Research Topics
Species | Herbert SteppSummaryAffiliation: University of Munich Country: Germany Publications
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Detail Information
Publications
The future of medical diagnostics: review paperWaseem K Jerjes
Head and Neck Optical Diagnostics Society Council, International Society of Minimally Invasive Diagnostics, University College London, London, UK
Head Neck Oncol 3:38. 2011..The meeting included 2 sections: oral communication sessions running in parallel to the IPA programme and poster presentation sessions combined with the IPA and EPPM posters sessions...- At the frontiers of surgery: reviewTahwinder Upile
The Head and Neck Optical Diagnostics Society Council, Head and Neck Centre, University College Hospital, 250 Euston Road, London, NW1 2PG, UK
Head Neck Oncol 3:7. 2011..We review the salient advances in the field and propose further directions of investigation... - Head & neck optical diagnostics: vision of the future of surgeryTahwinder Upile
The Head and Neck Optical Diagnostics Society Council, Head and Neck Centre, University College Hospital, 250 Euston Road, London, NW1 2PG, UK
Head Neck Oncol 1:25. 2009..We are fortunate that this is indeed a possibility and may fundamentally change current clinical and surgical practice to improve our patients' lives... - ALA and malignant glioma: fluorescence-guided resection and photodynamic treatmentHerbert Stepp
Laser Forschungslabor, LIFE Center, University Clinic Munich Grosshadern, Marchioninistr 23, 81377 Munich, Germany
J Environ Pathol Toxicol Oncol 26:157-64. 2007..In the past few years, we have participated in several clinical studies designed to investigate fluorescence guided resection (FGR) and photodynamic therapy (PDT)... - Possibilities of lasers within NOTESHerbert Stepp
Laser Research Laboratory, LIFE Centre at University Munich, Marchioninistrasse 23, Munich, Germany
Minim Invasive Ther Allied Technol 19:274-80. 2010..NOTES training centres may support the propagation of the complex handling and the safety aspects for clinical use to the benefit of the patient... - [Fluorescence diagnosis and photodynamic therapy in urology]H Stepp
Laser Forschungslabor, LIFE Zentrum, Klinikum der Universitat Munchen
Aktuelle Urol 38:455-64. 2007..By providing an overview over methods and procedures as well as hitherto the available clinical results, we hope to provide reader with a basis for obtaining his/her own judgement... - Interstitial photodynamic therapy of nonresectable malignant glioma recurrences using 5-aminolevulinic acid induced protoporphyrin IXTobias J Beck
Laser Research Laboratory, Ludwig Maximilians University, Marchioninistr 23, 81377 Munich, Germany
Lasers Surg Med 39:386-93. 2007.... - In vitro photodynamic therapy of nasopharyngeal carcinoma using 5-aminolevulinic acidChristian S Betz
Department of Otorhinolaryngology Head and Neck Surgery, University of Munich, Marchioninistrasse 15, 81377 Munich, Germany
Photochem Photobiol Sci 1:315-9. 2002..Our investigations show promising results of 5-ALA based PDT of nasopharyngeal carcinoma in vitro and set the basis for future studies in tumor models or humans, respectively... - Seven years' experience with 5-aminolevulinic acid in detection of transitional cell carcinoma of the bladderEdwin Hungerhuber
Department of Urology, Klinikum Grosshadern, Ludwig Maximilians University of Munich, Munich, Germany
Urology 69:260-4. 2007..We report on our clinical results with 875 patients (1713 PDD procedures) between March 1995 and March 2002... - Photobleaching-based method to individualize irradiation time during interstitial 5-aminolevulinic acid photodynamic therapyGeorg Hennig
Laser Forschungslabor, LIFE Center, University Hospital of Munich, Marchioninistraße 23, 81377 Munich, Germany
Photodiagnosis Photodyn Ther 8:275-81. 2011..In conclusion, the relative fluorescence method offers the potential to individualize irradiation times to consume the photosensitizer within the target tissue during iPDT... - Ultraviolet-excited (308 nm) autofluorescence for bladder cancer detectionDirk Zaak
Department of Urology, Klinikum Grosshadern, Ludwig-Maximilians University of Munich, Munich, Germany
Urology 60:1029-33. 2002.... - Photodynamic effects induced by aminolevulinic acid esters on human cervical carcinoma cells in cultureW Xiang
Department of Obstetrics and Gynecology, Klinikum Grosshadern, Ludwig-Maximilians University, Munich, Germany
