate aminotransferase peak values are associated with superior outcomes after orthotopic liver transplantation
    C Eisenbach
    Department of Gastroenterology, University of Heidelberg, Heidelberg, Germany
    Transplant Proc 41:1727-30. 2009
    ..Prediction of prognosis after liver transplantation (OLT) remains difficult. The present study determines if standard laboratory parameters measured within the first week after OLT correlate with outcome...
  43. ncbi Phosphatidylcholine and lysophosphatidylcholine in intestinal mucus of ulcerative colitis patients. A quantitative approach by nanoElectrospray-tandem mass spectrometry
    R Ehehalt
    Dept of Internal Medicine IV (Gastroenterology, University Hospital, Heidelberg, Germany
    Scand J Gastroenterol 39:737-42. 2004
    ..This suggests that a low amount of protective mucus PC is a characteristic feature in ulcerative colitis and explains an increased susceptibility to luminal contents...
  44. ncbi Clinical presentation, diagnosis and long-term outcome of Wilson's disease: a cohort study
    U Merle
    Department of Gastroenterology, University Hospital Heidelberg, Neuenheimer Feld 410, Heidelberg 69120, Germany
    Gut 56:115-20. 2007
    ..Wilson's disease is a rare inborn disease related to copper storage, leading to liver cirrhosis and neuropsychological deterioration. Clinical data on larger cohorts are limited owing to low disease frequency. Objective and..
  45. ncbi Regulatory CD4+CD25+ cells reverse imbalances in the T cell pool of bone marrow transplanted TGepsilon26 mice leading to the prevention of colitis
    C Veltkamp
    Department of Gastroenterology, University of Heidelberg, INF 410, 69120 Heidelberg, Germany
    Gut 54:207-14. 2005
    ..Colitis in bone marrow (BM) transplanted Tgepsilon26 mice is induced by abnormally activated T cells developing in an aberrant thymic microenvironment. We investigated the protective role of regulatory CD4+CD25+ T cells in this model...
  46. ncbi Progressive sclerosing cholangitis after septic shock: a new variant of vanishing bile duct disorders
    S Engler
    Department of Medicine, Division of Gastroenterology, Hepatology and Infectious Diseases, University of Heidelberg, Germany
    Gut 52:688-93. 2003
    ..We present nine patients with progressive sclerosing cholangitis after septic shock...
  47. ncbi Systemic chemotherapy with epirubicin for treatment of advanced or multifocal hepatocellular carcinoma
    J Pohl
    Department of Medicine, University Hospital, Heidelberg, Germany
    Chemotherapy 47:359-65. 2001
    ..The purpose of this retrospective study was to determine the response rate and effect on survival of chemotherapy with epirubicin in non-resectable advanced hepatocellular carcinoma (HCC)...
  48. ncbi Sodium, hydrogen antiporter activation by extracellular adenosine triphosphate in biliary epithelial cells
    C Elsing
    Department of Medicine, University of Heidelberg, Germany
    Gastroenterology 111:1321-32. 1996
    ..Extracellular nucleotides are secretagogues and influence ion permeability. The aim of this study was to investigate whether secretagogues activate transmembrane acid-base carriers, e.g., sodium, hydrogen antiporter in cholangiocytes...
  49. ncbi Seropositivity for MIA and S100 in patients with gastrointestinal carcinomas
    V Wagner
    Department of Medicine, Division of Gastroenterology, University of Heidelberg, Heidelberg, Germany
    Med Oncol 17:35-8. 2000
    ..Elevated serum levels of MIA and S100 are frequent in patients with gastrointestinal cancer. Further investigation is warranted to define the role of MIA or S100 seropositivity in gastrointestinal cancer with regard to follow-up...
  50. ncbi Immunogenicity of an accelerated vaccination regime with a combined hepatitis a/b vaccine in patients with chronic hepatitis C
    B Kallinowski
    Department of Internal Medicine IV, University of Heidelberg, Heidelberg, Germany
    Z Gastroenterol 41:983-90. 2003
    ..Hepatitis A (HAV) and B (HBV) vaccinations are recommended in patients with chronic liver diseases...
  51. ncbi CpG immuno-stimulatory motifs enhance humoral immune responses against hepatitis C virus core protein after DNA-based immunization
    J Encke
    Molecular Hepatology Laboratory, Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts, U S A
    Arch Virol 148:435-48. 2003
    ..Our results suggest that co-immunization with CpG-ODN may strengthen humoral immune responses but show no potential effect as an adjuvant to induce cellular immunity against HCV core...
