T Steiner

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. ncbi Low hemoglobin is associated with poor functional outcome after non-traumatic, supratentorial intracerebral hemorrhage
    Jennifer Diedler
    Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, Heidelberg, Germany
    Crit Care 14:R63. 2010
  2. ncbi [Acute stroke therapy. Current developments]
    T Steiner
    Neurologische Klinik, Universitatsklinikum, Heidelberg
    Nervenarzt 78:1147-54. 2007
  3. ncbi Dynamics of intraventricular hemorrhage in patients with spontaneous intracerebral hemorrhage: risk factors, clinical impact, and effect of hemostatic therapy with recombinant activated factor VII
    Thorsten Steiner
    Department of Neurology, Univesity of Heidelberg, Heidelberg, Germany
    Neurosurgery 59:767-73; discussion 773-4. 2006
  4. ncbi Early hemicraniectomy in patients with complete middle cerebral artery infarction
    S Schwab
    Department of Neurology, University of Heidelberg, Germany
    Stroke 29:1888-93. 1998
  5. ncbi Hemorrhagic transformation of ischemic brain tissue: asymptomatic or symptomatic?
    C Berger
    Department of Neurology, University of Heidelberg, Germany
    Stroke 32:1330-5. 2001
  6. ncbi [Intensive care management [corrected] of patients with intracerebral hemorrhage]
    J Diedler
    Neurologische Klinik, Ruprecht Karls Universitat Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg
    Nervenarzt 82:431-2, 434-6, 438-46. 2011
  7. ncbi EEG power spectrum to predict prognosis after hemicraniectomy for space-occupying middle cerebral artery infarction
    Jennifer Diedler
    Department of Neurology, University of Heidelberg, Heidelberg, Germany jennifer diedler med uni heidelberg de
    Cerebrovasc Dis 29:162-9. 2010
  8. ncbi Suboptimum hemicraniectomy as a cause of additional cerebral lesions in patients with malignant infarction of the middle cerebral artery
    S Wagner
    Department of Neurology, University of Heidelberg, Germany
    J Neurosurg 94:693-6. 2001
  9. ncbi Effect and feasibility of controlled rewarming after moderate hypothermia in stroke patients with malignant infarction of the middle cerebral artery
    T Steiner
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Stroke 32:2833-5. 2001
  10. ncbi Neurometabolic changes during treatment with moderate hypothermia in a patient suffering from severe middle cerebral artery infarction
    W R Schäbitz
    Department of Neurology, University of Heidelberg Medical School, Heidelberg, Germany
    Cerebrovasc Dis 12:298-302. 2001

Collaborators

Detail Information

Publications69

  1. ncbi Low hemoglobin is associated with poor functional outcome after non-traumatic, supratentorial intracerebral hemorrhage
    Jennifer Diedler
    Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, Heidelberg, Germany
    Crit Care 14:R63. 2010
    ..Here, we assessed the relationship between hemoglobin (HB) levels and clinical outcome after ICH...
  2. ncbi [Acute stroke therapy. Current developments]
    T Steiner
    Neurologische Klinik, Universitatsklinikum, Heidelberg
    Nervenarzt 78:1147-54. 2007
    ..We present preliminary results of the latest phase III trial (FAST: recombinant factor VIIa in acute hemorrhagic stroke), which tried to find whether the hemostatic effect will translate into clinical effect...
  3. ncbi Dynamics of intraventricular hemorrhage in patients with spontaneous intracerebral hemorrhage: risk factors, clinical impact, and effect of hemostatic therapy with recombinant activated factor VII
    Thorsten Steiner
    Department of Neurology, Univesity of Heidelberg, Heidelberg, Germany
    Neurosurgery 59:767-73; discussion 773-4. 2006
    ..To evaluate predictors of intraventricular hemorrhage (IVH) and IVH growth, impact of IVH growth on outcome, and impact of recombinant activated factor VII (rFVIIa) in patients with intracerebral hemorrhage (ICH)...