Photochem Photobiol 74:617-23. 2001..The results indicate that improved or at least comparable photodynamic effects can be achieved by using remarkably lower doses of ALA esters... - In-vivo kinetics of inhaled 5-aminolevulinic acid-induced protoporphyrin IX fluorescence in bronchial tissueHubert Hautmann
Medizinische Klinik I, Klinikum rechts der Isar, Technische Universitat, Munich, Germany
Respir Res 8:33. 2007..This investigation was to evaluate the in vivo tissue pharmacokinetics of inhaled 5-ALA within the bronchial mucosa in order to define the time optimum for its application prior to bronchoscopy... - 5-Aminolevulinic acid-induced protoporphyrin IX levels in tissue of human malignant brain tumorsAnn Johansson
Laser Forschungslabor, University Clinic Großhadern, Munich, Germany
Photochem Photobiol 86:1373-8. 2010..However, the feasibility of PDT for grade III brain tumors and for grade IV brain tumors displaying mainly necrotic tissue areas without solid tumor parts needs to be further investigated... - Quantification of 5-aminolevulinic acid induced fluorescence improves the specificity of bladder cancer detectionD Zaak
Department of Urology and Laser Research Laboratory, Klinikum Grosshadern, Ludwig-Maximilians-University of Munich, Munich, Germany
J Urol 166:1665-8; discussion 1668-9. 2001..It has the potential of eliminating human error by different surgeons with variable experience in fluorescence endoscopy... - Whole bladder photodynamic therapy with 5-aminolevulinic acid using a white light sourceR Waidelich
Department of Urology, University of Munich, Munich, Germany
Urology 61:332-7. 2003..The procedure is easy to perform and is not associated with any major side effects. The findings warrant long-term and multicenter studies... - Detection of bone marrow-derived cells expressing a neural phenotype in the human brainPetra Sostak
Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
J Neuropathol Exp Neurol 66:110-6. 2007..Cells with this specific phenotype may contribute to tissue repair in brain regions remote from neurogenic zones... - Integral spectrophotometric analysis of 5-aminolaevulinic acid-induced fluorescence cytology of the urinary bladderStephan Tauber
Urologische Klinik und Poliklinik, and Laser Forschungslabor, Klinikum Grosshadern der Universität München, Germany
BJU Int 97:992-6. 2006.... - Diagnosis of urothelial carcinoma of the bladder using fluorescence endoscopyDirk Zaak
Department of Urology, Klinikum Grosshadern, Ludwig Maixmilians University of Munich, Germany
BJU Int 96:217-22. 2005..However, the impact on the progression of disease remains unclear and must be investigated in prospective randomized trials... - [Fluorescence cytology. Improvement of urinary cytology]S Tritschler
Urologische Klinik und Poliklink, Klinikum Grosshadern, Ludwig Maximilians Universitat, Marchioninistrasse 15, 81377 Munchen
Urologe A 46:1121-3. 2007..This method is potentially able to compensate for the disadvantages of urinary cytology as it is an automated process that uses the principles of 5-Ala-induced photodynamic diagnosis (PDD)... - Optical coherence tomography for bladder cancer -- ready as a surrogate for optical biopsy? Results of a prospective mono-centre studyA Karl
Department of Urology, Ludwig Maximilians University Munich, Marchionistr 15, 81377 Munich, Germany
Eur J Med Res 15:131-4. 2010..The potential benefits and limitations of this new technology for the detection and evaluation of bladder cancer were examined in this study... - [Fluorescence cystoscopy at bladder cancer: present trials]D Zaak
Urologische Klinik und Poliklinik, Klinikum der Ludwig Maximilians Universität, Munchen, Germany
Urologe A 46:1519-27. 2007..Nevertheless, a resulting relatively decreased number of recurrences have still to be verified in prospective randomized trials... - Endoscopic measurements of free-flap perfusion in the head and neck region using red-excited Indocyanine Green: preliminary resultsC S Betz
Department of Otorhinolaryngology, Head and Neck Surgery, Ludwig Maximilian University, Grosshadern Medical Campus, Marchioninistr 15, D 81377 Munich, Germany
J Plast Reconstr Aesthet Surg 62:1602-8. 2009..Flap failures are relatively rare (<or=5%), and a high percentage can be salvaged if detected early. Indocyanine Green (ICG) angiography might be able to improve the detection of flap malperfusion at an early stage... - In vitro and in vivo evaluation of photodynamic techniques for the experimental treatment of human hepatoblastoma and neuroblastoma: preliminary resultsF Bergmann
Department of Pediatric Surgery, Dr v Haunersches Kinderspital, Ludwig Maximilians Universitat, Lindwurmstr 4, 80337, Munich, Germany