  52. ncbi Involvement of the CD95 (APO-1/Fas) receptor and ligand system in Helicobacter pylori-induced gastric epithelial apoptosis
    J Rudi
    Department of Medicine, Division of Gastroenterology, University of Heidelberg
    J Clin Invest 102:1506-14. 1998
    ..These findings suggest that H. pylori-associated chronic gastritis involves apoptosis of gastric epithelial cells by activation of the CD95 receptor and ligand system...
  53. ncbi [Imported tropical malaria after a sojourn in Kenya. Serious consequences of neglected chemoprophylaxis and delayed diagnosis]
    L Schwake
    Abteilung für Gastroenterologie, Infektionskrankheiten und Vergiftungen, Universitatsklinikums Heidelberg
    Dtsch Med Wochenschr 126:1428-30. 2001
    ..Physical findings on admission included enlargement of liver and spleen, marked dehydration and a body temperature of 40.1 degrees C...
  54. ncbi Endoscopic variceal ligation plus propranolol vs. transjugular intrahepatic portosystemic stent shunt: a long-term randomized trial
    P Sauer
    Department of Internal Medicine, University of Heidelberg, Germany
    Endoscopy 34:690-7. 2002
    ....
  55. ncbi Helicobacter pylori vacA genotypes and cagA gene in a series of 383 H. pylori-positive patients
    J Rudi
    Medizinische Klinik IV Abteilung für Gastroenterologie, Ruprecht Karls Universitat, Heidelberg
    Z Gastroenterol 38:559-64. 2000
    ..Apart from immunological factors in the host, virulence determinants of H. pylori such as the vacuolating cytotoxin (VacA) or the cytotoxin-associated protein A (CagA) might represent a predisposition for the development of PUD...
  56. ncbi Peritoneal tuberculosis with negative polymerase chain reaction results: report of two cases
    L Schwake
    Dept of Internal Medicine IV Gastroenterology, University Hospital Heidelberg, Heidelberg, Germany
    Scand J Gastroenterol 38:221-4. 2003
    ..Empirical antituberculous treatment is justified in patients with clinical and histological features highly suggestive of peritoneal tuberculosis, even in cases with negative results from microscopy, culture and PCR analysis...
  57. ncbi [Pulmonal sarcoidosis: A rare side effect of interferon-alpha treatment for chronic hepatitis C infection]
    J Pohl
    Innere Medizin IV der Medizinischen Klinik und Poliklinik, Ruprecht Karls Universitat Heidelberg
    Z Gastroenterol 38:951-5. 2000
    ..Although there are only few reports about pulmonary sarcoidosis associated with interferon-alpha treatment, this entity should be included in the differential diagnosis of putative side effects of interferon-alpha therapy...
  58. ncbi Measurement of gastric emptying by 13C-octanoic acid breath test versus scintigraphy in diabetics
    A Zahn
    Innere Medizin IV, Medizinische Klinik IV, Klinikum der Universitat Heidelberg
    Z Gastroenterol 41:383-90. 2003
    ..It is not possible to predict diabetic gastroparesis on the basis of other autonomic function disorders or because of dyspeptic symptoms...
  59. ncbi [Veno-occlusive liver disease after total infradiaphragmatic lymphoid irradiation. A rare complication]
    M Bischof
    Abteilung für Klinische Radiologie Schwerpunkt Strahlentherapie Radiologische Klinik, Universitat Heidelberg
    Strahlenther Onkol 177:296-301. 2001
    ..Frequent side effects are pancytopenia, nausea and abdominal discomfort. A radiation-induced liver injury with serious clinical symptoms and changes in liver function is a rare complication...
  60. ncbi [Integrated skills laboratory concept for undergraduate training in internal medicine]
    C Nikendei
    Abteilung für Allgemeine Klinische und Psychosomatische Medizin, Medizinische Universitatsklinik Heidelberg
    Dtsch Med Wochenschr 130:1133-8. 2005
    ..We report here on the implementation and evaluation of an obligatory, tutor-guided, and integrated skills laboratory concept in the field of internal medicine...
  61. ncbi Electrogenicity of hepatocellular fatty acid uptake
    C Elsing
    Gastroenterology, Department of Medicine, University of Heidelberg, Bergheimerstrasse 58, D 69115 Heidelberg, Germany
    Eur J Med Res 3:393-6. 1998
    ..These data show that, at low fatty acid concentrations, uptake is, in part, driven by an intracellular negative electric membrane potential...