  4. ncbi Early hemicraniectomy in patients with complete middle cerebral artery infarction
    S Schwab
    Department of Neurology, University of Heidelberg, Germany
    Stroke 29:1888-93. 1998
    ..Several reports indicate a beneficial effect of hemicraniectomy in this situation. However, whether and when decompressive surgery is indicated in these patients is still a matter of debate...
  5. ncbi Hemorrhagic transformation of ischemic brain tissue: asymptomatic or symptomatic?
    C Berger
    Department of Neurology, University of Heidelberg, Germany
    Stroke 32:1330-5. 2001
    ..The aim of this study was to assess which type of HT independently affects clinical outcome...
  6. ncbi [Intensive care management [corrected] of patients with intracerebral hemorrhage]
    J Diedler
    Neurologische Klinik, Ruprecht Karls Universitat Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg
    Nervenarzt 82:431-2, 434-6, 438-46. 2011
    ..Whether improved intensive care can contribute to improved outcome after ICH will be shown by data obtained in the coming years...
  7. ncbi EEG power spectrum to predict prognosis after hemicraniectomy for space-occupying middle cerebral artery infarction
    Jennifer Diedler
    Department of Neurology, University of Heidelberg, Heidelberg, Germany jennifer diedler med uni heidelberg de
    Cerebrovasc Dis 29:162-9. 2010
    ..Here we applied spectral EEG analysis to determine the prognosis early after hemicraniectomy, while the patient is still treated in the intensive care unit...
  8. ncbi Suboptimum hemicraniectomy as a cause of additional cerebral lesions in patients with malignant infarction of the middle cerebral artery
    S Wagner
    Department of Neurology, University of Heidelberg, Germany
    J Neurosurg 94:693-6. 2001
    ..The goal of this study was to determine the frequency of hemicraniectomy-associated lesions and their potential effect on the risk of mortality in patients suffering from malignant infarction of the middle cerebral artery MCA)...
  9. ncbi Effect and feasibility of controlled rewarming after moderate hypothermia in stroke patients with malignant infarction of the middle cerebral artery
    T Steiner
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Stroke 32:2833-5. 2001
    ..However, during passive rewarming, ICP continuously rises and some patients suffer transtentorial herniation...
  10. ncbi Neurometabolic changes during treatment with moderate hypothermia in a patient suffering from severe middle cerebral artery infarction
    W R Schäbitz
    Department of Neurology, University of Heidelberg Medical School, Heidelberg, Germany
    Cerebrovasc Dis 12:298-302. 2001
    ..Microdialysis monitoring of therapeutic hypothermia in severe hemispheric infarction might be a useful additional monitoring tool to assess the status of the brain and to predict further deterioration...
  11. ncbi Multimodal online monitoring in middle cerebral artery territory stroke
    T Steiner
    Department of Neurology, Institute for Applied Mathematics, University of Heidelberg, Heidelberg, Germany
    Stroke 32:2500-6. 2001
    ..Furthermore, the effects of what is considered to be standard antiedema medical treatment are not fully understood. We studied whether multimodal monitoring can help to overcome this problem...
  12. ncbi Changes in cerebral blood flow and oxygen metabolism during moderate hypothermia in patients with severe middle cerebral artery infarction
    E Keller
    Department of Neurology, Neurocritical Care Unit, University of Heidelberg, Heidelberg, Germany
    Neurosurg Focus 8:e4. 2000
    ..The effect of hypothermia on cerebral hemodynamics is a matter of controversial discussion in literature. Clinical studies have yet to be performed in patients with ischemic stroke after induction of hypothermia...
  13. ncbi Hematoma growth and outcome in treated neurocritical care patients with intracerebral hemorrhage related to oral anticoagulant therapy: comparison of acute treatment strategies using vitamin K, fresh frozen plasma, and prothrombin complex concentrates
    Hagen B Huttner
    Department of Neurology, University of Heidelberg, Germany
    Stroke 37:1465-70. 2006
    ..The aim of the present study was to compare the acute treatment strategies of OAT-associated ICH using vitamin K (VAK), fresh frozen plasma (FFP), and prothrombin complex concentrates (PCCs) with regard to hematoma growth and outcome...