Pediatr Surg Int 24:1331-3. 2008..The purpose of this study was to test the susceptibility of human hepatoblastoma and neuroblastoma cells to photodynamic diagnostics (PDD) and photodynamic therapy (PDT) using 5-aminolevulinic acid (5-ALA) as a photosensitizer... - Fluorescence staining of oral cancer using a topical application of 5-aminolevulinic acid: fluorescence microscopic studiesA Leunig
Department of Otorhinolaryngology, University of Munich, Klinikum Grosshadern, Germany
J Photochem Photobiol B 60:44-9. 2001.... - Transurethral resection and surveillance of bladder cancer supported by 5-aminolevulinic acid-induced fluorescence endoscopyM Kriegmair
Department of Urology, University of Munich, and Institute of Pathology, University of Regensburg, Germany
Eur Urol 36:386-92. 1999..We determined whether neoplastic disease, which was missed under white light can be found during transurethral resection of bladder cancer by 5-aminolevulinic acid-induced porphyrin fluorescence... - Low frequency of colorectal dysplasia in patients with long-standing inflammatory bowel disease colitis: detection by fluorescence endoscopyT Ochsenkuhn
Department of Medicine II, Klinikum Grosshadern, University of Munich, Germany
Endoscopy 38:477-82. 2006..We combined this technique with random biopsies to prospectively evaluate the occurrence of dysplasias in patients with long-standing IBD... - Photodynamic therapy of vulvar intraepithelial neoplasia using 5-aminolevulinic acidP Hillemanns
Department of Obstetrics and Gynecology, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
Int J Cancer 85:649-53. 2000..However, multifocal VIN disease with pigmented and hyperkeratinic lesions remains difficult to treat... - Fluorescence-guided resection of glioblastoma multiforme by using 5-aminolevulinic acid-induced porphyrins: a prospective study in 52 consecutive patientsW Stummer
Department of Neurosurgery, Institute for Neuropathology, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
J Neurosurg 93:1003-13. 2000..In this study the authors analyze the influence of fluorescence-guided resection on postoperative magnetic resonance (MR) imaging and survival in a series of patients who underwent surgery in the authors' department... - Endoscopic detection of transitional cell carcinoma with 5-aminolevulinic acid: results of 1012 fluorescence endoscopiesD Zaak
Department of Urology, Klinikum Grosshadern, Ludwig-Maximilians-University, Munich, Germany
Urology 57:690-4. 2001..7% of these additionally detected neoplastic foci had poorly differentiated histologic features. CONCLUSIONS: AFE has proved to be a clinically feasible procedure with an outstanding detection rate for flat, urothelial, high-risk lesions... - Clinical experience with 5-aminolevulinic acid and photodynamic therapy for refractory superficial bladder cancerR Waidelich
Department of Urology, University of Munich, Munich, Germany
J Urol 165:1904-7. 2001..One should be aware of hemodynamic instability after the oral administration of 5-aminolevulinic acid, particularly in patients with cardiovascular co-morbidity... - Autofluorescence imaging to optimize 5-ALA-induced fluorescence endoscopy of bladder carcinomaD Frimberger
Department of Urology, Universitaetskrankenhaus Grosshadern der Ludwig-Maximilians Universitaet, Munich, Germany
Urology 58:372-5. 2001..The value of the method in reducing the false-positive rate of the highly sensitive AFE needs to be validated with higher numbers. The combination of AF with AFE had a 20% higher specificity than AFE alone in our study... - Validation of an ex vivo human cervical tissue model for optical imaging studiesJulia Gallwas
Department of Obstetrics and Gynecology, Ludwig Maximilians University, Munich, Germany
Lasers Surg Med 44:245-8. 2012..To establish and validate an ex vivo human cervical tissue model for optical coherence tomography (OCT) studies with special emphasis on investigating time dependent structural changes of the epithelium... - Autofluorescence spectroscopy for the diagnosis of cervical intraepithelial neoplasiaHelmut Weingandt
Department of Obstetrics and Gynaecology, University Munich-Grosshadern, 81377 Munich, Germany
BJOG 109:947-51. 2002..Using an excitation wavelength band between 375 and 440 nm, significant differences between normal and precancerous lesions of the cervix can be seen... - Optical coherence tomography (OCT): ready for the diagnosis of a nephrogenic adenoma of the urinary bladder?Alexander Karl