  62. ncbi Perforation of the esophagus after dilation treatment for dysphagia in a patient with eosinophilic esophagitis
    C Eisenbach
    Dept. of Gastroenterology, Heidelberg University Hospital, Heidelberg, Germany
    Endoscopy 38:E43-4. 2006
  63. ncbi Clinical impact of hepatitis G virus infection in heart and liver transplant recipients
    B Kallinowski
    Department of Gastroenterology and Hepatology, University of Heidelberg, Heidelberg, Germany
    Transplant Proc 34:2288-91. 2002
  64. ncbi [Hemoptysis and acute renal failure in a 29-year-old patient with chronic hepatitis C infection]
    J Marx
    Medizinische Klinik IV für Gastroenterologie und Infektiologie, Universitatsklinikum Heidelberg, Im Neuenheimer Feld 410, Heidelberg, Germany
    Internist (Berl) 49:1120-5. 2008
    ..An autoimmune disease should also be taken into account if new symptoms develop under an ongoing interferon alpha therapy...
  65. ncbi Role of apoptosis and CD95-receptor/ligand system in aspirin- and Helicobacter pylori-induced cell death
    S Domhan
    Department of Medicine, University of Heidelberg, Heidelberg, Germany
    Eur J Clin Invest 34:422-8. 2004
    ..pylori-induced apoptosis. Collectively our data demonstrate the relation of aspirin- and H. pylori-induced apoptosis from a new perspective...
  66. ncbi Tissue distribution and cDNA cloning of a human fatty acid transport protein (hsFATP4)
    B A Fitscher
    Department of Medicine, University Hospital of Heidelberg, Internal Medicine IV, Bergheimer Str 58, 69115 Heidelberg, Germany
    Biochim Biophys Acta 1443:381-5. 1998
    ..6 kb partial cDNA clone was isolated from a human heart cDNA library. With 5' and 3' RACE procedures, the complete cDNA was isolated. Sequence comparisons with its mouse homologues identified this clone as hsFATP4...
  67. ncbi Pantoprazole induces severe acute hepatitis
    C Sandig
    Department of Gastroenterology and Hepatology, University Hospital of Heidelberg, Heidelberg, Germany
    Z Gastroenterol 49:207-10. 2011
    ..One year earlier the patient had been treated with pantoprazole before and had developed a milder form of hepatitis then. This case argues for an idiosyncratic hepatocellular damage caused by pantoprazole...
  68. ncbi Enhanced caspase-8 recruitment to and activation at the DISC is critical for sensitisation of human hepatocellular carcinoma cells to TRAIL-induced apoptosis by chemotherapeutic drugs
    T M Ganten
    Divison of Apoptosis Regulation, German Cancer Research Center (DKFZ, Heidelberg, Germany
    Cell Death Differ 11:S86-96. 2004
    ....
  69. ncbi Expression and localization of the multidrug resistance proteins MRP2 and MRP3 in human gallbladder epithelia
    D Rost
    Division of Tumor Biochemistry, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Gastroenterology 121:1203-8. 2001
    ..Localization of MRP2 and MRP3 may provide an explanation of how the products of phase II conjugation are effluxed from gallbladder epithelia...
  70. ncbi Prophylaxis of hepatitis B recurrence after liver transplantation with lamivudin and hepatitis B immunoglobulin
    S Engler
    Department of Medicine IV, University of Heidelberg, Heidelberg, Germany
    Transplant Proc 34:2285-7. 2002
  71. ncbi Severe rhabdomyolysis and renal failure triggered by a sauna visit in sickle cell trait: a case report
    Ch Eisenbach
    Department of Gastroenterology, Infectious Diseases and Intoxications, University of Heidelberg, Germany
    Clin Nephrol 63:229-31. 2005
    ..Cases of sudden excertional deaths in individuals with SCT have been described. We here report an exceptional case of excessive rhabdomyolysis and acute renal failure triggered by a sauna visit in a 29 year-old African American with SCT...
  72. ncbi Interleukin-6 expression and regulation in rat enteric glial cells
    A Ruhl
    Department of Gastroenterology, University of Heidelberg, Bergheimer Str 58, D 69115 Heidelberg, Germany
    Am J Physiol Gastrointest Liver Physiol 280:G1163-71. 2001
    ..These findings strongly support the contention that enteric glial cells act as immunomodulatory cells in the enteric nervous system...