  14. ncbi Intensive care management of acute stroke: general management
    J Diedler
    Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, Heidelberg 69120, Germany
    Int J Stroke 4:365-78. 2009
    ..In part II of the review, surgical management options for acute stroke will be discussed in detail...
  15. ncbi Stroke magnetic resonance imaging within 6 hours after onset of hyperacute cerebral ischemia
    P D Schellinger
    Department of Neurology, University of Heidelberg Medical School, Germany
    Ann Neurol 49:460-9. 2001
    ..Patients with proximal vessel occlusions have a larger amount of tissue at risk, a lower recanalization rate, and a worse outcome. Urgent recanalization seems to be of utmost importance for these patients...
  16. ncbi [Intracerebral hemorrhage related to anticoagulant therapy]
    H B Huttner
    Abteilung fur Neurologie, Ruprecht Karls Universitat Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg
    Nervenarzt 77:671-2, 674-6, 678-81. 2006
    ..This article reviews the epidemiology of OAT-ICH, its pathophysiology, and current treatment options and discusses open questions with particular respect to more recent pharmacological therapies...
  17. ncbi [Indian chef with amnesia and muscle pain]
    T Lenhard

    Radiologe 44:1206-10. 2004
  18. ncbi [Ethical and legal aspects of including patients unable to consent in acute therapy studies. Example of a medication study for the treatment of intracerebral hemorrhage--the Heidelberg procedure]
    T Steiner
    Neurologische Klinik, Universitat Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg
    Dtsch Med Wochenschr 133:787-92. 2008
    ..Translation of these prerequisites into practice needs the implementation of special inclusion procedures. These procedures will be explained using the example of the recombinant factor VIIa (rFVIIa) trials for intracerebral hemorrhage...
  19. ncbi [Sudden onset of unilateral right-sided symptoms. Unilateral venous infarct of the left thalamus in thrombosis of the internal cerebral veins]
    M-A Weber
    Abteilung Neuroradiologie, , Heidelberg
    Radiologe 43:77-80. 2003
  20. ncbi [Continuous monitoring of patients with extensive strokes. Importance of monitoring on the neurological intensive care unit]
    T Steiner
    Universitatsklinikum Heidelberg, Neurologische Klinik, Im Neuenheimer Feld 400, 69120 Heidelberg
    Nervenarzt 73:501-7. 2002
    ..The following article attempts to explain methods of neurointensive care monitoring and its importance for the treatment of stroke. Furthermore, we describe new developments in patient monitoring...
  21. ncbi Monitoring intravenous recombinant tissue plasminogen activator thrombolysis for acute ischemic stroke with diffusion and perfusion MRI
    P D Schellinger
    Department of Neuroradiology, University of Heidelberg Medical School, Germany
    Stroke 31:1318-28. 2000
    ..We studied the feasibility of stroke MRI for the initial evaluation and follow-up monitoring of patients undergoing intravenous thrombolysis...
  22. ncbi [Treatment of acute clinical stroke]
    T Steiner
    Neurologische Klinik der Universität Heidelberg
    Anaesthesist 49:2-8. 2000
    ..Complications of acute stroke comprise changes of blood pressure with hemodynamically relevant effects on cerebral perfusion pressure, acute post- ischemic brain edema, and intracerebral bleedings...
  23. ncbi An integrated approach for a knowledge-based clinical workstation: architecture and experience
    B Brigl
    Department of Medical Informatics, University of Heidelberg, Germany
    Methods Inf Med 37:16-25. 1998
    ..We show that, although our approach promotes the integration of decision support into hospital information systems, the success of decision support depends above all on an adequate transformation of clinical needs...