Ludwig Maximilians Universtiy, Department of Urology, Munich, Germany
J Endourol 22:2429-32. 2008..The examination of more NA cases would be necessary to base well-founded conclusions on. Further development of this technology could lead to an optical substitute for biopsies: especially apt for the field of endourology... - A comparative study of normal inspection, autofluorescence and 5-ALA-induced PPIX fluorescence for oral cancer diagnosisChristian S Betz
Department of Oto-Rhino-Laryngology/Head and Neck Surgery, Ludwig Maximilians University, Munich, Germany
Int J Cancer 97:245-52. 2002..The method is noninvasive, safe and easily reproducible... - Optical coherence tomography for the diagnosis of cervical intraepithelial neoplasiaJulia K S Gallwas
Department of Obstetrics and Gynecology, Ludwig Maximilian University Munich, Grosshadern Medical Campus, Marchioninistr 15, 81377 Munich, Germany
Lasers Surg Med 43:206-12. 2011..The purpose of this study was to evaluate the accuracy and reproducibility of OCT in the characterization of cervical intraepithelial neoplasia (CIN) and to distinguish between different CIN grades... - Transketolase-like protein 1 confers resistance to serum withdrawal in vitroDiana Hartmannsberger
Department of Otorhinolaryngology, Head and Neck Surgery, Grosshadern Medical Center, Ludwig Maximilians University of Munich, Marchioninistr 15, 81377 Munich, Germany
Cancer Lett 300:20-9. 2011..Primary head and neck squamous cell carcinomas of various localisations were characterised by a focal pattern with single cells strongly expressing TKTL1, rather than by a homogeneous expression pattern within the tumour mass... - Fluorescence diagnosis: a novel method to guide radical inguinal lymph node dissection in penile cancerD Frimberger
Department of Urology, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
World J Urol 22:150-4. 2004..More studies with higher patient numbers are necessary to evaluate optimal dosage and excitation conditions to detect tumor-bearing nodes in vivo... - Pharmacokinetics and selectivity of porphyrin synthesis after topical application of hexaminolevulinate in patients with cervical intraepithelial neoplasiaPeter Hillemanns
Department of Obstetrics and Gynecology, Hannover Medical School, Hannover, Germany
Am J Obstet Gynecol 198:300.e1-7. 2008..The purpose of this study was to examine the pharmacokinetics and selectivity of porphyrin synthesis after topical application of hexaminolevulinate (HAL) in patients with cervical intraepithelial neoplasia (CIN)... - Long-sustaining response in a patient with non-resectable, distant recurrence of glioblastoma multiforme treated by interstitial photodynamic therapy using 5-ALA: case reportWalter Stummer
Department of Neurosurgery, Heinrich Heine University, Moorenstr 5, 40225, Duesseldorf, Germany
J Neurooncol 87:103-9. 2008..Edema resolved completely. The patient is still free of recurrence 56 months after treatment, demonstrating an impressive and long-lasting response to this novel mode of therapy... - Role of 5-aminolevulinic acid in the detection of urothelial premalignant lesionsDirk Zaak
Department of Urology, Klinikum Grosshadern, Ludwig Maximilians University of Munich, Germany
Cancer 95:1234-8. 2002.... - [Fluorescence diagnosis with 5-ALA thermogel of cervical intraepithelial neoplasia]Vaagn Andikyan
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Gynakol Geburtshilfliche Rundsch 44:31-7. 2004..CONCLUSIONS: The thermogel Pluronic F127 seems to improve the local cervical drug application. Based on these results, we recommend the application of a 10% 5-ALA thermogel formulation 4-6 h prior to photodynamic therapy in CIN... - Study of protoporphyrin IX (PpIX) pharmacokinetics after topical application of 5-aminolevulinic acid in urethral condylomata acuminataXiu Li Wang
Shanghai Skin Diseases and STD Hospital, Shanghai, China, and University of Colorado at Denver, USA
Photochem Photobiol 83:1069-73. 2007..DNA typing showed that all patients were positive for low risk-HPV DNA and among them 18.3% of patients harbored high risk-HPV DNA... - Lymph node metastasis detection of ovarian cancer by porphyrin fluorescence photodetection: case reportPeter Hillemanns
Department of Obstetrics and Gynecology, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, 30625 Hannover, Germany
Lasers Med Sci 22:131-5. 2007..This data is a proof of the concept that porphyrin fluorescence-guided lymph node metastasis detection is possible in ovarian cancer and should stimulate further research in this field...