  73. ncbi IRP1 activation by extracellular oxidative stress in the perfused rat liver
    S Mueller
    Department of Internal Medicine IV, University of Heidelberg, Bergheimer Str 58, 69115, Germany
    J Biol Chem 276:23192-6. 2001
    ..It also provides a link between iron metabolism and the inflammatory response, as H(2)O(2) is a major product of the oxidative burst of neutrophils and macrophages...
  74. ncbi His1069Gln and six novel Wilson disease mutations: analysis of relevance for early diagnosis and phenotype
    H H Duc
    Department of Neurology, University Hospital, Dusseldorf, Germany
    Eur J Hum Genet 6:616-23. 1998
    ..Patients homozygous for the His1069Gln mutation showed almost the complete range of clinical presentations, and thus in our study this mutation is not associated with a late, neurological presentation...
  75. ncbi Copper in disorders with neurological symptoms: Alzheimer's, Menkes, and Wilson diseases
    D Strausak
    Center for Cellular and Molecular Biology, School of Biological and Chemical Sciences, Deakin University, Burwood, Victoria, Australia
    Brain Res Bull 55:175-85. 2001
    ..This could provide a rationale for a link between severely dysregulated metal-ion homeostasis and the selective neuronal pathology...
  76. ncbi Chances and shortcomins of adenovirus-mediated ATP7B gene transfer in Wilson disease: proof of principle demonstrated in a pilot study with LEC rats
    D Ha-Hao
    Medizinische Klinik IV, , Germany
    Z Gastroenterol 40:209-16. 2002
    ..As a consequence of successful but only transient therapeutic effect of adenoviral gene transfer we can now focus more efficient and permanent gene transfer strategies...
  77. ncbi [NASH -- nonalcoholic steatohepatitis]
    B Blechacz
    Medizinische Klinik der Universität Heidelberg, Abteilung Innere Medizin IV, Gastroenterologie, Infektionskrankheiten und Vergiftungen, Ruprecht Karls Universitat Heidelberg
    Z Gastroenterol 41:77-90. 2003
    ..The aim of this article is to show the actual knowledge of this disease, especially focussed on the pathogenesis, by review of the literature from 1979 up to the present time...
  78. ncbi Procalcitonin is a valid marker of infection in decompensated cirrhosis
    S Connert
    Department of Medicine, University of Heidelberg
    Z Gastroenterol 41:165-70. 2003
    ..CONCLUSION: In decompensated cirrhosis procalcitonin serum levels provided the most sensitive and specific tool for the initial diagnosis of bacterial infection...
  79. ncbi [Clinical usefulness and diagnostic value of percutaneous liver biopsy in patients with chronically elevated liver enzymes of non-viral origin]
    L Schwake
    Abteilung für Gastroenterologie, Infektionskrankheiten und Vergiftungen, Medizinische Klinik IV, Universitatsklinikum Heidelberg
    Z Gastroenterol 41:303-9. 2003
    ....
  80. ncbi [A young diabetic with small-nodule liver cirrhosis, high transferrin saturation and negative HFE test]
    M Eisold
    I. Medizinische Klinik,
    Dtsch Med Wochenschr 130:1494-6. 2005
    ..Therefore it is suggested to perform an ultrasound examination of the liver and an AFP-test every 6 months, whereas an MRI-scan should be performed once a year, as a basis for further treatment options...
  81. ncbi Interferon alfa2a induction therapy in combination with ribavirin and amantadine for the treatment of naive patients with chronic HCV infection
    S Engler
    Department of Medicine, Division of Gastroenterology, Hepatology and Infectious Diseases, University Hospital of Heidelberg, Germany
    J Viral Hepat 11:60-8. 2004
    ..In summary, induction therapy with 6 MU IFN alpha daily did not result in increased overall response rates compared with standard IFN alpha dosages of 6 MU tiw...
  82. ncbi The satiety factor apolipoprotein A-IV modulates intestinal epithelial permeability through its interaction with alpha-catenin: implications for inflammatory bowel diseases
    E Orso
    Institute for Clinical Chemistry and Laboratory Medicine, University Clinic of Regensburg, Regensburg, and Medical Clinic III, University Hospital Carl Gustav Carus, Dresden, Germany
    Horm Metab Res 39:601-11. 2007
    ..ApoA-IV was also analyzed in the intestinal mucosa of patients with inflammatory bowel diseases (IBD), together with other genes involved in epithelial junctional integrity...
  83. ncbi Immune responses against HCV-NS3 after accidental infection with HCV-NS3 recombinant vaccinia virus
    C Eisenbach
    J Viral Hepat 14:817-9. 2007