  24. ncbi Autonomic impairment in tetanus: delayed baroreflex involvement
    Marek Sykora
    Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany
    J Neurol Sci 270:201-4. 2008
    ..Blood pressure instability could not be explained by baroreflex dynamics. We suggest that a shift towards sympathetic activity possibly overruled the effects of decreased baroreflex sensitivity on blood pressure regulation...
  25. ncbi MRI of the perihemorrhagic zone in a rat ICH model: effect of hematoma evacuation
    Berk Orakcioglu
    Department of Neurosurgery, University Hospital Heidelberg, Im Neuenheimer Feld 400, Heidelberg, Germany
    Neurocrit Care 8:448-55. 2008
    ..Recently, ischemic changes in the perihemorrhagic zone (PHZ) have been discussed as a potential source of secondary damage. In this study, we focussed on diffusion and perfusion characteristics of experimental ICH...
  26. ncbi Impaired baroreflex sensitivity predicts outcome of acute intracerebral hemorrhage
    Marek Sykora
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Crit Care Med 36:3074-9. 2008
    ..Baroreflex sensitivity (BRS) in spontaneous intracerebral hemorrhage has not been investigated. We sought to examine BRS in patients with intracerebral hemorrhage and evaluate the relationship between BRS and short-term outcome measures...
  27. ncbi Impaired baroreceptor reflex sensitivity in acute stroke is associated with insular involvement, but not with carotid atherosclerosis
    Marek Sykora
    Department of Neurology, University of Heidelberg, Germany
    Stroke 40:737-42. 2009
    ..The insula may play a central role in baroreflex modulation. The aim of the study was therefore to examine BRS in patients with acute stroke with regard to carotid atherosclerosis and insular involvement...
  28. ncbi Autonomic shift and increased susceptibility to infections after acute intracerebral hemorrhage
    Marek Sykora
    Department of Neurology, University Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Stroke 42:1218-23. 2011
    ..However, the underlying pathophysiology remains unclear. The aim of the current study was to investigate the role of autonomic shift in increased susceptibility to infection after acute intracerebral hemorrhage (ICH)...
  29. ncbi Blood pressure course in acute stroke relates to baroreflex dysfunction
    Marek Sykora
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Cerebrovasc Dis 30:172-9. 2010
    ..Baroreflex dysfunction has repeatedly been reported in stroke patients. We hypothesize that blood pressure (BP) derangements in the acute phase relate to the impairment of baroreflex...
  30. ncbi Options to restrict hematoma expansion after spontaneous intracerebral hemorrhage
    Thorsten Steiner
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Stroke 41:402-9. 2010
    ..The aim of this topical review is to give a summary of current evidence- and experience-based options to avoid or attenuate hematoma expansion...
  31. ncbi Intensive care management of acute stroke: surgical treatment
    Marek Sykora
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Int J Stroke 5:170-7. 2010
    ..Most recently, hopeful preliminary data have emerged on new approaches in the treatment of intraventricular haemorrhage. In this article, we review the current neurosurgical options in acute ischaemic and haemorrhagic stroke...
  32. ncbi Baroreflex: a new therapeutic target in human stroke?
    Marek Sykora
    Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Stroke 40:e678-82. 2009
    ..CONCLUSIONS: We suggest therefore that the modifying of autonomic functions may have important therapeutic implications in acute ischemic as well as in hemorrhagic stroke...
  33. ncbi Autoregulation and brain metabolism in the perihematomal region of spontaneous intracerebral hemorrhage: an observational pilot study
    Jennifer Diedler
    Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    J Neurol Sci 295:16-22. 2010
    ..A study in a larger population is needed to clarify the relationship between PRx and ORx in ICH patients, the local metabolic effects of autoregulatory failure and its relation to brain edema formation and clinical outcome...
  34. ncbi Quantitative EEG correlates of low cerebral perfusion in severe stroke
    Jennifer Diedler
    Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Neurocrit Care 11:210-6. 2009
    ..We aimed to identify parameters that may be used for continuous monitoring even in patients with a burst-suppression baseline EEG pattern...
  35. ncbi Subacute perihematomal edema in intracerebral hemorrhage is associated with impaired blood pressure regulation
    Marek Sykora
    Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    J Neurol Sci 284:108-12. 2009
    ..The aims of our study were therefore to explore the effects of impaired baroreflex on edema in acute ICH and to evaluate the effects of perihematomal edema on early neurologic deterioration...
  36. ncbi C-reactive-protein levels associated with infection predict short- and long-term outcome after supratentorial intracerebral hemorrhage
    Jennifer Diedler
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Cerebrovasc Dis 27:272-9. 2009
    ..The aim of the current study was to assess the occurrence of infection and its impact on the short- and long-term outcome of patients with supratentorial intracerebral hemorrhage (ICH)...
  37. ncbi Impaired cerebral vasomotor activity in spontaneous intracerebral hemorrhage
    Jennifer Diedler
    Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Stroke 40:815-9. 2009
    ..In the current study, we aimed to investigate cerebrovascular reactivity and its significance for outcome in spontaneous intracerebral hemorrhage...
  38. ncbi [When should you suspect meningitis?]
    Sören Huwendiek
    Universitätsklinik für, Kinder und Jugendmedizin Heidelberg
    MMW Fortschr Med 149:15-8. 2007
    ..The important task of the primary physician is to recognize the life-threatening condition in time and to refer the patient immediately to the next hospital...
  39. ncbi Intracerebral hemorrhage associated with oral anticoagulant therapy: current practices and unresolved questions
    Thorsten Steiner
    Department of Neurology, University of Heidelberg, Germany
    Stroke 37:256-62. 2006
    ..Early intervention focuses on rapid correction of coagulopathy in order to prevent continued bleeding...
  40. ncbi Evolution of early perihemorrhagic changes--ischemia vs. edema: an MRI study in rats
    Berk Orakcioglu
    Department of Neurology, University of Heidelberg, Germany; Department of Neurosurgery, University of Heidelberg, Germany
    Exp Neurol 193:369-76. 2005
    ..Future studies should focus on perfusion and metabolic/neurotoxic studies of this particular area and neurotoxic properties of the surrounding edema...
  41. ncbi Stroke unit design: intensive monitoring should be a routine procedure
    Thorsten Steiner
    Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, Heidelberg, Germany
    Stroke 35:1018-9. 2004
  42. ncbi Treatment and prevention of spontaneous intracerebral hemorrhage: comparison of EUSI and AHA/ASA recommendations
    Eric Juttler
    University of Heidelberg, Department of Neurology, Im Neuenheimer Feld 400, D 69120 Heidelberg, Germany
    Expert Rev Neurother 7:1401-16. 2007
    ..This review gives a comprehensive overview and comparison of the two recommendations. Finally, we provide an overview of ongoing clinical trials in intracerebral hemorrhage...
  43. ncbi Jugular venous oxygen saturation thresholds in trauma patients may not extrapolate to ischemic stroke patients: lessons from a preliminary study
    Emanuela Keller
    Department of Neurology, Neurocritical Care Unit, University of Heidelberg, Germany
    J Neurosurg Anesthesiol 14:130-6. 2002
    ..Jugular bulb oximetry should interpreted with caution in patients with severe hemispheric infarction. Critical thresholds defined in trauma patients may not be extrapolated to ischemic stroke...
  44. ncbi Effects of hypothermia on excitatory amino acids and metabolism in stroke patients: a microdialysis study
    Christian Berger
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Stroke 33:519-24. 2002
    ....
  45. ncbi Comparison of ABC/2 estimation technique to computer-assisted planimetric analysis in warfarin-related intracerebral parenchymal hemorrhage
    Hagen B Huttner
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Stroke 37:404-8. 2006
    ..Our objective was to validate the ABC/2 technique based on analyses of the hematoma shapes in OAT-related ICH...
  46. ncbi Treatment options for large hemispheric stroke
    T Steiner
    Department of Neurology, Heidelberg University Clinic, Heidelberg, Germany
    Neurology 57:S61-8. 2001
    ..Moderate hypothermia (33-36 degrees C) has recently been shown to be effective in severe MCA infarction. Hypothermia induction within 14 hours of ischemic injury and maintained for 72 hours significantly reduced ICP and mortality (44%)...
  47. ncbi Recommendations for the management of intracranial haemorrhage - part I: spontaneous intracerebral haemorrhage. The European Stroke Initiative Writing Committee and the Writing Committee for the EUSI Executive Committee
    Thorsten Steiner
    Department of Neurology, Ruprecht Karls University Heidelberg Im Neuenheimer Feld 400, DE-69120 Heidelberg, Germany
    Cerebrovasc Dis 22:294-316. 2006
    ..These recommendations are endorsed by the 3 European societies which are represented in the EUSI: the European Stroke Council, the European Neurological Society and the European Federation of Neurological Societies...
  48. ncbi Prognosis of stroke patients requiring mechanical ventilation in a neurological critical care unit
    T Steiner
    Department of Neurology, University of Heidelberg, Germany
    Stroke 28:711-5. 1997
    ..This study was performed to prospectively assess the prognosis of stroke patients who require ventilation in a neurological intensive care unit and to determine factors that may influence outcome...
  49. ncbi Masking of vertebral artery dissection by severe trauma to the cervical spine
    P D Schellinger
    Department of Neurology, University of Heidelberg, Germany
    Spine (Phila Pa 1976) 26:314-9. 2001
    ..A prospective case study was performed...
  50. ncbi Association of non-diabetic hyperglycemia with autonomic shift in acute ischaemic stroke
    M Sykora
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Eur J Neurol 19:84-90. 2012
    ..We hypothesize that hyperglycemia in acute stroke relates to autonomic imbalance and that the respective deleterious effects on stroke outcome may be cross-linked...
  51. ncbi Point-of-care reversal treatment in phenprocoumon-related intracerebral hemorrhage
    Timolaos Rizos
    Department of Neurology, University Heidelberg, Heidelberg, Germany
    Ann Neurol 67:788-93. 2010
    ..Accuracy and effectiveness of point-of-care INR coagulometers (POCs) for INR reversal in OAC-ICH have not been evaluated...
  52. ncbi [Therapy for spontaneous intracerebral haemorrhage]
    E Sammler
    Neurologische Klinik, Universitat Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg
    Nervenarzt 77:S39-48; quiz S49-50. 2006
    ..Those recommendations form the basis of this article...
  53. ncbi Transcranial oximetry using fast near infrared spectroscopy can detect failure of collateral blood supply in humans
    R Stingele
    Department of Neurology, Ruprecht Karls University, Heidelberg, Germany
    Comp Biochem Physiol A Mol Integr Physiol 134:539-43. 2003
    ..81+/-0.028, which was significantly different from all other groups (P<0.05, one way-ANOVA). We conclude, that transcranial pulse oximetry can detect local hypoxia if collateral blood supply fails...
  54. ncbi Prediction of intracranial pressure from noninvasive transocular venous and arterial hemodynamic measurements: a pilot study
    Henry W Querfurth
    Division of Neurology, St Elizabeth s Medical Center and Tufts University, Boston, MA 02135, USA
    Neurocrit Care 1:183-94. 2004
    ..The arteries that perfuse and the vein that drains the orbit are exposed to the ambient ICP while coursing through the cerebrospinal fluid or optic nerve...
  55. ncbi Determinants of intracerebral hemorrhage growth: an exploratory analysis
    Joseph P Broderick
    Department of Neurology, The Neuroscience Institute, University of Cincinnati Medical Center, Cincinnati, OH, USA
    Stroke 38:1072-5. 2007
    ..We report an exploratory analysis from a randomized study of recombinant activated factor VII (rFVIIa) in patients with intracerebral hemorrhage (ICH) examining potential factors associated with hemorrhage growth...
  56. ncbi Recombinant activated factor VII for acute intracerebral hemorrhage: US phase IIA trial
    Stephan A Mayer
    Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Neurocrit Care 4:206-14. 2006
    ..We conducted this trial to evaluate the safety of activated recombinant factor VII (rFVIIa; NovoSeven) for preventing early hematoma growth in acute ICH...
  57. ncbi Magnetic resonance imaging evidence of cytotoxic cerebral edema in acute mountain sickness
    Kai Kallenberg
    Department of Neuroradiology, Georg August University Medical Centre, University of Gottingen, Gottingen, Germany
    J Cereb Blood Flow Metab 27:1064-71. 2007
    ..5% of total brain volume...
  58. ncbi Treatment of warfarin-associated intracerebral hemorrhage: literature review and expert opinion
    Maria I Aguilar
    Department of Neurology, Mayo Clinic College of Medicine, 13400 E Shea Blvd, Scottsdale, AZ 85259, USA
    Mayo Clin Proc 82:82-92. 2007
    ..Reasonable management based on expert opinion includes a wide range of additional measures to reverse anticoagulation in the absence of solid evidence...
  59. ncbi Impact of recombinant activated factor VII on health-related quality of life after intracerebral hemorrhage
    Michael N Diringer
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Cerebrovasc Dis 24:219-25. 2007
    ..29%) and poor outcome (modified Rankin Scale, mRS, 4-6, 53 vs. 69%). This analysis was performed to determine the impact of rFVIIa on health-related quality of life (HRQoL) in those patients...
  60. ncbi Risk of thromboembolic events in controlled trials of rFVIIa in spontaneous intracerebral hemorrhage
    Michael N Diringer
    Department of Neurology, Campus Box 8111, Washington University School of Medicine, 660 South Euclid Ave, St Louis, MO 63110, USA
    Stroke 39:850-6. 2008
    ..Despite low incidences of such events in rFVIIa-treated hemophiliacs, the frequency in older patients with more atherosclerosis and immobility has yet to be defined...
  61. ncbi Efficacy and safety of recombinant activated factor VII for acute intracerebral hemorrhage
    Stephan A Mayer
    Department of Neurology, Columbia University College of Physicians and Surgeons, New York, USA
    N Engl J Med 358:2127-37. 2008
    ..We performed this phase 3 trial to confirm a previous study in which recombinant activated factor VII (rFVIIa) reduced growth of the hematoma and improved survival and functional outcomes...
  62. ncbi Safety and feasibility of recombinant factor VIIa for acute intracerebral hemorrhage
    Stephan A Mayer
    Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Stroke 36:74-9. 2005
    ..Activated recombinant factor VII (rFVIIa) promotes hemostasis at sites of vascular injury and may minimize hematoma growth after ICH...
  63. ncbi Recombinant activated factor VII for acute intracerebral hemorrhage
    Stephan A Mayer
    Department of Neurology, Columbia University College of Physicians and Surgeons, New York, USA
    N Engl J Med 352:777-85. 2005
    ..We sought to determine whether recombinant activated factor VII (rFVIIa) can reduce hematoma growth after intracerebral hemorrhage...
  64. ncbi Timing is everything in intracerebral hemorrhage
    Thorsten Steiner
    Stroke 39:e117-8; author reply e119-20. 2008
  65. ncbi American guidelines for the management of spontaneous intracerebral hemorrhage in adults: European perspective
    Thorsten Steiner
    Pol Arch Med Wewn 118:181-2. 2008
  66. ncbi Repetitive asystole in right insular haemorrhage
    Marek Sykora
    J Neurol Neurosurg Psychiatry 78:1282-3. 2007
  67. ncbi Factor VIIa for ICH: behind the scenes of an academic-industry collaborative trial
    Stephan A Mayer
    Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Int J Stroke 2:164-8. 2007